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The map label for this gene is argF

Identifier: 41407463

GI number: 41407463

Start: 1467948

End: 1468877

Strand: Direct

Name: argF

Synonym: MAP1365

Alternate gene names: 41407463

Gene position: 1467948-1468877 (Clockwise)

Preceding gene: 41407462

Following gene: 41407464

Centisome position: 30.39

GC content: 70.65

Gene sequence:

>930_bases
ATGACCCCCCGGCATTTCCTGCGCGACGACGACCTGTCGCCGGCCGAGCAGGCCGAGGTGTTGGCGCTGGCCGCCGAGCT
GAAGAAGGACCCGTTCAGCGCGCGCCCGCTGGAGGGCCCGCGCGGGGTCGCGGTGCTCTTCGACAAGAACTCCACCCGCA
CCCGGTTCTCGTTCGAGGTGGGCATCGCCCAGCTCGGCGGGCACGCCGTGGTCGTCGACGCCCGCAGCACCCAGCTGGGC
CGCGACGAGACGCTGGAGGACACCGCCCGGGTGCTGTCCCGCTACGTCGAGGCCATCGTGTGGCGGACGTTCGAGCAGCA
GCGCCTCGAGGCGATGGCCGGCGCCGCGACCGTGCCGGTGATCAACGCGCTCTCCGACGAGTTCCATCCCTGCCAGATGC
TCGCCGACCTACAGGCCATCGCCGAGCACAAGGGGTCGCTGAGCGGCCTGCGGATGTGCTACCTCGGTGACGGCGCCAAC
AACATGGCCCACTCGCTGATGCTGGGCGGGGTCACGGCCGGCATCCACGTCACCATCGCCGCCCCGGACGGCTTCACCCC
CGCACCGGAATTCGTGGCGGCGGCGCGGCGGCGCGCCGAAAGCACCGGCGCCACGGTCACTCTCACCACCGACGCGCGGG
CGGCCGCGCGCGGTGTCGACGTCCTGGTCACCGACACCTGGACGTCGATGGGGCAGGAGGACGACGGCCTGGACCGCCGC
ACACCGTTTTGGCCGTATCAGCTCAACGCCGACCTGGTGTCCCTCGCGGATCCGGAAGCCATTGTGCTGCACTGCCTTCC
GGCCCACCGCGGCGAGGAGATCACCGACGAGGTGATGGACGGGCCGTCCAGCGTCGTCTGGGACGAGGCCGAAAACCGGT
TGCACGCGCAAAAGGCGCTGCTCACCTGGCTTTTGGAGCGGCAGTCATGA

Upstream 100 bases:

>100_bases
CCCCCGGCGTCATCCGGCTGGCGCCGCCGCTGATCGTCACCGAGGCCCAGATCGACGGCTTCATCGCCGCGCTGCCCGGC
ATTCTCGACAGGGCCGCGGC

Downstream 100 bases:

>100_bases
CCCGCTCGAAGAGCACCACCGAAACCACCCGGGCCGCCCGGCAGGCCCGCATCGTGGCGATCCTGTCGTCGGCGCAGGTG
CGCAGCCAGAGCGAGCTGGC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTPRHFLRDDDLSPAEQAEVLALAAELKKDPFSARPLEGPRGVAVLFDKNSTRTRFSFEVGIAQLGGHAVVVDARSTQLG
RDETLEDTARVLSRYVEAIVWRTFEQQRLEAMAGAATVPVINALSDEFHPCQMLADLQAIAEHKGSLSGLRMCYLGDGAN
NMAHSLMLGGVTAGIHVTIAAPDGFTPAPEFVAAARRRAESTGATVTLTTDARAAARGVDVLVTDTWTSMGQEDDGLDRR
TPFWPYQLNADLVSLADPEAIVLHCLPAHRGEEITDEVMDGPSSVVWDEAENRLHAQKALLTWLLERQS

Sequences:

>Translated_309_residues
MTPRHFLRDDDLSPAEQAEVLALAAELKKDPFSARPLEGPRGVAVLFDKNSTRTRFSFEVGIAQLGGHAVVVDARSTQLG
RDETLEDTARVLSRYVEAIVWRTFEQQRLEAMAGAATVPVINALSDEFHPCQMLADLQAIAEHKGSLSGLRMCYLGDGAN
NMAHSLMLGGVTAGIHVTIAAPDGFTPAPEFVAAARRRAESTGATVTLTTDARAAARGVDVLVTDTWTSMGQEDDGLDRR
TPFWPYQLNADLVSLADPEAIVLHCLPAHRGEEITDEVMDGPSSVVWDEAENRLHAQKALLTWLLERQS
>Mature_308_residues
TPRHFLRDDDLSPAEQAEVLALAAELKKDPFSARPLEGPRGVAVLFDKNSTRTRFSFEVGIAQLGGHAVVVDARSTQLGR
DETLEDTARVLSRYVEAIVWRTFEQQRLEAMAGAATVPVINALSDEFHPCQMLADLQAIAEHKGSLSGLRMCYLGDGANN
MAHSLMLGGVTAGIHVTIAAPDGFTPAPEFVAAARRRAESTGATVTLTTDARAAARGVDVLVTDTWTSMGQEDDGLDRRT
PFWPYQLNADLVSLADPEAIVLHCLPAHRGEEITDEVMDGPSSVVWDEAENRLHAQKALLTWLLERQS

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=305, Percent_Identity=39.672131147541, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI18105007, Length=311, Percent_Identity=26.0450160771704, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=36.4741641337386, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786469, Length=325, Percent_Identity=36.6153846153846, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI2367364, Length=313, Percent_Identity=32.5878594249201, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI48994908, Length=346, Percent_Identity=26.0115606936416, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193204318, Length=316, Percent_Identity=27.5316455696203, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322373, Length=311, Percent_Identity=36.3344051446945, Blast_Score=193, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6322331, Length=157, Percent_Identity=31.8471337579618, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24642586, Length=308, Percent_Identity=26.9480519480519, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 33595; Mature: 33464

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRHFLRDDDLSPAEQAEVLALAAELKKDPFSARPLEGPRGVAVLFDKNSTRTRFSFEV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEE
GIAQLGGHAVVVDARSTQLGRDETLEDTARVLSRYVEAIVWRTFEQQRLEAMAGAATVPV
CHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
INALSDEFHPCQMLADLQAIAEHKGSLSGLRMCYLGDGANNMAHSLMLGGVTAGIHVTIA
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCEEECEEEEEE
APDGFTPAPEFVAAARRRAESTGATVTLTTDARAAARGVDVLVTDTWTSMGQEDDGLDRR
CCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCEEEEEECHHHCCCCCCCCCCC
TPFWPYQLNADLVSLADPEAIVLHCLPAHRGEEITDEVMDGPSSVVWDEAENRLHAQKAL
CCCCCEEECCCEEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHH
LTWLLERQS
HHHHHHCCC
>Mature Secondary Structure 
TPRHFLRDDDLSPAEQAEVLALAAELKKDPFSARPLEGPRGVAVLFDKNSTRTRFSFEV
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEE
GIAQLGGHAVVVDARSTQLGRDETLEDTARVLSRYVEAIVWRTFEQQRLEAMAGAATVPV
CHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
INALSDEFHPCQMLADLQAIAEHKGSLSGLRMCYLGDGANNMAHSLMLGGVTAGIHVTIA
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCEEECEEEEEE
APDGFTPAPEFVAAARRRAESTGATVTLTTDARAAARGVDVLVTDTWTSMGQEDDGLDRR
CCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCEEEEEECHHHCCCCCCCCCCC
TPFWPYQLNADLVSLADPEAIVLHCLPAHRGEEITDEVMDGPSSVVWDEAENRLHAQKAL
CCCCCEEECCCEEECCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHH
LTWLLERQS
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA