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The map label for this gene is ppa

Identifier: 45659045

GI number: 45659045

Start: 3956832

End: 3957368

Strand: Reverse

Name: ppa

Synonym: LIC13223

Alternate gene names: 45659045

Gene position: 3957368-3956832 (Counterclockwise)

Preceding gene: 45659046

Following gene: 45659043

Centisome position: 92.52

GC content: 33.33

Gene sequence:

>537_bases
ATGGTACATCCTTGGCATGATATTTCTCCCGGCGATCAAAATCCTGAAATTGTAAATGGCGTCATAGAGATCAAACGCGG
CAGCCGCGCAAAATATGAAGTAGATAAAGAGTATGGAATTTTAAAACTAGATCGAGTTTTATATTCTTCTTTTTATTATC
CTGCAAATTATGGATTTATCCCTCAATCTTATTGTGGAGATCAAGATCCTCTTGATATTTTAGTTCTTTCTCAGGTAGAA
TTGGAACCTCTTTGTTTGGTAAAAGCAAAGGTTATAGGTGTGATGAGGATGTTAGATTCCGGAGAAGAAGACGATAAGAT
CATTGCGGTTGCGGCTAACGATATGTCAGTCAATCATATTAATGATATTTCGGAACTTCCTCCACATTTTACTTTGGAAT
TGAAACACTTTTTTGAAGACTATAAAAAATTGGAAAACAAAACGGTAGTTATCGAAGAATTTCAAAATGCAATTTTAGCG
CGAAAAATAGTTTTAGATTCTTTAGAATTATATAAAAAAACGTTTCCGAAAAAATAA

Upstream 100 bases:

>100_bases
TGCGTTACTCGCCATTACTTGGAATTGGAAACCTAAGGCATAGAATGAAGTTTTTATTTTACACTTGCTTTTCCTCTAAA
GGTTAAAATAGTTTTCTGTT

Downstream 100 bases:

>100_bases
AAGTATTTTGTAAGACTCGCAACAGATGACTAAACATATTAAAAAATCGATGTATTTTAGGGATAGAAATCAAATATATT
CTAATTTACTTAAATATATT

Product: inorganic pyrophosphatase

Products: NA

Alternate protein names: Pyrophosphate phospho-hydrolase; PPase

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MVHPWHDISPGDQNPEIVNGVIEIKRGSRAKYEVDKEYGILKLDRVLYSSFYYPANYGFIPQSYCGDQDPLDILVLSQVE
LEPLCLVKAKVIGVMRMLDSGEEDDKIIAVAANDMSVNHINDISELPPHFTLELKHFFEDYKKLENKTVVIEEFQNAILA
RKIVLDSLELYKKTFPKK

Sequences:

>Translated_178_residues
MVHPWHDISPGDQNPEIVNGVIEIKRGSRAKYEVDKEYGILKLDRVLYSSFYYPANYGFIPQSYCGDQDPLDILVLSQVE
LEPLCLVKAKVIGVMRMLDSGEEDDKIIAVAANDMSVNHINDISELPPHFTLELKHFFEDYKKLENKTVVIEEFQNAILA
RKIVLDSLELYKKTFPKK
>Mature_178_residues
MVHPWHDISPGDQNPEIVNGVIEIKRGSRAKYEVDKEYGILKLDRVLYSSFYYPANYGFIPQSYCGDQDPLDILVLSQVE
LEPLCLVKAKVIGVMRMLDSGEEDDKIIAVAANDMSVNHINDISELPPHFTLELKHFFEDYKKLENKTVVIEEFQNAILA
RKIVLDSLELYKKTFPKK

Specific function: Unknown

COG id: COG0221

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPase family

Homologues:

Organism=Homo sapiens, GI11056044, Length=207, Percent_Identity=28.9855072463768, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI29171702, Length=197, Percent_Identity=26.9035532994924, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1790673, Length=170, Percent_Identity=37.0588235294118, Blast_Score=114, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71984895, Length=203, Percent_Identity=26.1083743842365, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71984889, Length=204, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71984880, Length=203, Percent_Identity=26.1083743842365, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71984883, Length=204, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319483, Length=203, Percent_Identity=29.5566502463054, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323923, Length=188, Percent_Identity=29.2553191489362, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221468704, Length=203, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45549187, Length=203, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: 5480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): IPYR_LEPIC (Q72MG4)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_003131.1
- ProteinModelPortal:   Q72MG4
- SMR:   Q72MG4
- GeneID:   2772569
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC13223
- HOGENOM:   HBG529150
- OMA:   KKPGTCT
- ProtClustDB:   CLSK575092
- BioCyc:   LINT267671:LIC_13223-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00209
- InterPro:   IPR008162
- Gene3D:   G3DSA:3.90.80.10
- PANTHER:   PTHR10286

Pfam domain/function: PF00719 Pyrophosphatase; SSF50324 Pyrophosphatase

EC number: =3.6.1.1

Molecular weight: Translated: 20445; Mature: 20445

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHPWHDISPGDQNPEIVNGVIEIKRGSRAKYEVDKEYGILKLDRVLYSSFYYPANYGFI
CCCCCCCCCCCCCCHHHHHHHHEECCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCC
PQSYCGDQDPLDILVLSQVELEPLCLVKAKVIGVMRMLDSGEEDDKIIAVAANDMSVNHI
CHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
NDISELPPHFTLELKHFFEDYKKLENKTVVIEEFQNAILARKIVLDSLELYKKTFPKK
HHHHHCCCCEEEHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVHPWHDISPGDQNPEIVNGVIEIKRGSRAKYEVDKEYGILKLDRVLYSSFYYPANYGFI
CCCCCCCCCCCCCCHHHHHHHHEECCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCC
PQSYCGDQDPLDILVLSQVELEPLCLVKAKVIGVMRMLDSGEEDDKIIAVAANDMSVNHI
CHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHH
NDISELPPHFTLELKHFFEDYKKLENKTVVIEEFQNAILARKIVLDSLELYKKTFPKK
HHHHHCCCCEEEHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA