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The map label for this gene is asnC

Identifier: 45657877

GI number: 45657877

Start: 2442147

End: 2443454

Strand: Reverse

Name: asnC

Synonym: LIC12025

Alternate gene names: 45657877

Gene position: 2443454-2442147 (Counterclockwise)

Preceding gene: 45657883

Following gene: 45657876

Centisome position: 57.13

GC content: 39.07

Gene sequence:

>1308_bases
ATGTCTGAAACTCCAATTGTAAGTAATCATGATTTAGGAAAGTATGTGGATCAAAAGGTGGTCATCCAAGGTTGGGTGCA
CGGAATTAGAGGAAGCAACGCTAGACAATTTCTTTCTCTTAGAAACAGCGGAAAAATTTTACAGGTGCTTGCGGAAAAGG
AAATTTTAGGAGAAGAAGTTTTTCAAACCGTAAAACATCTTCGTCAGGAAACTTCTGTAACCGTAATTGGAAATTTGGTG
AAAAATGAAAAGTCTCCGATCGGATTCGAACTCGTAATGGAATCGATTCAAATCGTAGGGGAATCTGAAAATTATCCGAT
TACTCCGAAAGAACACGGGATTGATTTTTTAATTTCTCAAAGACATCTTTGGTTACGCTCTTCTAAACAATTGGCGATTT
TAAGAGTGAGGGACAATCTTTCTTTTGCGATTCGGAAATACTTTCATGAAAGAGATTTTTTACTGATAGATACTCCGATC
CTTACTGGGTCTGTGGGAGAAAGTGCGGGTACTTTATTTTCTACGGAATATTTTGATTTAGGAAACGCGTATCTAGCACA
AACGGGACAACTCTATTTGGAAACTGCAATTTTTGCGCATAACAAAGTATTTTGTTACGGCCCTACATTTCGTGCGGAAA
AGAGTAAAACTAGAAGACATCTCACTGAATTTTGGATGGTAGAAGCCGAAGTAGCATTCGCAACACATGCAGAAAATCTA
AAGTTACAAGAAGACTTTGTAAAAACGGTCATTAAAGAAACGGTTCAAAATTCATTCCAAGATTTGAAAGTATTGGAAAG
AGACCCGGCTCCATTACTTGCGTATTTAGAAAAAGATTTTCCGGTGATCGATTATACAAAGGCACTTGAGATTCTACAAT
CCAAAGGAGAAGATATAGTTTGGGGGGACGATATTAATTCCGAAAGAGAGCAAATATTGACTGTGGAATTTGGAGGTCCG
GTTTTTATCCAAAAGTATCCAAGGGAAGCAAAGGCATTTTATATGAAGGTCAACCCAGAAGATCCTAGGACTGTGTTAAA
CGCGGATTTAATCGCACCGGACGGGGTGGGGGAAATTATAGGTGGTTCAGAAAGAGAGGAGAACTACGAAAATATAGTTC
AACGTCTCAAAGAGGAAAAACTTCCCGTGGAATCTTATGACTGGTATTTGGATTTGAGAAAATACGGATCTGTTCCCCAT
TCCGGTTTTGGTTTGGGCTCGGAAAGATTGATCGCATGGATCTGTGGGTTGGCACATGTAAGGGAATGTATTCCTTTTCC
GAGGATGATGGAACGACTTTATCCTTAA

Upstream 100 bases:

>100_bases
CTAAAAGAACTGGATTCATACTTCTCAGGATTTAGAGACTGTCTTCTCTGTCAGGTAAAAAATATCCTTTCCGGTGGAAT
CAAAACCGTAAAATGGGTTC

Downstream 100 bases:

>100_bases
AACGCGATCCATAGAGCGTTTTGCTGAGTTCAACGCGATCCATAGATTAGTATGATTCTTGGACGTAAGACAAGTCGAAG
TGTGATACTCTTGAATCGAC

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSETPIVSNHDLGKYVDQKVVIQGWVHGIRGSNARQFLSLRNSGKILQVLAEKEILGEEVFQTVKHLRQETSVTVIGNLV
KNEKSPIGFELVMESIQIVGESENYPITPKEHGIDFLISQRHLWLRSSKQLAILRVRDNLSFAIRKYFHERDFLLIDTPI
LTGSVGESAGTLFSTEYFDLGNAYLAQTGQLYLETAIFAHNKVFCYGPTFRAEKSKTRRHLTEFWMVEAEVAFATHAENL
KLQEDFVKTVIKETVQNSFQDLKVLERDPAPLLAYLEKDFPVIDYTKALEILQSKGEDIVWGDDINSEREQILTVEFGGP
VFIQKYPREAKAFYMKVNPEDPRTVLNADLIAPDGVGEIIGGSEREENYENIVQRLKEEKLPVESYDWYLDLRKYGSVPH
SGFGLGSERLIAWICGLAHVRECIPFPRMMERLYP

Sequences:

>Translated_435_residues
MSETPIVSNHDLGKYVDQKVVIQGWVHGIRGSNARQFLSLRNSGKILQVLAEKEILGEEVFQTVKHLRQETSVTVIGNLV
KNEKSPIGFELVMESIQIVGESENYPITPKEHGIDFLISQRHLWLRSSKQLAILRVRDNLSFAIRKYFHERDFLLIDTPI
LTGSVGESAGTLFSTEYFDLGNAYLAQTGQLYLETAIFAHNKVFCYGPTFRAEKSKTRRHLTEFWMVEAEVAFATHAENL
KLQEDFVKTVIKETVQNSFQDLKVLERDPAPLLAYLEKDFPVIDYTKALEILQSKGEDIVWGDDINSEREQILTVEFGGP
VFIQKYPREAKAFYMKVNPEDPRTVLNADLIAPDGVGEIIGGSEREENYENIVQRLKEEKLPVESYDWYLDLRKYGSVPH
SGFGLGSERLIAWICGLAHVRECIPFPRMMERLYP
>Mature_434_residues
SETPIVSNHDLGKYVDQKVVIQGWVHGIRGSNARQFLSLRNSGKILQVLAEKEILGEEVFQTVKHLRQETSVTVIGNLVK
NEKSPIGFELVMESIQIVGESENYPITPKEHGIDFLISQRHLWLRSSKQLAILRVRDNLSFAIRKYFHERDFLLIDTPIL
TGSVGESAGTLFSTEYFDLGNAYLAQTGQLYLETAIFAHNKVFCYGPTFRAEKSKTRRHLTEFWMVEAEVAFATHAENLK
LQEDFVKTVIKETVQNSFQDLKVLERDPAPLLAYLEKDFPVIDYTKALEILQSKGEDIVWGDDINSEREQILTVEFGGPV
FIQKYPREAKAFYMKVNPEDPRTVLNADLIAPDGVGEIIGGSEREENYENIVQRLKEEKLPVESYDWYLDLRKYGSVPHS
GFGLGSERLIAWICGLAHVRECIPFPRMMERLYP

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI226491502, Length=440, Percent_Identity=36.1363636363636, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI4758762, Length=453, Percent_Identity=33.112582781457, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI45439306, Length=453, Percent_Identity=27.3730684326711, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1787161, Length=461, Percent_Identity=37.9609544468547, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1789256, Length=448, Percent_Identity=23.4375, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788173, Length=261, Percent_Identity=22.2222222222222, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71984122, Length=452, Percent_Identity=33.4070796460177, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17556372, Length=413, Percent_Identity=31.2348668280872, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17551876, Length=458, Percent_Identity=27.292576419214, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321807, Length=434, Percent_Identity=33.1797235023041, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6319872, Length=456, Percent_Identity=32.2368421052632, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323011, Length=464, Percent_Identity=28.8793103448276, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922416, Length=443, Percent_Identity=31.3769751693002, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI19921528, Length=435, Percent_Identity=32.183908045977, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17136276, Length=473, Percent_Identity=25.369978858351, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.22 [H]

Molecular weight: Translated: 49748; Mature: 49617

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETPIVSNHDLGKYVDQKVVIQGWVHGIRGSNARQFLSLRNSGKILQVLAEKEILGEEV
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
FQTVKHLRQETSVTVIGNLVKNEKSPIGFELVMESIQIVGESENYPITPKEHGIDFLISQ
HHHHHHHHHHCCHHEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEEEC
RHLWLRSSKQLAILRVRDNLSFAIRKYFHERDFLLIDTPILTGSVGESAGTLFSTEYFDL
CHHEECCCCCEEEEEEECCHHHHHHHHHCCCCEEEEECCEEECCCCCCCCCEEEEHHHHC
GNAYLAQTGQLYLETAIFAHNKVFCYGPTFRAEKSKTRRHLTEFWMVEAEVAFATHAENL
CCHHHHCCCHHHHHHHHEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KLQEDFVKTVIKETVQNSFQDLKVLERDPAPLLAYLEKDFPVIDYTKALEILQSKGEDIV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEHHHHHHHHHHCCCCEEE
WGDDINSEREQILTVEFGGPVFIQKYPREAKAFYMKVNPEDPRTVLNADLIAPDGVGEII
ECCCCCCCCCEEEEEEECCCEEEECCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCHHHC
GGSEREENYENIVQRLKEEKLPVESYDWYLDLRKYGSVPHSGFGLGSERLIAWICGLAHV
CCCCCCHHHHHHHHHHHHHCCCCCCCHHEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
RECIPFPRMMERLYP
HHHCCHHHHHHHHCC
>Mature Secondary Structure 
SETPIVSNHDLGKYVDQKVVIQGWVHGIRGSNARQFLSLRNSGKILQVLAEKEILGEEV
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
FQTVKHLRQETSVTVIGNLVKNEKSPIGFELVMESIQIVGESENYPITPKEHGIDFLISQ
HHHHHHHHHHCCHHEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEEEC
RHLWLRSSKQLAILRVRDNLSFAIRKYFHERDFLLIDTPILTGSVGESAGTLFSTEYFDL
CHHEECCCCCEEEEEEECCHHHHHHHHHCCCCEEEEECCEEECCCCCCCCCEEEEHHHHC
GNAYLAQTGQLYLETAIFAHNKVFCYGPTFRAEKSKTRRHLTEFWMVEAEVAFATHAENL
CCHHHHCCCHHHHHHHHEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KLQEDFVKTVIKETVQNSFQDLKVLERDPAPLLAYLEKDFPVIDYTKALEILQSKGEDIV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEHHHHHHHHHHCCCCEEE
WGDDINSEREQILTVEFGGPVFIQKYPREAKAFYMKVNPEDPRTVLNADLIAPDGVGEII
ECCCCCCCCCEEEEEEECCCEEEECCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCHHHC
GGSEREENYENIVQRLKEEKLPVESYDWYLDLRKYGSVPHSGFGLGSERLIAWICGLAHV
CCCCCCHHHHHHHHHHHHHCCCCCCCHHEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
RECIPFPRMMERLYP
HHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA