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The map label for this gene is lepB

Identifier: 45656376

GI number: 45656376

Start: 552136

End: 552732

Strand: Reverse

Name: lepB

Synonym: LIC10478

Alternate gene names: 45656376

Gene position: 552732-552136 (Counterclockwise)

Preceding gene: 45656377

Following gene: 45656374

Centisome position: 12.92

GC content: 35.01

Gene sequence:

>597_bases
TTGTCTTACGTTAATATGAAAAGTATCATAATGCAAAAAAGTACGAGAAAGTATCTACGCGTTATTCTACCCATATTTCT
TTCTTTATTTACAATTCTTCTAATACGAATTTTTTTATTTCAAATCTACTTCATCTCAGGTTATTCTATGGCTCCTTCTT
ACAAAGAAGGGGATTTAATCTTAGTTACCAAGTTTGGGTTTCCAACCCGTATCGGAAAGTGGGAAATATCTTTTGTTGAA
AGTAAAGTGAATCGTTTCGACGTTCTCGTTTTGGATGGATTTGAAGAAGAACTAAGTCTAAAAAGAGTCGTCGGATTACC
AGGTGATTATTTTCGTTTTGAAAACGATCGGATTCTAATCAACGATTCTCCTCTACAAGAAACATTTTTAAAACCTGGAT
TTAAAACCATCGCACCTTCTCTTTCCATGATCCCTATGACTGCAGCTAAAGGAAATGTTCCAATCGGAGACACTGGTAGA
ATTCCTCCGGGCTATTTTTTAATGTTAGGTGATAACCGTGAAAACTCTACAGATTCTAGGAATTACGGCTTGGTCCCATT
CCAAAAATTACGAGGTAGAGTTTGGATTTTTTTATAA

Upstream 100 bases:

>100_bases
ACTATAATTAAAAGTCCTAAAGTACATTTACGTTTCACGGAAATTCAATCCCGCTAAAAAACCTTTTTCGATTTGCCACG
TTCAGGAAGATTTTTAAACA

Downstream 100 bases:

>100_bases
ATCTCAGCCCGAATGATTATTTTTTTCAATATTAGAGTTGTTGAAAAATGAATCCTCCATCTTGTTTCAATTTCATGAAA
TGGTCGATTAAAGCAGCTTT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MSYVNMKSIIMQKSTRKYLRVILPIFLSLFTILLIRIFLFQIYFISGYSMAPSYKEGDLILVTKFGFPTRIGKWEISFVE
SKVNRFDVLVLDGFEEELSLKRVVGLPGDYFRFENDRILINDSPLQETFLKPGFKTIAPSLSMIPMTAAKGNVPIGDTGR
IPPGYFLMLGDNRENSTDSRNYGLVPFQKLRGRVWIFL

Sequences:

>Translated_198_residues
MSYVNMKSIIMQKSTRKYLRVILPIFLSLFTILLIRIFLFQIYFISGYSMAPSYKEGDLILVTKFGFPTRIGKWEISFVE
SKVNRFDVLVLDGFEEELSLKRVVGLPGDYFRFENDRILINDSPLQETFLKPGFKTIAPSLSMIPMTAAKGNVPIGDTGR
IPPGYFLMLGDNRENSTDSRNYGLVPFQKLRGRVWIFL
>Mature_197_residues
SYVNMKSIIMQKSTRKYLRVILPIFLSLFTILLIRIFLFQIYFISGYSMAPSYKEGDLILVTKFGFPTRIGKWEISFVES
KVNRFDVLVLDGFEEELSLKRVVGLPGDYFRFENDRILINDSPLQETFLKPGFKTIAPSLSMIPMTAAKGNVPIGDTGRI
PPGYFLMLGDNRENSTDSRNYGLVPFQKLRGRVWIFL

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 22772; Mature: 22641

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYVNMKSIIMQKSTRKYLRVILPIFLSLFTILLIRIFLFQIYFISGYSMAPSYKEGDLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
LVTKFGFPTRIGKWEISFVESKVNRFDVLVLDGFEEELSLKRVVGLPGDYFRFENDRILI
EEEECCCCCCCCCEEEHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCHHEEEECCEEEE
NDSPLQETFLKPGFKTIAPSLSMIPMTAAKGNVPIGDTGRIPPGYFLMLGDNRENSTDSR
CCCCHHHHHHCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
NYGLVPFQKLRGRVWIFL
CCCCCCHHHHCCEEEEEC
>Mature Secondary Structure 
SYVNMKSIIMQKSTRKYLRVILPIFLSLFTILLIRIFLFQIYFISGYSMAPSYKEGDLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
LVTKFGFPTRIGKWEISFVESKVNRFDVLVLDGFEEELSLKRVVGLPGDYFRFENDRILI
EEEECCCCCCCCCEEEHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCHHEEEECCEEEE
NDSPLQETFLKPGFKTIAPSLSMIPMTAAKGNVPIGDTGRIPPGYFLMLGDNRENSTDSR
CCCCHHHHHHCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
NYGLVPFQKLRGRVWIFL
CCCCCCHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8801417 [H]