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The map label for this gene is dxr

Identifier: 45656747

GI number: 45656747

Start: 1030924

End: 1032093

Strand: Direct

Name: dxr

Synonym: LIC10856

Alternate gene names: 45656747

Gene position: 1030924-1032093 (Clockwise)

Preceding gene: 45656746

Following gene: 45656748

Centisome position: 24.1

GC content: 41.71

Gene sequence:

>1170_bases
ATGACAACCTCCGTCTGTCTTTTAGGCGCTTCCGGTTCCGTTGGAGAATCTACTCTAAAGGTGCTTCGCGCTTATCCGGA
AAAATTTAGACTTCATTCTTTCAGCGTTCATTCTAATCTTGAAAAAGCAAAAGAGATCCAAAAAGAATTTTCTCCCGATT
TTATCTGTGTGAGTTCCGATTTTGCGGATGTCGGAGTTCTTGGAAATAAATTGGGTAGAACACAAATTCTCTACGGTGAA
TCCTCGCTTTGCGAACTAGTACGCGAACCCGAGGTGGAGATCGTAATCACTGCTATTGTGGGTTCTGTTGGTTTACGTCC
TACGATTGCGGCGATCACAGCGGGAAAAAGATTAGGAATTGCTAATAAAGAAACGTTAGTCACATCAGGTCCTCTGATTC
AATCTCTGATCGCAAAACACAATACAAAAGTAGTCCCGGTGGATTCAGAACACAATGCACTCTTTCAACTTTTAGAATCT
TTAAACCCTAACTCTGTGGAAAAAATTATTCTTACCGCGTCTGGAGGTGCTTTTCGGGATTTACCCGTAGAACAACTCTC
CTCCGTTACAAAAGAACAAGCATTACATCATCCTACTTGGAACATGGGGCCTAAGATTACGATCGATTCTAATGGTATGA
TTAATAAAGGACTTGAAGTGATCGAAGCTCATTTTTTGTTCAATGTTCCGTATGATAAAATTGGGGTTGTGATTCATCCT
CAGAGTATCGCTCACGGAATCGTAGAATTAAAGGACGGGGCTTCTTTTTTATACGCTTCTTATCCGGATATGATTTTCCC
GATTGCACATTCTCTCTTTCATCCGGAACCGGTTCCTAAAGTTTTACGGTCTTATCCTGCTAAGGATTGGGGAAAATTAG
AGTTCCGAGAACCTGATTTCAAACGTTATCCTGGTTTAGGTCTTGCGTTTGAGGCGGGTAAGGTAGGAGGAACGGCACCT
TGTATTTTTAACGCGGCTAATGAAGCCGCTGTAGAATTGTTTTTAAAAGATGAAATCCGTTTTATAGAAATTCCCGATTA
CATTCGGAAAACGTTAGACGAAATTAAAATTGAGTTCCCGTTGTCTCTAGAAGAATACGAGGAAGCGGATCGGATTGCCC
GCGAAACCGTCCGAAATCTGAAAGCAAGGAAGGTAGTATCCGCATGTTGA

Upstream 100 bases:

>100_bases
GCACGGTGGAATTTTAGATCTTGCGGATGCTCTTTTGATTACCATCCCCGTCTTGTATTACTATCTTCAGATCAAGGGGA
ATCTTGGAGTCTAATTGGAT

Downstream 100 bases:

>100_bases
TCATGGTATTAGGCGCTGTTTTTATGTTGGCGATTTCTATTTTTATACACGAGTTAGGTCATCTTCTTTGTGGAATGCTC
GTAGGCGTTAAGGCTAGAAT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTTSVCLLGASGSVGESTLKVLRAYPEKFRLHSFSVHSNLEKAKEIQKEFSPDFICVSSDFADVGVLGNKLGRTQILYGE
SSLCELVREPEVEIVITAIVGSVGLRPTIAAITAGKRLGIANKETLVTSGPLIQSLIAKHNTKVVPVDSEHNALFQLLES
LNPNSVEKIILTASGGAFRDLPVEQLSSVTKEQALHHPTWNMGPKITIDSNGMINKGLEVIEAHFLFNVPYDKIGVVIHP
QSIAHGIVELKDGASFLYASYPDMIFPIAHSLFHPEPVPKVLRSYPAKDWGKLEFREPDFKRYPGLGLAFEAGKVGGTAP
CIFNAANEAAVELFLKDEIRFIEIPDYIRKTLDEIKIEFPLSLEEYEEADRIARETVRNLKARKVVSAC

Sequences:

>Translated_389_residues
MTTSVCLLGASGSVGESTLKVLRAYPEKFRLHSFSVHSNLEKAKEIQKEFSPDFICVSSDFADVGVLGNKLGRTQILYGE
SSLCELVREPEVEIVITAIVGSVGLRPTIAAITAGKRLGIANKETLVTSGPLIQSLIAKHNTKVVPVDSEHNALFQLLES
LNPNSVEKIILTASGGAFRDLPVEQLSSVTKEQALHHPTWNMGPKITIDSNGMINKGLEVIEAHFLFNVPYDKIGVVIHP
QSIAHGIVELKDGASFLYASYPDMIFPIAHSLFHPEPVPKVLRSYPAKDWGKLEFREPDFKRYPGLGLAFEAGKVGGTAP
CIFNAANEAAVELFLKDEIRFIEIPDYIRKTLDEIKIEFPLSLEEYEEADRIARETVRNLKARKVVSAC
>Mature_388_residues
TTSVCLLGASGSVGESTLKVLRAYPEKFRLHSFSVHSNLEKAKEIQKEFSPDFICVSSDFADVGVLGNKLGRTQILYGES
SLCELVREPEVEIVITAIVGSVGLRPTIAAITAGKRLGIANKETLVTSGPLIQSLIAKHNTKVVPVDSEHNALFQLLESL
NPNSVEKIILTASGGAFRDLPVEQLSSVTKEQALHHPTWNMGPKITIDSNGMINKGLEVIEAHFLFNVPYDKIGVVIHPQ
SIAHGIVELKDGASFLYASYPDMIFPIAHSLFHPEPVPKVLRSYPAKDWGKLEFREPDFKRYPGLGLAFEAGKVGGTAPC
IFNAANEAAVELFLKDEIRFIEIPDYIRKTLDEIKIEFPLSLEEYEEADRIARETVRNLKARKVVSAC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=386, Percent_Identity=40.1554404145078, Blast_Score=269, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_LEPIC (Q72U08)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000833.1
- ProteinModelPortal:   Q72U08
- SMR:   Q72U08
- GeneID:   2770253
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10856
- NMPDR:   fig|267671.1.peg.833
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   LINT267671:LIC_10856-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42806; Mature: 42675

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSVCLLGASGSVGESTLKVLRAYPEKFRLHSFSVHSNLEKAKEIQKEFSPDFICVSSD
CCCEEEEEECCCCCCHHHHHHHHHCHHHHCEEEEHHHHHHHHHHHHHHHCCCCEEEEECC
FADVGVLGNKLGRTQILYGESSLCELVREPEVEIVITAIVGSVGLRPTIAAITAGKRLGI
CCHHHHHHHCCCCEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHEECCCCCCC
ANKETLVTSGPLIQSLIAKHNTKVVPVDSEHNALFQLLESLNPNSVEKIILTASGGAFRD
CCCCCEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
LPVEQLSSVTKEQALHHPTWNMGPKITIDSNGMINKGLEVIEAHFLFNVPYDKIGVVIHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHEEHHEEECCHHHEEEEECC
QSIAHGIVELKDGASFLYASYPDMIFPIAHSLFHPEPVPKVLRSYPAKDWGKLEFREPDF
HHHHHHHEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCH
KRYPGLGLAFEAGKVGGTAPCIFNAANEAAVELFLKDEIRFIEIPDYIRKTLDEIKIEFP
HHCCCCCEEEECCCCCCCCCEEEECCCHHHEEEEEECCEEEEECCHHHHHHHHHEEEECC
LSLEEYEEADRIARETVRNLKARKVVSAC
CCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTSVCLLGASGSVGESTLKVLRAYPEKFRLHSFSVHSNLEKAKEIQKEFSPDFICVSSD
CCEEEEEECCCCCCHHHHHHHHHCHHHHCEEEEHHHHHHHHHHHHHHHCCCCEEEEECC
FADVGVLGNKLGRTQILYGESSLCELVREPEVEIVITAIVGSVGLRPTIAAITAGKRLGI
CCHHHHHHHCCCCEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHEECCCCCCC
ANKETLVTSGPLIQSLIAKHNTKVVPVDSEHNALFQLLESLNPNSVEKIILTASGGAFRD
CCCCCEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
LPVEQLSSVTKEQALHHPTWNMGPKITIDSNGMINKGLEVIEAHFLFNVPYDKIGVVIHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHEEHHEEECCHHHEEEEECC
QSIAHGIVELKDGASFLYASYPDMIFPIAHSLFHPEPVPKVLRSYPAKDWGKLEFREPDF
HHHHHHHEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCH
KRYPGLGLAFEAGKVGGTAPCIFNAANEAAVELFLKDEIRFIEIPDYIRKTLDEIKIEFP
HHCCCCCEEEECCCCCCCCCEEEECCCHHHEEEEEECCEEEEECCHHHHHHHHHEEEECC
LSLEEYEEADRIARETVRNLKARKVVSAC
CCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA