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The map label for this gene is chaA

Identifier: 41407399

GI number: 41407399

Start: 1388812

End: 1389918

Strand: Direct

Name: chaA

Synonym: MAP1301

Alternate gene names: 41407399

Gene position: 1388812-1389918 (Clockwise)

Preceding gene: 41407398

Following gene: 41407401

Centisome position: 28.76

GC content: 70.55

Gene sequence:

>1107_bases
ATGTCGAAATGGTTGTCCCGGAACGTGTTGTCCTGGACCGTGGTGGTGCCGGTGCTCGCCGTCGTCGTGCTGGCATTGAT
CTGGGGCGAGCGACTGGGGCCGGTGCTGGTCGCGCTGGCCGCGCTGTTCCTGATCGGTGCGGTGGTGGCCGCGGTGCATC
ACGCCGAGGTGGTCGCGCACCGGATCGGCGAGCCGTTCGGGTCGCTGGTGCTCGCGGCCGCGGTGACCATCATCGAGGTG
GCGCTGATCGTCGAGTTGATGGCGTCCGGCGGCAACGAGACGGCGACCCTGGCCCGGGACACGGCGTTCGCCGCGCTGAT
GATCACCACCAACGGCATCGCCGGGCTGTCGCTGCTGCTCGGGTCGCGCCGCTACGGCGTCACGTTGTTCAACGCCGAGG
GCAGCGGCGCCGCGTTGGCCACGCTGACCACGCTGGCGACGCTGAGCCTGGTGCTGCCGGCGTTCACCACCACCCAGGTG
GGCAAGGAGTTCTCGCCCGGCCAGCTCACCTTCGCCGCGGTCGCCTCGCTGCTGGTCTACCTGCTGTTCGTGTTCACGCA
GACGGTGCGGCACCGCGACTTCTTCCTGCCGATCGCGCAGAAGGGGCAGAAGAGCCTGTTCGAGGACGAGAGCCACGCGG
ATCCGCCCAGCACCCGCGAGGCGCTGGTCAGCCTGGTGCTGCTGCTGTGTGCGCTGGTGGCGGTGGTGGGGCTGGCCGAG
GAGGAGTCACCGGCCGTCGAGCGGGCGGTCACCGCGGTGGGCTTCCCGCAGACGTTCGTGGGTGTGATCATCGCGGCGCT
GGTGCTGCTGCCCGAGACCCTGGCGGCCGTGCGGGCCGCCCGCCAGGGCCGCATCCAGATCAGCCTGAACCTGGCCTACG
GCTCGGCGATGGCCAGCATCGGGCTCACCATCCCGGCGATCGCGCTGGCCTCGATCTGGCTGAAGGGTCCGCTGGTGCTC
GGGCTGGGCGCCATCCAGCTGGTGTTGCTGGCCCTGACCGTGGTGATCAGCGTGCTGACCGTCGTGCCCGGGCGGGCCAC
CCGGCTGCAGGGCGAGGTGCATCTGGTGCTGCTGGCCGCCTACGTCTTCCTGGCGGTCAGCCCGTGA

Upstream 100 bases:

>100_bases
CGGGGTCAGGCCGGCGGCAGGTCGAGCCCGGCGCCTGACCAGCGTGTCGGGAGTCACTTCCGGGGGCGTCGGCGCATCAC
TTGGACGAGAATGGCACGCA

Downstream 100 bases:

>100_bases
CGGTCAGGCCCGGGCGCGCAGCGTGGCCAGCGCCTTGTCGGCGTGGGTGTCCATGTTGAACTCGCTGGAGATCACGTCGA
GCACGGTGCGGTCGGTGTCG

Product: ChaA

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSKWLSRNVLSWTVVVPVLAVVVLALIWGERLGPVLVALAALFLIGAVVAAVHHAEVVAHRIGEPFGSLVLAAAVTIIEV
ALIVELMASGGNETATLARDTAFAALMITTNGIAGLSLLLGSRRYGVTLFNAEGSGAALATLTTLATLSLVLPAFTTTQV
GKEFSPGQLTFAAVASLLVYLLFVFTQTVRHRDFFLPIAQKGQKSLFEDESHADPPSTREALVSLVLLLCALVAVVGLAE
EESPAVERAVTAVGFPQTFVGVIIAALVLLPETLAAVRAARQGRIQISLNLAYGSAMASIGLTIPAIALASIWLKGPLVL
GLGAIQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAAYVFLAVSP

Sequences:

>Translated_368_residues
MSKWLSRNVLSWTVVVPVLAVVVLALIWGERLGPVLVALAALFLIGAVVAAVHHAEVVAHRIGEPFGSLVLAAAVTIIEV
ALIVELMASGGNETATLARDTAFAALMITTNGIAGLSLLLGSRRYGVTLFNAEGSGAALATLTTLATLSLVLPAFTTTQV
GKEFSPGQLTFAAVASLLVYLLFVFTQTVRHRDFFLPIAQKGQKSLFEDESHADPPSTREALVSLVLLLCALVAVVGLAE
EESPAVERAVTAVGFPQTFVGVIIAALVLLPETLAAVRAARQGRIQISLNLAYGSAMASIGLTIPAIALASIWLKGPLVL
GLGAIQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAAYVFLAVSP
>Mature_367_residues
SKWLSRNVLSWTVVVPVLAVVVLALIWGERLGPVLVALAALFLIGAVVAAVHHAEVVAHRIGEPFGSLVLAAAVTIIEVA
LIVELMASGGNETATLARDTAFAALMITTNGIAGLSLLLGSRRYGVTLFNAEGSGAALATLTTLATLSLVLPAFTTTQVG
KEFSPGQLTFAAVASLLVYLLFVFTQTVRHRDFFLPIAQKGQKSLFEDESHADPPSTREALVSLVLLLCALVAVVGLAEE
ESPAVERAVTAVGFPQTFVGVIIAALVLLPETLAAVRAARQGRIQISLNLAYGSAMASIGLTIPAIALASIWLKGPLVLG
LGAIQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAAYVFLAVSP

Specific function: Possible cation transporter [H]

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1787468, Length=354, Percent_Identity=35.5932203389831, Blast_Score=192, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 38295; Mature: 38164

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKWLSRNVLSWTVVVPVLAVVVLALIWGERLGPVLVALAALFLIGAVVAAVHHAEVVAH
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIGEPFGSLVLAAAVTIIEVALIVELMASGGNETATLARDTAFAALMITTNGIAGLSLLL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEEEECCCHHHHHHHH
GSRRYGVTLFNAEGSGAALATLTTLATLSLVLPAFTTTQVGKEFSPGQLTFAAVASLLVY
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LLFVFTQTVRHRDFFLPIAQKGQKSLFEDESHADPPSTREALVSLVLLLCALVAVVGLAE
HHHHHHHHHHHHHHCCCHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
EESPAVERAVTAVGFPQTFVGVIIAALVLLPETLAAVRAARQGRIQISLNLAYGSAMASI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHH
GLTIPAIALASIWLKGPLVLGLGAIQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHH
YVFLAVSP
HHHHHCCC
>Mature Secondary Structure 
SKWLSRNVLSWTVVVPVLAVVVLALIWGERLGPVLVALAALFLIGAVVAAVHHAEVVAH
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIGEPFGSLVLAAAVTIIEVALIVELMASGGNETATLARDTAFAALMITTNGIAGLSLLL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEEEECCCHHHHHHHH
GSRRYGVTLFNAEGSGAALATLTTLATLSLVLPAFTTTQVGKEFSPGQLTFAAVASLLVY
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LLFVFTQTVRHRDFFLPIAQKGQKSLFEDESHADPPSTREALVSLVLLLCALVAVVGLAE
HHHHHHHHHHHHHHCCCHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
EESPAVERAVTAVGFPQTFVGVIIAALVLLPETLAAVRAARQGRIQISLNLAYGSAMASI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHH
GLTIPAIALASIWLKGPLVLGLGAIQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHH
YVFLAVSP
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]