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The map label for this gene is trpE

Identifier: 41407401

GI number: 41407401

Start: 1390530

End: 1392062

Strand: Direct

Name: trpE

Synonym: MAP1303

Alternate gene names: 41407401

Gene position: 1390530-1392062 (Clockwise)

Preceding gene: 41407399

Following gene: 41407402

Centisome position: 28.79

GC content: 70.97

Gene sequence:

>1533_bases
GTGCACGCCCACCTCGCCGCGACGACCTCACGAGAGGATTTCCGCCAGCTGGCAGCCGAGCACCGCGTGGTCCCGGTGAC
CCGCAAGGTGCTGGCCGACAGCGAGACGCCGCTGTCGGCCTACCGCAAACTCGCCGCCAACCGCCCGGGCACCTTCCTGC
TGGAGTCGGCCGAGCACGGCCGGTCCTGGTCGCGGTGGTCGTTCATCGGCGCCGGGTCGCCGTCGGCGCTGACCGTGCGC
GACGGGGAAGCCGGCTGGCTGGGGGTGGTGCCGCAGGACGCACCGACCGGCGGCGATCCGCTGCAGGCACTGCGCGCCAC
CCTGGACCTGCTGGCCACCGGGCCGCTGAGCGGGCTGCCGCCGTTGTCGGGCGGCATGGTCGGCTTCTTCGCCTACGACC
TGGTGCGGCGCCTGGAGCGGCTGCCCGAGCTGGCCGTCGACGACCTGGGCCTGCCGGACATGCTGCTGCTGCTGGCCACC
GATCTGGCGGCCGTCGACCACCACGAGGGCACCATCACGCTGATCGCCAACGCGGTGAACTGGAACGGGACCGACGAACG
GGTCGACGAGGCCTACGACGACGCCGTCGCCCGGCTGGACGTGATGACCGCGGCGCTGGGCCAGCCGCTAGCCTCCACCG
TGGCCACCTTCGAGCGGCCCGAGCCGCGCTACCGCGCGCAGCGCAGCGTCGAGGAGTACGGCAAGATCGTCGACTACCTC
GTCGAGCAGATCGCCGCCGGTGAGGCGTTTCAGGTGGTGCCCTCGCAGCGGTTCGAAATGGACACCGACGTCGACCCGAT
CGACGTGTACCGGATGTTGCGGGTCACCAACCCCAGCCCCTACATGTATCTGCTGCATGTACCGAATGATGCTGGGGGAA
CGGACTTTTCGATCGTCGGGTCCAGCCCGGAGGCTCTGGTCACGGTGGCCGACGGCGTCGCGACCACCCACCCGATCGCC
GGGACCCGGTGGCGCGGGCAGACCGACGACGAGGACCAGCTGCTGGAAAAGGAGCTGCTGGCCGACGAGAAGGAACGCGC
CGAGCATCTGATGCTGGTCGATCTGGGCCGCAACGATCTGGGCCGGGTGTGCGCGCCGGGCACCGTCCGGGTCGACGACT
ACAGCCACATCGAGCGCTACAGCCACGTCATGCATCTGGTCTCGACGGTGACCGGCGTGCTCGACGCGGGCAGGACCGCC
CTGGACGCGGTGACGGCCTGCTTCCCGGCCGGCACCCTGTCGGGTGCGCCGAAGGTCCGGGCGATGGAGCTGATCGAAGA
GGTGGAGAAGACGCGCCGCGGCCTCTACGGCGGCGTGGTCGGCTACCTGGACTTCGCCGGCAACGCCGACTTCGCCATCG
CCATCCGCACCGCGCTGATGCGCGGCGGCACCGCCTACGTGCAATCGGGTGGCGGGGTGGTGGCGGACTCCAACGGCCCC
TACGAATACACCGAGGCCACCAACAAGGCGCGCGCGGTGCTCGGCGCGATCGCGGCCGCCGAGACGCTGACCGAACCGGG
CGCGCGGCGATGA

Upstream 100 bases:

>100_bases
ATGGGCCGCGAATTCGCCGTGGCGTTACATCCGCGGGCGGGTCGGGCCACCGGGCCGCGGGCGGGTCGGGCCACCGCGCC
GCGTCTGGGAGGATGGGTCG

Downstream 100 bases:

>100_bases
CCGAGGCCCGCGCGCGGAGGCTGGACGGCCGCTGGTTGATCCGGATCGCCCAGCTGCTGCTGGTGATCGCGGCCGTGGGC
TTGTGGGTGGCCGCGCGCCT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MHAHLAATTSREDFRQLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAEHGRSWSRWSFIGAGSPSALTVR
DGEAGWLGVVPQDAPTGGDPLQALRATLDLLATGPLSGLPPLSGGMVGFFAYDLVRRLERLPELAVDDLGLPDMLLLLAT
DLAAVDHHEGTITLIANAVNWNGTDERVDEAYDDAVARLDVMTAALGQPLASTVATFERPEPRYRAQRSVEEYGKIVDYL
VEQIAAGEAFQVVPSQRFEMDTDVDPIDVYRMLRVTNPSPYMYLLHVPNDAGGTDFSIVGSSPEALVTVADGVATTHPIA
GTRWRGQTDDEDQLLEKELLADEKERAEHLMLVDLGRNDLGRVCAPGTVRVDDYSHIERYSHVMHLVSTVTGVLDAGRTA
LDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRGGTAYVQSGGGVVADSNGP
YEYTEATNKARAVLGAIAAAETLTEPGARR

Sequences:

>Translated_510_residues
MHAHLAATTSREDFRQLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAEHGRSWSRWSFIGAGSPSALTVR
DGEAGWLGVVPQDAPTGGDPLQALRATLDLLATGPLSGLPPLSGGMVGFFAYDLVRRLERLPELAVDDLGLPDMLLLLAT
DLAAVDHHEGTITLIANAVNWNGTDERVDEAYDDAVARLDVMTAALGQPLASTVATFERPEPRYRAQRSVEEYGKIVDYL
VEQIAAGEAFQVVPSQRFEMDTDVDPIDVYRMLRVTNPSPYMYLLHVPNDAGGTDFSIVGSSPEALVTVADGVATTHPIA
GTRWRGQTDDEDQLLEKELLADEKERAEHLMLVDLGRNDLGRVCAPGTVRVDDYSHIERYSHVMHLVSTVTGVLDAGRTA
LDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRGGTAYVQSGGGVVADSNGP
YEYTEATNKARAVLGAIAAAETLTEPGARR
>Mature_510_residues
MHAHLAATTSREDFRQLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAEHGRSWSRWSFIGAGSPSALTVR
DGEAGWLGVVPQDAPTGGDPLQALRATLDLLATGPLSGLPPLSGGMVGFFAYDLVRRLERLPELAVDDLGLPDMLLLLAT
DLAAVDHHEGTITLIANAVNWNGTDERVDEAYDDAVARLDVMTAALGQPLASTVATFERPEPRYRAQRSVEEYGKIVDYL
VEQIAAGEAFQVVPSQRFEMDTDVDPIDVYRMLRVTNPSPYMYLLHVPNDAGGTDFSIVGSSPEALVTVADGVATTHPIA
GTRWRGQTDDEDQLLEKELLADEKERAEHLMLVDLGRNDLGRVCAPGTVRVDDYSHIERYSHVMHLVSTVTGVLDAGRTA
LDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRGGTAYVQSGGGVVADSNGP
YEYTEATNKARAVLGAIAAAETLTEPGARR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=386, Percent_Identity=43.0051813471503, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI1788114, Length=458, Percent_Identity=32.9694323144105, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786809, Length=252, Percent_Identity=28.968253968254, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082077, Length=261, Percent_Identity=24.5210727969349, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=483, Percent_Identity=40.1656314699793, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6324361, Length=401, Percent_Identity=23.1920199501247, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54848; Mature: 54848

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAHLAATTSREDFRQLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAEHG
CCCCEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCC
RSWSRWSFIGAGSPSALTVRDGEAGWLGVVPQDAPTGGDPLQALRATLDLLATGPLSGLP
CCCCCEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PLSGGMVGFFAYDLVRRLERLPELAVDDLGLPDMLLLLATDLAAVDHHEGTITLIANAVN
CCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
WNGTDERVDEAYDDAVARLDVMTAALGQPLASTVATFERPEPRYRAQRSVEEYGKIVDYL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VEQIAAGEAFQVVPSQRFEMDTDVDPIDVYRMLRVTNPSPYMYLLHVPNDAGGTDFSIVG
HHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEC
SSPEALVTVADGVATTHPIAGTRWRGQTDDEDQLLEKELLADEKERAEHLMLVDLGRNDL
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCEEEEEECCCCCC
GRVCAPGTVRVDDYSHIERYSHVMHLVSTVTGVLDAGRTALDAVTACFPAGTLSGAPKVR
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHH
AMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRGGTAYVQSGGGVVADSNGP
HHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCEEEECCCCEEECCCCC
YEYTEATNKARAVLGAIAAAETLTEPGARR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHAHLAATTSREDFRQLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAEHG
CCCCEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCC
RSWSRWSFIGAGSPSALTVRDGEAGWLGVVPQDAPTGGDPLQALRATLDLLATGPLSGLP
CCCCCEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PLSGGMVGFFAYDLVRRLERLPELAVDDLGLPDMLLLLATDLAAVDHHEGTITLIANAVN
CCCCCHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
WNGTDERVDEAYDDAVARLDVMTAALGQPLASTVATFERPEPRYRAQRSVEEYGKIVDYL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VEQIAAGEAFQVVPSQRFEMDTDVDPIDVYRMLRVTNPSPYMYLLHVPNDAGGTDFSIVG
HHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEC
SSPEALVTVADGVATTHPIAGTRWRGQTDDEDQLLEKELLADEKERAEHLMLVDLGRNDL
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCEEEEEECCCCCC
GRVCAPGTVRVDDYSHIERYSHVMHLVSTVTGVLDAGRTALDAVTACFPAGTLSGAPKVR
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHH
AMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRGGTAYVQSGGGVVADSNGP
HHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCCEEEECCCCEEECCCCC
YEYTEATNKARAVLGAIAAAETLTEPGARR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]