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The map label for this gene is ntpA

Identifier: 46447314

GI number: 46447314

Start: 2017158

End: 2018939

Strand: Reverse

Name: ntpA

Synonym: pc1680

Alternate gene names: 46447314

Gene position: 2018939-2017158 (Counterclockwise)

Preceding gene: 46447315

Following gene: 46447313

Centisome position: 83.62

GC content: 37.88

Gene sequence:

>1782_bases
ATGAAAACTTTAGAGACTAGAAAAGAAAAAAAAGCCCAAGGAAAAGTTCTTAAAGCTTTTGGAAACTTACTTCAAGTTAC
ATTTGAAGGAAATATTCGACAAGGTGAAGTGGCTATGGTTCATGTGGACAACCTTCAACTAAAATCGGAAGTAATTGAAA
TTCTTGGTAATCAAGCTAAAATTCAAGTATTTGAAGATACAAAAGGAGTTCGTTTAGGTAGCTTAGTTAGTTTTACAGGA
GATTTGTTAGAAGCTGAATTAGGCCCGGGTCTTTTAAGTTCGATTTTTGATGGTCTGCAAAATCCTTTAGTGGATGTTGC
TGATCAAGCTGGCCTCTTTTTACCAAAAGGAATTTATTTATCTGCGCTGGATCGTCAAAGGAAATGGGATTTTGAATCTT
CTGCTAAGGTTGGGGATGTTCTTTTCAGAGGAGATCGGATTGGTTCGACAAAAGAGGGTCGTTTTCATCACTTTATTATG
GTTCCATTCTCATTATATGGAAAATATCGCTTAACATGGGTAATAAATTCAGGTTCTTACACTGTTGATACAGTTGTTGC
CAAAGCTATAGATGAATCCGGCCAAGAACATTCTTTTACCATGGTTCAAAAATGGCCTGTCAAAAATGCCCTTATCCATG
GAGAAAAAATTAAGCCGACTAAGATGATGGATACCGGCGAAAGGATTATAGATACACAATTTCCTTTAATGAAAGGGGGT
ACCTTTTGTACTCCTGGGCCATTTGGAGCTGGTAAAACTGTTTTGCAGCATCATCTTTCGAAATATGCGGCAGTGGACAT
TGTTTTATTTGTAGCTTGTGGAGAACGTGCAGGAGAAGTTGTTGAAGTATTAAGAGAGTTTCCGCATTTGATTGATCCCC
ATACTGACGAAGCACTAATGAAGAGAACAGTGATTATTTGCAACACTTCATCTATGCCTGTTGCCGCTCGAGAGTCATCT
ATTTATATGGGTATTACCATAGCTGAGTATTATAGACAGATGGGGTTGGATGTTCTAGTTTTAGCTGATTCAACTTCCAG
ATGGGCTCAGGCTTTGCGTGAAATGTCCGGGCGATTAGAAGAAATTCCAGGAGAGGAAGCTTTTCCCGCTTATTTATCTT
CCCGAATAGCAGAGTTTTACGAGCGTTCTGGTGTGGTCTCTCTTCGTCATGGTAAACCAGGCTCTATTACGATCGGAGGA
GCAGTTTCACCTGCAGGAGGAAACTTCGAGGAACCTGTAACGCAAGCAACTTTATCAGTGGTAGGTGCTTTCCTTGGGCT
ATCAAGAGCTCGTTCTGATTCAAGACGTTACCCAGCAATAGATCCATTATTATCTTGGTCTAAGTATGTTGATACAGTTG
GAAATGAACTTAGTCATCAAGTTGATGGATGGGATCAAATGGTTAAGCGAGCTCGGCATATTTTATTTAATGGAAATGAA
ATTGGAAAGCGAATGGAAGTGGTGGGAGAAGAGGGAATATCGATGGAAGATATGCTTACTTATCTCAAAGCTGAGCTTTA
TGATTTTAGTTATTTACAGCAAAATGCTTTTGACAAAGAAGATGCTTATTGCCCGTTAAAAAGGCAAATAGCTTTGTTTC
AATTAATTAATCAAATTTTTGACACAACTTTCGATTTTCATACACATGATCAAGCTCGTGAATTTTTCTTGGATTTACAA
AATCGTATTAAAAACATGAATTTTATTTCTTTTGATACTGAACAATACCGAAAGGTATTTGCAGAAATTAAAAGCATTAT
CGAACAACAATCTCGGAAATAA

Upstream 100 bases:

>100_bases
TTAGCTTATACGATACAGCTTGTCATCCTTGAAAAATGGTTTGAATTAGACAAACAGAAGGGAAAAGAAATCATCGATAG
GATTGTGAGGGGAACATAGC

Downstream 100 bases:

>100_bases
TTAAAGGATACCATCATATGAAAATTGTTTATGATCGAATCAATAATATGCGTGGAAACCTTATTACGATAACAGCTGAA
GGAGTTAGTCTCGGTGAACT

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MKTLETRKEKKAQGKVLKAFGNLLQVTFEGNIRQGEVAMVHVDNLQLKSEVIEILGNQAKIQVFEDTKGVRLGSLVSFTG
DLLEAELGPGLLSSIFDGLQNPLVDVADQAGLFLPKGIYLSALDRQRKWDFESSAKVGDVLFRGDRIGSTKEGRFHHFIM
VPFSLYGKYRLTWVINSGSYTVDTVVAKAIDESGQEHSFTMVQKWPVKNALIHGEKIKPTKMMDTGERIIDTQFPLMKGG
TFCTPGPFGAGKTVLQHHLSKYAAVDIVLFVACGERAGEVVEVLREFPHLIDPHTDEALMKRTVIICNTSSMPVAARESS
IYMGITIAEYYRQMGLDVLVLADSTSRWAQALREMSGRLEEIPGEEAFPAYLSSRIAEFYERSGVVSLRHGKPGSITIGG
AVSPAGGNFEEPVTQATLSVVGAFLGLSRARSDSRRYPAIDPLLSWSKYVDTVGNELSHQVDGWDQMVKRARHILFNGNE
IGKRMEVVGEEGISMEDMLTYLKAELYDFSYLQQNAFDKEDAYCPLKRQIALFQLINQIFDTTFDFHTHDQAREFFLDLQ
NRIKNMNFISFDTEQYRKVFAEIKSIIEQQSRK

Sequences:

>Translated_593_residues
MKTLETRKEKKAQGKVLKAFGNLLQVTFEGNIRQGEVAMVHVDNLQLKSEVIEILGNQAKIQVFEDTKGVRLGSLVSFTG
DLLEAELGPGLLSSIFDGLQNPLVDVADQAGLFLPKGIYLSALDRQRKWDFESSAKVGDVLFRGDRIGSTKEGRFHHFIM
VPFSLYGKYRLTWVINSGSYTVDTVVAKAIDESGQEHSFTMVQKWPVKNALIHGEKIKPTKMMDTGERIIDTQFPLMKGG
TFCTPGPFGAGKTVLQHHLSKYAAVDIVLFVACGERAGEVVEVLREFPHLIDPHTDEALMKRTVIICNTSSMPVAARESS
IYMGITIAEYYRQMGLDVLVLADSTSRWAQALREMSGRLEEIPGEEAFPAYLSSRIAEFYERSGVVSLRHGKPGSITIGG
AVSPAGGNFEEPVTQATLSVVGAFLGLSRARSDSRRYPAIDPLLSWSKYVDTVGNELSHQVDGWDQMVKRARHILFNGNE
IGKRMEVVGEEGISMEDMLTYLKAELYDFSYLQQNAFDKEDAYCPLKRQIALFQLINQIFDTTFDFHTHDQAREFFLDLQ
NRIKNMNFISFDTEQYRKVFAEIKSIIEQQSRK
>Mature_593_residues
MKTLETRKEKKAQGKVLKAFGNLLQVTFEGNIRQGEVAMVHVDNLQLKSEVIEILGNQAKIQVFEDTKGVRLGSLVSFTG
DLLEAELGPGLLSSIFDGLQNPLVDVADQAGLFLPKGIYLSALDRQRKWDFESSAKVGDVLFRGDRIGSTKEGRFHHFIM
VPFSLYGKYRLTWVINSGSYTVDTVVAKAIDESGQEHSFTMVQKWPVKNALIHGEKIKPTKMMDTGERIIDTQFPLMKGG
TFCTPGPFGAGKTVLQHHLSKYAAVDIVLFVACGERAGEVVEVLREFPHLIDPHTDEALMKRTVIICNTSSMPVAARESS
IYMGITIAEYYRQMGLDVLVLADSTSRWAQALREMSGRLEEIPGEEAFPAYLSSRIAEFYERSGVVSLRHGKPGSITIGG
AVSPAGGNFEEPVTQATLSVVGAFLGLSRARSDSRRYPAIDPLLSWSKYVDTVGNELSHQVDGWDQMVKRARHILFNGNE
IGKRMEVVGEEGISMEDMLTYLKAELYDFSYLQQNAFDKEDAYCPLKRQIALFQLINQIFDTTFDFHTHDQAREFFLDLQ
NRIKNMNFISFDTEQYRKVFAEIKSIIEQQSRK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=550, Percent_Identity=39.8181818181818, Blast_Score=398, Evalue=1e-110,
Organism=Homo sapiens, GI32189394, Length=390, Percent_Identity=28.974358974359, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI19913426, Length=331, Percent_Identity=24.773413897281, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI19913428, Length=265, Percent_Identity=25.2830188679245, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790170, Length=410, Percent_Identity=26.0975609756098, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1790172, Length=249, Percent_Identity=25.7028112449799, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788251, Length=361, Percent_Identity=23.5457063711911, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17565854, Length=512, Percent_Identity=41.2109375, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI25144756, Length=334, Percent_Identity=28.4431137724551, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17570191, Length=229, Percent_Identity=26.6375545851528, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17510931, Length=205, Percent_Identity=28.2926829268293, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320016, Length=265, Percent_Identity=44.9056603773585, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6322581, Length=364, Percent_Identity=27.4725274725275, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319603, Length=336, Percent_Identity=23.8095238095238, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129479, Length=517, Percent_Identity=40.4255319148936, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24583988, Length=551, Percent_Identity=39.2014519056261, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583986, Length=551, Percent_Identity=39.2014519056261, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583984, Length=551, Percent_Identity=39.2014519056261, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24583992, Length=552, Percent_Identity=38.0434782608696, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI28574560, Length=339, Percent_Identity=30.3834808259587, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24638766, Length=341, Percent_Identity=28.7390029325513, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281361666, Length=278, Percent_Identity=25.5395683453237, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646341, Length=278, Percent_Identity=25.5395683453237, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136796, Length=278, Percent_Identity=25.5395683453237, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24658560, Length=262, Percent_Identity=25.5725190839695, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA_PARUW (Q6MAJ5)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008679.1
- ProteinModelPortal:   Q6MAJ5
- SMR:   Q6MAJ5
- STRING:   Q6MAJ5
- GeneID:   2780894
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1680
- NMPDR:   fig|264201.1.peg.1680
- eggNOG:   COG1155
- HOGENOM:   HBG288114
- OMA:   QMGLDIL
- ProtClustDB:   PRK04192
- BioCyc:   CPRO264201:PC1680-MONOMER
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C

EC number: =3.6.3.14

Molecular weight: Translated: 66547; Mature: 66547

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLETRKEKKAQGKVLKAFGNLLQVTFEGNIRQGEVAMVHVDNLQLKSEVIEILGNQAK
CCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCEE
IQVFEDTKGVRLGSLVSFTGDLLEAELGPGLLSSIFDGLQNPLVDVADQAGLFLPKGIYL
EEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHH
SALDRQRKWDFESSAKVGDVLFRGDRIGSTKEGRFHHFIMVPFSLYGKYRLTWVINSGSY
HHHHHHHCCCCCCCCCHHHHEEECCCCCCCCCCCEEEEEEEEHHHCCCEEEEEEECCCCE
TVDTVVAKAIDESGQEHSFTMVQKWPVKNALIHGEKIKPTKMMDTGERIIDTQFPLMKGG
EHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCCHHHCCCCHHHCCCCCHHCCC
TFCTPGPFGAGKTVLQHHLSKYAAVDIVLFVACGERAGEVVEVLREFPHLIDPHTDEALM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCCHHHH
KRTVIICNTSSMPVAARESSIYMGITIAEYYRQMGLDVLVLADSTSRWAQALREMSGRLE
HCEEEEECCCCCCCEECCCCEEEEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCHHH
EIPGEEAFPAYLSSRIAEFYERSGVVSLRHGKPGSITIGGAVSPAGGNFEEPVTQATLSV
HCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEECCEECCCCCCCCHHHHHHHHHH
VGAFLGLSRARSDSRRYPAIDPLLSWSKYVDTVGNELSHQVDGWDQMVKRARHILFNGNE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCHH
IGKRMEVVGEEGISMEDMLTYLKAELYDFSYLQQNAFDKEDAYCPLKRQIALFQLINQIF
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
DTTFDFHTHDQAREFFLDLQNRIKNMNFISFDTEQYRKVFAEIKSIIEQQSRK
HCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTLETRKEKKAQGKVLKAFGNLLQVTFEGNIRQGEVAMVHVDNLQLKSEVIEILGNQAK
CCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCEE
IQVFEDTKGVRLGSLVSFTGDLLEAELGPGLLSSIFDGLQNPLVDVADQAGLFLPKGIYL
EEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHH
SALDRQRKWDFESSAKVGDVLFRGDRIGSTKEGRFHHFIMVPFSLYGKYRLTWVINSGSY
HHHHHHHCCCCCCCCCHHHHEEECCCCCCCCCCCEEEEEEEEHHHCCCEEEEEEECCCCE
TVDTVVAKAIDESGQEHSFTMVQKWPVKNALIHGEKIKPTKMMDTGERIIDTQFPLMKGG
EHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCCCCCCHHHCCCCHHHCCCCCHHCCC
TFCTPGPFGAGKTVLQHHLSKYAAVDIVLFVACGERAGEVVEVLREFPHLIDPHTDEALM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCCCHHHH
KRTVIICNTSSMPVAARESSIYMGITIAEYYRQMGLDVLVLADSTSRWAQALREMSGRLE
HCEEEEECCCCCCCEECCCCEEEEEEHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCHHH
EIPGEEAFPAYLSSRIAEFYERSGVVSLRHGKPGSITIGGAVSPAGGNFEEPVTQATLSV
HCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEECCEECCCCCCCCHHHHHHHHHH
VGAFLGLSRARSDSRRYPAIDPLLSWSKYVDTVGNELSHQVDGWDQMVKRARHILFNGNE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCHH
IGKRMEVVGEEGISMEDMLTYLKAELYDFSYLQQNAFDKEDAYCPLKRQIALFQLINQIF
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
DTTFDFHTHDQAREFFLDLQNRIKNMNFISFDTEQYRKVFAEIKSIIEQQSRK
HCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA