| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
Click here to switch to the map view.
The map label for this gene is pcrA [H]
Identifier: 45658426
GI number: 45658426
Start: 3134244
End: 3136268
Strand: Reverse
Name: pcrA [H]
Synonym: LIC12588
Alternate gene names: 45658426
Gene position: 3136268-3134244 (Counterclockwise)
Preceding gene: 45658437
Following gene: 45658425
Centisome position: 73.33
GC content: 38.12
Gene sequence:
>2025_bases ATGAAACTTAGTCCTGAACAGGAAAAAGCAGTTCGTCACGTAGACGGTCCTATTCTAATTTTTGCAGGCGCGGGCTCTGG AAAAACCAGGGTAATCTCTAACCGGATTGCGCATTTGATCGAAAACGCGGGAGTTCCCGCAGGAAAAATTGTAGCACTAT CTTTTACCAATAAAAGCGCGAGGGAAATGGAAGAGCGGGTTCGAAAGATGATTCCAAGGCAAAAGCTCAAGGGGATCGTA CTTTCCACGTTTCATTCTTTAGGACTGAACATACTCAAAAAACACATAGGACTTTTGGGATACAAACATCCGTTCCTATT GATGAATCAGAATGATCAGGAAGGATTTTTAACAACATTACTGATTGCTAATAAAGTAGAATTAAAAAAAGCGAAAGTAT CGGAGATACTCGGAAAAATATCCAGGATTAAAAACTCGGGACTCGCATACAGGGAATATCTGGATTCCTCTCTTGTAGAA TCTGATCAGGTGGCCAACTTAGTTTATGATAGTTATCAGAAATCTCTAAAAGAACAAAATTCCCTCGACTTTGATGACCT TATACTTTTGCCGGGAATATTACTACGAGAGTTTTCGGAGGTTAGAGAAGAATATCATAAAAAGTATCAATACTTTATGG TGGATGAGTTTCAAGATACCAATCAAACTCAATACATATTTTTAAGAGCTCTCATGGGAGAAAATCGGAATTTATGCGTA GTAGGAGACGACGATCAATCTATCTATGCGTTTCGAGGATCAGATCTAAGTCTGATCTTAAATTTTGAAAAAGATTTTCC GGAAGCAAACGTAGTTCGTCTTTTAGAAAATTATAGATCCACTTCTGTGATTATACAAGGAGCCAATTCGCTTATCAAAA ATAACCTTTCTAGAAGATCAAAAGAACTTTTCTCTTCCATACCCGGCGGAAGAAAAATCCGTTATTTGGAAAGGATGGAT GAAAAGGATGAAGCTGCTTATGTAGTGGATTGTATTCGAGAAGAGATGATTAAAGACGCAAGGGTAGGAAGTCAAATTTC TATATTATTCAGAACTAATTTTCAAACCAGACCCTTCGAAGAAGAACTTAGAAGCAGATCTATAGCGTATAAACTCGTGG GAGGATACAATTTTTTTGATCGAAAAGAAGTTCGGGATATGATTTCTTATATCCGATTGATTGCCAATACAAGAGACGAT GCTTCTTTACTTCGAATTTTAAATTATCCAAAACGAGGGATCGGACCTGGAAGTATTTCACTCATTCACGAGAAGGCTTC TCAAATGGGAGAATCTTTATACGAAATTCTTTTTAGAGTTTGTGAGTCTCCAGATTTTATTCCTAACTTACAAAAAAAGA TTCAGTCAGAAATTTACAATTTTGTAAACTTGATCGAAAGGACTAAGAAAAAATTTTCCACGGCGCCTAAGATGTATTAT GCGTTCCGGGAATTTATCCAAGAAGTGGGAATCGAAAAGGAGATTCTACTCGAAGAAAAAGACGAGAAAGTAGCAAAGGC ACGTACTTTCAATTTATCTGAACTAGTAAACATGATGTCTTACTTTGAGGAAAATCACGATTCACCTGAAAAACCAACGT TGTTTGATTTTATCAATCGACTGAATTTACTCATGGAAGACGAAAATCCGTCCGATGAGGATAAGGAAGACAATCGTGTA CAGTTGTTAACAATCCATCAATCCAAGGGATTAGAATTTGAATCGGTTTATGTTCCTGGAATGGAGGAAGGAATTCTTCC TAACTCTAGAGTATTAACTGAAGAGTCTTCCGTGGATGAAGAAAGACGTCTACTATACGTTGCGATGACCCGCGCGAGAA AGCATTTATGCTTGACAGGTGCCGCAAATAGACGAAAGTTTGGGGAGCAAACAGCTACCCAAGCCTCCCGATTTCTAACT GAAATCGATCCGGAGACTATGGACTGGGTTTCCAATGATGAGGTTCGACAGCAAGAGACAGAAGATTTTTTTGCCGAACT GGAAAAATTGAAAACAGGATCGTAA
Upstream 100 bases:
>100_bases TTTTCAATAAAACTCGATTTAAGAAATAGAAAACAAAGAGTTGGGCAAGGGTGTACATGATTGACAGAATCCTTCTTTCC CGAACTATGTCACATGTTTT
Downstream 100 bases:
>100_bases GTATGACATTCAATACAACAATCATTACTGTAATAACCTTGTTTCTATTTATATCTGGTTGTACTAGCAGTCAGAAAACA GTGGATTCCGGACTTTCTCA
Product: ATP-dependent DNA helicase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 674; Mature: 674
Protein sequence:
>674_residues MKLSPEQEKAVRHVDGPILIFAGAGSGKTRVISNRIAHLIENAGVPAGKIVALSFTNKSAREMEERVRKMIPRQKLKGIV LSTFHSLGLNILKKHIGLLGYKHPFLLMNQNDQEGFLTTLLIANKVELKKAKVSEILGKISRIKNSGLAYREYLDSSLVE SDQVANLVYDSYQKSLKEQNSLDFDDLILLPGILLREFSEVREEYHKKYQYFMVDEFQDTNQTQYIFLRALMGENRNLCV VGDDDQSIYAFRGSDLSLILNFEKDFPEANVVRLLENYRSTSVIIQGANSLIKNNLSRRSKELFSSIPGGRKIRYLERMD EKDEAAYVVDCIREEMIKDARVGSQISILFRTNFQTRPFEEELRSRSIAYKLVGGYNFFDRKEVRDMISYIRLIANTRDD ASLLRILNYPKRGIGPGSISLIHEKASQMGESLYEILFRVCESPDFIPNLQKKIQSEIYNFVNLIERTKKKFSTAPKMYY AFREFIQEVGIEKEILLEEKDEKVAKARTFNLSELVNMMSYFEENHDSPEKPTLFDFINRLNLLMEDENPSDEDKEDNRV QLLTIHQSKGLEFESVYVPGMEEGILPNSRVLTEESSVDEERRLLYVAMTRARKHLCLTGAANRRKFGEQTATQASRFLT EIDPETMDWVSNDEVRQQETEDFFAELEKLKTGS
Sequences:
>Translated_674_residues MKLSPEQEKAVRHVDGPILIFAGAGSGKTRVISNRIAHLIENAGVPAGKIVALSFTNKSAREMEERVRKMIPRQKLKGIV LSTFHSLGLNILKKHIGLLGYKHPFLLMNQNDQEGFLTTLLIANKVELKKAKVSEILGKISRIKNSGLAYREYLDSSLVE SDQVANLVYDSYQKSLKEQNSLDFDDLILLPGILLREFSEVREEYHKKYQYFMVDEFQDTNQTQYIFLRALMGENRNLCV VGDDDQSIYAFRGSDLSLILNFEKDFPEANVVRLLENYRSTSVIIQGANSLIKNNLSRRSKELFSSIPGGRKIRYLERMD EKDEAAYVVDCIREEMIKDARVGSQISILFRTNFQTRPFEEELRSRSIAYKLVGGYNFFDRKEVRDMISYIRLIANTRDD ASLLRILNYPKRGIGPGSISLIHEKASQMGESLYEILFRVCESPDFIPNLQKKIQSEIYNFVNLIERTKKKFSTAPKMYY AFREFIQEVGIEKEILLEEKDEKVAKARTFNLSELVNMMSYFEENHDSPEKPTLFDFINRLNLLMEDENPSDEDKEDNRV QLLTIHQSKGLEFESVYVPGMEEGILPNSRVLTEESSVDEERRLLYVAMTRARKHLCLTGAANRRKFGEQTATQASRFLT EIDPETMDWVSNDEVRQQETEDFFAELEKLKTGS >Mature_674_residues MKLSPEQEKAVRHVDGPILIFAGAGSGKTRVISNRIAHLIENAGVPAGKIVALSFTNKSAREMEERVRKMIPRQKLKGIV LSTFHSLGLNILKKHIGLLGYKHPFLLMNQNDQEGFLTTLLIANKVELKKAKVSEILGKISRIKNSGLAYREYLDSSLVE SDQVANLVYDSYQKSLKEQNSLDFDDLILLPGILLREFSEVREEYHKKYQYFMVDEFQDTNQTQYIFLRALMGENRNLCV VGDDDQSIYAFRGSDLSLILNFEKDFPEANVVRLLENYRSTSVIIQGANSLIKNNLSRRSKELFSSIPGGRKIRYLERMD EKDEAAYVVDCIREEMIKDARVGSQISILFRTNFQTRPFEEELRSRSIAYKLVGGYNFFDRKEVRDMISYIRLIANTRDD ASLLRILNYPKRGIGPGSISLIHEKASQMGESLYEILFRVCESPDFIPNLQKKIQSEIYNFVNLIERTKKKFSTAPKMYY AFREFIQEVGIEKEILLEEKDEKVAKARTFNLSELVNMMSYFEENHDSPEKPTLFDFINRLNLLMEDENPSDEDKEDNRV QLLTIHQSKGLEFESVYVPGMEEGILPNSRVLTEESSVDEERRLLYVAMTRARKHLCLTGAANRRKFGEQTATQASRFLT EIDPETMDWVSNDEVRQQETEDFFAELEKLKTGS
Specific function: Essential helicase. May act as a helicase in plasmid pT181 replication [H]
COG id: COG0210
COG function: function code L; Superfamily I DNA and RNA helicases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]
Homologues:
Organism=Escherichia coli, GI48994965, Length=677, Percent_Identity=37.5184638109306, Blast_Score=416, Evalue=1e-117, Organism=Escherichia coli, GI2367296, Length=646, Percent_Identity=33.7461300309598, Blast_Score=356, Evalue=2e-99, Organism=Escherichia coli, GI1787196, Length=394, Percent_Identity=27.1573604060914, Blast_Score=111, Evalue=2e-25, Organism=Saccharomyces cerevisiae, GI6322369, Length=736, Percent_Identity=26.9021739130435, Blast_Score=204, Evalue=4e-53,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005751 - InterPro: IPR013986 - InterPro: IPR014017 - InterPro: IPR000212 - InterPro: IPR014016 [H]
Pfam domain/function: PF00580 UvrD-helicase [H]
EC number: =3.6.4.12 [H]
Molecular weight: Translated: 77738; Mature: 77738
Theoretical pI: Translated: 6.10; Mature: 6.10
Prosite motif: PS00165 DEHYDRATASE_SER_THR
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKLSPEQEKAVRHVDGPILIFAGAGSGKTRVISNRIAHLIENAGVPAGKIVALSFTNKSA CCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHH REMEERVRKMIPRQKLKGIVLSTFHSLGLNILKKHIGLLGYKHPFLLMNQNDQEGFLTTL HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH LIANKVELKKAKVSEILGKISRIKNSGLAYREYLDSSLVESDQVANLVYDSYQKSLKEQN HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC SLDFDDLILLPGILLREFSEVREEYHKKYQYFMVDEFQDTNQTQYIFLRALMGENRNLCV CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCEEE VGDDDQSIYAFRGSDLSLILNFEKDFPEANVVRLLENYRSTSVIIQGANSLIKNNLSRRS ECCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHH KELFSSIPGGRKIRYLERMDEKDEAAYVVDCIREEMIKDARVGSQISILFRTNFQTRPFE HHHHHHCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHH EELRSRSIAYKLVGGYNFFDRKEVRDMISYIRLIANTRDDASLLRILNYPKRGIGPGSIS HHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHH LIHEKASQMGESLYEILFRVCESPDFIPNLQKKIQSEIYNFVNLIERTKKKFSTAPKMYY HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH AFREFIQEVGIEKEILLEEKDEKVAKARTFNLSELVNMMSYFEENHDSPEKPTLFDFINR HHHHHHHHHCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH LNLLMEDENPSDEDKEDNRVQLLTIHQSKGLEFESVYVPGMEEGILPNSRVLTEESSVDE HHHEECCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCEECCCCCCCH ERRLLYVAMTRARKHLCLTGAANRRKFGEQTATQASRFLTEIDPETMDWVSNDEVRQQET HHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHH EDFFAELEKLKTGS HHHHHHHHHHCCCC >Mature Secondary Structure MKLSPEQEKAVRHVDGPILIFAGAGSGKTRVISNRIAHLIENAGVPAGKIVALSFTNKSA CCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHH REMEERVRKMIPRQKLKGIVLSTFHSLGLNILKKHIGLLGYKHPFLLMNQNDQEGFLTTL HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHH LIANKVELKKAKVSEILGKISRIKNSGLAYREYLDSSLVESDQVANLVYDSYQKSLKEQN HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC SLDFDDLILLPGILLREFSEVREEYHKKYQYFMVDEFQDTNQTQYIFLRALMGENRNLCV CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHCCCCCEEE VGDDDQSIYAFRGSDLSLILNFEKDFPEANVVRLLENYRSTSVIIQGANSLIKNNLSRRS ECCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHH KELFSSIPGGRKIRYLERMDEKDEAAYVVDCIREEMIKDARVGSQISILFRTNFQTRPFE HHHHHHCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHH EELRSRSIAYKLVGGYNFFDRKEVRDMISYIRLIANTRDDASLLRILNYPKRGIGPGSIS HHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHH LIHEKASQMGESLYEILFRVCESPDFIPNLQKKIQSEIYNFVNLIERTKKKFSTAPKMYY HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH AFREFIQEVGIEKEILLEEKDEKVAKARTFNLSELVNMMSYFEENHDSPEKPTLFDFINR HHHHHHHHHCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH LNLLMEDENPSDEDKEDNRVQLLTIHQSKGLEFESVYVPGMEEGILPNSRVLTEESSVDE HHHEECCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCEECCCCCCCH ERRLLYVAMTRARKHLCLTGAANRRKFGEQTATQASRFLTEIDPETMDWVSNDEVRQQET HHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHH EDFFAELEKLKTGS HHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8232203 [H]