Click here to switch to the map view.

The map label for this gene is adhB [H]

Identifier: 41408464

GI number: 41408464

Start: 2659384

End: 2660973

Strand: Direct

Name: adhB [H]

Synonym: MAP2366

Alternate gene names: 41408464

Gene position: 2659384-2660973 (Clockwise)

Preceding gene: 41408463

Following gene: 41408470

Centisome position: 55.06

GC content: 67.17

Gene sequence:

>1590_bases
ATGAAAAGCCGGGCAGCGATCCTGCATGACGTCGGCGGCCCTTGGTCGGTCGAGGAGTTCGAGCTGGACCCGCCGCGCGC
CGGGGAGGTCCTGGTGCAGATGGCCGCCGCCGGTTTGTGCCACTCCGACGACCACATCCTCAAGGGCGACATGTCGGCGC
CCAACGAGGTGATGCGATCGCTGGGGCTGCCCACCATGTTCCCCACCATCGGCGGCCACGAGGGTTCGGGCATCGTGCGC
GAGGTGGGTGAGGGCGTCACCGATTTCGCGCCGGGCGATCACGTGGTGATGTCGTTCGTCGCCGTGTGCGGCCAATGCCG
TTGGTGCGCAAGCGGAATGGAGTACCTCTGCGACGTGGGCATCGGCACCATGATCCCTGGGATGCCCACCGACGGCACCT
TCCGCCACCACACGGCCGGCGGCGGCAATCTCGGCCACATCGCGAAGATCGGCGCCTTCGCCGAACACACTGTGGTGTCG
ACGAATTCGCTGGTGAAGATCGAGCAGCAGTTGCCGCTGGCGCCGAGCGCGCTGCTGTCCTGCGCCATCCCGACCGGCTA
CGGCTCGGCCGCCAACCGGGCCGGGGTGCGCGGCGGGGACGCCGTGGTGGTGATCGGCGCCGGCGGCATCGGCACCGGAG
CCATCCAGGGCGCCCGGATCAGCGGTGCCGCGCAGATCGTCGCGGTCGACCCAGTGGAGTTCAAGCAGAAGTCGGCGCTG
CGGTTCGGCGCCACGCACAGCGTGGCGACCATCGCCGAGGCCCTGGACCTGGTGCGGGACTTGACTTATGGGGTGATGGC
CGACGCGGTGGTGGTCTCGCCGTCGTTGATCACAGCCGATGACGTGCGCGACGCGCTGAAGCTGACCCGCAAGGGCGGAA
CCTGTGTGCTCACCGGCATGACGTCGCAGTTGACCCGGTCGGTCAACATCGAGCTGCAGGACTTCATCCTGATGAACAAG
ACGCTGGCGGGCACCATCTTCGGCTCGTGCAACCCCAGGGCCGACATCTCCCGGCTGGCCAGGCTCTATCAGTCCGGTCA
GCTGCAGCTGGACGAGATGATCACCAAGCGCTATCGCCTGGACGAGTCAACGACGCCTACGACGACCTGCTCAACGGCAA
AATCGTGCGGGGCATCATCGATTTCGGGATCGCCTGAGCGCGCGGCCTACATCTTGATCGCGGGGAACAGCCTGCTGAGG
TTCCACAGCCGGTCTCTGCGCGCCGATAGACACGAGATCGCCAGTGCGACGGCCGTTATCGCGGCCAGCACGATGATCGC
CTGCCACAGTCGGGCGTCGATGCCGCCGAGGATGAGCTGCCGGAGTCCGTTGACGCCGTACGTCATCGGGTCGAAGCGGT
GCAGGACCTGGAACGGCCGCGACGTGGTTTCCACGGGATACATCCCGCCCGCGCTGACGAGCTGCAGCATGAGCAGGGCC
ATGATCAGCACCCGGCCCACCGCCGGACCGACAAGAGCGTTGATGGCCTGCGTCGCGGCCACGAACGCGCCGGAAATCAG
CACCATGAACCCCAGCATCGCCACCGGGTGGACGGCGTGCATGCCGAGGGCGAACCGGACCACACAGTAG

Upstream 100 bases:

>100_bases
TGGCGTTCGTGCCCGACGACGGAACCGGCGAGGAGTCCAAGATCGTCGGGCTCACCTTCCGCTCCCCCAACAAGCTTCCC
GTCACGTTCGCGCCCGCCGC

Downstream 100 bases:

>100_bases
AGAACGACGGCCTGGAACAGCGCGATCGCAGCGGCGGGCAGGTAGCTGGCGAGCACCACGCGGATCGCGATCACCTCCGC
GGCGATCGCACGATATTGCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MKSRAAILHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPNEVMRSLGLPTMFPTIGGHEGSGIVR
EVGEGVTDFAPGDHVVMSFVAVCGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAGGGNLGHIAKIGAFAEHTVVS
TNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVRGGDAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSAL
RFGATHSVATIAEALDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCVLTGMTSQLTRSVNIELQDFILMNK
TLAGTIFGSCNPRADISRLARLYQSGQLQLDEMITKRYRLDESTTPTTTCSTAKSCGASSISGSPERAAYILIAGNSLLR
FHSRSLRADRHEIASATAVIAASTMIACHSRASMPPRMSCRSPLTPYVIGSKRCRTWNGRDVVSTGYIPPALTSCSMSRA
MISTRPTAGPTRALMACVAATNAPEISTMNPSIATGWTACMPRANRTTQ

Sequences:

>Translated_529_residues
MKSRAAILHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPNEVMRSLGLPTMFPTIGGHEGSGIVR
EVGEGVTDFAPGDHVVMSFVAVCGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAGGGNLGHIAKIGAFAEHTVVS
TNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVRGGDAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSAL
RFGATHSVATIAEALDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCVLTGMTSQLTRSVNIELQDFILMNK
TLAGTIFGSCNPRADISRLARLYQSGQLQLDEMITKRYRLDESTTPTTTCSTAKSCGASSISGSPERAAYILIAGNSLLR
FHSRSLRADRHEIASATAVIAASTMIACHSRASMPPRMSCRSPLTPYVIGSKRCRTWNGRDVVSTGYIPPALTSCSMSRA
MISTRPTAGPTRALMACVAATNAPEISTMNPSIATGWTACMPRANRTTQ
>Mature_529_residues
MKSRAAILHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPNEVMRSLGLPTMFPTIGGHEGSGIVR
EVGEGVTDFAPGDHVVMSFVAVCGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAGGGNLGHIAKIGAFAEHTVVS
TNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVRGGDAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSAL
RFGATHSVATIAEALDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCVLTGMTSQLTRSVNIELQDFILMNK
TLAGTIFGSCNPRADISRLARLYQSGQLQLDEMITKRYRLDESTTPTTTCSTAKSCGASSISGSPERAAYILIAGNSLLR
FHSRSLRADRHEIASATAVIAASTMIACHSRASMPPRMSCRSPLTPYVIGSKRCRTWNGRDVVSTGYIPPALTSCSMSRA
MISTRPTAGPTRALMACVAATNAPEISTMNPSIATGWTACMPRANRTTQ

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=32.6145552560647, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=32.8840970350404, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI156523966, Length=385, Percent_Identity=31.6883116883117, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI4501939, Length=385, Percent_Identity=31.6883116883117, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=32.5136612021858, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI71565154, Length=373, Percent_Identity=32.171581769437, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI262073058, Length=366, Percent_Identity=32.2404371584699, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI71743840, Length=366, Percent_Identity=32.2404371584699, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI71565152, Length=370, Percent_Identity=30.8108108108108, Blast_Score=160, Evalue=4e-39,
Organism=Escherichia coli, GI1786552, Length=365, Percent_Identity=34.5205479452055, Blast_Score=152, Evalue=7e-38,
Organism=Escherichia coli, GI1788073, Length=367, Percent_Identity=27.5204359673025, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87081918, Length=325, Percent_Identity=27.3846153846154, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082125, Length=373, Percent_Identity=25.201072386059, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788075, Length=352, Percent_Identity=26.4204545454545, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=330, Percent_Identity=26.969696969697, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787863, Length=311, Percent_Identity=25.7234726688103, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786825, Length=389, Percent_Identity=24.4215938303342, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790045, Length=338, Percent_Identity=25.7396449704142, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI226510992, Length=347, Percent_Identity=25.9365994236311, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=380, Percent_Identity=33.1578947368421, Blast_Score=188, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI71997431, Length=382, Percent_Identity=33.2460732984293, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17565904, Length=339, Percent_Identity=33.0383480825959, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71988145, Length=365, Percent_Identity=27.9452054794521, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=27.8592375366569, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=358, Percent_Identity=26.8156424581006, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=368, Percent_Identity=26.0869565217391, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=258, Percent_Identity=27.1317829457364, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320033, Length=377, Percent_Identity=34.4827586206897, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6319621, Length=351, Percent_Identity=26.2108262108262, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=349, Percent_Identity=24.3553008595989, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=348, Percent_Identity=23.5632183908046, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=321, Percent_Identity=25.5451713395639, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=347, Percent_Identity=27.6657060518732, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=347, Percent_Identity=27.6657060518732, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=244, Percent_Identity=29.5081967213115, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=33.1506849315069, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17737897, Length=225, Percent_Identity=30.2222222222222, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 55423; Mature: 55423

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAILHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPNEVMRS
CCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHH
LGLPTMFPTIGGHEGSGIVREVGEGVTDFAPGDHVVMSFVAVCGQCRWCASGMEYLCDVG
CCCCEECCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCC
IGTMIPGMPTDGTFRHHTAGGGNLGHIAKIGAFAEHTVVSTNSLVKIEQQLPLAPSALLS
HHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHEEECCCCEEEEHHHCCCCHHHHHH
CAIPTGYGSAANRAGVRGGDAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSAL
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCEEEEEECCHHHHHHHHH
RFGATHSVATIAEALDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCVLTGM
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEHHHHHHHHHHHCCCCEEEEECC
TSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADISRLARLYQSGQLQLDEMITKRYRL
HHHHHHCCCCEEHHHEEHHHHHHEEEECCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHCC
DESTTPTTTCSTAKSCGASSISGSPERAAYILIAGNSLLRFHSRSLRADRHEIASATAVI
CCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHH
AASTMIACHSRASMPPRMSCRSPLTPYVIGSKRCRTWNGRDVVSTGYIPPALTSCSMSRA
HHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHH
MISTRPTAGPTRALMACVAATNAPEISTMNPSIATGWTACMPRANRTTQ
HHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHCCCCCCCCC
>Mature Secondary Structure
MKSRAAILHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPNEVMRS
CCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHH
LGLPTMFPTIGGHEGSGIVREVGEGVTDFAPGDHVVMSFVAVCGQCRWCASGMEYLCDVG
CCCCEECCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCC
IGTMIPGMPTDGTFRHHTAGGGNLGHIAKIGAFAEHTVVSTNSLVKIEQQLPLAPSALLS
HHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHEEECCCCEEEEHHHCCCCHHHHHH
CAIPTGYGSAANRAGVRGGDAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSAL
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCEEEEEECCHHHHHHHHH
RFGATHSVATIAEALDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCVLTGM
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEHHHHHHHHHHHCCCCEEEEECC
TSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADISRLARLYQSGQLQLDEMITKRYRL
HHHHHHCCCCEEHHHEEHHHHHHEEEECCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHCC
DESTTPTTTCSTAKSCGASSISGSPERAAYILIAGNSLLRFHSRSLRADRHEIASATAVI
CCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHH
AASTMIACHSRASMPPRMSCRSPLTPYVIGSKRCRTWNGRDVVSTGYIPPALTSCSMSRA
HHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHH
MISTRPTAGPTRALMACVAATNAPEISTMNPSIATGWTACMPRANRTTQ
HHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]