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The map label for this gene is clpP

Identifier: 45657293

GI number: 45657293

Start: 1743348

End: 1743944

Strand: Direct

Name: clpP

Synonym: LIC11417

Alternate gene names: 45657293

Gene position: 1743348-1743944 (Clockwise)

Preceding gene: 45657292

Following gene: 45657294

Centisome position: 40.76

GC content: 38.19

Gene sequence:

>597_bases
ATGAGCGTAATCCCGTATGTGATCGAACAAACGAGTAGAGGGGAAAGATCGTATGATATATTTTCCCGACTTTTAAAAGA
TAGAATCATATTTTTAGGGAATGCAATCAACGACGATTATGCAAATGTCATTACAGCTCAATTGTTGTTTTTAGAAGCCG
AAAATCCAGAAAGAGATATTTATCTTTATCTTAATTCTCCGGGCGGATATGTTTCTTCTGGTCTTGCAATTTATGACACG
ATGCAGTATATTAAACCGGATGTAAGAACTCTTTGTTTAGGTCAGGCTTCTTCTATGGCGGCGTTACTTCTTGCGGGAGG
GGCGGCTGGAAAACGTTCTGCATTGCCAAATGCAAGAATCATGATGCATCAGCCTATGGGTGGAGCTACTGGTCAGGCGA
GTGATATTGAGATTCAGGCGAGAGAGGTACTCAAGCTGAAAGAAATTCTTAATTCTATCTATCATAAACACACAGGTAAA
ACTGTGGAACAAATTCAAAAAGATACAGAAAGAAATTTTTACATGACAGCAGATGAAGCGAAAAATTACGGAATCATTGA
TACTGTAATTCAGATCGATCGTAAACAAACTGAATAA

Upstream 100 bases:

>100_bases
TAGATAATATACTCTTTGATCTTGTAGAAAAGAAATATACTGACAAATTGAACATTGGGCAGATAAAAGATTATCTCAAC
CAAAAGGAAGAAGTGAAAGC

Downstream 100 bases:

>100_bases
GGAGTTTCACTTGGCTAAGAAAACACCGGGAAACAACGGTAAACAAAAACTATTCTGCTCTTTTTGCGGAAAGGAACAGG
ACGCGGTAAAACGTTTAGTC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MSVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDIYLYLNSPGGYVSSGLAIYDT
MQYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNARIMMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGK
TVEQIQKDTERNFYMTADEAKNYGIIDTVIQIDRKQTE

Sequences:

>Translated_198_residues
MSVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDIYLYLNSPGGYVSSGLAIYDT
MQYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNARIMMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGK
TVEQIQKDTERNFYMTADEAKNYGIIDTVIQIDRKQTE
>Mature_197_residues
SVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDIYLYLNSPGGYVSSGLAIYDTM
QYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNARIMMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGKT
VEQIQKDTERNFYMTADEAKNYGIIDTVIQIDRKQTE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=54.2105263157895, Blast_Score=226, Evalue=1e-59,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=61.0526315789474, Blast_Score=269, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.1505376344086, Blast_Score=210, Evalue=5e-55,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=58.6387434554974, Blast_Score=239, Evalue=9e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_LEPIC (Q72SG6)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001379.1
- ProteinModelPortal:   Q72SG6
- SMR:   Q72SG6
- GeneID:   2770815
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11417
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   LINT267671:LIC_11417-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22113; Mature: 21981

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDI
CCCCCHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHEEEECCCCCCEE
YLYLNSPGGYVSSGLAIYDTMQYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNARI
EEEECCCCCCHHCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEE
MMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGKTVEQIQKDTERNFYMTADEA
EEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCC
KNYGIIDTVIQIDRKQTE
CCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDI
CCCCHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHEEEECCCCCCEE
YLYLNSPGGYVSSGLAIYDTMQYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNARI
EEEECCCCCCHHCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEE
MMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGKTVEQIQKDTERNFYMTADEA
EEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCC
KNYGIIDTVIQIDRKQTE
CCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA