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The map label for this gene is argG

Identifier: 41407465

GI number: 41407465

Start: 1469396

End: 1470592

Strand: Direct

Name: argG

Synonym: MAP1367

Alternate gene names: 41407465

Gene position: 1469396-1470592 (Clockwise)

Preceding gene: 41407464

Following gene: 41407466

Centisome position: 30.42

GC content: 67.42

Gene sequence:

>1197_bases
ATGTCAGAACGCGTCATCCTGGCGTATTCCGGCGGTCTGGACACCTCGGTGGCCATCAGCTGGATCGGCAAGGAGACCGG
CCGTGAGGTCGTAGCGGTGGCGATCGACCTCGGCCAGGGCGGCGAAGACATGGAGGTCATCCGCCAGCGCGCCCTGGACT
GCGGCGCGGTGGAGGCCGTCGTTGTGGACGCCCGCGACGAATTCGCCGAGGGCTATTGCCTGCCCACCATCCGCAACAAC
GCCCTCTACATGGACCGCTACCCGCTGGTGTCGGCGATCAGCCGGCCGCTGATCGTCAAGCACCTGGTGGCCGCGGCCCG
CGAGCACGGCGGCAGCACCGTCGCGCACGGCTGCACCGGCAAGGGCAACGACCAGGTCCGCTTCGAGGTCGGATTCGCTT
CGCTGGCACCGGATCTCGAGGTGCTGGCCCCGGTGCGCGATTACGCGTGGACGCGGGAGAAGGCGATCGCGTTCGCCGAG
GAGAACGCCATCCCGATCAACGTGACCAAACGCTCGCCGTTCTCCATCGACCAGAACGTGTGGGGTCGCGCGGTGGAAAC
CGGTTTCCTGGAACACCTTTGGAACGCGCCCACCAAGGACGTCTACGCCTACACCGAGGACCCCACGCTGAACTGGAGCA
CCCCCGACGAGGTGATCGTCGGGTTCGAGCGCGGGGTTCCGGTGTCCATCGACGGCAAGCCGGTGTCGGTGCTGGGCGCC
ATCGAGGAACTCAACGCCCGCGCCGGCGCCAAGGGGGTAGGGCGCCTGGACGTCGTGGAGGACCGGCTGGTGGGCATCAA
GAGCCGCGAGATCTACGAGGCGCCCGGCGCCATGGTGCTCATCACCGCGCACACCGAGCTCGAGCACGTCACCCTGGAGC
GGGAGCTGGGCCGGTTCAAGCGGCACACCGATCAGCGCTGGGCCGAGCTGGTGTACGACGGGTTGTGGTATTCGCCGCTG
AAGGCTGCGCTGGAAAGCTTCGTCGACAAGACCCAGGAGCACGTCACCGGCGAGATCCGAATGGTGTTGCACGGCGGCCA
CATTGCGGTCAACGGCCGGCGCAGCGCCGAATCGCTCTACGACTTCAACCTGGCCACCTACGACGAGGGCGACAGCTTCG
ACCAGTCGGCGGCGAAGGGTTTCGTCTACGTGCACGGGCTGTCGTCGAAGATCGCCTCCCGCCGGGACCAGCGGTGA

Upstream 100 bases:

>100_bases
CACCGTGTTCGTCGCCGCCCGCGATCCGATGACGGGCGCGGAGTTGGCCGACACATTGGAAAAACTCACCTAAAGCGGTT
CAACTTAAGGAGATTGGTTC

Downstream 100 bases:

>100_bases
GCTTTCCCGCAAGAGGGCGCGCGGAGGGGCGCGCGTGAGCACCCGCGAGGGGTCGCTGTGGGGCGGGCGGTTCGCCGACG
GCCCGTCCGACGCGCTGGCC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVIRQRALDCGAVEAVVVDARDEFAEGYCLPTIRNN
ALYMDRYPLVSAISRPLIVKHLVAAAREHGGSTVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAE
ENAIPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDVYAYTEDPTLNWSTPDEVIVGFERGVPVSIDGKPVSVLGA
IEELNARAGAKGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFKRHTDQRWAELVYDGLWYSPL
KAALESFVDKTQEHVTGEIRMVLHGGHIAVNGRRSAESLYDFNLATYDEGDSFDQSAAKGFVYVHGLSSKIASRRDQR

Sequences:

>Translated_398_residues
MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVIRQRALDCGAVEAVVVDARDEFAEGYCLPTIRNN
ALYMDRYPLVSAISRPLIVKHLVAAAREHGGSTVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAE
ENAIPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDVYAYTEDPTLNWSTPDEVIVGFERGVPVSIDGKPVSVLGA
IEELNARAGAKGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFKRHTDQRWAELVYDGLWYSPL
KAALESFVDKTQEHVTGEIRMVLHGGHIAVNGRRSAESLYDFNLATYDEGDSFDQSAAKGFVYVHGLSSKIASRRDQR
>Mature_397_residues
SERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVIRQRALDCGAVEAVVVDARDEFAEGYCLPTIRNNA
LYMDRYPLVSAISRPLIVKHLVAAAREHGGSTVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEE
NAIPINVTKRSPFSIDQNVWGRAVETGFLEHLWNAPTKDVYAYTEDPTLNWSTPDEVIVGFERGVPVSIDGKPVSVLGAI
EELNARAGAKGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFKRHTDQRWAELVYDGLWYSPLK
AALESFVDKTQEHVTGEIRMVLHGGHIAVNGRRSAESLYDFNLATYDEGDSFDQSAAKGFVYVHGLSSKIASRRDQR

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=396, Percent_Identity=38.8888888888889, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI16950633, Length=396, Percent_Identity=38.8888888888889, Blast_Score=268, Evalue=9e-72,
Organism=Escherichia coli, GI1789563, Length=398, Percent_Identity=29.8994974874372, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324514, Length=406, Percent_Identity=35.2216748768473, Blast_Score=250, Evalue=3e-67,
Organism=Drosophila melanogaster, GI21358151, Length=400, Percent_Identity=35.5, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_MYCPA (P61525)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_960301.1
- ProteinModelPortal:   P61525
- SMR:   P61525
- EnsemblBacteria:   EBMYCT00000037923
- GeneID:   2720352
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1367
- NMPDR:   fig|262316.1.peg.1367
- GeneTree:   EBGT00050000017658
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- ProtClustDB:   PRK00509
- BRENDA:   6.3.4.5
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 43769; Mature: 43638

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 87-87 BINDING 117-117 BINDING 119-119 BINDING 123-123 BINDING 123-123 BINDING 124-124 BINDING 127-127 BINDING 175-175 BINDING 260-260 BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVIRQRALDCGAVEAV
CCCCEEEEECCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCEEEE
VVDARDEFAEGYCLPTIRNNALYMDRYPLVSAISRPLIVKHLVAAAREHGGSTVAHGCTG
EEECCHHHHCCEECEEECCCEEEEECCHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCC
KGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENAIPINVTKRSPFSIDQNV
CCCCEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCHHH
WGRAVETGFLEHLWNAPTKDVYAYTEDPTLNWSTPDEVIVGFERGVPVSIDGKPVSVLGA
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHH
IEELNARAGAKGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFK
HHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCHHHHHHHHHHHHHH
RHTDQRWAELVYDGLWYSPLKAALESFVDKTQEHVTGEIRMVLHGGHIAVNGRRSAESLY
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCHHHH
DFNLATYDEGDSFDQSAAKGFVYVHGLSSKIASRRDQR
CCCEEECCCCCCCCHHHCCCEEEEEECHHHHHHHCCCC
>Mature Secondary Structure 
SERVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVIRQRALDCGAVEAV
CCCEEEEECCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCEEEE
VVDARDEFAEGYCLPTIRNNALYMDRYPLVSAISRPLIVKHLVAAAREHGGSTVAHGCTG
EEECCHHHHCCEECEEECCCEEEEECCHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCC
KGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAEENAIPINVTKRSPFSIDQNV
CCCCEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCHHH
WGRAVETGFLEHLWNAPTKDVYAYTEDPTLNWSTPDEVIVGFERGVPVSIDGKPVSVLGA
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHH
IEELNARAGAKGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHTELEHVTLERELGRFK
HHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCHHHHHHHHHHHHHH
RHTDQRWAELVYDGLWYSPLKAALESFVDKTQEHVTGEIRMVLHGGHIAVNGRRSAESLY
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCHHHH
DFNLATYDEGDSFDQSAAKGFVYVHGLSSKIASRRDQR
CCCEEECCCCCCCCHHHCCCEEEEEECHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA