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The map label for this gene is fabG [C]

Identifier: 41408446

GI number: 41408446

Start: 2639541

End: 2640257

Strand: Direct

Name: fabG [C]

Synonym: MAP2348

Alternate gene names: 41408446

Gene position: 2639541-2640257 (Clockwise)

Preceding gene: 41408445

Following gene: 41408448

Centisome position: 54.65

GC content: 70.29

Gene sequence:

>717_bases
ATGCGAACCGCATTGGTCACCGGTGGCAGCGGCGGGATCGGTAAGGGGTGCGCTCGCAAGCTGGTCGAACGCGGCTACGA
CGTGTTGCTGTGCGCCCGCCGCGAAGCCCCGTTGCGCGCGGCGGCCGAGGAGATCGGTGCCCGCCACGTCGTGGCCGATG
CCTCCGATCCGATCGGATTCCCCTCTGCCCTAAGCACATTGGAGACGGTCGACCTCGTCGTCCACGCGGCGGGCGCGCTG
GGCGGAACCTACGCGCGCAAGCAGACCTTCGAGCAGTGGCGGGCCATCATCTCGGCCAACCTGGATTCGTGCTTCGTGGT
GACCTCGGCGGTGCTGCCCAAGATGACAGCCGGCTCCCGGCTGGTGTTCATCTCGTCCTCGGCGGCGCACGAACCGATGC
CGGCCCGCACCGCCTACTCCGCGTCGAAGGCCGGCATGAATGCGTTCGCGCGGGCGCTGGCGCTCGAGGTCGATCGCGAC
GGGATCAGCGTGCACCTCGTCACGCCGGGCCCGGTGGCCACCGAGATGCTGCAGGACGTGCCGTTCGAGATGTATGCGAT
CGCGGTGTCCGACGTCGCCGAGGCGGTCGTCTTTCTGGACACCGTCGACCCGTCGGTCGATCTGCCCGAGATCCGGTTGT
CCGCCGTCCAGCGCGGCCCGTTCGCCCGCCCGCCGGTGGTGCCCACCGAGGCCCGCCGCCGCGCCCAACGGGGTTGA

Upstream 100 bases:

>100_bases
CTCTCCGGTCAGCCCGATCAACGGATTCACGCGTTCTCCCCGCAGGCGCTGGCGCGGCCGCGGGACCTCCGGCGCTCCTG
AAGGGCGGCCTGCGATCCTC

Downstream 100 bases:

>100_bases
CGCTCACCGGGCCGGGAAGGCCGTGATCACCGATTCGCCGAACTCGCGCAGCGAATCCGGAGCGGCGAAGTCGGCGAACC
ACACGTAGAACCGCTCGACG

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRTALVTGGSGGIGKGCARKLVERGYDVLLCARREAPLRAAAEEIGARHVVADASDPIGFPSALSTLETVDLVVHAAGAL
GGTYARKQTFEQWRAIISANLDSCFVVTSAVLPKMTAGSRLVFISSSAAHEPMPARTAYSASKAGMNAFARALALEVDRD
GISVHLVTPGPVATEMLQDVPFEMYAIAVSDVAEAVVFLDTVDPSVDLPEIRLSAVQRGPFARPPVVPTEARRRAQRG

Sequences:

>Translated_238_residues
MRTALVTGGSGGIGKGCARKLVERGYDVLLCARREAPLRAAAEEIGARHVVADASDPIGFPSALSTLETVDLVVHAAGAL
GGTYARKQTFEQWRAIISANLDSCFVVTSAVLPKMTAGSRLVFISSSAAHEPMPARTAYSASKAGMNAFARALALEVDRD
GISVHLVTPGPVATEMLQDVPFEMYAIAVSDVAEAVVFLDTVDPSVDLPEIRLSAVQRGPFARPPVVPTEARRRAQRG
>Mature_238_residues
MRTALVTGGSGGIGKGCARKLVERGYDVLLCARREAPLRAAAEEIGARHVVADASDPIGFPSALSTLETVDLVVHAAGAL
GGTYARKQTFEQWRAIISANLDSCFVVTSAVLPKMTAGSRLVFISSSAAHEPMPARTAYSASKAGMNAFARALALEVDRD
GISVHLVTPGPVATEMLQDVPFEMYAIAVSDVAEAVVFLDTVDPSVDLPEIRLSAVQRGPFARPPVVPTEARRRAQRG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI226371731, Length=193, Percent_Identity=34.1968911917098, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI40254992, Length=211, Percent_Identity=32.7014218009479, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI33667109, Length=203, Percent_Identity=31.5270935960591, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI5031737, Length=189, Percent_Identity=32.8042328042328, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI19923817, Length=191, Percent_Identity=26.1780104712042, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI20149619, Length=189, Percent_Identity=27.5132275132275, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=183, Percent_Identity=32.7868852459016, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788459, Length=188, Percent_Identity=29.7872340425532, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787820, Length=235, Percent_Identity=26.3829787234043, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1789378, Length=195, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI87082100, Length=192, Percent_Identity=31.7708333333333, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1786701, Length=236, Percent_Identity=27.9661016949153, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786812, Length=181, Percent_Identity=26.5193370165746, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI2367365, Length=176, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787526, Length=195, Percent_Identity=30.7692307692308, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI2367175, Length=231, Percent_Identity=28.5714285714286, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=192, Percent_Identity=31.25, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=191, Percent_Identity=29.3193717277487, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=219, Percent_Identity=26.9406392694064, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=191, Percent_Identity=28.2722513089005, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=191, Percent_Identity=27.2251308900524, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=191, Percent_Identity=27.7486910994764, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=196, Percent_Identity=27.5510204081633, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=223, Percent_Identity=32.2869955156951, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI161076933, Length=187, Percent_Identity=31.5508021390374, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584748, Length=187, Percent_Identity=31.5508021390374, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574402, Length=192, Percent_Identity=28.125, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24584744, Length=192, Percent_Identity=28.125, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640442, Length=192, Percent_Identity=30.7291666666667, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357041, Length=187, Percent_Identity=32.0855614973262, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24643142, Length=180, Percent_Identity=28.8888888888889, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21358495, Length=191, Percent_Identity=28.7958115183246, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571387, Length=243, Percent_Identity=28.3950617283951, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571526, Length=191, Percent_Identity=27.2251308900524, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644339, Length=187, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25098; Mature: 25098

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTALVTGGSGGIGKGCARKLVERGYDVLLCARREAPLRAAAEEIGARHVVADASDPIGF
CCEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCEEEECCCCCCCC
PSALSTLETVDLVVHAAGALGGTYARKQTFEQWRAIISANLDSCFVVTSAVLPKMTAGSR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCE
LVFISSSAAHEPMPARTAYSASKAGMNAFARALALEVDRDGISVHLVTPGPVATEMLQDV
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHC
PFEMYAIAVSDVAEAVVFLDTVDPSVDLPEIRLSAVQRGPFARPPVVPTEARRRAQRG
CHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MRTALVTGGSGGIGKGCARKLVERGYDVLLCARREAPLRAAAEEIGARHVVADASDPIGF
CCEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCEEEECCCCCCCC
PSALSTLETVDLVVHAAGALGGTYARKQTFEQWRAIISANLDSCFVVTSAVLPKMTAGSR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCE
LVFISSSAAHEPMPARTAYSASKAGMNAFARALALEVDRDGISVHLVTPGPVATEMLQDV
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHHHHHHC
PFEMYAIAVSDVAEAVVFLDTVDPSVDLPEIRLSAVQRGPFARPPVVPTEARRRAQRG
CHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]