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The map label for this gene is hisI

Identifier: 41407398

GI number: 41407398

Start: 1388362

End: 1388709

Strand: Direct

Name: hisI

Synonym: MAP1300

Alternate gene names: 41407398

Gene position: 1388362-1388709 (Clockwise)

Preceding gene: 41407397

Following gene: 41407399

Centisome position: 28.75

GC content: 68.68

Gene sequence:

>348_bases
ATGACGCTCGACCCGCAGATCGCCGCGCGGCTGAAGCGCAACGCCGACGGCCTGGTCACGGCGGTGGTGCAGGAGCGCGG
CAGCAAGGACGTGCTGATGGTCGCCTGGATGGACGACGCGGCATTGGCCCGCACGCTGGAAACCCGTGAGGCAACCTACT
ATTCGCGCTCACGCGGCCAGCAGTGGGTCAAGGGGGAGACGTCGGGGCACACCCAGTACGTCCACTCGGTGCGGCTGGAC
TGCGACGGCGACACCGTGTTGTTGACCGTCGATCAGGTCGGCGGCGCCTGCCACACCGGCGACCACAGCTGCTTCGACGC
CGACGTGCTGCTGCACCCGCAGGACTAG

Upstream 100 bases:

>100_bases
ACGCGGTGTTGGCGGCCAGCGTTTTCCACTTCCGGGAGCTGACCATCGGACAGGTCAAGGCCGCCATGGCCGAGGCGGGC
ATACCGGTGAGGATGGTGCG

Downstream 100 bases:

>100_bases
GGCGGGGTCAGGCCGGCGGCAGGTCGAGCCCGGCGCCTGACCAGCGTGTCGGGAGTCACTTCCGGGGGCGTCGGCGCATC
ACTTGGACGAGAATGGCACG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 115; Mature: 114

Protein sequence:

>115_residues
MTLDPQIAARLKRNADGLVTAVVQERGSKDVLMVAWMDDAALARTLETREATYYSRSRGQQWVKGETSGHTQYVHSVRLD
CDGDTVLLTVDQVGGACHTGDHSCFDADVLLHPQD

Sequences:

>Translated_115_residues
MTLDPQIAARLKRNADGLVTAVVQERGSKDVLMVAWMDDAALARTLETREATYYSRSRGQQWVKGETSGHTQYVHSVRLD
CDGDTVLLTVDQVGGACHTGDHSCFDADVLLHPQD
>Mature_114_residues
TLDPQIAARLKRNADGLVTAVVQERGSKDVLMVAWMDDAALARTLETREATYYSRSRGQQWVKGETSGHTQYVHSVRLDC
DGDTVLLTVDQVGGACHTGDHSCFDADVLLHPQD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=90, Percent_Identity=44.4444444444444, Blast_Score=89, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=36.2637362637363, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 12644; Mature: 12513

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDPQIAARLKRNADGLVTAVVQERGSKDVLMVAWMDDAALARTLETREATYYSRSRGQ
CCCCHHHHHHHHCCCCCEEEEEEHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
QWVKGETSGHTQYVHSVRLDCDGDTVLLTVDQVGGACHTGDHSCFDADVLLHPQD
EEECCCCCCCEEEEEEEEEECCCCEEEEEECCCCCEEECCCCCCCCCEEEEECCC
>Mature Secondary Structure 
TLDPQIAARLKRNADGLVTAVVQERGSKDVLMVAWMDDAALARTLETREATYYSRSRGQ
CCCHHHHHHHHCCCCCEEEEEEHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
QWVKGETSGHTQYVHSVRLDCDGDTVLLTVDQVGGACHTGDHSCFDADVLLHPQD
EEECCCCCCCEEEEEEEEEECCCCEEEEEECCCCCEEECCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA