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The map label for this gene is bioF

Identifier: 41407373

GI number: 41407373

Start: 1362196

End: 1363341

Strand: Direct

Name: bioF

Synonym: MAP1275

Alternate gene names: 41407373

Gene position: 1362196-1363341 (Clockwise)

Preceding gene: 41407372

Following gene: 41407374

Centisome position: 28.2

GC content: 76.53

Gene sequence:

>1146_bases
ATGAAAGCACCCATCGAGGTTTCCCCGCTGGCCTGGCTGGACGCGGTCGAACAGCAGCGCCGCGCGGCCGGGCTGCGCCG
CTCGCTGCGGCCGCGGCCGCCCGTGGCCACCGAGCTGGACCTGGCCTCCAACGACTACCTCGGGCTGTCCCAGCACCCCG
ACGTGATCGACGGCGGGGTCGCCGCGCTGCGCATGTGGGGCGCCGGGGCGACCGGGTCGCGGCTGGTCACCGGGGATACC
GAGCTGCACCAGCAGTTCGAGTCCGAGCTCGCCGACTACGTCGGCGCGGCCAGCGGGCTGCTGTTCTCGTCGGGCTACGC
GGCCAACCTGGGGGCCGTCGTGGGCCTGTCGGGCCGCGGGGCGCTGGTGGTCTCCGACGCGTACTCGCACGCCTCGCTGG
TGGATGCCTGCCGGCTGTCGCGGGCGCGGGTGGTAGTGACGCCGCATCGCGACGTCGACGCGGTGCGGGCGGCGCTGCAG
GACCGCGACGAGGAACGCGCCGTCGTCATCACCGAGTCGGTGTTCTCCACCGACGGCGCCCTGGCGCCGCTGCGCGAACT
GCACGAGGTGTGCCGCCGGCACCGGGCCCTGCTGATCGTCGACGAGGCGCACGGCCTGGGGGTGCGCGGCGGCGGGCGCG
GGCTGGTGTTCGAGGCCGGCCTGGCCGGCGCGCCCGACGTGGTCATGACCACCACGCTGTCCAAGGCGCTGGGCAGCCAG
GGCGGCGCGGTGCTGGGGCCGGCGGCGGTGCGGGCCCATCTGATCGACGCGGCGCGCACGTTCATCTTCGACACCGGCCT
GGCCCCGGCGGCGGTGGGCGCCGCGCGCGCCGCGCTGGGCGTGCTGCGCGCCGAACCCTGGCGGTCCGGCGCGGTGCTGC
GCCACGCCGGCGTGCTGGCCGAGGTCTGCCGGGTTCGCGAGGCGCCGCAGTCGGCGGTGGTGTCGGTGATCCTGGGCGAC
CCGGACGTGGCGGTGGCCGCCGCGACCGCCTGCCTGGACGGCGGTGTGCGGGTGGGCTGCTTTCGTCCCCCGACGGTGCC
CGCCGGGACGTCGCGGCTACGGCTGACCGCCCGCGCGTCGCTGGACGACGCCGAACTGGAGGTCGCGCGCCGGGTGCTCA
CCGATGTGCTCGCCGGGCTCGGCTGA

Upstream 100 bases:

>100_bases
GCCATGCCGCCCTACATCTGCCCGCCCGACGAGATCGCCCGGATCGCCTCGGCGATGGTGCAGGTCGCCGCGCGCCTCGG
CTCTCGTAGGCTCTAGGTCG

Downstream 100 bases:

>100_bases
GGCCGTGACGGTTCTGGTCGTCACCGGCACCGACACCGGGGTCGGAAAGACGGTCGCCACGGCGGCGCTGGCGTGTCATG
CCCGTCAGGCCGGCATCGAC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKAPIEVSPLAWLDAVEQQRRAAGLRRSLRPRPPVATELDLASNDYLGLSQHPDVIDGGVAALRMWGAGATGSRLVTGDT
ELHQQFESELADYVGAASGLLFSSGYAANLGAVVGLSGRGALVVSDAYSHASLVDACRLSRARVVVTPHRDVDAVRAALQ
DRDEERAVVITESVFSTDGALAPLRELHEVCRRHRALLIVDEAHGLGVRGGGRGLVFEAGLAGAPDVVMTTTLSKALGSQ
GGAVLGPAAVRAHLIDAARTFIFDTGLAPAAVGAARAALGVLRAEPWRSGAVLRHAGVLAEVCRVREAPQSAVVSVILGD
PDVAVAAATACLDGGVRVGCFRPPTVPAGTSRLRLTARASLDDAELEVARRVLTDVLAGLG

Sequences:

>Translated_381_residues
MKAPIEVSPLAWLDAVEQQRRAAGLRRSLRPRPPVATELDLASNDYLGLSQHPDVIDGGVAALRMWGAGATGSRLVTGDT
ELHQQFESELADYVGAASGLLFSSGYAANLGAVVGLSGRGALVVSDAYSHASLVDACRLSRARVVVTPHRDVDAVRAALQ
DRDEERAVVITESVFSTDGALAPLRELHEVCRRHRALLIVDEAHGLGVRGGGRGLVFEAGLAGAPDVVMTTTLSKALGSQ
GGAVLGPAAVRAHLIDAARTFIFDTGLAPAAVGAARAALGVLRAEPWRSGAVLRHAGVLAEVCRVREAPQSAVVSVILGD
PDVAVAAATACLDGGVRVGCFRPPTVPAGTSRLRLTARASLDDAELEVARRVLTDVLAGLG
>Mature_381_residues
MKAPIEVSPLAWLDAVEQQRRAAGLRRSLRPRPPVATELDLASNDYLGLSQHPDVIDGGVAALRMWGAGATGSRLVTGDT
ELHQQFESELADYVGAASGLLFSSGYAANLGAVVGLSGRGALVVSDAYSHASLVDACRLSRARVVVTPHRDVDAVRAALQ
DRDEERAVVITESVFSTDGALAPLRELHEVCRRHRALLIVDEAHGLGVRGGGRGLVFEAGLAGAPDVVMTTTLSKALGSQ
GGAVLGPAAVRAHLIDAARTFIFDTGLAPAAVGAARAALGVLRAEPWRSGAVLRHAGVLAEVCRVREAPQSAVVSVILGD
PDVAVAAATACLDGGVRVGCFRPPTVPAGTSRLRLTARASLDDAELEVARRVLTDVLAGLG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=353, Percent_Identity=32.5779036827195, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI284448556, Length=353, Percent_Identity=32.5779036827195, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI83977442, Length=332, Percent_Identity=33.433734939759, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI83977440, Length=332, Percent_Identity=33.433734939759, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI83977444, Length=332, Percent_Identity=33.433734939759, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4502025, Length=337, Percent_Identity=32.9376854599407, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI40316939, Length=337, Percent_Identity=32.9376854599407, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4758668, Length=246, Percent_Identity=27.6422764227642, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI119220554, Length=233, Percent_Identity=27.0386266094421, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI5454084, Length=260, Percent_Identity=25, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786993, Length=354, Percent_Identity=36.7231638418079, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1790046, Length=357, Percent_Identity=31.0924369747899, Blast_Score=147, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=331, Percent_Identity=32.02416918429, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI32566772, Length=228, Percent_Identity=30.7017543859649, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17560912, Length=256, Percent_Identity=24.609375, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17560914, Length=256, Percent_Identity=24.609375, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71982625, Length=272, Percent_Identity=26.1029411764706, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982617, Length=272, Percent_Identity=26.1029411764706, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320438, Length=391, Percent_Identity=29.156010230179, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=277, Percent_Identity=27.4368231046931, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320267, Length=365, Percent_Identity=24.1095890410959, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24662918, Length=350, Percent_Identity=30.8571428571429, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI17137420, Length=368, Percent_Identity=31.25, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24653280, Length=260, Percent_Identity=23.4615384615385, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24653276, Length=260, Percent_Identity=23.4615384615385, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24653278, Length=260, Percent_Identity=23.4615384615385, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136286, Length=235, Percent_Identity=28.936170212766, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 39440; Mature: 39440

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAPIEVSPLAWLDAVEQQRRAAGLRRSLRPRPPVATELDLASNDYLGLSQHPDVIDGGV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCHHCHH
AALRMWGAGATGSRLVTGDTELHQQFESELADYVGAASGLLFSSGYAANLGAVVGLSGRG
HHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
ALVVSDAYSHASLVDACRLSRARVVVTPHRDVDAVRAALQDRDEERAVVITESVFSTDGA
EEEEECCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEEHHHCCCCC
LAPLRELHEVCRRHRALLIVDEAHGLGVRGGGRGLVFEAGLAGAPDVVMTTTLSKALGSQ
HHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
GGAVLGPAAVRAHLIDAARTFIFDTGLAPAAVGAARAALGVLRAEPWRSGAVLRHAGVLA
CCCEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
EVCRVREAPQSAVVSVILGDPDVAVAAATACLDGGVRVGCFRPPTVPAGTSRLRLTARAS
HHHHHHCCCCHHEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEECC
LDDAELEVARRVLTDVLAGLG
CCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAPIEVSPLAWLDAVEQQRRAAGLRRSLRPRPPVATELDLASNDYLGLSQHPDVIDGGV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCHHCHH
AALRMWGAGATGSRLVTGDTELHQQFESELADYVGAASGLLFSSGYAANLGAVVGLSGRG
HHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
ALVVSDAYSHASLVDACRLSRARVVVTPHRDVDAVRAALQDRDEERAVVITESVFSTDGA
EEEEECCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEEHHHCCCCC
LAPLRELHEVCRRHRALLIVDEAHGLGVRGGGRGLVFEAGLAGAPDVVMTTTLSKALGSQ
HHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
GGAVLGPAAVRAHLIDAARTFIFDTGLAPAAVGAARAALGVLRAEPWRSGAVLRHAGVLA
CCCEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
EVCRVREAPQSAVVSVILGDPDVAVAAATACLDGGVRVGCFRPPTVPAGTSRLRLTARAS
HHHHHHCCCCHHEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEECC
LDDAELEVARRVLTDVLAGLG
CCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA