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The map label for this gene is yegE [H]

Identifier: 45657883

GI number: 45657883

Start: 2449725

End: 2451944

Strand: Reverse

Name: yegE [H]

Synonym: LIC12031

Alternate gene names: 45657883

Gene position: 2451944-2449725 (Counterclockwise)

Preceding gene: 45657884

Following gene: 45657877

Centisome position: 57.33

GC content: 36.17

Gene sequence:

>2220_bases
ATGATTCACATTCTTAAAGCTATTTTAGAACAGGCACACGCAGGATATTGGGAAAAAAATTTTTCTGAAAATAAAAGTTA
TTTGAGCCCTGGTTGGAAATCTATGTTGGGCTATCAAAAAGAAGAATTGGAGGACTCTATATCAGCTTGGCAGTCTCATA
TTTTTCCGGAAGATCTAAATCCAATTCGTAACGAATTTGAAGATTATTTAAAGACGGACCTGAGTCAATCATACGAAGCG
GATATTCGTTTTTTACATAAAAACGGAAACATCATTTGGTTTAAATGTACTTGTAAGGTAGTAGAAAAAGATTCATTAGG
AAAACCGATTCTAATGATTGGAACTTACTTTGACGTTACAAAATCCAAAAAAATAGAATCCGAATTACAACACACCGTTG
ACCGTCTTGCTCTTGCCACTCAAACGGCGAGGGTAGGAATTTGGGATCTGGATTTTACTTCCGGGAAAATATCTTGGGAT
GATACTATGTTCGAACTTTATGGAATTACTCGAGAGAAATTTTCAGGAACCGTATTAGACTGGGAGTCTAGTTTACATCC
GGATGATTTGGAAAGATGCAGATCGGAATATGCAGAAGCTCTTTCTGGAGAAAAAGAATTCGACACTCAGTTTAGGGTAG
TCTGGCCGGATGGTTCCATACATTTTATTAAGGCGATTGCAATCGTTCAAAGAATGGCTTCTGGAAAACCTTTTCGGATG
TTAGGAACGAATTGGGATATTACCAAACATAAAAACGCAGAAATTGCATTAAAAGAAAGTTATGAACTGACTAAAGTATT
TATTGAAAACGCTCCTTCTGCGATTGCTATGTTTGATACGAACATGAAATATATGGCCGCTTCCCAACAGTGGCTTGTTG
ATTATTATTTGGGCGGAATAGAAATTATCGGTCGTTCTCATTATGAAATTTTTCCTGAAATTGGAGACGAATGGAAATCG
ATTCACCAAGAATGTTTACGTGGAAGGGTAATTCGAAAAGAAGAGGAAGCTTTTACCCGTTTAGATGGAACGGTTCAGTG
GATTATCTGGGAAGTAAGACCTTGGTATGCTTCTCCCAATGTAGTAGGCGGTATTTTGATGTATACCGCAGATATTACTA
CTCTGAAACGAAAGGAGTTCGAAAGAAGTAAGTTGGAGGAAATTCTAACCAGGACCAACGAAGCCGCGCAGATAGGATCT
TGGGAATTGGATTTAGAAACGAACACAAGAGTTTGGAGTAAGGTGACAAAAGCGATTTTCGAATTGCCAGAAGATTATAA
ACCGGATGGTAAGGAAGTAGGAAATTTTTTTAGGAATGAAGAAGATAGAAAAAAGTCTGCGGATATTTTGACGGAATCGA
TTCAAACGGGCAAACCGTTTGACGTCGAAGTGGAAATTTTGACTGCAAAGGGAAATGTAGTATGGACTCGATCAATTGGA
AAGCCGGAGTATAAAGATGGAAAGTGTATTCGTGTTTCAGGTACATTTCAGAATATCCAGGAACAAAAATTAAAAGAACT
GGCTCTTCAGAGAACTTTAGATCTATTAAATAATCAGAATGAAAGATTATTAAATTTTGCTCATATAGTTTCGCATAATC
TCCGTTCCCATTCTGGAAATATATCAATGCTTCTTAAAATTTTACAAGAATCTAAAAACGAATCTGAAAAAGAGAAGATG
ATACAATATATCGCAAAGGCTTCGGACAGTCTGATGGATACGGTTTGGAATTTGAACGAAGTAGTTTCAATTCAAACGAA
TAAAAATCTTCAAAATGCTGAAATTAGTCTTAGAGATTATATCGAAAAGGCGACTCAGACGATCGGAGGAGAAATTCAGA
AATATCAGGTTCAAATTCATAATTTAGTTTCGGATTCAATTCGAGTTCGTTGTAACGCATCTTATATGGAAAGTATTCTT
CTAAATTTTCTTACAAATGCTGTAAAATATAGACATCCGGATAGAGTTCCAGAGATCACTTTAAACGCGGAACGTCAAGA
GAATCGGTTGATTCTTAGTATTAAAGACAATGGTCTTGGGATCGATATGAAAAAATACGGAGATAAACTTTTCGGGATGT
ATAAAACTTTTCACAATAATAAGGACGCTAAGGGAATCGGATTATTTATCACTAAAAATCAAGTAGAAGCCATGGGTGGG
AAAATTGAAGTGGAAAGTCGGTTGAATAATGGAACTACTTTTAGAATCATTTTTCTTTGA

Upstream 100 bases:

>100_bases
CTAATTTTCATTCTACTTGATCGGAAAGGTCAAGGCGATAATTCAAATGCCATGCTTTCGCGTGTCAGACTCTTTTAAAA
ATTCGAAATATTGATAAACG

Downstream 100 bases:

>100_bases
ATTGTAAATGGAATAAAGTAAACTTTGAACGTGGGAACTCTTAACAAAATTAGGACTTCTTTGAATTATTTATGGATTTA
AAGTATAGTAATAGTATAAA

Product: histidine kinase sensor protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MIHILKAILEQAHAGYWEKNFSENKSYLSPGWKSMLGYQKEELEDSISAWQSHIFPEDLNPIRNEFEDYLKTDLSQSYEA
DIRFLHKNGNIIWFKCTCKVVEKDSLGKPILMIGTYFDVTKSKKIESELQHTVDRLALATQTARVGIWDLDFTSGKISWD
DTMFELYGITREKFSGTVLDWESSLHPDDLERCRSEYAEALSGEKEFDTQFRVVWPDGSIHFIKAIAIVQRMASGKPFRM
LGTNWDITKHKNAEIALKESYELTKVFIENAPSAIAMFDTNMKYMAASQQWLVDYYLGGIEIIGRSHYEIFPEIGDEWKS
IHQECLRGRVIRKEEEAFTRLDGTVQWIIWEVRPWYASPNVVGGILMYTADITTLKRKEFERSKLEEILTRTNEAAQIGS
WELDLETNTRVWSKVTKAIFELPEDYKPDGKEVGNFFRNEEDRKKSADILTESIQTGKPFDVEVEILTAKGNVVWTRSIG
KPEYKDGKCIRVSGTFQNIQEQKLKELALQRTLDLLNNQNERLLNFAHIVSHNLRSHSGNISMLLKILQESKNESEKEKM
IQYIAKASDSLMDTVWNLNEVVSIQTNKNLQNAEISLRDYIEKATQTIGGEIQKYQVQIHNLVSDSIRVRCNASYMESIL
LNFLTNAVKYRHPDRVPEITLNAERQENRLILSIKDNGLGIDMKKYGDKLFGMYKTFHNNKDAKGIGLFITKNQVEAMGG
KIEVESRLNNGTTFRIIFL

Sequences:

>Translated_739_residues
MIHILKAILEQAHAGYWEKNFSENKSYLSPGWKSMLGYQKEELEDSISAWQSHIFPEDLNPIRNEFEDYLKTDLSQSYEA
DIRFLHKNGNIIWFKCTCKVVEKDSLGKPILMIGTYFDVTKSKKIESELQHTVDRLALATQTARVGIWDLDFTSGKISWD
DTMFELYGITREKFSGTVLDWESSLHPDDLERCRSEYAEALSGEKEFDTQFRVVWPDGSIHFIKAIAIVQRMASGKPFRM
LGTNWDITKHKNAEIALKESYELTKVFIENAPSAIAMFDTNMKYMAASQQWLVDYYLGGIEIIGRSHYEIFPEIGDEWKS
IHQECLRGRVIRKEEEAFTRLDGTVQWIIWEVRPWYASPNVVGGILMYTADITTLKRKEFERSKLEEILTRTNEAAQIGS
WELDLETNTRVWSKVTKAIFELPEDYKPDGKEVGNFFRNEEDRKKSADILTESIQTGKPFDVEVEILTAKGNVVWTRSIG
KPEYKDGKCIRVSGTFQNIQEQKLKELALQRTLDLLNNQNERLLNFAHIVSHNLRSHSGNISMLLKILQESKNESEKEKM
IQYIAKASDSLMDTVWNLNEVVSIQTNKNLQNAEISLRDYIEKATQTIGGEIQKYQVQIHNLVSDSIRVRCNASYMESIL
LNFLTNAVKYRHPDRVPEITLNAERQENRLILSIKDNGLGIDMKKYGDKLFGMYKTFHNNKDAKGIGLFITKNQVEAMGG
KIEVESRLNNGTTFRIIFL
>Mature_739_residues
MIHILKAILEQAHAGYWEKNFSENKSYLSPGWKSMLGYQKEELEDSISAWQSHIFPEDLNPIRNEFEDYLKTDLSQSYEA
DIRFLHKNGNIIWFKCTCKVVEKDSLGKPILMIGTYFDVTKSKKIESELQHTVDRLALATQTARVGIWDLDFTSGKISWD
DTMFELYGITREKFSGTVLDWESSLHPDDLERCRSEYAEALSGEKEFDTQFRVVWPDGSIHFIKAIAIVQRMASGKPFRM
LGTNWDITKHKNAEIALKESYELTKVFIENAPSAIAMFDTNMKYMAASQQWLVDYYLGGIEIIGRSHYEIFPEIGDEWKS
IHQECLRGRVIRKEEEAFTRLDGTVQWIIWEVRPWYASPNVVGGILMYTADITTLKRKEFERSKLEEILTRTNEAAQIGS
WELDLETNTRVWSKVTKAIFELPEDYKPDGKEVGNFFRNEEDRKKSADILTESIQTGKPFDVEVEILTAKGNVVWTRSIG
KPEYKDGKCIRVSGTFQNIQEQKLKELALQRTLDLLNNQNERLLNFAHIVSHNLRSHSGNISMLLKILQESKNESEKEKM
IQYIAKASDSLMDTVWNLNEVVSIQTNKNLQNAEISLRDYIEKATQTIGGEIQKYQVQIHNLVSDSIRVRCNASYMESIL
LNFLTNAVKYRHPDRVPEITLNAERQENRLILSIKDNGLGIDMKKYGDKLFGMYKTFHNNKDAKGIGLFITKNQVEAMGG
KIEVESRLNNGTTFRIIFL

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=249, Percent_Identity=28.5140562248996, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=26.4957264957265, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=276, Percent_Identity=25.7246376811594, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 85323; Mature: 85323

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHILKAILEQAHAGYWEKNFSENKSYLSPGWKSMLGYQKEELEDSISAWQSHIFPEDLN
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCH
PIRNEFEDYLKTDLSQSYEADIRFLHKNGNIIWFKCTCKVVEKDSLGKPILMIGTYFDVT
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEEEEEECCCCCCCEEEEEEECCCH
KSKKIESELQHTVDRLALATQTARVGIWDLDFTSGKISWDDTMFELYGITREKFSGTVLD
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEECCCHHHHHHHCCHHHHCCCCEEE
WESSLHPDDLERCRSEYAEALSGEKEFDTQFRVVWPDGSIHFIKAIAIVQRMASGKPFRM
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEE
LGTNWDITKHKNAEIALKESYELTKVFIENAPSAIAMFDTNMKYMAASQQWLVDYYLGGI
ECCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCHHHHCCHHHHHHHHHCCE
EIIGRSHYEIFPEIGDEWKSIHQECLRGRVIRKEEEAFTRLDGTVQWIIWEVRPWYASPN
EEEECCCCEECHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEEEEEEECCCCCCC
VVGGILMYTADITTLKRKEFERSKLEEILTRTNEAAQIGSWELDLETNTRVWSKVTKAIF
HHHHHEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
ELPEDYKPDGKEVGNFFRNEEDRKKSADILTESIQTGKPFDVEVEILTAKGNVVWTRSIG
HCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEEECCC
KPEYKDGKCIRVSGTFQNIQEQKLKELALQRTLDLLNNQNERLLNFAHIVSHNLRSHSGN
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
ISMLLKILQESKNESEKEKMIQYIAKASDSLMDTVWNLNEVVSIQTNKNLQNAEISLRDY
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCHHHHHHH
IEKATQTIGGEIQKYQVQIHNLVSDSIRVRCNASYMESILLNFLTNAVKYRHPDRVPEIT
HHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEEE
LNAERQENRLILSIKDNGLGIDMKKYGDKLFGMYKTFHNNKDAKGIGLFITKNQVEAMGG
EECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHCCC
KIEVESRLNNGTTFRIIFL
EEEEEECCCCCCEEEEEEC
>Mature Secondary Structure
MIHILKAILEQAHAGYWEKNFSENKSYLSPGWKSMLGYQKEELEDSISAWQSHIFPEDLN
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCH
PIRNEFEDYLKTDLSQSYEADIRFLHKNGNIIWFKCTCKVVEKDSLGKPILMIGTYFDVT
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEEEEEECCCCCCCEEEEEEECCCH
KSKKIESELQHTVDRLALATQTARVGIWDLDFTSGKISWDDTMFELYGITREKFSGTVLD
HHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEECCCHHHHHHHCCHHHHCCCCEEE
WESSLHPDDLERCRSEYAEALSGEKEFDTQFRVVWPDGSIHFIKAIAIVQRMASGKPFRM
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEE
LGTNWDITKHKNAEIALKESYELTKVFIENAPSAIAMFDTNMKYMAASQQWLVDYYLGGI
ECCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCHHHHCCHHHHHHHHHCCE
EIIGRSHYEIFPEIGDEWKSIHQECLRGRVIRKEEEAFTRLDGTVQWIIWEVRPWYASPN
EEEECCCCEECHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEEEEEEECCCCCCC
VVGGILMYTADITTLKRKEFERSKLEEILTRTNEAAQIGSWELDLETNTRVWSKVTKAIF
HHHHHEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
ELPEDYKPDGKEVGNFFRNEEDRKKSADILTESIQTGKPFDVEVEILTAKGNVVWTRSIG
HCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEEECCC
KPEYKDGKCIRVSGTFQNIQEQKLKELALQRTLDLLNNQNERLLNFAHIVSHNLRSHSGN
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
ISMLLKILQESKNESEKEKMIQYIAKASDSLMDTVWNLNEVVSIQTNKNLQNAEISLRDY
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCHHHHHHH
IEKATQTIGGEIQKYQVQIHNLVSDSIRVRCNASYMESILLNFLTNAVKYRHPDRVPEIT
HHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEEE
LNAERQENRLILSIKDNGLGIDMKKYGDKLFGMYKTFHNNKDAKGIGLFITKNQVEAMGG
EECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHCCC
KIEVESRLNNGTTFRIIFL
EEEEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]