BacMap

Definition	Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence.
Accession	NC_005823
Length	4,277,185

Click here to switch to the map view.

The map label for this gene is ppi

Identifier: 45657314

GI number: 45657314

Start: 1772588

End: 1773046

Strand: Direct

Name: ppi

Synonym: LIC11438

Alternate gene names: 45657314

Gene position: 1772588-1773046 (Clockwise)

Preceding gene: 45657310

Following gene: 45657315

Centisome position: 41.44

GC content: 37.25

Gene sequence:

>459_bases
ATGCCGACTGCGATATTTAAAACAAATTTTGGAAACTTTTCGGTTTATTTGGATGAGGAAAAGGCTCCCATTACCGCGGG
TAATTTTATCAAATTGGCTAAAGATGGATTTTACAATGGACTTACATTCCATCGAGTTATCAAAAATTTTATGATTCAGG
GAGGTTGTCCTGTTGGAAATGGAACGGGTGGGCCTGGTTATAAAATCCAAGATGAGTTTCATAAGGATCTGAAGAACGAA
AAATTTACCCTTTCGATGGCAAATGCAGGACCGAACACGGGCGGATCTCAATTTTTTATCAATGTAAGAGATAATTTTTA
CTTAGATAATAGACACGCTGTCTTTGGAAGGGTTACGGAAGGAATGGATATAGTAGAAACGATTTCGGAAACGGAAACAG
GATTTCAAGACAAACCTACAAAATCAGTGATTATAGAAACAATTACGGTTTCTCCTTGA

Upstream 100 bases:

>100_bases
AGCGTTTTTGTTCGTTTTTTGTAAGAAATCGCTTTCTATCGTACTCTAGTATCGGAAAATGGAAATAAATTCTTAAAATA
GAGGAGTTAAAGAGGAGAGA

Downstream 100 bases:

>100_bases
ACTTAGATCTCCACTTAATTTTTCTTTGAAGGATCTTAGAGTGTTGTTTAGAACAGAATGTCTTAGAATTTTGTTTCTAA
AACCTGGATTTGTCTCTAAT

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Cyclophilin ScCypB; Rotamase B; S-cyclophilin [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MPTAIFKTNFGNFSVYLDEEKAPITAGNFIKLAKDGFYNGLTFHRVIKNFMIQGGCPVGNGTGGPGYKIQDEFHKDLKNE
KFTLSMANAGPNTGGSQFFINVRDNFYLDNRHAVFGRVTEGMDIVETISETETGFQDKPTKSVIIETITVSP

Sequences:

>Translated_152_residues
MPTAIFKTNFGNFSVYLDEEKAPITAGNFIKLAKDGFYNGLTFHRVIKNFMIQGGCPVGNGTGGPGYKIQDEFHKDLKNE
KFTLSMANAGPNTGGSQFFINVRDNFYLDNRHAVFGRVTEGMDIVETISETETGFQDKPTKSVIIETITVSP
>Mature_151_residues
PTAIFKTNFGNFSVYLDEEKAPITAGNFIKLAKDGFYNGLTFHRVIKNFMIQGGCPVGNGTGGPGYKIQDEFHKDLKNEK
FTLSMANAGPNTGGSQFFINVRDNFYLDNRHAVFGRVTEGMDIVETISETETGFQDKPTKSVIIETITVSP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=153, Percent_Identity=49.0196078431373, Blast_Score=136, Evalue=7e-33,
Organism=Homo sapiens, GI7706339, Length=151, Percent_Identity=45.6953642384106, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI19557636, Length=153, Percent_Identity=37.9084967320261, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI4758950, Length=130, Percent_Identity=48.4615384615385, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI22547215, Length=150, Percent_Identity=42.6666666666667, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI22547212, Length=148, Percent_Identity=43.2432432432432, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI7657473, Length=148, Percent_Identity=43.2432432432432, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI64276486, Length=119, Percent_Identity=40.3361344537815, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI4505991, Length=138, Percent_Identity=43.4782608695652, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI5174637, Length=142, Percent_Identity=42.9577464788732, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI5454154, Length=151, Percent_Identity=41.0596026490066, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=47.65625, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI20911035, Length=146, Percent_Identity=40.4109589041096, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI45439316, Length=129, Percent_Identity=43.4108527131783, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI6631100, Length=112, Percent_Identity=46.4285714285714, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI5031987, Length=143, Percent_Identity=43.3566433566434, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI303305009, Length=125, Percent_Identity=44, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI42560244, Length=112, Percent_Identity=43.75, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI310129267, Length=126, Percent_Identity=46.031746031746, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI310120620, Length=126, Percent_Identity=46.031746031746, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI256017253, Length=125, Percent_Identity=45.6, Blast_Score=83, Evalue=7e-17,
Organism=Homo sapiens, GI221139811, Length=125, Percent_Identity=45.6, Blast_Score=83, Evalue=7e-17,
Organism=Homo sapiens, GI256017251, Length=125, Percent_Identity=45.6, Blast_Score=83, Evalue=7e-17,
Organism=Homo sapiens, GI310127646, Length=133, Percent_Identity=42.1052631578947, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310114371, Length=133, Percent_Identity=42.1052631578947, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310119221, Length=133, Percent_Identity=42.1052631578947, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI169163387, Length=126, Percent_Identity=44.4444444444444, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310110104, Length=126, Percent_Identity=46.031746031746, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI169164185, Length=126, Percent_Identity=44.4444444444444, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI169163623, Length=126, Percent_Identity=44.4444444444444, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4826932, Length=151, Percent_Identity=40.3973509933775, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI178057341, Length=126, Percent_Identity=44.4444444444444, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI209417936, Length=142, Percent_Identity=41.5492957746479, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI30102944, Length=142, Percent_Identity=41.5492957746479, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI219842199, Length=142, Percent_Identity=41.5492957746479, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI310132444, Length=133, Percent_Identity=39.8496240601504, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310113152, Length=133, Percent_Identity=39.8496240601504, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI150418007, Length=127, Percent_Identity=40.9448818897638, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310127745, Length=118, Percent_Identity=40.6779661016949, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI310119290, Length=118, Percent_Identity=40.6779661016949, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI310114540, Length=118, Percent_Identity=40.6779661016949, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI169214050, Length=135, Percent_Identity=39.2592592592593, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI239751853, Length=135, Percent_Identity=39.2592592592593, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI113428306, Length=135, Percent_Identity=39.2592592592593, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=40.1234567901235, Blast_Score=111, Evalue=2e-26,
Organism=Escherichia coli, GI1786736, Length=160, Percent_Identity=40.625, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506311, Length=153, Percent_Identity=46.4052287581699, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17539496, Length=148, Percent_Identity=44.5945945945946, Blast_Score=123, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17532641, Length=144, Percent_Identity=46.5277777777778, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17506307, Length=144, Percent_Identity=47.9166666666667, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17552780, Length=142, Percent_Identity=45.0704225352113, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17559074, Length=149, Percent_Identity=43.6241610738255, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71997782, Length=120, Percent_Identity=41.6666666666667, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17551284, Length=114, Percent_Identity=50.8771929824561, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17551282, Length=114, Percent_Identity=50.8771929824561, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71980594, Length=152, Percent_Identity=34.8684210526316, Blast_Score=96, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71980590, Length=141, Percent_Identity=36.1702127659575, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17532643, Length=148, Percent_Identity=43.2432432432432, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17566266, Length=132, Percent_Identity=44.6969696969697, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17539498, Length=151, Percent_Identity=41.7218543046358, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI32563659, Length=160, Percent_Identity=33.125, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17552782, Length=149, Percent_Identity=39.5973154362416, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17565860, Length=150, Percent_Identity=44, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17552784, Length=151, Percent_Identity=35.0993377483444, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323562, Length=150, Percent_Identity=44, Blast_Score=98, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320359, Length=140, Percent_Identity=46.4285714285714, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321848, Length=134, Percent_Identity=45.5223880597015, Blast_Score=89, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320510, Length=133, Percent_Identity=45.8646616541353, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323246, Length=150, Percent_Identity=42, Blast_Score=85, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322492, Length=189, Percent_Identity=33.8624338624339, Blast_Score=71, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17986117, Length=144, Percent_Identity=44.4444444444444, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI19922376, Length=147, Percent_Identity=42.1768707482993, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922912, Length=152, Percent_Identity=46.7105263157895, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130249, Length=142, Percent_Identity=42.9577464788732, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24664125, Length=145, Percent_Identity=47.5862068965517, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21357783, Length=145, Percent_Identity=47.5862068965517, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45549139, Length=143, Percent_Identity=44.7552447552448, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24650807, Length=139, Percent_Identity=40.2877697841727, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21357249, Length=137, Percent_Identity=35.7664233576642, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647301, Length=143, Percent_Identity=41.958041958042, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24586038, Length=160, Percent_Identity=38.75, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136360, Length=135, Percent_Identity=37.7777777777778, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=34.0909090909091, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355677, Length=160, Percent_Identity=29.375, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16784; Mature: 16653

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTAIFKTNFGNFSVYLDEEKAPITAGNFIKLAKDGFYNGLTFHRVIKNFMIQGGCPVGN
CCCEEEEECCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCC
GTGGPGYKIQDEFHKDLKNEKFTLSMANAGPNTGGSQFFINVRDNFYLDNRHAVFGRVTE
CCCCCCCEECHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCEEECCCEEEEEECCC
GMDIVETISETETGFQDKPTKSVIIETITVSP
CHHHHHHHHHHCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
PTAIFKTNFGNFSVYLDEEKAPITAGNFIKLAKDGFYNGLTFHRVIKNFMIQGGCPVGN
CCEEEEECCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCC
GTGGPGYKIQDEFHKDLKNEKFTLSMANAGPNTGGSQFFINVRDNFYLDNRHAVFGRVTE
CCCCCCCEECHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCEEECCCEEEEEECCC
GMDIVETISETETGFQDKPTKSVIIETITVSP
CHHHHHHHHHHCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9025285 [H]