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The map label for this gene is ilvC

Identifier: 45659210

GI number: 45659210

Start: 4157938

End: 4159062

Strand: Reverse

Name: ilvC

Synonym: LIC13393

Alternate gene names: 45659210

Gene position: 4159062-4157938 (Counterclockwise)

Preceding gene: 45659211

Following gene: 45659209

Centisome position: 97.24

GC content: 40.09

Gene sequence:

>1125_bases
TTGCTTAAAATTTGCAAAGTTCAAATTACAAAGCACCTGGTGAACTTTTCCAGGGTTATTTCAGTTGTCATTCTATCCTT
TTTCAAATGTTTAGTAAAAAGGAAACATTCGAGGAAAGAGAAAATGGCAAATATCTATTACGACTCCGATTGTGATTTAA
ACTCGCTAAAAGGTAAAACCATCGCAGTAATCGGTTATGGAAGCCAGGGACATGCCCAGGCTCAAAATATGAAAGATTCC
GGACTGAAAGTAATTATTGGTTTAAAAGAAGGATCTAAATCCATTCAAGACGCAAAGAATGCTGGTTTTGAAGTGTATAG
CGTTTCAGAAGCATCACAGAAAGCGGACATCATACAAATTCTAGCGCCCGATACGATTCAAGCGGATCTTTATAAAAAAG
ATATTGAACCGAATCTTAAAAAAGGAGATGCGCTCGTTTTTTCTCATGGGTTTAACATTCATTACGATTTTATAAAACCT
CCAAAAGAAGTAGATGTGTATATGGTTGCTCCTAAAGGCCCAGGCCATCTAGTTCGTAGAGTTTATACGGAAGGAGGGGG
AGTTCCCTGTTTGATTGCGATCTATCAAGATTCATCCGGCGAAGCAAAAAAAAGAGCGCTTGCTCACGCAGCTGGAGTCG
GTGGAGGTCGTGCTGGAATTTTGGAAACTTCTTTCCGTGAGGAAACCGAAACGGATCTTTTTGGAGAACAAGTCGTTCTT
TGCGGGGGGCTCTCCAATTTAATCATGGCTGGTTTTGAAACCTTGACCGAAGCAGGATATGATCCTGAAATCGCGTATTT
TGAATGCCTTCACGAAGTGAAGCTGATTACAGATCTAATTTACGAAGGTGGATTGGCAAGAATGAGATTTTCCATCTCTG
ATACTGCGGAATACGGAGATTATGTAAGTGGTCCTCGTGTGATCGATCCAGGCGTAAAACAGAGAATGAAAGAAGTTCTC
AACGATATTCAAAAAGATAAAGGGGCAAAATTTGCCACCAACTGGATGGCCGAAACGAAGGCGGGCTATCCGAACTTTAA
GAATATGAGAGACAAAAATGCATCTCATCCGATCGAGTCTGTAGGTAAAAAATTAAGAAGTATGATGAAATGGTTATCTA
AGTAA

Upstream 100 bases:

>100_bases
AATTATAGGCAGCGGTGGATAAGATCGCAATTGATATGATCCTTTCTTGCCTTTGAGAAAATTCTGAGTATTTTATGATC
GTGTTTGAGATAAGAAATGA

Downstream 100 bases:

>100_bases
ACTGATTCCAATTTTAAATCTTCTTTGAATCAACAAGACCCGGCGGATTTCTAAGTCTTCCGGGTTTTTTATTTTTTCTC
GATTCAGCGATTGAAATGGA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLKICKVQITKHLVNFSRVISVVILSFFKCLVKRKHSRKEKMANIYYDSDCDLNSLKGKTIAVIGYGSQGHAQAQNMKDS
GLKVIIGLKEGSKSIQDAKNAGFEVYSVSEASQKADIIQILAPDTIQADLYKKDIEPNLKKGDALVFSHGFNIHYDFIKP
PKEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDSSGEAKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVL
CGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIYEGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVL
NDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNASHPIESVGKKLRSMMKWLSK

Sequences:

>Translated_374_residues
MLKICKVQITKHLVNFSRVISVVILSFFKCLVKRKHSRKEKMANIYYDSDCDLNSLKGKTIAVIGYGSQGHAQAQNMKDS
GLKVIIGLKEGSKSIQDAKNAGFEVYSVSEASQKADIIQILAPDTIQADLYKKDIEPNLKKGDALVFSHGFNIHYDFIKP
PKEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDSSGEAKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVL
CGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIYEGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVL
NDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNASHPIESVGKKLRSMMKWLSK
>Mature_374_residues
MLKICKVQITKHLVNFSRVISVVILSFFKCLVKRKHSRKEKMANIYYDSDCDLNSLKGKTIAVIGYGSQGHAQAQNMKDS
GLKVIIGLKEGSKSIQDAKNAGFEVYSVSEASQKADIIQILAPDTIQADLYKKDIEPNLKKGDALVFSHGFNIHYDFIKP
PKEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDSSGEAKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVL
CGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIYEGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVL
NDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNASHPIESVGKKLRSMMKWLSK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=295, Percent_Identity=36.271186440678, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=281, Percent_Identity=34.5195729537367, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 41347; Mature: 41347

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKICKVQITKHLVNFSRVISVVILSFFKCLVKRKHSRKEKMANIYYDSDCDLNSLKGKT
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCE
IAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNAGFEVYSVSEASQKADIIQI
EEEEEECCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCEEEEEECCHHCCCCEEEE
LAPDTIQADLYKKDIEPNLKKGDALVFSHGFNIHYDFIKPPKEVDVYMVAPKGPGHLVRR
ECCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEEECCCCCCCCCEEEEECCCCHHHHHHH
VYTEGGGVPCLIAIYQDSSGEAKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVL
HHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHCCCCEEE
CGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIYEGGLARMRFSISDTAEYGD
ECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCC
YVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNASHPIES
CCCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
VGKKLRSMMKWLSK
HHHHHHHHHHHHCC
>Mature Secondary Structure
MLKICKVQITKHLVNFSRVISVVILSFFKCLVKRKHSRKEKMANIYYDSDCDLNSLKGKT
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCE
IAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNAGFEVYSVSEASQKADIIQI
EEEEEECCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCEEEEEECCHHCCCCEEEE
LAPDTIQADLYKKDIEPNLKKGDALVFSHGFNIHYDFIKPPKEVDVYMVAPKGPGHLVRR
ECCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEEECCCCCCCCCEEEEECCCCHHHHHHH
VYTEGGGVPCLIAIYQDSSGEAKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVL
HHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHCCCCEEE
CGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIYEGGLARMRFSISDTAEYGD
ECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCC
YVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNASHPIES
CCCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
VGKKLRSMMKWLSK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA