BacMap

Definition	Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence.
Accession	NC_005823
Length	4,277,185

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The map label for this gene is ybbO [C]

Identifier: 45658518

GI number: 45658518

Start: 3252109

End: 3252972

Strand: Reverse

Name: ybbO [C]

Synonym: LIC12682

Alternate gene names: 45658518

Gene position: 3252972-3252109 (Counterclockwise)

Preceding gene: 45658519

Following gene: 45658516

Centisome position: 76.05

GC content: 36.81

Gene sequence:

>864_bases
TTGAATATGAAATCAAATCATTTGAGATTTGAAGGTAGAAACGTTTTTATTATTGGCGGTTCGGCTGGAATTGGAAAAGG
ACTTGCACTGGAGTTTGCAAAACAAGGGGCAAACGTAGTTATTGCTGCTAGAAATAAAAAAGCTTTGGAAACAACTGTTA
CCGAATTAAGAACGATCGGTTTTAAAAACGCGATTTTTGATTTTGTAGTCGCGGATGTTTCTAACGTTTTGCAAATTCAA
AAGGTCGCAAAGAAGGTTCTCAAAATTTTAAGAGGTCTAGACCTTCTAATATGTAACAGTGGTTATGCGAAAGTGGGTAA
GGTTGAGGATTTAAGCGAATCGGATTTTAGAACACTGATGGAGGTGAATTTTTTTGGACATGTGAACTTCGTTCGTGCCT
TTCACGCTCATTTTCTTAAACAAGGTTTTGGAGATATTGTTCTTGTTTCTTCCATGCTTGCTACGTTTTCTATTTACGGT
TACGGAGCGTATTCTGCTAGTAAGTTTGCGATTATTGGTTTTGCACAATCTTTGCGACAAGAAATGATGTTTCACGGAGT
TAGAGTAAAAGTTTTTCTTCCTCCTACTACGGATACTCCCGGTTTAGAAAAAGAAAATCGGGATAAACCAGAACTCGTAA
AAGAAATGGAAATGGGTTCAGCGATCAATTCGGTTCATTCCGTAGGAAAAGTAGTGAACTCATTTATGAATTGGTTTCCT
AAAAAGAAATTTTTAGGTTACGCTACCTGGGATTCTTGGCTTCAATATTTTTTAGCGAGACATTTTCCCGAATGGACTTT
AAGGATTGCAGATGCTGAACTTAGGGCCGCACAAAAAAGATTAGAACAAAAAAATAATTACTGA

Upstream 100 bases:

>100_bases
CGTGGGAGTAAGTCTTACGATGGTTTTTGTTTTTCTTTCGATTTGTTTGTGTCTGGTTTGGATGATTTTTAAAACCGGTT
ACAAAATTAAAAAATAAATT

Downstream 100 bases:

>100_bases
TTTCTGTATAATAAAGTATTTTTAATTTTATATTTAAAAGAATCGATCTCAATCTCCTTAGAAAGAATTTTTAAAAAATG
AATTTCTTCATTTAAACGAA

Product: 3-oxoacyl-(acyl carrier protein)

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MNMKSNHLRFEGRNVFIIGGSAGIGKGLALEFAKQGANVVIAARNKKALETTVTELRTIGFKNAIFDFVVADVSNVLQIQ
KVAKKVLKILRGLDLLICNSGYAKVGKVEDLSESDFRTLMEVNFFGHVNFVRAFHAHFLKQGFGDIVLVSSMLATFSIYG
YGAYSASKFAIIGFAQSLRQEMMFHGVRVKVFLPPTTDTPGLEKENRDKPELVKEMEMGSAINSVHSVGKVVNSFMNWFP
KKKFLGYATWDSWLQYFLARHFPEWTLRIADAELRAAQKRLEQKNNY

Sequences:

>Translated_287_residues
MNMKSNHLRFEGRNVFIIGGSAGIGKGLALEFAKQGANVVIAARNKKALETTVTELRTIGFKNAIFDFVVADVSNVLQIQ
KVAKKVLKILRGLDLLICNSGYAKVGKVEDLSESDFRTLMEVNFFGHVNFVRAFHAHFLKQGFGDIVLVSSMLATFSIYG
YGAYSASKFAIIGFAQSLRQEMMFHGVRVKVFLPPTTDTPGLEKENRDKPELVKEMEMGSAINSVHSVGKVVNSFMNWFP
KKKFLGYATWDSWLQYFLARHFPEWTLRIADAELRAAQKRLEQKNNY
>Mature_287_residues
MNMKSNHLRFEGRNVFIIGGSAGIGKGLALEFAKQGANVVIAARNKKALETTVTELRTIGFKNAIFDFVVADVSNVLQIQ
KVAKKVLKILRGLDLLICNSGYAKVGKVEDLSESDFRTLMEVNFFGHVNFVRAFHAHFLKQGFGDIVLVSSMLATFSIYG
YGAYSASKFAIIGFAQSLRQEMMFHGVRVKVFLPPTTDTPGLEKENRDKPELVKEMEMGSAINSVHSVGKVVNSFMNWFP
KKKFLGYATWDSWLQYFLARHFPEWTLRIADAELRAAQKRLEQKNNY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4503817, Length=205, Percent_Identity=39.0243902439024, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI32455239, Length=187, Percent_Identity=33.6898395721925, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI5031765, Length=187, Percent_Identity=33.6898395721925, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4504505, Length=196, Percent_Identity=29.5918367346939, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI7706318, Length=279, Percent_Identity=25.8064516129032, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI38348362, Length=186, Percent_Identity=32.258064516129, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI20149619, Length=184, Percent_Identity=32.0652173913043, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38424085, Length=185, Percent_Identity=30.8108108108108, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI157739938, Length=186, Percent_Identity=28.494623655914, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI150247226, Length=286, Percent_Identity=25.8741258741259, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI142976729, Length=224, Percent_Identity=30.8035714285714, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI210032110, Length=242, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40807363, Length=264, Percent_Identity=27.6515151515151, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI66933014, Length=206, Percent_Identity=29.6116504854369, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI40254986, Length=222, Percent_Identity=26.5765765765766, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI40548397, Length=213, Percent_Identity=31.924882629108, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI214010158, Length=213, Percent_Identity=31.924882629108, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI214010156, Length=213, Percent_Identity=31.924882629108, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI22758144, Length=213, Percent_Identity=31.924882629108, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI32483357, Length=180, Percent_Identity=24.4444444444444, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI5031737, Length=188, Percent_Identity=26.063829787234, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI33667109, Length=183, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7657478, Length=177, Percent_Identity=32.2033898305085, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19923817, Length=188, Percent_Identity=23.936170212766, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI223718074, Length=182, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI50726952, Length=198, Percent_Identity=28.2828282828283, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI4557649, Length=208, Percent_Identity=29.3269230769231, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786701, Length=255, Percent_Identity=27.0588235294118, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI87082100, Length=219, Percent_Identity=29.6803652968037, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786812, Length=198, Percent_Identity=31.3131313131313, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787335, Length=199, Percent_Identity=24.6231155778894, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082160, Length=202, Percent_Identity=24.7524752475248, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787526, Length=193, Percent_Identity=27.979274611399, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787905, Length=152, Percent_Identity=30.2631578947368, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789208, Length=214, Percent_Identity=23.8317757009346, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367365, Length=197, Percent_Identity=27.9187817258883, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=205, Percent_Identity=32.1951219512195, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17564282, Length=238, Percent_Identity=30.2521008403361, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71997402, Length=229, Percent_Identity=30.1310043668122, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17570069, Length=180, Percent_Identity=34.4444444444444, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17507613, Length=201, Percent_Identity=29.3532338308458, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32563809, Length=201, Percent_Identity=29.3532338308458, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=213, Percent_Identity=30.0469483568075, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=205, Percent_Identity=32.1951219512195, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=198, Percent_Identity=25.7575757575758, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=265, Percent_Identity=24.5283018867925, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=191, Percent_Identity=31.9371727748691, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=185, Percent_Identity=28.6486486486486, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=193, Percent_Identity=28.4974093264249, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=219, Percent_Identity=27.8538812785388, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=189, Percent_Identity=28.042328042328, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193210355, Length=185, Percent_Identity=28.6486486486486, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=198, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=216, Percent_Identity=28.7037037037037, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=195, Percent_Identity=28.7179487179487, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=198, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=191, Percent_Identity=28.2722513089005, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=193, Percent_Identity=27.4611398963731, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=198, Percent_Identity=28.7878787878788, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=194, Percent_Identity=27.8350515463918, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=193, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=235, Percent_Identity=25.531914893617, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=192, Percent_Identity=29.1666666666667, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=202, Percent_Identity=31.6831683168317, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356301, Length=256, Percent_Identity=35.15625, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI21358495, Length=187, Percent_Identity=32.0855614973262, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18859837, Length=255, Percent_Identity=26.2745098039216, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24581726, Length=177, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355631, Length=177, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640492, Length=219, Percent_Identity=28.310502283105, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644339, Length=192, Percent_Identity=29.1666666666667, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24639444, Length=214, Percent_Identity=27.5700934579439, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357041, Length=222, Percent_Identity=27.027027027027, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643142, Length=185, Percent_Identity=30.2702702702703, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571387, Length=203, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28571526, Length=185, Percent_Identity=28.1081081081081, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 32318; Mature: 32318

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKSNHLRFEGRNVFIIGGSAGIGKGLALEFAKQGANVVIAARNKKALETTVTELRTIG
CCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHH
FKNAIFDFVVADVSNVLQIQKVAKKVLKILRGLDLLICNSGYAKVGKVEDLSESDFRTLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
EVNFFGHVNFVRAFHAHFLKQGFGDIVLVSSMLATFSIYGYGAYSASKFAIIGFAQSLRQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
EMMFHGVRVKVFLPPTTDTPGLEKENRDKPELVKEMEMGSAINSVHSVGKVVNSFMNWFP
HHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KKKFLGYATWDSWLQYFLARHFPEWTLRIADAELRAAQKRLEQKNNY
HHHHEEEHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNMKSNHLRFEGRNVFIIGGSAGIGKGLALEFAKQGANVVIAARNKKALETTVTELRTIG
CCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHH
FKNAIFDFVVADVSNVLQIQKVAKKVLKILRGLDLLICNSGYAKVGKVEDLSESDFRTLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
EVNFFGHVNFVRAFHAHFLKQGFGDIVLVSSMLATFSIYGYGAYSASKFAIIGFAQSLRQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
EMMFHGVRVKVFLPPTTDTPGLEKENRDKPELVKEMEMGSAINSVHSVGKVVNSFMNWFP
HHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KKKFLGYATWDSWLQYFLARHFPEWTLRIADAELRAAQKRLEQKNNY
HHHHEEEHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]