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The map label for this gene is tig

Identifier: 45657292

GI number: 45657292

Start: 1741996

End: 1743351

Strand: Direct

Name: tig

Synonym: LIC11416

Alternate gene names: 45657292

Gene position: 1741996-1743351 (Clockwise)

Preceding gene: 45657291

Following gene: 45657293

Centisome position: 40.73

GC content: 33.78

Gene sequence:

>1356_bases
ATGGATTATAAAACAAAAAAAAATTCTAACGCTACCGTTGATATTAAACTTACATTCGAAGCTTCTGACATAGAAAAAGC
TTTTGATAAAACGTATGAGGAAAAACAAAAAAATGTAAAAATTCCAGGCTTTCGTCCAGGAAAGGCTCCTCTTAACATGG
TCAAACGTCATTTAGGCGATAGTGTAGCCAGTGATGCGATCAATACTTTGATCGTAGATGGAATGACTTCCATTCTTTCG
AAGTTGGAACATCCAATGATTCGATTTCCTAAATTTGAAATTCAAGATTATCAACCAGGCAAAAATCTGATCGCTACCGC
GATTTATGAAACTAATCCAGAAATTACTTTGGGAAAATACAAAAAAATAAAAATCAAACTTCCGGAAGTTTCCGTTTCTG
ATTTGGACGTTTCTGAAGAGGTCGAAAAGGTTCGTAAAAATCTCGCTCGTAAACAGTTGAAGGAAGAAGGCCAGGCTGCC
GTCGCCGGAGATATTATCGATATGGAATATACGGTTTGCGAAAAAGGTCAGGAATCTAAAAATTCTGGGAATACATCTAA
CGACTATCACTTAGGTCACGAAAACAATTTGAAAGGTTTTGATGAAAATCTTTATGGAATGAAATCTGGAGAGAAAAAGG
ATTTTGTCCATACGTTTCCAGAAGATTATTCTCAAAACGAAGTTGCAGGGAAGACGTTTGAATATTCCGTTACGATTAAA
GCTCTTTATGCGAATATACTTCCAGCCGTGGATGATGATCTTGCATCTGAATTTGACGGTTCTGAATCTTTAAATGTTCT
TAAAGATAAAATTCGTAAAAATTTAAAAGAAGGTTTTGAAGACAGAGTTAAAAACAAAAAGTTAGACGAGATTTATAAAG
AAATTATAGACGATTCCAAATATGTTTTTCCCGAATCTTATCTTAGGGAAGAATCAGAACACGTATTTCACAATATGATC
CATGAATTCAAACTTCCTCATATGACGATGGAAAAATATGCTAATATGGTTCAAAAGGATTTAAAGGAAGTCCAAGAATC
CTTTCAAAAATTGGCCGAAACTCGTCTCAAACATTATTTTACACGTCAAAAAATTGCAGAGATAGAGAATATTTCTTATT
CTGAGCAAGATTTTGATGCGGATTTAGAAAAACTTGCGTCAAGTTATCAAATTTCTCTGTCCGATCTTAAAAAAGAACTG
GAAAAAGGAAAACTCATGGAACAATATCGGGAGAATTTTTTCGCAAAAAAGATAGATAATATACTCTTTGATCTTGTAGA
AAAGAAATATACTGACAAATTGAACATTGGGCAGATAAAAGATTATCTCAACCAAAAGGAAGAAGTGAAAGCATGA

Upstream 100 bases:

>100_bases
ATAGCTCAGTGGTAGAGCACCTCCTTGCCAAGGAGGGGGTCGCGGGTTCGAATCCCGTTTCCCGCTTTTTCTTTTATATC
ACCCTTCCCCAGGTCGATTC

Downstream 100 bases:

>100_bases
GCGTAATCCCGTATGTGATCGAACAAACGAGTAGAGGGGAAAGATCGTATGATATATTTTCCCGACTTTTAAAAGATAGA
ATCATATTTTTAGGGAATGC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (w =0) [C]

Alternate protein names: TF

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MDYKTKKNSNATVDIKLTFEASDIEKAFDKTYEEKQKNVKIPGFRPGKAPLNMVKRHLGDSVASDAINTLIVDGMTSILS
KLEHPMIRFPKFEIQDYQPGKNLIATAIYETNPEITLGKYKKIKIKLPEVSVSDLDVSEEVEKVRKNLARKQLKEEGQAA
VAGDIIDMEYTVCEKGQESKNSGNTSNDYHLGHENNLKGFDENLYGMKSGEKKDFVHTFPEDYSQNEVAGKTFEYSVTIK
ALYANILPAVDDDLASEFDGSESLNVLKDKIRKNLKEGFEDRVKNKKLDEIYKEIIDDSKYVFPESYLREESEHVFHNMI
HEFKLPHMTMEKYANMVQKDLKEVQESFQKLAETRLKHYFTRQKIAEIENISYSEQDFDADLEKLASSYQISLSDLKKEL
EKGKLMEQYRENFFAKKIDNILFDLVEKKYTDKLNIGQIKDYLNQKEEVKA

Sequences:

>Translated_451_residues
MDYKTKKNSNATVDIKLTFEASDIEKAFDKTYEEKQKNVKIPGFRPGKAPLNMVKRHLGDSVASDAINTLIVDGMTSILS
KLEHPMIRFPKFEIQDYQPGKNLIATAIYETNPEITLGKYKKIKIKLPEVSVSDLDVSEEVEKVRKNLARKQLKEEGQAA
VAGDIIDMEYTVCEKGQESKNSGNTSNDYHLGHENNLKGFDENLYGMKSGEKKDFVHTFPEDYSQNEVAGKTFEYSVTIK
ALYANILPAVDDDLASEFDGSESLNVLKDKIRKNLKEGFEDRVKNKKLDEIYKEIIDDSKYVFPESYLREESEHVFHNMI
HEFKLPHMTMEKYANMVQKDLKEVQESFQKLAETRLKHYFTRQKIAEIENISYSEQDFDADLEKLASSYQISLSDLKKEL
EKGKLMEQYRENFFAKKIDNILFDLVEKKYTDKLNIGQIKDYLNQKEEVKA
>Mature_451_residues
MDYKTKKNSNATVDIKLTFEASDIEKAFDKTYEEKQKNVKIPGFRPGKAPLNMVKRHLGDSVASDAINTLIVDGMTSILS
KLEHPMIRFPKFEIQDYQPGKNLIATAIYETNPEITLGKYKKIKIKLPEVSVSDLDVSEEVEKVRKNLARKQLKEEGQAA
VAGDIIDMEYTVCEKGQESKNSGNTSNDYHLGHENNLKGFDENLYGMKSGEKKDFVHTFPEDYSQNEVAGKTFEYSVTIK
ALYANILPAVDDDLASEFDGSESLNVLKDKIRKNLKEGFEDRVKNKKLDEIYKEIIDDSKYVFPESYLREESEHVFHNMI
HEFKLPHMTMEKYANMVQKDLKEVQESFQKLAETRLKHYFTRQKIAEIENISYSEQDFDADLEKLASSYQISLSDLKKEL
EKGKLMEQYRENFFAKKIDNILFDLVEKKYTDKLNIGQIKDYLNQKEEVKA

Specific function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation

COG id: COG0544

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Escherichia coli, GI1786640, Length=333, Percent_Identity=26.7267267267267, Blast_Score=106, Evalue=4e-24,

Paralogues:

None

Copy number: 1070 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 500 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 340 Molecules/Cell In: Growth-Phase, Mini

Swissprot (AC and ID): TIG_LEPIC (Q72SG7)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001378.1
- ProteinModelPortal:   Q72SG7
- GeneID:   2772717
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11416
- HOGENOM:   HBG531038
- OMA:   RFIPGFE
- ProtClustDB:   CLSK574478
- BioCyc:   LINT267671:LIC_11416-MONOMER
- HAMAP:   MF_00303
- InterPro:   IPR001179
- InterPro:   IPR005215
- InterPro:   IPR008880
- InterPro:   IPR008881
- Gene3D:   G3DSA:1.10.3120.10
- Gene3D:   G3DSA:3.30.70.1050
- PIRSF:   PIRSF003095
- TIGRFAMs:   TIGR00115

Pfam domain/function: PF00254 FKBP_C; PF05698 Trigger_C; PF05697 Trigger_N; SSF109998 Trigger_fac_C_bac; SSF102735 Trigger_fac_ribosome-bd_bac

EC number: NA

Molecular weight: Translated: 52146; Mature: 52146

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKTKKNSNATVDIKLTFEASDIEKAFDKTYEEKQKNVKIPGFRPGKAPLNMVKRHLGD
CCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCH
SVASDAINTLIVDGMTSILSKLEHPMIRFPKFEIQDYQPGKNLIATAIYETNPEITLGKY
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCHHEEEEEEECCCCEEECCC
KKIKIKLPEVSVSDLDVSEEVEKVRKNLARKQLKEEGQAAVAGDIIDMEYTVCEKGQESK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHCCHHHHHHCCCCCC
NSGNTSNDYHLGHENNLKGFDENLYGMKSGEKKDFVHTFPEDYSQNEVAGKTFEYSVTIK
CCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEEEHHH
ALYANILPAVDDDLASEFDGSESLNVLKDKIRKNLKEGFEDRVKNKKLDEIYKEIIDDSK
HHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
YVFPESYLREESEHVFHNMIHEFKLPHMTMEKYANMVQKDLKEVQESFQKLAETRLKHYF
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRQKIAEIENISYSEQDFDADLEKLASSYQISLSDLKKELEKGKLMEQYRENFFAKKIDN
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILFDLVEKKYTDKLNIGQIKDYLNQKEEVKA
HHHHHHHHHHCCCCCHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MDYKTKKNSNATVDIKLTFEASDIEKAFDKTYEEKQKNVKIPGFRPGKAPLNMVKRHLGD
CCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCH
SVASDAINTLIVDGMTSILSKLEHPMIRFPKFEIQDYQPGKNLIATAIYETNPEITLGKY
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCHHEEEEEEECCCCEEECCC
KKIKIKLPEVSVSDLDVSEEVEKVRKNLARKQLKEEGQAAVAGDIIDMEYTVCEKGQESK
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHCCHHHHHHCCCCCC
NSGNTSNDYHLGHENNLKGFDENLYGMKSGEKKDFVHTFPEDYSQNEVAGKTFEYSVTIK
CCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEEEHHH
ALYANILPAVDDDLASEFDGSESLNVLKDKIRKNLKEGFEDRVKNKKLDEIYKEIIDDSK
HHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
YVFPESYLREESEHVFHNMIHEFKLPHMTMEKYANMVQKDLKEVQESFQKLAETRLKHYF
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRQKIAEIENISYSEQDFDADLEKLASSYQISLSDLKKELEKGKLMEQYRENFFAKKIDN
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILFDLVEKKYTDKLNIGQIKDYLNQKEEVKA
HHHHHHHHHHCCCCCHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: peptidylproline (w =180) [C]

Specific reaction: peptidylproline (w =180) = peptidylproline (w =0) [C]

General reaction: Isomerases; cis-trans-Isomerases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA