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The map label for this gene is tcmR [H]

Identifier: 41409809

GI number: 41409809

Start: 4127939

End: 4128541

Strand: Reverse

Name: tcmR [H]

Synonym: MAP3711c

Alternate gene names: 41409809

Gene position: 4128541-4127939 (Counterclockwise)

Preceding gene: 41409811

Following gene: 41409808

Centisome position: 85.48

GC content: 68.49

Gene sequence:

>603_bases
ATGCGGGAGAATCGGCCCATGCCGGCCAGTGAGGCTCCCCCGGGCCTGCGGGAGCGCAAGAAGATCAAGACCCGCCAGGC
CATCAGGCGCGAGGCGTTTCGCCTCATCGAGCAGAACGGCTACGCCGCGACCACCGTCGAACAGATCGCCGAGGCCGCCG
ACGTGTCGCCGAGCACCTTCTTCCGCTACTTCGGGTCCAAGGAGTCGCTGCTGCTGGCCGACGACCTGGACCCGCTGATC
CTGGACGCCCTCAAGGCGCAGCCGCGCGAGCTGTCGCTGCCGCAGGCGTTCCGCCGGGCCTATGCGACGGTGCTGTCCCA
GCTGCCCGACGACCAGCTGGAGTTCGAGAGCACCCGGCAGCGGCTGATGTTCTCCATCCCCGAGCTCAAGGCAGCCATGT
ACGACGAGTACTACCGCACCGTGACCGTCGCCGCCGAGGCGATCGCGCATCGGATCGGCCGGGCCGCAGACGATTTCGAG
GTCCGGGTGTTCGCCGGGGCGTTGACCGGCGCCATGATGGCGGCCTTTGACAGCGCCCCCACCACGCCCGAGACCATCTA
CCGGGCACTGGATTTCATGGACGCCGGGATGCCGCTGGACTGA

Upstream 100 bases:

>100_bases
TGCACAGTTACGCCGGCGCTACGCAGAAATCGCAACGGCCCACCCGGCTTTGTCAGAACTTCGCAACGCGTGGCCGTGCT
GCGGGCGCGGGCCGGCGCCG

Downstream 100 bases:

>100_bases
GCGGCCTCACCAGCGCGGCGATGGGTGTGTGGGGGCGGAACGCGATACTCTCACGCGATGCGACAGGGATGGAATCGACG
GGGATTCTTGCAGCTCGCAG

Product: hypothetical protein

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MRENRPMPASEAPPGLRERKKIKTRQAIRREAFRLIEQNGYAATTVEQIAEAADVSPSTFFRYFGSKESLLLADDLDPLI
LDALKAQPRELSLPQAFRRAYATVLSQLPDDQLEFESTRQRLMFSIPELKAAMYDEYYRTVTVAAEAIAHRIGRAADDFE
VRVFAGALTGAMMAAFDSAPTTPETIYRALDFMDAGMPLD

Sequences:

>Translated_200_residues
MRENRPMPASEAPPGLRERKKIKTRQAIRREAFRLIEQNGYAATTVEQIAEAADVSPSTFFRYFGSKESLLLADDLDPLI
LDALKAQPRELSLPQAFRRAYATVLSQLPDDQLEFESTRQRLMFSIPELKAAMYDEYYRTVTVAAEAIAHRIGRAADDFE
VRVFAGALTGAMMAAFDSAPTTPETIYRALDFMDAGMPLD
>Mature_200_residues
MRENRPMPASEAPPGLRERKKIKTRQAIRREAFRLIEQNGYAATTVEQIAEAADVSPSTFFRYFGSKESLLLADDLDPLI
LDALKAQPRELSLPQAFRRAYATVLSQLPDDQLEFESTRQRLMFSIPELKAAMYDEYYRTVTVAAEAIAHRIGRAADDFE
VRVFAGALTGAMMAAFDSAPTTPETIYRALDFMDAGMPLD

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 22445; Mature: 22445

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRENRPMPASEAPPGLRERKKIKTRQAIRREAFRLIEQNGYAATTVEQIAEAADVSPSTF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
FRYFGSKESLLLADDLDPLILDALKAQPRELSLPQAFRRAYATVLSQLPDDQLEFESTRQ
HHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RLMFSIPELKAAMYDEYYRTVTVAAEAIAHRIGRAADDFEVRVFAGALTGAMMAAFDSAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
TTPETIYRALDFMDAGMPLD
CCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRENRPMPASEAPPGLRERKKIKTRQAIRREAFRLIEQNGYAATTVEQIAEAADVSPSTF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHH
FRYFGSKESLLLADDLDPLILDALKAQPRELSLPQAFRRAYATVLSQLPDDQLEFESTRQ
HHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RLMFSIPELKAAMYDEYYRTVTVAAEAIAHRIGRAADDFEVRVFAGALTGAMMAAFDSAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
TTPETIYRALDFMDAGMPLD
CCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]