Definition Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession NC_002944
Length 4,829,781

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The map label for this gene is ucpA [C]

Identifier: 41407478

GI number: 41407478

Start: 1492207

End: 1493019

Strand: Direct

Name: ucpA [C]

Synonym: MAP1380

Alternate gene names: 41407478

Gene position: 1492207-1493019 (Clockwise)

Preceding gene: 41407477

Following gene: 41407479

Centisome position: 30.9

GC content: 66.17

Gene sequence:

>813_bases
TTGGCGGACAACAAAGTAGCTCTCATCACCGGAGCCGCGCGCGGGCAGGGACGTGCCCACGCGGTGCGGCTGAGCGCCGG
CGGCGCCGACATAATCGCGGTCGACATCGCCGGGCGGCTACCGGAAAGCGTCCCATATGAGTCGCCGACTCGCGATGATC
TCGCCGAGACCGCGCGGCTCGTTGAAGCCAACGGCCGGCGCGCGATCACCGCGGCGATCGATGTGCGCGACGCCGAAAAG
CTGAGCGCGGCCGTCGGCCACGCGGTCGCCGAGCTCGGCCGCCTCGACATCATCGTCGCCAACGCGGGAATTTGTTGCCC
GGCACCATGGGACCAAATCACGGGCCAGGCGTTCCGCGACACCATCGACACCAACGTGATCGGCACGTGGAACACCGTCA
TGGCAGGCGCTCACCACATCATCGCAGGGCGACGGGGCGGGTCGATCATCCTGATCGGTTCCGCTGCAGGTGTGAAAATG
CAAGCGTTCATGGTGCATTACACGGCGAGCAAGCACGCCATCACCGGCATGGCCCGGGCCTTCGCCGCCGAGCTGGGCCG
CTACAACATCCGCGTTAACAGCCTTCACCCCGGAGCTGTCGACACACCCATGGGAACCGGACGTATGCGCGACGCGCTCG
AGTCGGCGGCCGCGACGTATCCCCATTTGGAAGGCCTGCACAAGCCGCTGCTGCCCGACGGCATTGCGCAACCCGAAGAC
ATCGCCGACGCGGTGGCCTGGCTCGCATCGGATCAATCGAGATTCGTTACCGCATCCGGTATCTCGGTCGACCTGGGTGT
CGCCTACTGCTAG

Upstream 100 bases:

>100_bases
GCAGCAAGCCGGTGTGCGCTACCGCTGGGACGGCGAGGAGACCTACGGCATGCTCGAACGCTCCAACCCGCTCGACAAGA
TTCATCGGGACTGAACTGCC

Downstream 100 bases:

>100_bases
CGAGAGGATGGGCCCGTGCGCGGATTACAGGGCAAGACGTTCATCGTTGCGGGCGGATCGACCGGAATCGGAGCCGCAAC
CGCCGAACGCCTCGCCAGCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MADNKVALITGAARGQGRAHAVRLSAGGADIIAVDIAGRLPESVPYESPTRDDLAETARLVEANGRRAITAAIDVRDAEK
LSAAVGHAVAELGRLDIIVANAGICCPAPWDQITGQAFRDTIDTNVIGTWNTVMAGAHHIIAGRRGGSIILIGSAAGVKM
QAFMVHYTASKHAITGMARAFAAELGRYNIRVNSLHPGAVDTPMGTGRMRDALESAAATYPHLEGLHKPLLPDGIAQPED
IADAVAWLASDQSRFVTASGISVDLGVAYC

Sequences:

>Translated_270_residues
MADNKVALITGAARGQGRAHAVRLSAGGADIIAVDIAGRLPESVPYESPTRDDLAETARLVEANGRRAITAAIDVRDAEK
LSAAVGHAVAELGRLDIIVANAGICCPAPWDQITGQAFRDTIDTNVIGTWNTVMAGAHHIIAGRRGGSIILIGSAAGVKM
QAFMVHYTASKHAITGMARAFAAELGRYNIRVNSLHPGAVDTPMGTGRMRDALESAAATYPHLEGLHKPLLPDGIAQPED
IADAVAWLASDQSRFVTASGISVDLGVAYC
>Mature_269_residues
ADNKVALITGAARGQGRAHAVRLSAGGADIIAVDIAGRLPESVPYESPTRDDLAETARLVEANGRRAITAAIDVRDAEKL
SAAVGHAVAELGRLDIIVANAGICCPAPWDQITGQAFRDTIDTNVIGTWNTVMAGAHHIIAGRRGGSIILIGSAAGVKMQ
AFMVHYTASKHAITGMARAFAAELGRYNIRVNSLHPGAVDTPMGTGRMRDALESAAATYPHLEGLHKPLLPDGIAQPEDI
ADAVAWLASDQSRFVTASGISVDLGVAYC

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=266, Percent_Identity=30.4511278195489, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI15277342, Length=272, Percent_Identity=30.5147058823529, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI7705925, Length=264, Percent_Identity=28.030303030303, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI31542939, Length=274, Percent_Identity=28.8321167883212, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI59889578, Length=207, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI19923817, Length=269, Percent_Identity=24.5353159851301, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI32483357, Length=264, Percent_Identity=26.5151515151515, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4758504, Length=240, Percent_Identity=28.75, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4504505, Length=218, Percent_Identity=27.9816513761468, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI223718074, Length=198, Percent_Identity=30.8080808080808, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40254992, Length=177, Percent_Identity=31.638418079096, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7706318, Length=198, Percent_Identity=29.2929292929293, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI224922801, Length=182, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI20149619, Length=201, Percent_Identity=29.8507462686567, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI87082100, Length=263, Percent_Identity=31.1787072243346, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789208, Length=264, Percent_Identity=30.3030303030303, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788459, Length=262, Percent_Identity=29.0076335877863, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787335, Length=266, Percent_Identity=27.8195488721804, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787905, Length=268, Percent_Identity=30.9701492537313, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1790717, Length=263, Percent_Identity=29.277566539924, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI2367365, Length=263, Percent_Identity=31.1787072243346, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786812, Length=266, Percent_Identity=28.9473684210526, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1789378, Length=261, Percent_Identity=28.735632183908, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI87082160, Length=272, Percent_Identity=27.2058823529412, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI2367175, Length=263, Percent_Identity=26.615969581749, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787526, Length=269, Percent_Identity=25.2788104089219, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=275, Percent_Identity=28, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=275, Percent_Identity=26.5454545454545, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=278, Percent_Identity=29.8561151079137, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=272, Percent_Identity=31.9852941176471, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=269, Percent_Identity=27.5092936802974, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=268, Percent_Identity=27.2388059701493, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=271, Percent_Identity=31.3653136531365, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=276, Percent_Identity=27.536231884058, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=210, Percent_Identity=32.8571428571429, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71997099, Length=241, Percent_Identity=29.4605809128631, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=271, Percent_Identity=30.9963099630996, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=276, Percent_Identity=28.9855072463768, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=270, Percent_Identity=29.6296296296296, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=270, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=265, Percent_Identity=27.9245283018868, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=197, Percent_Identity=27.9187817258883, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=203, Percent_Identity=24.6305418719212, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=270, Percent_Identity=26.2962962962963, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=275, Percent_Identity=29.4545454545455, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=29.0441176470588, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=268, Percent_Identity=26.865671641791, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555612, Length=276, Percent_Identity=30.0724637681159, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=267, Percent_Identity=26.5917602996255, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=267, Percent_Identity=28.0898876404494, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=271, Percent_Identity=28.0442804428044, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=275, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=264, Percent_Identity=24.2424242424242, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=265, Percent_Identity=27.1698113207547, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=28.7878787878788, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=261, Percent_Identity=28.735632183908, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24639444, Length=265, Percent_Identity=28.6792452830189, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357041, Length=267, Percent_Identity=28.0898876404494, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=28.3018867924528, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24643142, Length=262, Percent_Identity=29.0076335877863, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737361, Length=240, Percent_Identity=28.75, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644339, Length=262, Percent_Identity=24.8091603053435, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648944, Length=252, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI23397609, Length=269, Percent_Identity=27.5092936802974, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281364892, Length=229, Percent_Identity=24.8908296943231, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355319, Length=268, Percent_Identity=26.865671641791, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581726, Length=217, Percent_Identity=26.7281105990783, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI116007236, Length=260, Percent_Identity=25.7692307692308, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24663911, Length=255, Percent_Identity=28.2352941176471, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641232, Length=256, Percent_Identity=26.5625, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24644337, Length=174, Percent_Identity=28.1609195402299, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 28132; Mature: 28001

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MADNKVALITGAARGQGRAHAVRLSAGGADIIAVDIAGRLPESVPYESPTRDDLAETARL
CCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VEANGRRAITAAIDVRDAEKLSAAVGHAVAELGRLDIIVANAGICCPAPWDQITGQAFRD
HHCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCEECCCCHHHHCCHHHHH
TIDTNVIGTWNTVMAGAHHIIAGRRGGSIILIGSAAGVKMQAFMVHYTASKHAITGMARA
HHCCCCEECHHHHHHCCCEEEEECCCCEEEEEECCCCCEEEEEEEEEECCHHHHHHHHHH
FAAELGRYNIRVNSLHPGAVDTPMGTGRMRDALESAAATYPHLEGLHKPLLPDGIAQPED
HHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHH
IADAVAWLASDQSRFVTASGISVDLGVAYC
HHHHHHHHHCCCCCEEEECCCEEEEEEECC
>Mature Secondary Structure 
ADNKVALITGAARGQGRAHAVRLSAGGADIIAVDIAGRLPESVPYESPTRDDLAETARL
CCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VEANGRRAITAAIDVRDAEKLSAAVGHAVAELGRLDIIVANAGICCPAPWDQITGQAFRD
HHCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCEECCCCHHHHCCHHHHH
TIDTNVIGTWNTVMAGAHHIIAGRRGGSIILIGSAAGVKMQAFMVHYTASKHAITGMARA
HHCCCCEECHHHHHHCCCEEEEECCCCEEEEEECCCCCEEEEEEEEEECCHHHHHHHHHH
FAAELGRYNIRVNSLHPGAVDTPMGTGRMRDALESAAATYPHLEGLHKPLLPDGIAQPED
HHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHH
IADAVAWLASDQSRFVTASGISVDLGVAYC
HHHHHHHHHCCCCCEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA