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The map label for this gene is pdhA [H]

Identifier: 46447367

GI number: 46447367

Start: 2072904

End: 2073932

Strand: Reverse

Name: pdhA [H]

Synonym: pc1733

Alternate gene names: 46447367

Gene position: 2073932-2072904 (Counterclockwise)

Preceding gene: 46447368

Following gene: 46447366

Centisome position: 85.9

GC content: 38.97

Gene sequence:

>1029_bases
ATGAAAACAGACGTTTTACCCCAGTTTTTTTCTGTAGACCAAGATGCTGTCATAAAAAAATTGGGACCGCAAGCTCTCAT
TGAATGCTTTCAGCAAATGTTAAAGATTCGAAATTTTGAACTTCGAGCAGAATCGGCCTATCAACAAGGTAAAATAGGGG
GATTCTTTCATGCTTATGTCGGCCAGGAAGCTATTCAGACAGCTGCTGTGCAAGCCATCGGGCAAAGCAATTGGTATGCA
ACTTCTTATCGTTGTCATGCTTTAGCTTTATTGCTCGGAGCTACTCCTAATGAATTAATGGCAGAACTTTATGGTCGAGC
AACAGGAAATGCAAAGGGCCGGGGAGGTTCCATGCATTTTTTCACTGATCGTTTGCTAGGAGGGTTTGGAATTGTAACAG
GTCAAGTTCCTATTGCTACTGGAGCTGCTTTTGCTTTAAAATATAAAGGAAATAAAAACGAAGTTGCTGTTTGTTTTATG
GGTGATGGGGCGGTTCCTCAAGGATCTTTTCATGAGTCATTAAATTTGGCTTCATTATGGAACTTACCTTGCATCTACGT
TATTGAAAATAATCAATGGGGAATGGGAACTGCTATTCAAAAAGCTGTAAGCGTTAAACGTTTGGCGGAAGATAAAGCAA
GTGGCTATAACATGAAAGCCTATACTCTTGATGGGATGGATTTTTTTAATTGTTATGGTGGTTTTGCTCAGATTCATCAA
GAAGTTTTACAAAGACAAAGACCGGTGCTAGTAGAAGTTGTTACTGAAAGATTTAAAGGACATTCTATTTCTGATCCGGG
TCTTTATCGTGCAAAAGATACCCTCAAGCAAATTATGGCAAAAGATCCGATTCTTGCTCTTCAAGCAGTTTTGATTAAAA
AAGGAATTTTAACAGAAGATATGGTCAAGCAAATGAACAAAGAAAACCGAGAGAAAATTATTGAGGCAATGTCTTTTGCA
GAAAATAGCCCATGGCCTGATCCGCAAACATTGGAAGAAGACGTATTCGCCCCCAATTTCATTGTATAG

Upstream 100 bases:

>100_bases
AAGAATTCAAAAAAAAATTTATAAACTATTTATTTTTTGTTTGCTATTTTTAATAATGGCGATAAAAGAAGATCCCAAAA
AAATGAAATGTAAGGCAGAA

Downstream 100 bases:

>100_bases
GAGTATACTCAATGAGCACTGAAAAGCAAACTATCGACATTAGAGAAGCGTTACGACAAGCAATTAATGAGGAAATGGCA
AGGGATTCTAGCGTTTTTGT

Product: putative pyruvate dehydrogenase (lipoamide), E1 component, alpha chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKTDVLPQFFSVDQDAVIKKLGPQALIECFQQMLKIRNFELRAESAYQQGKIGGFFHAYVGQEAIQTAAVQAIGQSNWYA
TSYRCHALALLLGATPNELMAELYGRATGNAKGRGGSMHFFTDRLLGGFGIVTGQVPIATGAAFALKYKGNKNEVAVCFM
GDGAVPQGSFHESLNLASLWNLPCIYVIENNQWGMGTAIQKAVSVKRLAEDKASGYNMKAYTLDGMDFFNCYGGFAQIHQ
EVLQRQRPVLVEVVTERFKGHSISDPGLYRAKDTLKQIMAKDPILALQAVLIKKGILTEDMVKQMNKENREKIIEAMSFA
ENSPWPDPQTLEEDVFAPNFIV

Sequences:

>Translated_342_residues
MKTDVLPQFFSVDQDAVIKKLGPQALIECFQQMLKIRNFELRAESAYQQGKIGGFFHAYVGQEAIQTAAVQAIGQSNWYA
TSYRCHALALLLGATPNELMAELYGRATGNAKGRGGSMHFFTDRLLGGFGIVTGQVPIATGAAFALKYKGNKNEVAVCFM
GDGAVPQGSFHESLNLASLWNLPCIYVIENNQWGMGTAIQKAVSVKRLAEDKASGYNMKAYTLDGMDFFNCYGGFAQIHQ
EVLQRQRPVLVEVVTERFKGHSISDPGLYRAKDTLKQIMAKDPILALQAVLIKKGILTEDMVKQMNKENREKIIEAMSFA
ENSPWPDPQTLEEDVFAPNFIV
>Mature_342_residues
MKTDVLPQFFSVDQDAVIKKLGPQALIECFQQMLKIRNFELRAESAYQQGKIGGFFHAYVGQEAIQTAAVQAIGQSNWYA
TSYRCHALALLLGATPNELMAELYGRATGNAKGRGGSMHFFTDRLLGGFGIVTGQVPIATGAAFALKYKGNKNEVAVCFM
GDGAVPQGSFHESLNLASLWNLPCIYVIENNQWGMGTAIQKAVSVKRLAEDKASGYNMKAYTLDGMDFFNCYGGFAQIHQ
EVLQRQRPVLVEVVTERFKGHSISDPGLYRAKDTLKQIMAKDPILALQAVLIKKGILTEDMVKQMNKENREKIIEAMSFA
ENSPWPDPQTLEEDVFAPNFIV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=312, Percent_Identity=36.2179487179487, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI4505685, Length=312, Percent_Identity=35.2564102564103, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI291084742, Length=312, Percent_Identity=35.2564102564103, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI291084744, Length=319, Percent_Identity=34.4827586206897, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI291084757, Length=313, Percent_Identity=30.9904153354633, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI258645172, Length=321, Percent_Identity=27.7258566978193, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI11386135, Length=321, Percent_Identity=27.7258566978193, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI32564172, Length=318, Percent_Identity=36.1635220125786, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17536047, Length=318, Percent_Identity=36.1635220125786, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI86563355, Length=330, Percent_Identity=26.6666666666667, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI86563357, Length=330, Percent_Identity=26.6666666666667, Blast_Score=120, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6321026, Length=315, Percent_Identity=38.4126984126984, Blast_Score=215, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24639748, Length=322, Percent_Identity=35.0931677018634, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24639740, Length=323, Percent_Identity=34.6749226006192, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24639744, Length=323, Percent_Identity=34.6749226006192, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI28571106, Length=323, Percent_Identity=34.6749226006192, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24639746, Length=310, Percent_Identity=35.1612903225806, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21355903, Length=349, Percent_Identity=23.7822349570201, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37821; Mature: 37821

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDVLPQFFSVDQDAVIKKLGPQALIECFQQMLKIRNFELRAESAYQQGKIGGFFHAYV
CCCCCCCHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHH
GQEAIQTAAVQAIGQSNWYATSYRCHALALLLGATPNELMAELYGRATGNAKGRGGSMHF
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHH
FTDRLLGGFGIVTGQVPIATGAAFALKYKGNKNEVAVCFMGDGAVPQGSFHESLNLASLW
HHHHHHCCCEEEECCCEEECCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHCCCHHHHH
NLPCIYVIENNQWGMGTAIQKAVSVKRLAEDKASGYNMKAYTLDGMDFFNCYGGFAQIHQ
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCHHHHHH
EVLQRQRPVLVEVVTERFKGHSISDPGLYRAKDTLKQIMAKDPILALQAVLIKKGILTED
HHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
MVKQMNKENREKIIEAMSFAENSPWPDPQTLEEDVFAPNFIV
HHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MKTDVLPQFFSVDQDAVIKKLGPQALIECFQQMLKIRNFELRAESAYQQGKIGGFFHAYV
CCCCCCCHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHH
GQEAIQTAAVQAIGQSNWYATSYRCHALALLLGATPNELMAELYGRATGNAKGRGGSMHF
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCHH
FTDRLLGGFGIVTGQVPIATGAAFALKYKGNKNEVAVCFMGDGAVPQGSFHESLNLASLW
HHHHHHCCCEEEECCCEEECCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHCCCHHHHH
NLPCIYVIENNQWGMGTAIQKAVSVKRLAEDKASGYNMKAYTLDGMDFFNCYGGFAQIHQ
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCHHHHHH
EVLQRQRPVLVEVVTERFKGHSISDPGLYRAKDTLKQIMAKDPILALQAVLIKKGILTED
HHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
MVKQMNKENREKIIEAMSFAENSPWPDPQTLEEDVFAPNFIV
HHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA