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The map label for this gene is bioA

Identifier: 41407372

GI number: 41407372

Start: 1360875

End: 1362191

Strand: Direct

Name: bioA

Synonym: MAP1274

Alternate gene names: 41407372

Gene position: 1360875-1362191 (Clockwise)

Preceding gene: 41407365

Following gene: 41407373

Centisome position: 28.18

GC content: 72.97

Gene sequence:

>1317_bases
ATGCCCGCGGCGAAGGCCGGGCTGACGCCCGAGCAGATCAGCGCGATCGACGCCGCGCACCTGTGGCACCCCTACAGCAC
CATCGGCGCCGAATCCGTCGCCCCGGTGGTGGCAGTCGGCGCCCGCGGCGCCTGGCTGACCCTGATCCGCGACGGCGCCG
AGGTCCGGGCGCTCGACGCCATGAGCTCCTGGTGGACCGCGATCCACGGCCACGGCCACCCGGTGCTGGACGCGGCGCTG
TCCGACCAGCTCGCCGCCATGAACCACGTCATGTTCGGCGGGCTCACCCACGAACCCGCGGCGCGGCTGGCCCAGCTGCT
GGTGAGCATCACCCCGGCCGGGCTGGACACCGTGTTCTTCAGCGACTCGGGGTCGGTGTCGGTCGAGGTGGCGGTGAAGA
TGGCGCTGCAGTACTGGCGCAGCCGCCACCGGCCGGCCAAGCACCGGCTGATGACCTGGCGCGGCGGCTACCACGGCGAC
ACCTTCACCCCGATGAGCGTCTGCGACCCCGAGGGCGGCATGCATTCGCTGTGGACCGACATCCTGGCCCGGCAGGTGTT
CGCCCCGCAGGTGCCCCGTGACTACGACCCGGCCTACAGCGCGGCGTTCGAGGCGCAGCTGGCCCGGCACGCCGACGAGC
TGGCCGCGGTGATCGTCGAGCCCGTCGTGCAGGGTGCCGGCGGCATGCGGTTCCACGACCCGCGGTATCTTGGCGACCTG
CGCGAGGCCTGCACCCGGCGCGACGTGCTGTTGATCTTCGACGAGATCGCCACCGGGTTCGGCCGCACCGGCGAGCTCTT
CGCCGCCGACCACGCCCGGGTCAGCCCCGACATCATGTGCGTCGGCAAGGCGCTGACCGGCGGATACCTCAGCCTGGCCG
CCACCCTGTGCAGCACCGACATCGCGCAGGTCATCAGCGCCGGCGAGGCCGGGGCGCTGATGCACGGGCCCACCTTCATG
GCCAACGCGCTGGCCTGCGCCGTGTCGATGGCCAGCGTCGAGGTGCTGCTCGGGCAGGACTGGCGGTCGCGGGTCGCCGA
GATCTCCGCCGGCCTGGCGGCCGGGCTGGAACCCGCCCGGGAGCTACCCGGCGTGACCGACGTCCGGGTGCGCGGCGCCA
TCGGCGTCATCGAATGCGACCGGCCTGTCGACCTGGCCGTCGCCACCCCGGCGGCGCTGGACCACGGCGTCTGGCTGCGC
CCGTTCCGCAACCTGATCTACGCCATGCCGCCCTACATCTGCCCGCCCGACGAGATCGCCCGGATCGCCTCGGCGATGGT
GCAGGTCGCCGCGCGCCTCGGCTCTCGTAGGCTCTAG

Upstream 100 bases:

>100_bases
TCGGGGCCCGACCCGTCGGGCGGCTGCGGGGTGGCCATGCTGTCCCATGCTTCCCGACGGCCCGGTTTTGCGCGAATCGG
CTGCTCTACCCTCGATCACT

Downstream 100 bases:

>100_bases
GTCGATGAAAGCACCCATCGAGGTTTCCCCGCTGGCCTGGCTGGACGCGGTCGAACAGCAGCGCCGCGCGGCCGGGCTGC
GCCGCTCGCTGCGGCCGCGG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MPAAKAGLTPEQISAIDAAHLWHPYSTIGAESVAPVVAVGARGAWLTLIRDGAEVRALDAMSSWWTAIHGHGHPVLDAAL
SDQLAAMNHVMFGGLTHEPAARLAQLLVSITPAGLDTVFFSDSGSVSVEVAVKMALQYWRSRHRPAKHRLMTWRGGYHGD
TFTPMSVCDPEGGMHSLWTDILARQVFAPQVPRDYDPAYSAAFEAQLARHADELAAVIVEPVVQGAGGMRFHDPRYLGDL
REACTRRDVLLIFDEIATGFGRTGELFAADHARVSPDIMCVGKALTGGYLSLAATLCSTDIAQVISAGEAGALMHGPTFM
ANALACAVSMASVEVLLGQDWRSRVAEISAGLAAGLEPARELPGVTDVRVRGAIGVIECDRPVDLAVATPAALDHGVWLR
PFRNLIYAMPPYICPPDEIARIASAMVQVAARLGSRRL

Sequences:

>Translated_438_residues
MPAAKAGLTPEQISAIDAAHLWHPYSTIGAESVAPVVAVGARGAWLTLIRDGAEVRALDAMSSWWTAIHGHGHPVLDAAL
SDQLAAMNHVMFGGLTHEPAARLAQLLVSITPAGLDTVFFSDSGSVSVEVAVKMALQYWRSRHRPAKHRLMTWRGGYHGD
TFTPMSVCDPEGGMHSLWTDILARQVFAPQVPRDYDPAYSAAFEAQLARHADELAAVIVEPVVQGAGGMRFHDPRYLGDL
REACTRRDVLLIFDEIATGFGRTGELFAADHARVSPDIMCVGKALTGGYLSLAATLCSTDIAQVISAGEAGALMHGPTFM
ANALACAVSMASVEVLLGQDWRSRVAEISAGLAAGLEPARELPGVTDVRVRGAIGVIECDRPVDLAVATPAALDHGVWLR
PFRNLIYAMPPYICPPDEIARIASAMVQVAARLGSRRL
>Mature_437_residues
PAAKAGLTPEQISAIDAAHLWHPYSTIGAESVAPVVAVGARGAWLTLIRDGAEVRALDAMSSWWTAIHGHGHPVLDAALS
DQLAAMNHVMFGGLTHEPAARLAQLLVSITPAGLDTVFFSDSGSVSVEVAVKMALQYWRSRHRPAKHRLMTWRGGYHGDT
FTPMSVCDPEGGMHSLWTDILARQVFAPQVPRDYDPAYSAAFEAQLARHADELAAVIVEPVVQGAGGMRFHDPRYLGDLR
EACTRRDVLLIFDEIATGFGRTGELFAADHARVSPDIMCVGKALTGGYLSLAATLCSTDIAQVISAGEAGALMHGPTFMA
NALACAVSMASVEVLLGQDWRSRVAEISAGLAAGLEPARELPGVTDVRVRGAIGVIECDRPVDLAVATPAALDHGVWLRP
FRNLIYAMPPYICPPDEIARIASAMVQVAARLGSRRL

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=411, Percent_Identity=29.1970802919708, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI284507298, Length=305, Percent_Identity=31.8032786885246, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI13994255, Length=411, Percent_Identity=27.4939172749392, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI226442709, Length=390, Percent_Identity=22.8205128205128, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI37574042, Length=390, Percent_Identity=22.8205128205128, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786991, Length=417, Percent_Identity=52.0383693045564, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI145693181, Length=344, Percent_Identity=32.5581395348837, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1788044, Length=267, Percent_Identity=37.4531835205993, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1789759, Length=267, Percent_Identity=36.3295880149813, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789016, Length=318, Percent_Identity=29.559748427673, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1787560, Length=324, Percent_Identity=28.3950617283951, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786349, Length=361, Percent_Identity=28.808864265928, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=447, Percent_Identity=25.0559284116331, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=261, Percent_Identity=29.5019157088123, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17541228, Length=343, Percent_Identity=25.3644314868805, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324386, Length=472, Percent_Identity=39.4067796610169, Blast_Score=336, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6323470, Length=427, Percent_Identity=29.2740046838407, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=320, Percent_Identity=26.25, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357415, Length=407, Percent_Identity=28.2555282555283, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46746; Mature: 46615

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAKAGLTPEQISAIDAAHLWHPYSTIGAESVAPVVAVGARGAWLTLIRDGAEVRALDA
CCCCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHCHHHEECCCCEEEEEEECCCHHHHHHH
MSSWWTAIHGHGHPVLDAALSDQLAAMNHVMFGGLTHEPAARLAQLLVSITPAGLDTVFF
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEE
SDSGSVSVEVAVKMALQYWRSRHRPAKHRLMTWRGGYHGDTFTPMSVCDPEGGMHSLWTD
CCCCCEEHHHHHHHHHHHHHHHCCCHHHCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHH
ILARQVFAPQVPRDYDPAYSAAFEAQLARHADELAAVIVEPVVQGAGGMRFHDPRYLGDL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
REACTRRDVLLIFDEIATGFGRTGELFAADHARVSPDIMCVGKALTGGYLSLAATLCSTD
HHHHHHCCCEEEEHHHHHCCCCCCCEEECCCCCCCCCEEEECHHHCCHHHHHHHHHHHHH
IAQVISAGEAGALMHGPTFMANALACAVSMASVEVLLGQDWRSRVAEISAGLAAGLEPAR
HHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHH
ELPGVTDVRVRGAIGVIECDRPVDLAVATPAALDHGVWLRPFRNLIYAMPPYICPPDEIA
HCCCCCCEEEECCEEEEECCCCCCEEEECCHHHCCCCHHHHHHHHHHHCCCCCCCHHHHH
RIASAMVQVAARLGSRRL
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PAAKAGLTPEQISAIDAAHLWHPYSTIGAESVAPVVAVGARGAWLTLIRDGAEVRALDA
CCCCCCCCHHHHHHHHHHHHCCCHHHCCHHHHCHHHEECCCCEEEEEEECCCHHHHHHH
MSSWWTAIHGHGHPVLDAALSDQLAAMNHVMFGGLTHEPAARLAQLLVSITPAGLDTVFF
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEE
SDSGSVSVEVAVKMALQYWRSRHRPAKHRLMTWRGGYHGDTFTPMSVCDPEGGMHSLWTD
CCCCCEEHHHHHHHHHHHHHHHCCCHHHCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHH
ILARQVFAPQVPRDYDPAYSAAFEAQLARHADELAAVIVEPVVQGAGGMRFHDPRYLGDL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
REACTRRDVLLIFDEIATGFGRTGELFAADHARVSPDIMCVGKALTGGYLSLAATLCSTD
HHHHHHCCCEEEEHHHHHCCCCCCCEEECCCCCCCCCEEEECHHHCCHHHHHHHHHHHHH
IAQVISAGEAGALMHGPTFMANALACAVSMASVEVLLGQDWRSRVAEISAGLAAGLEPAR
HHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHH
ELPGVTDVRVRGAIGVIECDRPVDLAVATPAALDHGVWLRPFRNLIYAMPPYICPPDEIA
HCCCCCCEEEECCEEEEECCCCCCEEEECCHHHCCCCHHHHHHHHHHHCCCCCCCHHHHH
RIASAMVQVAARLGSRRL
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]