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The map label for this gene is argH

Identifier: 41407466

GI number: 41407466

Start: 1470627

End: 1472045

Strand: Direct

Name: argH

Synonym: MAP1368

Alternate gene names: 41407466

Gene position: 1470627-1472045 (Clockwise)

Preceding gene: 41407465

Following gene: 41407467

Centisome position: 30.45

GC content: 74.07

Gene sequence:

>1419_bases
GTGAGCACCCGCGAGGGGTCGCTGTGGGGCGGGCGGTTCGCCGACGGCCCGTCCGACGCGCTGGCCGCCCTGAGCAAGTC
CACCCACTTCGACTGGGTGCTGGCCCCCTACGACATCGTCGCCTCCCGGGCGCACACCGTGATCCTGTACCGGGCCGGGC
TGCTGTCCGAGGAGCAGCGCGACGGGCTGTTGGCCGGGCTGGACAGCCTGGCGGAAGACGTGGCCGACGGCAGCTTCACC
CCGCTGGTCACCGACGAGGACGTGCACGCGGCGCTGGAGCGCGGCCTCATCGACCGCGTCGGGCCCGACCTGGGTGGGCG
GCTGCGGGCCGGCCGGTCGCGCAACGACCAGGTGGCCACCCTGTTCCGGATGTGGCTGCGCGACGCCGTGCGCCGCGTCG
CGGCCGGGGCGCTGGACGTGGTGGGGGCGCTGGTCGCCCAGGCCGCCGCCCACCCCGAGGCCATCATGCCGGGCAAGACG
CACCTGCAGTCCGCGCAGCCGGTGCTGCTGGCCCACCATCTGCTCGCGCACGCCCACCCGCTGCTGCGCGACGTCGACCG
CATCGTCGACTTCGACAAGCGCGCCGCGGTGTCCCCGTACGGCTCGGGGGCGCTGGCCGGCTCGTCGCTGGGCCTGGACC
CGGACGCGATCGCCGCGGAGCTGGGGTTTGCCAGCGCCGCCGACAATTCGATCGACGCCACCGCGTCCCGGGACTTCGCC
GCCGAGGCCGCGTTCGTCTTCGCCATGATCGGTGTCGACCTGTCCCGGCTGGCCGAGGACGTCATCCTGTGGAGCTCGAC
GGAGTTCGGCTACGTCAAGCTGCACGACGCCTGGTCCACCGGCAGCTCGATCATGCCGCAGAAGAAGAACCCGGACATCG
CCGAGCTGGCCCGCGGCAAGTCCGGGCGGCTGATCGGCAACCTGGCCGGGCTGCTGGCCACGCTGAAGGCCCAACCGCTG
GCCTACAACCGCGACCTGCAGGAGGACAAGGAACCGGTGTTCGACGCGGTGGCCCAGCTGGAGCTGGTGTTGCCCGCGAT
GGCCGGGCTGGTCGGCAGCCTGACCTTCGACGTGCAGCGGATGGCCGCGCTGGCACCCGCCGGCTACACGCTGGCCACCG
ACATCGCCGAATGGCTGGTGCGCCAGGGCGTGCCGTTCCGGTCCGCGCACGAGGCCGCCGGGGCCGCGGTGCGCGCCGCC
GAGCAGCGGGCCGTCGGGCTCGACGAGCTCACCGACGACGAACTGGCCGCCATCAGCCCGGCCCTGACGCCGCAAGTACG
GGAGGTTTTGACGATCGAGGGCTCGGTGTCCTCCCGGGACGCGCGGGGCGGCACCGCGCCGGCGCGGGTCGCCGAGCAGA
TCGACACCGTGGCGGCCACCGCCGCGCGGCTGCGCGAACGGCTCGGCGGCCCGGCCTGA

Upstream 100 bases:

>100_bases
GCGAAGGGTTTCGTCTACGTGCACGGGCTGTCGTCGAAGATCGCCTCCCGCCGGGACCAGCGGTGAGCTTTCCCGCAAGA
GGGCGCGCGGAGGGGCGCGC

Downstream 100 bases:

>100_bases
GATGGCCTCGATTTACCTGCCGGTAAATTGCAACCGGACTAGACTTCCCGCTCGAGCGATGCGGCTGAACCTGTCAGCCC
GACCGGTCGTGATCAAGGGG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSTREGSLWGGRFADGPSDALAALSKSTHFDWVLAPYDIVASRAHTVILYRAGLLSEEQRDGLLAGLDSLAEDVADGSFT
PLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALDVVGALVAQAAAHPEAIMPGKT
HLQSAQPVLLAHHLLAHAHPLLRDVDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAAELGFASAADNSIDATASRDFA
AEAAFVFAMIGVDLSRLAEDVILWSSTEFGYVKLHDAWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPL
AYNRDLQEDKEPVFDAVAQLELVLPAMAGLVGSLTFDVQRMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGAAVRAA
EQRAVGLDELTDDELAAISPALTPQVREVLTIEGSVSSRDARGGTAPARVAEQIDTVAATAARLRERLGGPA

Sequences:

>Translated_472_residues
MSTREGSLWGGRFADGPSDALAALSKSTHFDWVLAPYDIVASRAHTVILYRAGLLSEEQRDGLLAGLDSLAEDVADGSFT
PLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALDVVGALVAQAAAHPEAIMPGKT
HLQSAQPVLLAHHLLAHAHPLLRDVDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAAELGFASAADNSIDATASRDFA
AEAAFVFAMIGVDLSRLAEDVILWSSTEFGYVKLHDAWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPL
AYNRDLQEDKEPVFDAVAQLELVLPAMAGLVGSLTFDVQRMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGAAVRAA
EQRAVGLDELTDDELAAISPALTPQVREVLTIEGSVSSRDARGGTAPARVAEQIDTVAATAARLRERLGGPA
>Mature_471_residues
STREGSLWGGRFADGPSDALAALSKSTHFDWVLAPYDIVASRAHTVILYRAGLLSEEQRDGLLAGLDSLAEDVADGSFTP
LVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALDVVGALVAQAAAHPEAIMPGKTH
LQSAQPVLLAHHLLAHAHPLLRDVDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAAELGFASAADNSIDATASRDFAA
EAAFVFAMIGVDLSRLAEDVILWSSTEFGYVKLHDAWSTGSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLA
YNRDLQEDKEPVFDAVAQLELVLPAMAGLVGSLTFDVQRMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGAAVRAAE
QRAVGLDELTDDELAAISPALTPQVREVLTIEGSVSSRDARGGTAPARVAEQIDTVAATAARLRERLGGPA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=460, Percent_Identity=44.3478260869565, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=460, Percent_Identity=44.3478260869565, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI68303549, Length=460, Percent_Identity=41.9565217391304, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI68303547, Length=460, Percent_Identity=41.5217391304348, Blast_Score=334, Evalue=9e-92,
Organism=Escherichia coli, GI1790398, Length=449, Percent_Identity=42.7616926503341, Blast_Score=331, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6321806, Length=462, Percent_Identity=40.04329004329, Blast_Score=332, Evalue=1e-91,
Organism=Drosophila melanogaster, GI221473854, Length=458, Percent_Identity=41.0480349344978, Blast_Score=342, Evalue=4e-94,
Organism=Drosophila melanogaster, GI78706858, Length=458, Percent_Identity=41.0480349344978, Blast_Score=342, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 49712; Mature: 49580

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTREGSLWGGRFADGPSDALAALSKSTHFDWVLAPYDIVASRAHTVILYRAGLLSEEQR
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECHHHHHHHCCCEEEEEECCCCCCHHH
DGLLAGLDSLAEDVADGSFTPLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAT
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LFRMWLRDAVRRVAAGALDVVGALVAQAAAHPEAIMPGKTHLQSAQPVLLAHHLLAHAHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHH
LLRDVDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAAELGFASAADNSIDATASRDFA
HHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHH
AEAAFVFAMIGVDLSRLAEDVILWSSTEFGYVKLHDAWSTGSSIMPQKKNPDIAELARGK
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDAVAQLELVLPAMAGLVGSLTFDVQR
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGAAVRAAEQRAVGLDELTDDELAAISP
HHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHCC
ALTPQVREVLTIEGSVSSRDARGGTAPARVAEQIDTVAATAARLRERLGGPA
CCCHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STREGSLWGGRFADGPSDALAALSKSTHFDWVLAPYDIVASRAHTVILYRAGLLSEEQR
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECHHHHHHHCCCEEEEEECCCCCCHHH
DGLLAGLDSLAEDVADGSFTPLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAT
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LFRMWLRDAVRRVAAGALDVVGALVAQAAAHPEAIMPGKTHLQSAQPVLLAHHLLAHAHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHH
LLRDVDRIVDFDKRAAVSPYGSGALAGSSLGLDPDAIAAELGFASAADNSIDATASRDFA
HHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHH
AEAAFVFAMIGVDLSRLAEDVILWSSTEFGYVKLHDAWSTGSSIMPQKKNPDIAELARGK
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDAVAQLELVLPAMAGLVGSLTFDVQR
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGAAVRAAEQRAVGLDELTDDELAAISP
HHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHCC
ALTPQVREVLTIEGSVSSRDARGGTAPARVAEQIDTVAATAARLRERLGGPA
CCCHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA