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The map label for this gene is clpX

Identifier: 45657294

GI number: 45657294

Start: 1743955

End: 1745217

Strand: Direct

Name: clpX

Synonym: LIC11418

Alternate gene names: 45657294

Gene position: 1743955-1745217 (Clockwise)

Preceding gene: 45657293

Following gene: 45657299

Centisome position: 40.77

GC content: 39.11

Gene sequence:

>1263_bases
TTGGCTAAGAAAACACCGGGAAACAACGGTAAACAAAAACTATTCTGCTCTTTTTGCGGAAAGGAACAGGACGCGGTAAA
ACGTTTAGTCGCTGGACCGGGTGTTTATATCTGCGACGAGTGTATTTCTCTTTGTAACGAAATTATTGCAGAAGACCATG
AACATTCTCACGAAAAGTCTGAAGTTTTTAGTGAGGTTCCAAGTCCAGCCGACATCAAGTCCATTTTGGATCAATATGTA
ATTGGACAAGATCACGCAAAAAAGGCACTTTCTGTAGCAGTTTACAACCATTACAAAAGAGTGAATCTCAAAGAAAAGAA
ATCAGACGTAGAAATCGAAAAATCGAATATTCTATTGATTGGACCGACTGGAAGTGGTAAAACTCTTTTGGCTCAAACTC
TTGCAAGAATTATCAAGGTTCCGTTTGCGATCGTGGACGCGACTGCACTTACGGAAGCAGGTTACGTAGGAGAGGACGTA
GAAAACATCATTCTCAAGTTGATTCAAAACGCGGACAACGATATTAAAAAAGCAGAAGTCGGTATTATATACATAGACGA
AGTAGATAAGATAGCGCGTAAATCGGATAGTGCGTCTATTACGAGAGACGTGAGTGGAGAAGGTGTACAACAAGCGCTTT
TAAAAATCATCGAGGGAACTGTGGCTAACGTTCCTCCTCAAGGTGGAAGAAAACATCCTCATCAAGAATATTTACAAGTG
GATACCAAAAATATACTTTTTATTTTAGGCGGCGCTTTTGTAGATCTCCCCAATATTATCAAGTCCAGAACGGGAATTAA
AACGATCGGTTTTGGTTCCGAAGAACAAAGAATTCAATCGGAAAACAAAGACGTATTGATGGAACAAGTGATTCCAGAAG
ATTTAATCAAGTTTGGTCTAATTCCTGAATTTATTGGAAGACTTCCAATCGTTGCTACTTTGCAAGAGCTGAATGTGGAT
ATGCTGAGACAAATTTTCCGAGAGCCTAAAAATTCAGTTCTCAAACAATATACTCGTCTTTTAGAACTCGAAAACGTAAA
GCTTACTTTCCATGACGAAGCGATCGATAAGATTGCAGAACTCGCGATCAAAAGGGAATCTGGTGCTAGAGGATTGCGCG
CCATTGTGGAAAATATCATGTTGGATTTGATGTTTGATATTCCTTCTCGCAAGGATATAGAAGAAGTAATCATCACTGCA
GAAGTAATTGCAAACAGAGTGGCTCCTACTTTGATTCTCAAAAAAGAATCTAAGATTGCTTAA

Upstream 100 bases:

>100_bases
GAAAGAAATTTTTACATGACAGCAGATGAAGCGAAAAATTACGGAATCATTGATACTGTAATTCAGATCGATCGTAAACA
AACTGAATAAGGAGTTTCAC

Downstream 100 bases:

>100_bases
TTCGTTACTTTTTAAGAGTTCACTTCTTGAAAGGTGATTCCGGTAAATTTTTTAGAAATCAATTCTTCTTTCGTTTTAGG
TCCCACAATCAAGATGGGAC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MAKKTPGNNGKQKLFCSFCGKEQDAVKRLVAGPGVYICDECISLCNEIIAEDHEHSHEKSEVFSEVPSPADIKSILDQYV
IGQDHAKKALSVAVYNHYKRVNLKEKKSDVEIEKSNILLIGPTGSGKTLLAQTLARIIKVPFAIVDATALTEAGYVGEDV
ENIILKLIQNADNDIKKAEVGIIYIDEVDKIARKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYLQV
DTKNILFILGGAFVDLPNIIKSRTGIKTIGFGSEEQRIQSENKDVLMEQVIPEDLIKFGLIPEFIGRLPIVATLQELNVD
MLRQIFREPKNSVLKQYTRLLELENVKLTFHDEAIDKIAELAIKRESGARGLRAIVENIMLDLMFDIPSRKDIEEVIITA
EVIANRVAPTLILKKESKIA

Sequences:

>Translated_420_residues
MAKKTPGNNGKQKLFCSFCGKEQDAVKRLVAGPGVYICDECISLCNEIIAEDHEHSHEKSEVFSEVPSPADIKSILDQYV
IGQDHAKKALSVAVYNHYKRVNLKEKKSDVEIEKSNILLIGPTGSGKTLLAQTLARIIKVPFAIVDATALTEAGYVGEDV
ENIILKLIQNADNDIKKAEVGIIYIDEVDKIARKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYLQV
DTKNILFILGGAFVDLPNIIKSRTGIKTIGFGSEEQRIQSENKDVLMEQVIPEDLIKFGLIPEFIGRLPIVATLQELNVD
MLRQIFREPKNSVLKQYTRLLELENVKLTFHDEAIDKIAELAIKRESGARGLRAIVENIMLDLMFDIPSRKDIEEVIITA
EVIANRVAPTLILKKESKIA
>Mature_419_residues
AKKTPGNNGKQKLFCSFCGKEQDAVKRLVAGPGVYICDECISLCNEIIAEDHEHSHEKSEVFSEVPSPADIKSILDQYVI
GQDHAKKALSVAVYNHYKRVNLKEKKSDVEIEKSNILLIGPTGSGKTLLAQTLARIIKVPFAIVDATALTEAGYVGEDVE
NIILKLIQNADNDIKKAEVGIIYIDEVDKIARKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYLQVD
TKNILFILGGAFVDLPNIIKSRTGIKTIGFGSEEQRIQSENKDVLMEQVIPEDLIKFGLIPEFIGRLPIVATLQELNVDM
LRQIFREPKNSVLKQYTRLLELENVKLTFHDEAIDKIAELAIKRESGARGLRAIVENIMLDLMFDIPSRKDIEEVIITAE
VIANRVAPTLILKKESKIA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP [H]

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=332, Percent_Identity=46.6867469879518, Blast_Score=284, Evalue=9e-77,
Organism=Escherichia coli, GI1786642, Length=418, Percent_Identity=60.5263157894737, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1790366, Length=123, Percent_Identity=39.8373983739837, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=314, Percent_Identity=44.9044585987261, Blast_Score=270, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI71982908, Length=314, Percent_Identity=44.9044585987261, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71988663, Length=401, Percent_Identity=36.4089775561097, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71988660, Length=247, Percent_Identity=39.2712550607287, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319704, Length=412, Percent_Identity=38.8349514563107, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24648291, Length=322, Percent_Identity=46.2732919254658, Blast_Score=294, Evalue=6e-80,
Organism=Drosophila melanogaster, GI24648289, Length=322, Percent_Identity=46.2732919254658, Blast_Score=294, Evalue=7e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603 [H]

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX [H]

EC number: NA

Molecular weight: Translated: 46563; Mature: 46431

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKTPGNNGKQKLFCSFCGKEQDAVKRLVAGPGVYICDECISLCNEIIAEDHEHSHEKS
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
EVFSEVPSPADIKSILDQYVIGQDHAKKALSVAVYNHYKRVNLKEKKSDVEIEKSNILLI
HHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEECCEEEE
GPTGSGKTLLAQTLARIIKVPFAIVDATALTEAGYVGEDVENIILKLIQNADNDIKKAEV
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHC
GIIYIDEVDKIARKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYLQV
CEEEECCHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCCCHHHHHHH
DTKNILFILGGAFVDLPNIIKSRTGIKTIGFGSEEQRIQSENKDVLMEQVIPEDLIKFGL
CCCCEEEEECCHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCHHHHHHHHCHHHHHHHCC
IPEFIGRLPIVATLQELNVDMLRQIFREPKNSVLKQYTRLLELENVKLTFHDEAIDKIAE
HHHHHCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHH
LAIKRESGARGLRAIVENIMLDLMFDIPSRKDIEEVIITAEVIANRVAPTLILKKESKIA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure 
AKKTPGNNGKQKLFCSFCGKEQDAVKRLVAGPGVYICDECISLCNEIIAEDHEHSHEKS
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
EVFSEVPSPADIKSILDQYVIGQDHAKKALSVAVYNHYKRVNLKEKKSDVEIEKSNILLI
HHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEECCEEEE
GPTGSGKTLLAQTLARIIKVPFAIVDATALTEAGYVGEDVENIILKLIQNADNDIKKAEV
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHC
GIIYIDEVDKIARKSDSASITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPHQEYLQV
CEEEECCHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHCHHCCCCCCCCCCCCHHHHHHH
DTKNILFILGGAFVDLPNIIKSRTGIKTIGFGSEEQRIQSENKDVLMEQVIPEDLIKFGL
CCCCEEEEECCHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCHHHHHHHHCHHHHHHHCC
IPEFIGRLPIVATLQELNVDMLRQIFREPKNSVLKQYTRLLELENVKLTFHDEAIDKIAE
HHHHHCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHH
LAIKRESGARGLRAIVENIMLDLMFDIPSRKDIEEVIITAEVIANRVAPTLILKKESKIA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA