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The map label for this gene is aaaT [C]

Identifier: 46447368

GI number: 46447368

Start: 2074246

End: 2075505

Strand: Reverse

Name: aaaT [C]

Synonym: pc1734

Alternate gene names: 46447368

Gene position: 2075505-2074246 (Counterclockwise)

Preceding gene: 46447369

Following gene: 46447367

Centisome position: 85.96

GC content: 35.48

Gene sequence:

>1260_bases
ATGTGCAAAGAAGTCAAACACAAAATAAATCCAAATATATTTTTTGCTTTAGCAATCGTACTTGGTGTTTGTGCTGGCTA
TGTTCAAGAGCCTCTTATCTTTCAGACAGCAGAAACAATTTCTCAATTATTCATTAATTTGTTGAAATTAGTTAGTTTAC
CCATCATTTTTCTTTCCATTGTATCGACAGCTTCTGGAATGGAGAGTATGCATCAAATTAAAGTATTAGGCAAAAAAGTT
GCAAAATATACGCTTTTAACAACTATCATCGCTGCGACAATTGCTCTAATCCTATTTGTGGTTATTGATCCAGTTAGAGG
GCAAATCACTGTTAACGCCCAAGAAACGATCACTCAATCTTCGCAACCAACCTATCTAAAATTTTTTATCCAAATTATCC
CCTCTAATGTCATTCAACCATTTAATGAAAACAATGTGATTGGAGTTTTATTTTTAGCAATGTTACTTAGCTTTGCCATT
GTTTCTTTGCCCACTCAATCGAGAGCTGTCCTTCATTCTTTTTTTTCTAGTATTTATGCAGCGATTATTGTTATTACTCG
TTGGGTTGTGGCGCTTATGCCTATTGCAATTTGGGCATTTATTACTTTATTCATGTATGATTTAAAACAAGGATTAGACG
TCAAAAGCCTTGCACTTTATTTAACCGTTGTGATTTCCGCCAACCTTATTCAAGCTGGGTGCGTTTTACCTTTATTACTG
AAGTTAAAAAAAATTTCACCTCTTTTTATGATAAAAGGAATGCTACCGGCTTTGTCAATTGCATTTTTTACTAAATCTTC
TGCTGCTGCCTTACCAATGGCTATGCGTTGTGCAGAAGAAAATGTGGGAATTTCTCGCAAGGTTGCCAGTTTTACCCTTC
CTCTTTGTATAACAATTAATATGAATGCTTGCGCTGCATTTATATTGACAACTGTCTTGTTTGTTTCGATGAGCCAGGGC
ATTACCTATAGTTTTGCTGAAATGGGGCTTTGGATTATCTTATCAACAATTGCAGCCATAGGCAATGCTGGGGTTCCTAT
GGGTTGTTACTTTTTAGCCAGTGCGTTTTTAGCCGCTATGAATGTGCCTCTTCATATTTTAGGAATTATTTTACCTTTCT
ATTCGTTGATAGATATGCTAGAAAGTGCAATTAACGTATGGTCTGATTCTTGTGTAGCTGCGGTTGTTAATCAAGAAGTG
AAGCAAGAGCAAATTTCTTTCGATCAAACACCCATAGATTTGAATTCTGTCATTATTTAA

Upstream 100 bases:

>100_bases
CGTTGAATACTTCTCTTGAACCTTTGTAATTTTGTTAAAAGTAGAATGTTTAAGAGACTTACATGCATAAATTTTTCAGC
TCATTAACAAAAGGTTATCA

Downstream 100 bases:

>100_bases
ATTTAAGTTAACCAACTTTTTAACAACGGCAGTTGGTTGTTATTATCAATTGTCAACGAATTGGTTGTATTCTTATACCA
TTTCTTTTTAAAAAGAAAAT

Product: putative neutral amino acid (glutamate) transporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MCKEVKHKINPNIFFALAIVLGVCAGYVQEPLIFQTAETISQLFINLLKLVSLPIIFLSIVSTASGMESMHQIKVLGKKV
AKYTLLTTIIAATIALILFVVIDPVRGQITVNAQETITQSSQPTYLKFFIQIIPSNVIQPFNENNVIGVLFLAMLLSFAI
VSLPTQSRAVLHSFFSSIYAAIIVITRWVVALMPIAIWAFITLFMYDLKQGLDVKSLALYLTVVISANLIQAGCVLPLLL
KLKKISPLFMIKGMLPALSIAFFTKSSAAALPMAMRCAEENVGISRKVASFTLPLCITINMNACAAFILTTVLFVSMSQG
ITYSFAEMGLWIILSTIAAIGNAGVPMGCYFLASAFLAAMNVPLHILGIILPFYSLIDMLESAINVWSDSCVAAVVNQEV
KQEQISFDQTPIDLNSVII

Sequences:

>Translated_419_residues
MCKEVKHKINPNIFFALAIVLGVCAGYVQEPLIFQTAETISQLFINLLKLVSLPIIFLSIVSTASGMESMHQIKVLGKKV
AKYTLLTTIIAATIALILFVVIDPVRGQITVNAQETITQSSQPTYLKFFIQIIPSNVIQPFNENNVIGVLFLAMLLSFAI
VSLPTQSRAVLHSFFSSIYAAIIVITRWVVALMPIAIWAFITLFMYDLKQGLDVKSLALYLTVVISANLIQAGCVLPLLL
KLKKISPLFMIKGMLPALSIAFFTKSSAAALPMAMRCAEENVGISRKVASFTLPLCITINMNACAAFILTTVLFVSMSQG
ITYSFAEMGLWIILSTIAAIGNAGVPMGCYFLASAFLAAMNVPLHILGIILPFYSLIDMLESAINVWSDSCVAAVVNQEV
KQEQISFDQTPIDLNSVII
>Mature_419_residues
MCKEVKHKINPNIFFALAIVLGVCAGYVQEPLIFQTAETISQLFINLLKLVSLPIIFLSIVSTASGMESMHQIKVLGKKV
AKYTLLTTIIAATIALILFVVIDPVRGQITVNAQETITQSSQPTYLKFFIQIIPSNVIQPFNENNVIGVLFLAMLLSFAI
VSLPTQSRAVLHSFFSSIYAAIIVITRWVVALMPIAIWAFITLFMYDLKQGLDVKSLALYLTVVISANLIQAGCVLPLLL
KLKKISPLFMIKGMLPALSIAFFTKSSAAALPMAMRCAEENVGISRKVASFTLPLCITINMNACAAFILTTVLFVSMSQG
ITYSFAEMGLWIILSTIAAIGNAGVPMGCYFLASAFLAAMNVPLHILGIILPFYSLIDMLESAINVWSDSCVAAVVNQEV
KQEQISFDQTPIDLNSVII

Specific function: This Carrier Protein Is Part Of The Na(+)-Independent, Binding-Protein-Independent Glutamate-Aspartate Transport System. [C]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=411, Percent_Identity=24.5742092457421, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI169790839, Length=483, Percent_Identity=24.8447204968944, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI223468566, Length=270, Percent_Identity=26.6666666666667, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4827012, Length=280, Percent_Identity=28.2142857142857, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI223468564, Length=262, Percent_Identity=26.7175572519084, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI5032093, Length=270, Percent_Identity=26.6666666666667, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI40254478, Length=471, Percent_Identity=22.9299363057325, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI66773030, Length=266, Percent_Identity=26.3157894736842, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI194239697, Length=261, Percent_Identity=27.2030651340996, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI262359914, Length=218, Percent_Identity=30.7339449541284, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI301601644, Length=142, Percent_Identity=29.5774647887324, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790514, Length=424, Percent_Identity=23.8207547169811, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789947, Length=411, Percent_Identity=24.330900243309, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788024, Length=389, Percent_Identity=23.6503856041131, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193206505, Length=438, Percent_Identity=27.6255707762557, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=463, Percent_Identity=26.7818574514039, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71983099, Length=460, Percent_Identity=25.2173913043478, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=460, Percent_Identity=25.2173913043478, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17537407, Length=446, Percent_Identity=25.3363228699552, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17541374, Length=414, Percent_Identity=26.3285024154589, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI193206654, Length=415, Percent_Identity=26.0240963855422, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24583025, Length=406, Percent_Identity=24.6305418719212, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17137668, Length=406, Percent_Identity=24.6305418719212, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24583023, Length=406, Percent_Identity=24.6305418719212, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45675; Mature: 45675

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]