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The map label for this gene is accD4_2

Identifier: 41408470

GI number: 41408470

Start: 2666136

End: 2667632

Strand: Direct

Name: accD4_2

Synonym: MAP2372

Alternate gene names: 41408470

Gene position: 2666136-2667632 (Clockwise)

Preceding gene: 41408464

Following gene: 41408475

Centisome position: 55.2

GC content: 70.14

Gene sequence:

>1497_bases
ATGCCGAAAGCCCAGGACTGGGAAGAAACGCTCGCCGATCTCCAGCGGCGCCGTCAGCACGCGTTCGACATGGGCGGCCC
GGAGCGGCTGGACAAACACCGCAACAAGGGCAAACTCGACGCCCGCGCCCGTATCGAATACCTGCTCGACCCGGGCACGT
TCCGCGAACTCGGCACCCTGGTCGGTGGCGAGATCGCCGCCGACGGCCTGGTGGTCGGCTCCGGCGAGATCAACGGCACG
CCGGTGATGCTGGGCGCCGAGGATTTCACCACCCTGGCGGGCAGCATCGGGCCCGGCGGCAACTCGAAGCGCTACCGCAT
CGCCGAACTGGCGTTGCGGGACAAGATTCCGTTGGTCATGCTGCTCGAGGGCGCGGGCTTTCGCCCCACCGGCGGGCATT
ACGGCCGCACCCCGACCGACCTGCTGGCCCAGGCGCAGTGCTCGGGTCGGGTTCCGACCGTCGCCGCCGTGCTCGGCCCG
TCGGCCGGACACGGCGCGCTGGTGGCCCCGGTCTGCGACTTCCGGATCATGAGCAGGCAGGGGGCGATCTTCACCGCCGG
GCCTCCCGTCGTCAAAGAGTCCACCGGAGAAGACATTTCGAAAGAGGACCTGGGCGGGCCGGATGTCGCGCTGCCCAGCG
GCGTGATCCACAACGTCGCCGAAAACGACGAAGCGGCGCTCGACGACGTCCGCCGCTACCTGTCCTACTTCCCGCCCAGC
GCCTGGTCGTACCCGCCGTCGCTGCCGCCCGGCGACGCCGCCATGCCGCGGCCGACGCCGGAGCTGCTGGACATCGTCTC
CCGGGACAACCGCCGCGTCTACGACATGCGCGCCGTGCTCGACGTGGTGTTCGACAGCCCCGACTGGTTCGAGGTGCAAC
CCCAGTTCGGCAAGGCGATCATCTGCGCGCTCGCCCACCTCGGCGGCCACCCCGTCGCGGTGGTGGCCAACCAGCCTCAG
GTGCTGGCCGGCTCCATCGACGCCGACGCCGCCGACAAGGCGGCACACTTCATCATGGTGGCCGACTCGTTCCACCTGCC
GATCGTCTTCCTCGCCGATAACCCGGGCATGCTGCCCGGCAGCCGGTCCGAACGCAGCGGTGTGCTGCGCGCCGGCGCGC
GGATGTTCGCCGCCCAGACCGCGGCGACCACGTTGAAGCTGCACGTCACGCTGCGCAAGGCGTACGGGTTCGGGTCGATG
GTCATGTCGCTGTTGGGGTTCGACCATCAGGTCGCGACGTTCGCCTACCCGGGTGCGACCATGGGCGCGATGAGCGCGGC
GGCGCTGAGCCGCGCCTCGCACGCCGGTGAGGACCTCTCCACCAAGCTGCGCAACGCCGAGCTGCAGGCCTCCTACCGGT
CGGCCGAGCACATGGGGTTCGATGAACTCATCGACCCGCGTGAGACGCGGGACGCGTTGCTGGCGTCGTTGCGGCGCGGC
CTATCCAGCCGGCAGGCCGCCGCCGAACCGGTGAGCCGGACCGTCATCATGCCCTGA

Upstream 100 bases:

>100_bases
GGGTAACTTTACAGTAAGCAATCCAGTATGTGACCCTGCAGATCTGCGGCCCGCCCCCGACTGGTCGCGCGACGAATCCT
CCATGAGGTAGGACATAGGC

Downstream 100 bases:

>100_bases
ACCGGTACGCCGCGAGAGTGCAACTACCGACGGCACCTCTCGGGAAACGCGTCGCTAGTTGCACTTTCGCGGTCAGCCGG
CTCGGTATGCGGCGACGATC

Product: AccD4_2

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MPKAQDWEETLADLQRRRQHAFDMGGPERLDKHRNKGKLDARARIEYLLDPGTFRELGTLVGGEIAADGLVVGSGEINGT
PVMLGAEDFTTLAGSIGPGGNSKRYRIAELALRDKIPLVMLLEGAGFRPTGGHYGRTPTDLLAQAQCSGRVPTVAAVLGP
SAGHGALVAPVCDFRIMSRQGAIFTAGPPVVKESTGEDISKEDLGGPDVALPSGVIHNVAENDEAALDDVRRYLSYFPPS
AWSYPPSLPPGDAAMPRPTPELLDIVSRDNRRVYDMRAVLDVVFDSPDWFEVQPQFGKAIICALAHLGGHPVAVVANQPQ
VLAGSIDADAADKAAHFIMVADSFHLPIVFLADNPGMLPGSRSERSGVLRAGARMFAAQTAATTLKLHVTLRKAYGFGSM
VMSLLGFDHQVATFAYPGATMGAMSAAALSRASHAGEDLSTKLRNAELQASYRSAEHMGFDELIDPRETRDALLASLRRG
LSSRQAAAEPVSRTVIMP

Sequences:

>Translated_498_residues
MPKAQDWEETLADLQRRRQHAFDMGGPERLDKHRNKGKLDARARIEYLLDPGTFRELGTLVGGEIAADGLVVGSGEINGT
PVMLGAEDFTTLAGSIGPGGNSKRYRIAELALRDKIPLVMLLEGAGFRPTGGHYGRTPTDLLAQAQCSGRVPTVAAVLGP
SAGHGALVAPVCDFRIMSRQGAIFTAGPPVVKESTGEDISKEDLGGPDVALPSGVIHNVAENDEAALDDVRRYLSYFPPS
AWSYPPSLPPGDAAMPRPTPELLDIVSRDNRRVYDMRAVLDVVFDSPDWFEVQPQFGKAIICALAHLGGHPVAVVANQPQ
VLAGSIDADAADKAAHFIMVADSFHLPIVFLADNPGMLPGSRSERSGVLRAGARMFAAQTAATTLKLHVTLRKAYGFGSM
VMSLLGFDHQVATFAYPGATMGAMSAAALSRASHAGEDLSTKLRNAELQASYRSAEHMGFDELIDPRETRDALLASLRRG
LSSRQAAAEPVSRTVIMP
>Mature_497_residues
PKAQDWEETLADLQRRRQHAFDMGGPERLDKHRNKGKLDARARIEYLLDPGTFRELGTLVGGEIAADGLVVGSGEINGTP
VMLGAEDFTTLAGSIGPGGNSKRYRIAELALRDKIPLVMLLEGAGFRPTGGHYGRTPTDLLAQAQCSGRVPTVAAVLGPS
AGHGALVAPVCDFRIMSRQGAIFTAGPPVVKESTGEDISKEDLGGPDVALPSGVIHNVAENDEAALDDVRRYLSYFPPSA
WSYPPSLPPGDAAMPRPTPELLDIVSRDNRRVYDMRAVLDVVFDSPDWFEVQPQFGKAIICALAHLGGHPVAVVANQPQV
LAGSIDADAADKAAHFIMVADSFHLPIVFLADNPGMLPGSRSERSGVLRAGARMFAAQTAATTLKLHVTLRKAYGFGSMV
MSLLGFDHQVATFAYPGATMGAMSAAALSRASHAGEDLSTKLRNAELQASYRSAEHMGFDELIDPRETRDALLASLRRGL
SSRQAAAEPVSRTVIMP

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=487, Percent_Identity=32.4435318275154, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI295821216, Length=507, Percent_Identity=31.5581854043393, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI11545863, Length=521, Percent_Identity=29.1746641074856, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25147359, Length=484, Percent_Identity=31.8181818181818, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI25147362, Length=484, Percent_Identity=31.8181818181818, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17552936, Length=522, Percent_Identity=27.3946360153257, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71997163, Length=267, Percent_Identity=25.0936329588015, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323863, Length=262, Percent_Identity=24.8091603053435, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24586065, Length=532, Percent_Identity=30.0751879699248, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 53119; Mature: 52988

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKAQDWEETLADLQRRRQHAFDMGGPERLDKHRNKGKLDARARIEYLLDPGTFRELGTL
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHEEEEEEECCCHHHHHHHH
VGGEIAADGLVVGSGEINGTPVMLGAEDFTTLAGSIGPGGNSKRYRIAELALRDKIPLVM
HCCCEECCCEEEECCCCCCCEEEECCHHHHHHHCCCCCCCCCCCEEHHHHHHHCCCCEEE
LLEGAGFRPTGGHYGRTPTDLLAQAQCSGRVPTVAAVLGPSAGHGALVAPVCDFRIMSRQ
EEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEHHHCCCEECCC
GAIFTAGPPVVKESTGEDISKEDLGGPDVALPSGVIHNVAENDEAALDDVRRYLSYFPPS
CCEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCC
AWSYPPSLPPGDAAMPRPTPELLDIVSRDNRRVYDMRAVLDVVFDSPDWFEVQPQFGKAI
CCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHH
ICALAHLGGHPVAVVANQPQVLAGSIDADAADKAAHFIMVADSFHLPIVFLADNPGMLPG
HHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCC
SRSERSGVLRAGARMFAAQTAATTLKLHVTLRKAYGFGSMVMSLLGFDHQVATFAYPGAT
CCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEEHHCCHHHHHHHHHCCCCCCEEEECCCCH
MGAMSAAALSRASHAGEDLSTKLRNAELQASYRSAEHMGFDELIDPRETRDALLASLRRG
HHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHC
LSSRQAAAEPVSRTVIMP
HHHHHHHHHHHCCEECCC
>Mature Secondary Structure 
PKAQDWEETLADLQRRRQHAFDMGGPERLDKHRNKGKLDARARIEYLLDPGTFRELGTL
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHEEEEEEECCCHHHHHHHH
VGGEIAADGLVVGSGEINGTPVMLGAEDFTTLAGSIGPGGNSKRYRIAELALRDKIPLVM
HCCCEECCCEEEECCCCCCCEEEECCHHHHHHHCCCCCCCCCCCEEHHHHHHHCCCCEEE
LLEGAGFRPTGGHYGRTPTDLLAQAQCSGRVPTVAAVLGPSAGHGALVAPVCDFRIMSRQ
EEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEHHHCCCEECCC
GAIFTAGPPVVKESTGEDISKEDLGGPDVALPSGVIHNVAENDEAALDDVRRYLSYFPPS
CCEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCC
AWSYPPSLPPGDAAMPRPTPELLDIVSRDNRRVYDMRAVLDVVFDSPDWFEVQPQFGKAI
CCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHH
ICALAHLGGHPVAVVANQPQVLAGSIDADAADKAAHFIMVADSFHLPIVFLADNPGMLPG
HHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCC
SRSERSGVLRAGARMFAAQTAATTLKLHVTLRKAYGFGSMVMSLLGFDHQVATFAYPGAT
CCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEEHHCCHHHHHHHHHCCCCCCEEEECCCCH
MGAMSAAALSRASHAGEDLSTKLRNAELQASYRSAEHMGFDELIDPRETRDALLASLRRG
HHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHC
LSSRQAAAEPVSRTVIMP
HHHHHHHHHHHCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]