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The map label for this gene is glpT

Identifier: 45659046

GI number: 45659046

Start: 3957426

End: 3958757

Strand: Reverse

Name: glpT

Synonym: LIC13224

Alternate gene names: 45659046

Gene position: 3958757-3957426 (Counterclockwise)

Preceding gene: 45659047

Following gene: 45659045

Centisome position: 92.56

GC content: 38.06

Gene sequence:

>1332_bases
ATGATTTCACCGTTACGTTGGCTACTCCCTGCAAAAGCAAAGCCATTATTATCAAAAGAATTAATAGATCGATCTTATCC
GCGTTTTAGATGGAGGATTTTAGAAGCAACCTTTATCGGTTATGCGACGTTTTATCTCGTAAGGAATAATTTTCCAGTTA
TTTCCAAAGAAATGGGAGAAGCCCTTCATTATAGTCAAGAACAAATCACAAACATTTTAGCAGTGACTGCGATCACATAC
GGGATAGGAAAATTTTTAATGGGAATCTTATCCGATCGTAGTAATCCAAAATACTTCATGCCATTGGGTTTGATTTTAAC
CGCGATTTGTAATTTGTTTTTCGGAGCATCAAATCAGTACGAAATTCATTTTTATCTTTGGGCATTAAACGGATTGATGC
AAGGGATGGGATGGCCTCCTTGTGGACGTTCTCTTGGTCATTGGTTCGGAGTTTCCGAAAGAGGATCTAAATTTGCAATT
TGGAACATAGCGCATAACGTGGGAGGAGGTTTGGTAGGAATTATCGCAGCTTACAGCGCATCTTGGTGGGGTTGGAGGAA
TGCGTTTTATATTCCCGCTTTGATTGCGATTGTGACCGCGATTTATCTTTTATTTCGATTGGTGGATACACCTCAGTCGG
TTGGTCTTCCTCCAATCGAAGAATATCAAAAAGATCCGGAAAAGGAGGTAAGACTTTCTATACAAGAACAAGAAAAGGAA
CTTTCTTTTCGAGAAATCATTTTAGGTTCTGTATTAAAAAATCATTATGTTTGGACTTTTGCATTTGCTAATTTTTTCGT
TTATGTGGTTCGATATGGTTTGACGGATATAGGTCCTACTTATTTAAAACTTTCTAAAGGAGCTTCTTTAGAAAAAGGTG
GGATCAGCACGTTGATCTACGAATTTGCCGGAATTGCTTCTACCCTTCTTGTAGGATGGGGTTCCGATAAGCTGGGGGGT
AAAAGAGGAATGGTAAGTCTTTTATGTATGCTTCCTATTTTGTTTGCTTTAATTTCATTATTATTTACTCCTTTAGGATT
TCTATGGTTGGATCTTGTATTGTTCGGAATCATCGGTTTTTTTATCTATCCACCTGTTATGTTGTTAGGTGTTGCTGGGC
TTGATTTTACTTCTAAAAAAGCGGTTGGAGCTGCAGCCGGTTTTATAGGTTTATTCGGTTATTTGGGAAGGACGATTCTT
TCAAAATCGGTAGGATGGTTGAGTAAACAAACTGGATTTCATTGGGAACAACCTATGTATTTAATGATCGGTGCGACTTT
AATTTCAATTGCGTTACTCGCCATTACTTGGAATTGGAAACCTAAGGCATAG

Upstream 100 bases:

>100_bases
CTATAAAATTTTAGAACCAACTTCCACACAAATAACTAAATGATCAATTGATTCATGAAAATCACCTTGTAAGCGATACT
ATATCTTTGAAACTGACCTA

Downstream 100 bases:

>100_bases
AATGAAGTTTTTATTTTACACTTGCTTTTCCTCTAAAGGTTAAAATAGTTTTCTGTTATGGTACATCCTTGGCATGATAT
TTCTCCCGGCGATCAAAATC

Product: glycerol-3-phosphate Pi antiporter

Products: Proton [Cytoplasm]; glycerol-3-phosphate [Cytoplasm] [C]

Alternate protein names: G-3-P transporter; G-3-P permease [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MISPLRWLLPAKAKPLLSKELIDRSYPRFRWRILEATFIGYATFYLVRNNFPVISKEMGEALHYSQEQITNILAVTAITY
GIGKFLMGILSDRSNPKYFMPLGLILTAICNLFFGASNQYEIHFYLWALNGLMQGMGWPPCGRSLGHWFGVSERGSKFAI
WNIAHNVGGGLVGIIAAYSASWWGWRNAFYIPALIAIVTAIYLLFRLVDTPQSVGLPPIEEYQKDPEKEVRLSIQEQEKE
LSFREIILGSVLKNHYVWTFAFANFFVYVVRYGLTDIGPTYLKLSKGASLEKGGISTLIYEFAGIASTLLVGWGSDKLGG
KRGMVSLLCMLPILFALISLLFTPLGFLWLDLVLFGIIGFFIYPPVMLLGVAGLDFTSKKAVGAAAGFIGLFGYLGRTIL
SKSVGWLSKQTGFHWEQPMYLMIGATLISIALLAITWNWKPKA

Sequences:

>Translated_443_residues
MISPLRWLLPAKAKPLLSKELIDRSYPRFRWRILEATFIGYATFYLVRNNFPVISKEMGEALHYSQEQITNILAVTAITY
GIGKFLMGILSDRSNPKYFMPLGLILTAICNLFFGASNQYEIHFYLWALNGLMQGMGWPPCGRSLGHWFGVSERGSKFAI
WNIAHNVGGGLVGIIAAYSASWWGWRNAFYIPALIAIVTAIYLLFRLVDTPQSVGLPPIEEYQKDPEKEVRLSIQEQEKE
LSFREIILGSVLKNHYVWTFAFANFFVYVVRYGLTDIGPTYLKLSKGASLEKGGISTLIYEFAGIASTLLVGWGSDKLGG
KRGMVSLLCMLPILFALISLLFTPLGFLWLDLVLFGIIGFFIYPPVMLLGVAGLDFTSKKAVGAAAGFIGLFGYLGRTIL
SKSVGWLSKQTGFHWEQPMYLMIGATLISIALLAITWNWKPKA
>Mature_443_residues
MISPLRWLLPAKAKPLLSKELIDRSYPRFRWRILEATFIGYATFYLVRNNFPVISKEMGEALHYSQEQITNILAVTAITY
GIGKFLMGILSDRSNPKYFMPLGLILTAICNLFFGASNQYEIHFYLWALNGLMQGMGWPPCGRSLGHWFGVSERGSKFAI
WNIAHNVGGGLVGIIAAYSASWWGWRNAFYIPALIAIVTAIYLLFRLVDTPQSVGLPPIEEYQKDPEKEVRLSIQEQEKE
LSFREIILGSVLKNHYVWTFAFANFFVYVVRYGLTDIGPTYLKLSKGASLEKGGISTLIYEFAGIASTLLVGWGSDKLGG
KRGMVSLLCMLPILFALISLLFTPLGFLWLDLVLFGIIGFFIYPPVMLLGVAGLDFTSKKAVGAAAGFIGLFGYLGRTIL
SKSVGWLSKQTGFHWEQPMYLMIGATLISIALLAITWNWKPKA

Specific function: Responsible for glycerol-3-phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=387, Percent_Identity=28.4237726098191, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4503847, Length=387, Percent_Identity=28.4237726098191, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI256219483, Length=387, Percent_Identity=28.4237726098191, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI256219543, Length=407, Percent_Identity=28.009828009828, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI256219564, Length=316, Percent_Identity=28.4810126582279, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI46361976, Length=388, Percent_Identity=26.2886597938144, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI38093649, Length=476, Percent_Identity=24.1596638655462, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI14150047, Length=173, Percent_Identity=31.2138728323699, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI223717983, Length=476, Percent_Identity=24.1596638655462, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI49619231, Length=302, Percent_Identity=26.158940397351, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1788573, Length=433, Percent_Identity=41.5704387990762, Blast_Score=324, Evalue=9e-90,
Organism=Escherichia coli, GI87082310, Length=391, Percent_Identity=39.386189258312, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI2367259, Length=371, Percent_Identity=33.4231805929919, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI2367379, Length=329, Percent_Identity=25.2279635258359, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790306, Length=228, Percent_Identity=26.3157894736842, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17542316, Length=412, Percent_Identity=25.7281553398058, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI133930953, Length=424, Percent_Identity=23.1132075471698, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI133901856, Length=442, Percent_Identity=24.4343891402715, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133901854, Length=442, Percent_Identity=24.4343891402715, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17564204, Length=265, Percent_Identity=23.7735849056604, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17564202, Length=259, Percent_Identity=23.9382239382239, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24656866, Length=492, Percent_Identity=22.7642276422764, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45550478, Length=492, Percent_Identity=22.7642276422764, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24656861, Length=492, Percent_Identity=22.7642276422764, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005267
- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49513; Mature: 49513

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPLRWLLPAKAKPLLSKELIDRSYPRFRWRILEATFIGYATFYLVRNNFPVISKEMGE
CCCCHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHH
ALHYSQEQITNILAVTAITYGIGKFLMGILSDRSNPKYFMPLGLILTAICNLFFGASNQY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCCCE
EIHFYLWALNGLMQGMGWPPCGRSLGHWFGVSERGSKFAIWNIAHNVGGGLVGIIAAYSA
EEEEEHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEEEEEHHHHCCHHHHHHHHHHC
SWWGWRNAFYIPALIAIVTAIYLLFRLVDTPQSVGLPPIEEYQKDPEKEVRLSIQEQEKE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHCCCCHHHHHHHHHHHHH
LSFREIILGSVLKNHYVWTFAFANFFVYVVRYGLTDIGPTYLKLSKGASLEKGGISTLIY
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCCCCHHHHHH
EFAGIASTLLVGWGSDKLGGKRGMVSLLCMLPILFALISLLFTPLGFLWLDLVLFGIIGF
HHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIYPPVMLLGVAGLDFTSKKAVGAAAGFIGLFGYLGRTILSKSVGWLSKQTGFHWEQPMY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LMIGATLISIALLAITWNWKPKA
HHHHHHHHHHHHHHHEECCCCCC
>Mature Secondary Structure
MISPLRWLLPAKAKPLLSKELIDRSYPRFRWRILEATFIGYATFYLVRNNFPVISKEMGE
CCCCHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHH
ALHYSQEQITNILAVTAITYGIGKFLMGILSDRSNPKYFMPLGLILTAICNLFFGASNQY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCCCE
EIHFYLWALNGLMQGMGWPPCGRSLGHWFGVSERGSKFAIWNIAHNVGGGLVGIIAAYSA
EEEEEHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEEEEEHHHHCCHHHHHHHHHHC
SWWGWRNAFYIPALIAIVTAIYLLFRLVDTPQSVGLPPIEEYQKDPEKEVRLSIQEQEKE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHCCCCHHHHHHHHHHHHH
LSFREIILGSVLKNHYVWTFAFANFFVYVVRYGLTDIGPTYLKLSKGASLEKGGISTLIY
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCCCCHHHHHH
EFAGIASTLLVGWGSDKLGGKRGMVSLLCMLPILFALISLLFTPLGFLWLDLVLFGIIGF
HHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIYPPVMLLGVAGLDFTSKKAVGAAAGFIGLFGYLGRTILSKSVGWLSKQTGFHWEQPMY
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LMIGATLISIALLAITWNWKPKA
HHHHHHHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glycerol-3-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glycerol-3-phosphate [Periplasm] = Proton [Cytoplasm] + glycerol-3-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3329281; 9205837; 9278503; 3141744; 12893936 [H]