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The map label for this gene is yaeL [C]

Identifier: 45656748

GI number: 45656748

Start: 1032087

End: 1033814

Strand: Direct

Name: yaeL [C]

Synonym: LIC10857

Alternate gene names: 45656748

Gene position: 1032087-1033814 (Clockwise)

Preceding gene: 45656747

Following gene: 45656749

Centisome position: 24.13

GC content: 41.49

Gene sequence:

>1728_bases
ATGTTGATCATGGTATTAGGCGCTGTTTTTATGTTGGCGATTTCTATTTTTATACACGAGTTAGGTCATCTTCTTTGTGG
AATGCTCGTAGGCGTTAAGGCTAGAATTTTTTCGATTGGTTACGGAAGGGGAATTTGGAAAAAAAAAGTTGGTGAAACCA
CTTACCAGATCACCGCAATTCCTGTCGGAGGATATGTTCTATTTAAAGGAGATGACTACGGCGGGGACGTAAAAGGGGAA
CCCGGCGAACTTCTTTCTACACCTCCTCTCAAAAGAATGATCCCCGTTTTGGGCGGTCCTCTTTTTAATCTATTTCTTGG
TTTTGGAATATTATTGATTTTGAATTTTCTAGGTCACAATCCTCCCGGAAACAGAGTTTTTATCGATCCAGCCGATCAGG
AATTTTCAGCGGCGTATCAATCTGGACTTCGAACGGGGGATAGAATCCTTTCTATAGACGGAAACAAAACCGAAAAGTTC
GAGGACATAGTGACTAACGTTGGTTTGTCTTCCGGTAATTCTCTTAAAATTTTAGGAGAAAGAGAAGGAAAACCGATGGA
ATGGAACGTAACTCCTAGAATTATCTATAACCCGAAACGTTCTTCCGGAATTCCTACCATAGGAGTGGAACCTTTTGGAG
AAAGAAGAGTGGTCGCCACCTTTAGTTATCCAGAACAGTTTCAACACTGGCTGTCTTCTCGTTTAGATAAATCTCACGAA
GCCGAAAACTATTACCAAGAACGTCTGAAAAAAGCGGTGGAAGGTAGGGATATTCCCGCCGAGGTTCTTTTGGAAAAAGA
GAAAGAAGAAAAAGAAAATCTTCTGCGTTCCCGAGCCCTGAGTTATTTGAATGACGGAGACGTGATCCAAACGGTGAACG
GGAAAACGATTTCTACCGTTGGAGAACTTCAAAAAATTTTGGGAGAATATCAAAATCGAAAGGTAAACATAGTAGTCGAT
CGTAAAACCTATCCATTGGTCAATCCTTGGTCTACGGAAATGGTCTCTGTGGAAGTTCCTGTTTTAGGTGCCAATATATT
AGAATTTAAGAATATTCGAGATCGTAAATATCCTGAGTTAAATTTGGAATCCTATCAGTTTGCTAGTTATGATCCGGAGC
TTGGTCAAAAACTTTTGAACCTTGCCGTGGACGGGCAGACCTTTCCGAGTTTCGAGGAACTTCTCGCGTATGTTAAAACG
AAGAACGGAAATATCGTTACGATCGATATGGGAAATCTTAAGTTAGAAGCCGAACCTAAGGTTCGTCCGATCGGACTTCT
TGGGTTTAGGCCGAATATGAAGTTCAATCCGGAACCTATGCAGAGAGATCTGGGTTTTTTAGAGTCCTTTGCGGTTGCTG
GTAAGGATGTTTATGAAAACGTTGAGACCACTCTTAAAGGAATTGGAATGTTGTTCTCTGGAATTCTTTCCGTTAAAGAC
AGTTTGTCTGGTCCGGTGGGAATCGTTTCGTATGCTGGAATCAGTTTAGAAATTGGTTGGGAAACGTATTTAGAGTTTGT
CGCTAGGATCTCAATCGCTTTGATGATTATGAATTTACTTCCCATTCCGATGGCGGACGGTGGACATATCGTATTGTATG
CGTATGAAGCGATTACAGGAAGACCCCTTCCCGGCAAAGTGATCGAGTCTATTTTTAGAATCGGATTTTTATTCCTACTC
GGACTTGGGCTCTACGTCACCTTCAACGATGTAATGCGAATTTTCTAA

Upstream 100 bases:

>100_bases
TTAAAATTGAGTTCCCGTTGTCTCTAGAAGAATACGAGGAAGCGGATCGGATTGCCCGCGAAACCGTCCGAAATCTGAAA
GCAAGGAAGGTAGTATCCGC

Downstream 100 bases:

>100_bases
AACGCATGAAAGCATCGAAATACATTCTTCCCACAGAAAAAGAAAATCCTGCGGACGCGGTTGTCGCCTCCCATCGTTTG
ATGATTCGCGCCGGTTTGGT

Product: integral membrane zinc metalloprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MLIMVLGAVFMLAISIFIHELGHLLCGMLVGVKARIFSIGYGRGIWKKKVGETTYQITAIPVGGYVLFKGDDYGGDVKGE
PGELLSTPPLKRMIPVLGGPLFNLFLGFGILLILNFLGHNPPGNRVFIDPADQEFSAAYQSGLRTGDRILSIDGNKTEKF
EDIVTNVGLSSGNSLKILGEREGKPMEWNVTPRIIYNPKRSSGIPTIGVEPFGERRVVATFSYPEQFQHWLSSRLDKSHE
AENYYQERLKKAVEGRDIPAEVLLEKEKEEKENLLRSRALSYLNDGDVIQTVNGKTISTVGELQKILGEYQNRKVNIVVD
RKTYPLVNPWSTEMVSVEVPVLGANILEFKNIRDRKYPELNLESYQFASYDPELGQKLLNLAVDGQTFPSFEELLAYVKT
KNGNIVTIDMGNLKLEAEPKVRPIGLLGFRPNMKFNPEPMQRDLGFLESFAVAGKDVYENVETTLKGIGMLFSGILSVKD
SLSGPVGIVSYAGISLEIGWETYLEFVARISIALMIMNLLPIPMADGGHIVLYAYEAITGRPLPGKVIESIFRIGFLFLL
GLGLYVTFNDVMRIF

Sequences:

>Translated_575_residues
MLIMVLGAVFMLAISIFIHELGHLLCGMLVGVKARIFSIGYGRGIWKKKVGETTYQITAIPVGGYVLFKGDDYGGDVKGE
PGELLSTPPLKRMIPVLGGPLFNLFLGFGILLILNFLGHNPPGNRVFIDPADQEFSAAYQSGLRTGDRILSIDGNKTEKF
EDIVTNVGLSSGNSLKILGEREGKPMEWNVTPRIIYNPKRSSGIPTIGVEPFGERRVVATFSYPEQFQHWLSSRLDKSHE
AENYYQERLKKAVEGRDIPAEVLLEKEKEEKENLLRSRALSYLNDGDVIQTVNGKTISTVGELQKILGEYQNRKVNIVVD
RKTYPLVNPWSTEMVSVEVPVLGANILEFKNIRDRKYPELNLESYQFASYDPELGQKLLNLAVDGQTFPSFEELLAYVKT
KNGNIVTIDMGNLKLEAEPKVRPIGLLGFRPNMKFNPEPMQRDLGFLESFAVAGKDVYENVETTLKGIGMLFSGILSVKD
SLSGPVGIVSYAGISLEIGWETYLEFVARISIALMIMNLLPIPMADGGHIVLYAYEAITGRPLPGKVIESIFRIGFLFLL
GLGLYVTFNDVMRIF
>Mature_575_residues
MLIMVLGAVFMLAISIFIHELGHLLCGMLVGVKARIFSIGYGRGIWKKKVGETTYQITAIPVGGYVLFKGDDYGGDVKGE
PGELLSTPPLKRMIPVLGGPLFNLFLGFGILLILNFLGHNPPGNRVFIDPADQEFSAAYQSGLRTGDRILSIDGNKTEKF
EDIVTNVGLSSGNSLKILGEREGKPMEWNVTPRIIYNPKRSSGIPTIGVEPFGERRVVATFSYPEQFQHWLSSRLDKSHE
AENYYQERLKKAVEGRDIPAEVLLEKEKEEKENLLRSRALSYLNDGDVIQTVNGKTISTVGELQKILGEYQNRKVNIVVD
RKTYPLVNPWSTEMVSVEVPVLGANILEFKNIRDRKYPELNLESYQFASYDPELGQKLLNLAVDGQTFPSFEELLAYVKT
KNGNIVTIDMGNLKLEAEPKVRPIGLLGFRPNMKFNPEPMQRDLGFLESFAVAGKDVYENVETTLKGIGMLFSGILSVKD
SLSGPVGIVSYAGISLEIGWETYLEFVARISIALMIMNLLPIPMADGGHIVLYAYEAITGRPLPGKVIESIFRIGFLFLL
GLGLYVTFNDVMRIF

Specific function: Unknown

COG id: COG0750

COG function: function code M; Predicted membrane-associated Zn-dependent proteases 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1786373, Length=203, Percent_Identity=30.5418719211823, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR004387
- InterPro:   IPR008915 [H]

Pfam domain/function: PF00595 PDZ; PF02163 Peptidase_M50 [H]

EC number: NA

Molecular weight: Translated: 63975; Mature: 63975

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIMVLGAVFMLAISIFIHELGHLLCGMLVGVKARIFSIGYGRGIWKKKVGETTYQITAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHCCCCEEEEEEE
PVGGYVLFKGDDYGGDVKGEPGELLSTPPLKRMIPVLGGPLFNLFLGFGILLILNFLGHN
EECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
PPGNRVFIDPADQEFSAAYQSGLRTGDRILSIDGNKTEKFEDIVTNVGLSSGNSLKILGE
CCCCEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEC
REGKPMEWNVTPRIIYNPKRSSGIPTIGVEPFGERRVVATFSYPEQFQHWLSSRLDKSHE
CCCCCEEECCCCEEEECCCCCCCCCEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCC
AENYYQERLKKAVEGRDIPAEVLLEKEKEEKENLLRSRALSYLNDGDVIQTVNGKTISTV
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
GELQKILGEYQNRKVNIVVDRKTYPLVNPWSTEMVSVEVPVLGANILEFKNIRDRKYPEL
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEECEECCHHHHHHCCCCCCCCCC
NLESYQFASYDPELGQKLLNLAVDGQTFPSFEELLAYVKTKNGNIVTIDMGNLKLEAEPK
CCCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEECCEEEECCCC
VRPIGLLGFRPNMKFNPEPMQRDLGFLESFAVAGKDVYENVETTLKGIGMLFSGILSVKD
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLSGPVGIVSYAGISLEIGWETYLEFVARISIALMIMNLLPIPMADGGHIVLYAYEAITG
HCCCCEEEEEECCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEHHCC
RPLPGKVIESIFRIGFLFLLGLGLYVTFNDVMRIF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLIMVLGAVFMLAISIFIHELGHLLCGMLVGVKARIFSIGYGRGIWKKKVGETTYQITAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHCCCCEEEEEEE
PVGGYVLFKGDDYGGDVKGEPGELLSTPPLKRMIPVLGGPLFNLFLGFGILLILNFLGHN
EECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
PPGNRVFIDPADQEFSAAYQSGLRTGDRILSIDGNKTEKFEDIVTNVGLSSGNSLKILGE
CCCCEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEC
REGKPMEWNVTPRIIYNPKRSSGIPTIGVEPFGERRVVATFSYPEQFQHWLSSRLDKSHE
CCCCCEEECCCCEEEECCCCCCCCCEECCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCC
AENYYQERLKKAVEGRDIPAEVLLEKEKEEKENLLRSRALSYLNDGDVIQTVNGKTISTV
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
GELQKILGEYQNRKVNIVVDRKTYPLVNPWSTEMVSVEVPVLGANILEFKNIRDRKYPEL
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEECEECCHHHHHHCCCCCCCCCC
NLESYQFASYDPELGQKLLNLAVDGQTFPSFEELLAYVKTKNGNIVTIDMGNLKLEAEPK
CCCCEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEECCEEEECCCC
VRPIGLLGFRPNMKFNPEPMQRDLGFLESFAVAGKDVYENVETTLKGIGMLFSGILSVKD
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLSGPVGIVSYAGISLEIGWETYLEFVARISIALMIMNLLPIPMADGGHIVLYAYEAITG
HCCCCEEEEEECCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEHHCC
RPLPGKVIESIFRIGFLFLLGLGLYVTFNDVMRIF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]