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The map label for this gene is atpB

Identifier: 46447313

GI number: 46447313

Start: 2015824

End: 2017140

Strand: Reverse

Name: atpB

Synonym: pc1679

Alternate gene names: 46447313

Gene position: 2017140-2015824 (Counterclockwise)

Preceding gene: 46447314

Following gene: 46447312

Centisome position: 83.54

GC content: 36.6

Gene sequence:

>1317_bases
ATGAAAATTGTTTATGATCGAATCAATAATATGCGTGGAAACCTTATTACGATAACAGCTGAAGGAGTTAGTCTCGGTGA
ACTAGCACGTATAGATTTAAAAGATGGAAGAAATATTTATGCTTCCGTACTCCGTATCGACGGAGATCAAGTAACCTTAC
AAGTGTTTCAGACGACTCGTGGAATTTCAACTAGTGATCAAGTCACTTTTTTAAATCGACAAATGCAAGCAGTTTATGGA
GACACTTTACTTGGAAGGCGTTTAAGTGGAACTGGATTACCTATTGACGGAGGACCTCAGGTTATAGGAGAGTCAATTGA
TATTGGATCAACTTCTTTCAATCCTGTTAAGAGAATTGTTCCAAGAGATATGGTTCGAACAAATATTCCTATGATTGATG
TTTTCAATTGCCTAGTCAAATCTCAAAAAATTCCCATTTTTTCAGTTCCTGGAGAGCCATATAATGCTCTTCTTATGCGT
ATTGCGAATCAAACTGATGCAGATGTCGTCATAATTGGTGGGATGGGATTAACCTTTAAAGAATATCAAGCTTTTATTGA
AAATGCTGAAACAGCCGGAACAATTAATAAAACTGTGATGTTTATTCATCGAGCAACTGACCCAGCTGTTGAATGCTTAC
TTGTACCAGATATGGCTCTTGCTTGCGCTGAACGTTTTGCAACAGATGGTAAAAATGTTTTAGTGCTATTAACAGATATG
ACTGCTTTTGCAGATGCAATTAAAGAAATAGCAATTACGATGGACCAAGTCCCTTCCAATCGAGGTTATCCAGGTTCTTT
ATATTCTGATTTGGCATCTCGATATGAAAAAGCAGTCTCTATCGAAGATAGCGGTTCAATTACAGTTATTGGGGTAACTA
CAATGCCCGGAGATGATGTGACTCATCCAGTTCCTGATAATACTGGTTACATCACTGAAGGACAGTTTTATTTACACCAT
GGTAAAATAGATCCTTTTGGATCTTTATCTCGTTTGAAACAACTTGTGATTGGGAAAGTCACTCGAGATGATCATGGTGA
TTTAGCCAATGCGATGATTCGTTTGTATGCTGAATCCAAAAAAGCAAGAGAGCGGCAAGCTATGGGTTTTAAACTTTCTA
AGTGGGATGAAAAGCTTCTTACTTATTCTCATTTATTTGAAGAAAGAATGATGAATTTAGAAGTAAATTATACTTTAGAA
GAAGCTTTAGATCTTGGATGGGAAACGTTAGCAGAATGCTTTCTAGCAAGCGAAGTTGGAATTAAGGAAAGTGTTATTTC
TAAATATTGGCCAGAAATTGCTCAAATAAGTAAGTGA

Upstream 100 bases:

>100_bases
ATTTTATTTCTTTTGATACTGAACAATACCGAAAGGTATTTGCAGAAATTAAAAGCATTATCGAACAACAATCTCGGAAA
TAATTAAAGGATACCATCAT

Downstream 100 bases:

>100_bases
TTGAGGGGTGATTTGTGGCTGATGTCAAATTAACAAAAAATGAGTTGCGTGACCAACAAATGCAACTTGTACAATTAGAA
AAGTATTTGCCAACTTTACA

Product: V-type ATP synthase subunit B

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit B

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKIVYDRINNMRGNLITITAEGVSLGELARIDLKDGRNIYASVLRIDGDQVTLQVFQTTRGISTSDQVTFLNRQMQAVYG
DTLLGRRLSGTGLPIDGGPQVIGESIDIGSTSFNPVKRIVPRDMVRTNIPMIDVFNCLVKSQKIPIFSVPGEPYNALLMR
IANQTDADVVIIGGMGLTFKEYQAFIENAETAGTINKTVMFIHRATDPAVECLLVPDMALACAERFATDGKNVLVLLTDM
TAFADAIKEIAITMDQVPSNRGYPGSLYSDLASRYEKAVSIEDSGSITVIGVTTMPGDDVTHPVPDNTGYITEGQFYLHH
GKIDPFGSLSRLKQLVIGKVTRDDHGDLANAMIRLYAESKKARERQAMGFKLSKWDEKLLTYSHLFEERMMNLEVNYTLE
EALDLGWETLAECFLASEVGIKESVISKYWPEIAQISK

Sequences:

>Translated_438_residues
MKIVYDRINNMRGNLITITAEGVSLGELARIDLKDGRNIYASVLRIDGDQVTLQVFQTTRGISTSDQVTFLNRQMQAVYG
DTLLGRRLSGTGLPIDGGPQVIGESIDIGSTSFNPVKRIVPRDMVRTNIPMIDVFNCLVKSQKIPIFSVPGEPYNALLMR
IANQTDADVVIIGGMGLTFKEYQAFIENAETAGTINKTVMFIHRATDPAVECLLVPDMALACAERFATDGKNVLVLLTDM
TAFADAIKEIAITMDQVPSNRGYPGSLYSDLASRYEKAVSIEDSGSITVIGVTTMPGDDVTHPVPDNTGYITEGQFYLHH
GKIDPFGSLSRLKQLVIGKVTRDDHGDLANAMIRLYAESKKARERQAMGFKLSKWDEKLLTYSHLFEERMMNLEVNYTLE
EALDLGWETLAECFLASEVGIKESVISKYWPEIAQISK
>Mature_438_residues
MKIVYDRINNMRGNLITITAEGVSLGELARIDLKDGRNIYASVLRIDGDQVTLQVFQTTRGISTSDQVTFLNRQMQAVYG
DTLLGRRLSGTGLPIDGGPQVIGESIDIGSTSFNPVKRIVPRDMVRTNIPMIDVFNCLVKSQKIPIFSVPGEPYNALLMR
IANQTDADVVIIGGMGLTFKEYQAFIENAETAGTINKTVMFIHRATDPAVECLLVPDMALACAERFATDGKNVLVLLTDM
TAFADAIKEIAITMDQVPSNRGYPGSLYSDLASRYEKAVSIEDSGSITVIGVTTMPGDDVTHPVPDNTGYITEGQFYLHH
GKIDPFGSLSRLKQLVIGKVTRDDHGDLANAMIRLYAESKKARERQAMGFKLSKWDEKLLTYSHLFEERMMNLEVNYTLE
EALDLGWETLAECFLASEVGIKESVISKYWPEIAQISK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit

COG id: COG1156

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit B

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913426, Length=441, Percent_Identity=35.827664399093, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI19913428, Length=467, Percent_Identity=34.9036402569593, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI32189394, Length=309, Percent_Identity=23.6245954692557, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788251, Length=347, Percent_Identity=26.2247838616715, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790170, Length=324, Percent_Identity=24.0740740740741, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790172, Length=348, Percent_Identity=22.7011494252874, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17570191, Length=465, Percent_Identity=35.0537634408602, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17510931, Length=464, Percent_Identity=34.9137931034483, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71988080, Length=295, Percent_Identity=24.7457627118644, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71988063, Length=295, Percent_Identity=24.7457627118644, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25144756, Length=304, Percent_Identity=24.6710526315789, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988074, Length=131, Percent_Identity=28.2442748091603, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319603, Length=443, Percent_Identity=35.8916478555305, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319370, Length=296, Percent_Identity=25, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322581, Length=313, Percent_Identity=23.3226837060703, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281361666, Length=464, Percent_Identity=34.4827586206897, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24646341, Length=464, Percent_Identity=34.4827586206897, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI17136796, Length=464, Percent_Identity=34.4827586206897, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24658560, Length=290, Percent_Identity=24.8275862068966, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24638766, Length=293, Percent_Identity=24.2320819112628, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574560, Length=318, Percent_Identity=25.4716981132075, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): VATB_PARUW (Q6MAJ6)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008678.1
- ProteinModelPortal:   Q6MAJ6
- SMR:   Q6MAJ6
- STRING:   Q6MAJ6
- GeneID:   2779778
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1679
- NMPDR:   fig|264201.1.peg.1679
- eggNOG:   COG1156
- HOGENOM:   HBG565875
- OMA:   KMENGFD
- PhylomeDB:   Q6MAJ6
- ProtClustDB:   PRK02118
- BioCyc:   CPRO264201:PC1679-MONOMER
- HAMAP:   MF_00310
- InterPro:   IPR000194
- InterPro:   IPR004100
- InterPro:   IPR022879

Pfam domain/function: PF00006 ATP-synt_ab; PF02874 ATP-synt_ab_N

EC number: 3.6.3.14

Molecular weight: Translated: 48438; Mature: 48438

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVYDRINNMRGNLITITAEGVSLGELARIDLKDGRNIYASVLRIDGDQVTLQVFQTTR
CEEEHHHHCCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEEEEECCCEEEEEEEEHHC
GISTSDQVTFLNRQMQAVYGDTLLGRRLSGTGLPIDGGPQVIGESIDIGSTSFNPVKRIV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHC
PRDMVRTNIPMIDVFNCLVKSQKIPIFSVPGEPYNALLMRIANQTDADVVIIGGMGLTFK
CHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCCHH
EYQAFIENAETAGTINKTVMFIHRATDPAVECLLVPDMALACAERFATDGKNVLVLLTDM
HHHHHHHCCCCCCCCCEEEEEEEECCCCHHEEEECCHHHHHHHHHHHCCCCCEEEEEECH
TAFADAIKEIAITMDQVPSNRGYPGSLYSDLASRYEKAVSIEDSGSITVIGVTTMPGDDV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEECCCCEEEEEEEECCCCCC
THPVPDNTGYITEGQFYLHHGKIDPFGSLSRLKQLVIGKVTRDDHGDLANAMIRLYAESK
CCCCCCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
KARERQAMGFKLSKWDEKLLTYSHLFEERMMNLEVNYTLEEALDLGWETLAECFLASEVG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHCCHHHHHHHHHHHHCC
IKESVISKYWPEIAQISK
HHHHHHHHHCHHHHHCCC
>Mature Secondary Structure
MKIVYDRINNMRGNLITITAEGVSLGELARIDLKDGRNIYASVLRIDGDQVTLQVFQTTR
CEEEHHHHCCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEEEEECCCEEEEEEEEHHC
GISTSDQVTFLNRQMQAVYGDTLLGRRLSGTGLPIDGGPQVIGESIDIGSTSFNPVKRIV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHC
PRDMVRTNIPMIDVFNCLVKSQKIPIFSVPGEPYNALLMRIANQTDADVVIIGGMGLTFK
CHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCCHH
EYQAFIENAETAGTINKTVMFIHRATDPAVECLLVPDMALACAERFATDGKNVLVLLTDM
HHHHHHHCCCCCCCCCEEEEEEEECCCCHHEEEECCHHHHHHHHHHHCCCCCEEEEEECH
TAFADAIKEIAITMDQVPSNRGYPGSLYSDLASRYEKAVSIEDSGSITVIGVTTMPGDDV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEECCCCEEEEEEEECCCCCC
THPVPDNTGYITEGQFYLHHGKIDPFGSLSRLKQLVIGKVTRDDHGDLANAMIRLYAESK
CCCCCCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
KARERQAMGFKLSKWDEKLLTYSHLFEERMMNLEVNYTLEEALDLGWETLAECFLASEVG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHCCHHHHHHHHHHHHCC
IKESVISKYWPEIAQISK
HHHHHHHHHCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Borate; Diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines various reactions catalyzed by ATPase, analogs; Oligomycin; Quercetin; Trialkyl tinderivatives; Venturicidin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA