Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 41406987

GI number: 41406987

Start: 915458

End: 916321

Strand: Direct

Name: mutM [H]

Synonym: MAP0889

Alternate gene names: 41406987

Gene position: 915458-916321 (Clockwise)

Preceding gene: 41406986

Following gene: 41406988

Centisome position: 18.95

GC content: 70.37

Gene sequence:

>864_bases
GTGCCCGAACTGCCCGAGATCGAAGCGCTGGCCGACCACCTGCGGCGCCATGCCGTCGGGCTGCCGATCGGCCGGGTCGA
CGTCGCCGCCCTGTCCGTGCTCAAGACGTTCGACCCGCCGATCAGCGCGCTGCACGGGCAGACCGTGGTGGGCGCCGAGC
GCTGGGGCAAATACCTGGGCCTGCGGACCGAGGGCCTTTTCCTGATCGCCCATCTGTCCCGGGCGGGCTGGTTGCGCTGG
TCGGACCGGCTGACCGCGGCGCCGCTGCGGCCCGGCAAGGGCCCGATCGCACTGCGGGTGCATCTGGGCACACCCGGCGC
GGCCCCCGGCTTCGACCTGACCGAGGCCGGCACCCAGAAGCGGCTGGCGGTGTGGCTCGTCGACGACCCGGCGCGGGTGC
CTGGGATCGCCGCCCTGGGCCCGGACGCCCTGGACCTGGACGTCGACGCGCTGGCCGACCTGCTGGCCGGCAACACCGGC
CGGATCAAGACGGTGATCACCGACCAGAAGGTGATCGCCGGGATCGGCAACGCCTACAGCGACGAGATCCTGCACGTCGC
GAAGATCTCCCCGTTCGCCACGGCCGGCAAGTTGTCTGACAAACAGCTGGCCACCCTGCATGACGCCATGGTCACGGTGC
TCACCGACGCGGTGAGCCGGTCCGTTGGCCAGGGGGCGGCCATGCTCAAGGGCGAGAAGCGTTCCGGATTGCGGGTGCAT
GCCCGTACCGGGTTGCCGTGCCCGGTGTGTGGCGACACCGTGCGCGAAGTGTCGTTCGCGGACAAGTCTTTTCAGTATTG
CCCGACGTGCCAGACCGGCGGCAAGATCCTGGCCGACCGGCGGATGTCGCGTTTGCTGAAGTAG

Upstream 100 bases:

>100_bases
GGCGAGGTGGGGCCCCGCATCGCGGCGCTGCGCGCGCAGGCCCGCGCCCGGCACGGCTGGATCATGGACACCTATTTGCT
GCGACCGGCACACTGAAACC

Downstream 100 bases:

>100_bases
CCGCCGGCCGCGGACTTGACACCTGTCGATATGCTGCCGGAGATGACTCGCCAGAAGATCCTCATCACCGGCGCCAGCTC
GGGCCTGGGCGCCGGGATGG

Product: hypothetical protein

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPELPEIEALADHLRRHAVGLPIGRVDVAALSVLKTFDPPISALHGQTVVGAERWGKYLGLRTEGLFLIAHLSRAGWLRW
SDRLTAAPLRPGKGPIALRVHLGTPGAAPGFDLTEAGTQKRLAVWLVDDPARVPGIAALGPDALDLDVDALADLLAGNTG
RIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSDKQLATLHDAMVTVLTDAVSRSVGQGAAMLKGEKRSGLRVH
ARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKILADRRMSRLLK

Sequences:

>Translated_287_residues
MPELPEIEALADHLRRHAVGLPIGRVDVAALSVLKTFDPPISALHGQTVVGAERWGKYLGLRTEGLFLIAHLSRAGWLRW
SDRLTAAPLRPGKGPIALRVHLGTPGAAPGFDLTEAGTQKRLAVWLVDDPARVPGIAALGPDALDLDVDALADLLAGNTG
RIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSDKQLATLHDAMVTVLTDAVSRSVGQGAAMLKGEKRSGLRVH
ARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKILADRRMSRLLK
>Mature_286_residues
PELPEIEALADHLRRHAVGLPIGRVDVAALSVLKTFDPPISALHGQTVVGAERWGKYLGLRTEGLFLIAHLSRAGWLRWS
DRLTAAPLRPGKGPIALRVHLGTPGAAPGFDLTEAGTQKRLAVWLVDDPARVPGIAALGPDALDLDVDALADLLAGNTGR
IKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSDKQLATLHDAMVTVLTDAVSRSVGQGAAMLKGEKRSGLRVHA
RTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKILADRRMSRLLK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=283, Percent_Identity=28.6219081272085, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30489; Mature: 30357

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEIEALADHLRRHAVGLPIGRVDVAALSVLKTFDPPISALHGQTVVGAERWGKYLG
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCEEECHHHHHHHHC
LRTEGLFLIAHLSRAGWLRWSDRLTAAPLRPGKGPIALRVHLGTPGAAPGFDLTEAGTQK
CCCCCEEEEEEHHHCCCEEECCCCEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
RLAVWLVDDPARVPGIAALGPDALDLDVDALADLLAGNTGRIKTVITDQKVIAGIGNAYS
EEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCHH
DEILHVAKISPFATAGKLSDKQLATLHDAMVTVLTDAVSRSVGQGAAMLKGEKRSGLRVH
HHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEE
ARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKILADRRMSRLLK
ECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PELPEIEALADHLRRHAVGLPIGRVDVAALSVLKTFDPPISALHGQTVVGAERWGKYLG
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCEEECHHHHHHHHC
LRTEGLFLIAHLSRAGWLRWSDRLTAAPLRPGKGPIALRVHLGTPGAAPGFDLTEAGTQK
CCCCCEEEEEEHHHCCCEEECCCCEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
RLAVWLVDDPARVPGIAALGPDALDLDVDALADLLAGNTGRIKTVITDQKVIAGIGNAYS
EEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCHH
DEILHVAKISPFATAGKLSDKQLATLHDAMVTVLTDAVSRSVGQGAAMLKGEKRSGLRVH
HHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEE
ARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKILADRRMSRLLK
ECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA