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The map label for this gene is atoC [H]

Identifier: 46446998

GI number: 46446998

Start: 1633654

End: 1634979

Strand: Reverse

Name: atoC [H]

Synonym: pc1364

Alternate gene names: 46446998

Gene position: 1634979-1633654 (Counterclockwise)

Preceding gene: 46446999

Following gene: 46446996

Centisome position: 67.72

GC content: 36.65

Gene sequence:

>1326_bases
ATGACCATTGAAAAAATTTTAATTGTTGATGATGAATTGATTATGCGAAACTTTCTTACAGAAGCTCTGAAACGAAAAGG
AATTGAAGCCATTGCCGCAGAAAATGGGGAAAAGGCTATTAAAATTGTCCAAGAGCAATCTTTTGATATGGTTATCACAG
ATATGAAAATGCCTGGATTGAATGGTATTGATGTTCTTCAAAAAATTAAAGAACTATCTCCCCAAACACTGGTTATTGTG
ATGACAGCTTTTGGAACAATTGAAAATGCTGTAGATGCGATGAAATTAGGAGCTTTTCATTACATCATTAAACCGTTCTC
CTTAGAAAGTTTAATGGCTAATATTGAAAAGGCCAATCAACACGTGGTATTAGTCGAAGAGAATCAATACCTGCGGCAAC
AAATTGGGGTGAGCTCTTCTCGTCATGTAATTGCTGAAAGCCCTGCAATGCAGCAAGTTTTAAAAGATATTGAAAGAATT
GCTAAAAGTAATGCCAGTGTCTTTATTAATGGGGAAACCGGAACTGGAAAAGAGGTGATTGCGCATCTCGTTCATTATAG
TTCTCCAAGAGCTAATCAACCATTTATTAAAGTTAACTGTGCGGCAGTGCCTGATACCTTAGTAGAATCAGAATTTTTTG
GGCATGAAAAAGGAGCTTTTACAGGAGCAGCTAATAAAAGGCTGGGTCGCTTTGAGTTAGCAAATGGAGGAACGCTTCTC
TTGGACGAAGTGACTGAAATTCCTCTTGTTTTGCAATCAAAGCTTCTTCGTGTAACGCAAGAACAAGAATTTGAAAGAGT
TGGGGGAGCAAAGCCTATTAAAGTCGATGTCCGTTTGGTTTCTACTTCCAATCGTGATGTGAAAGAAGCTATTGCAAACA
AATATTTACGAGAAGATCTTTACTACCGTTTAAATGTTGTTCCACTTTATCTTCCACCATTAAGAGAAAGAAAAGAAGAT
ATTATTCCATTAGCTGAGCATTTTATCGAGAAAATTTGCCAAGAAAATCATACCGAGAAGAAAAAATTAAGTGAGAGCGC
ACAAAAAAAATTACTCCTTTATCGTTGGCCTGGAAATGTTAGAGAACTTGCTAATGTCGTTGAACGATCGGTTGTCATGG
ATCCGGGCAAAATTATTCAAGGCGATCATCTTTATTTAGAGGGACCTGGGGTGAATGTCATGGCAGGAAAAACTATTCAA
GAACTAGAAAAACAGTTAATTGTAGAAACGTTGCAAATGCATCAAAATAGAACAAAAGTAGCAGAAACACTAGGAATTAG
CGTTAAAGTATTACGAGATAAACTTGAAGAATACAAACTTGTCTAG

Upstream 100 bases:

>100_bases
AACAATTGAAGTAAAATCTGAAGTTGGTAATGGAACTTCTTTTACTATCAAACTTCCTTTAAAAGTCGTTCAATAAATCA
TTCAATGTAAGGGCAAAATT

Downstream 100 bases:

>100_bases
TCACTACAAAATGATGATTTAATTGAGACATTTTGTTTACAGGCAAATTAATTTTTTCCACAAAGCTAAGCGGAGAAGGC
TGAGAGGAATGAAATTCTAT

Product: two-component response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTIEKILIVDDELIMRNFLTEALKRKGIEAIAAENGEKAIKIVQEQSFDMVITDMKMPGLNGIDVLQKIKELSPQTLVIV
MTAFGTIENAVDAMKLGAFHYIIKPFSLESLMANIEKANQHVVLVEENQYLRQQIGVSSSRHVIAESPAMQQVLKDIERI
AKSNASVFINGETGTGKEVIAHLVHYSSPRANQPFIKVNCAAVPDTLVESEFFGHEKGAFTGAANKRLGRFELANGGTLL
LDEVTEIPLVLQSKLLRVTQEQEFERVGGAKPIKVDVRLVSTSNRDVKEAIANKYLREDLYYRLNVVPLYLPPLRERKED
IIPLAEHFIEKICQENHTEKKKLSESAQKKLLLYRWPGNVRELANVVERSVVMDPGKIIQGDHLYLEGPGVNVMAGKTIQ
ELEKQLIVETLQMHQNRTKVAETLGISVKVLRDKLEEYKLV

Sequences:

>Translated_441_residues
MTIEKILIVDDELIMRNFLTEALKRKGIEAIAAENGEKAIKIVQEQSFDMVITDMKMPGLNGIDVLQKIKELSPQTLVIV
MTAFGTIENAVDAMKLGAFHYIIKPFSLESLMANIEKANQHVVLVEENQYLRQQIGVSSSRHVIAESPAMQQVLKDIERI
AKSNASVFINGETGTGKEVIAHLVHYSSPRANQPFIKVNCAAVPDTLVESEFFGHEKGAFTGAANKRLGRFELANGGTLL
LDEVTEIPLVLQSKLLRVTQEQEFERVGGAKPIKVDVRLVSTSNRDVKEAIANKYLREDLYYRLNVVPLYLPPLRERKED
IIPLAEHFIEKICQENHTEKKKLSESAQKKLLLYRWPGNVRELANVVERSVVMDPGKIIQGDHLYLEGPGVNVMAGKTIQ
ELEKQLIVETLQMHQNRTKVAETLGISVKVLRDKLEEYKLV
>Mature_440_residues
TIEKILIVDDELIMRNFLTEALKRKGIEAIAAENGEKAIKIVQEQSFDMVITDMKMPGLNGIDVLQKIKELSPQTLVIVM
TAFGTIENAVDAMKLGAFHYIIKPFSLESLMANIEKANQHVVLVEENQYLRQQIGVSSSRHVIAESPAMQQVLKDIERIA
KSNASVFINGETGTGKEVIAHLVHYSSPRANQPFIKVNCAAVPDTLVESEFFGHEKGAFTGAANKRLGRFELANGGTLLL
DEVTEIPLVLQSKLLRVTQEQEFERVGGAKPIKVDVRLVSTSNRDVKEAIANKYLREDLYYRLNVVPLYLPPLRERKEDI
IPLAEHFIEKICQENHTEKKKLSESAQKKLLLYRWPGNVRELANVVERSVVMDPGKIIQGDHLYLEGPGVNVMAGKTIQE
LEKQLIVETLQMHQNRTKVAETLGISVKVLRDKLEEYKLV

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=46.9026548672566, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1790437, Length=438, Percent_Identity=41.7808219178082, Blast_Score=347, Evalue=9e-97,
Organism=Escherichia coli, GI1790299, Length=372, Percent_Identity=43.5483870967742, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1788905, Length=374, Percent_Identity=38.7700534759358, Blast_Score=294, Evalue=9e-81,
Organism=Escherichia coli, GI87082117, Length=258, Percent_Identity=49.6124031007752, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789087, Length=259, Percent_Identity=51.3513513513513, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1789233, Length=324, Percent_Identity=41.6666666666667, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=48.2758620689655, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=40.1869158878505, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI1787583, Length=314, Percent_Identity=36.3057324840764, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786524, Length=312, Percent_Identity=39.4230769230769, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI87081858, Length=324, Percent_Identity=29.0123456790123, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1789828, Length=247, Percent_Identity=32.7935222672065, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786784, Length=111, Percent_Identity=32.4324324324324, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789809, Length=111, Percent_Identity=29.7297297297297, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082012, Length=118, Percent_Identity=28.8135593220339, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786599, Length=120, Percent_Identity=30, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789402, Length=112, Percent_Identity=26.7857142857143, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367329, Length=113, Percent_Identity=36.283185840708, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1790863, Length=114, Percent_Identity=34.2105263157895, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49595; Mature: 49464

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEKILIVDDELIMRNFLTEALKRKGIEAIAAENGEKAIKIVQEQSFDMVITDMKMPGL
CCCCEEEEECHHHHHHHHHHHHHHHCCCCEEHHCCCHHHHHHHHHCCCCEEEEECCCCCC
NGIDVLQKIKELSPQTLVIVMTAFGTIENAVDAMKLGAFHYIIKPFSLESLMANIEKANQ
CHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
HVVLVEENQYLRQQIGVSSSRHVIAESPAMQQVLKDIERIAKSNASVFINGETGTGKEVI
EEEEEECCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHH
AHLVHYSSPRANQPFIKVNCAAVPDTLVESEFFGHEKGAFTGAANKRLGRFELANGGTLL
HHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCEEE
LDEVTEIPLVLQSKLLRVTQEQEFERVGGAKPIKVDVRLVSTSNRDVKEAIANKYLREDL
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHH
YYRLNVVPLYLPPLRERKEDIIPLAEHFIEKICQENHTEKKKLSESAQKKLLLYRWPGNV
HEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCEEEEECCCCH
RELANVVERSVVMDPGKIIQGDHLYLEGPGVNVMAGKTIQELEKQLIVETLQMHQNRTKV
HHHHHHHHHHHCCCCCCEEECCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
AETLGISVKVLRDKLEEYKLV
HHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIEKILIVDDELIMRNFLTEALKRKGIEAIAAENGEKAIKIVQEQSFDMVITDMKMPGL
CCCEEEEECHHHHHHHHHHHHHHHCCCCEEHHCCCHHHHHHHHHCCCCEEEEECCCCCC
NGIDVLQKIKELSPQTLVIVMTAFGTIENAVDAMKLGAFHYIIKPFSLESLMANIEKANQ
CHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
HVVLVEENQYLRQQIGVSSSRHVIAESPAMQQVLKDIERIAKSNASVFINGETGTGKEVI
EEEEEECCHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHH
AHLVHYSSPRANQPFIKVNCAAVPDTLVESEFFGHEKGAFTGAANKRLGRFELANGGTLL
HHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCEEE
LDEVTEIPLVLQSKLLRVTQEQEFERVGGAKPIKVDVRLVSTSNRDVKEAIANKYLREDL
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHH
YYRLNVVPLYLPPLRERKEDIIPLAEHFIEKICQENHTEKKKLSESAQKKLLLYRWPGNV
HEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCEEEEECCCCH
RELANVVERSVVMDPGKIIQGDHLYLEGPGVNVMAGKTIQELEKQLIVETLQMHQNRTKV
HHHHHHHHHHHCCCCCCEEECCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
AETLGISVKVLRDKLEEYKLV
HHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]