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The map label for this gene is rad50 [H]

Identifier: 39996824

GI number: 39996824

Start: 1889279

End: 1891720

Strand: Direct

Name: rad50 [H]

Synonym: GSU1725

Alternate gene names: 39996824

Gene position: 1889279-1891720 (Clockwise)

Preceding gene: 39996823

Following gene: 39996826

Centisome position: 49.53

GC content: 60.28

Gene sequence:

>2442_bases
ATGCGGATACTCTCCATCCATCTGAAGAACATAAAATCCCACCGCGACACGGAGCTGACCTTCTCCGCCGGTATCAATGT
CCTTTCCGGCCCCAACGGCGTCGGCAAGAGCACGGTGTTCGAGGCGATCGGCTACGCTCTGTTCGGGGTGGACGCCCGGG
ACTTCGTCTCCAACGTGGACCGGTTTCTCTCCATCGGCACCAAGAAGGGAGAGATCGCCGTCGCCTTCTGCACGGATGCC
GGAGAAACCTGGCGGGTGACCCGAACCGTCGGCACCCCGGCCAAGTGGCTCCTGGCCAGGGAGCAGGGTGGGGCCTTCGA
GGTGGAGGAGCACGCCCGAATCGAAGAAACCGAGGCCCGCATCGCCGAACTCCTCGGTCTCGACAACGGCCGTCCCCTGG
CGGAGCAGTTCAAACTGGTGATCGGCCCCTTCCAGAACGAATTCCTCGGCCCATTCGTCATCAAGCAGCCCACCAAACGC
CAGGAGGCCTTCGACGAGATCCTCGGCATCGATGCCTGGCGCAAGACCTACAAGAGCACCAGCTCGCTCCTCTCCGCTGT
GCAGGAAAAAATCAAGATTATCGCCGTGGAGATTGAGGCGAAAGAAGCCCAGGTTGCGGTCCTGCCCGAGCGTGAGGATG
AACTGGCAAAGATAAAAACCGATGCCGAGGCGCTCCGGAAAGTCCTTTCATCACAAGCGGATGCCCTGCGGGACGTGGAG
AAGCAGCTGGTCGAGCTCGATGACCAGGAAAAGGGAATAGCCGCGCTCCAGGCCGAGATCCAGATCCTCGTTAACCGCAT
CACTGATGGCGAAGGCAAGATCAAGGATCAGGGGCAAAGGGTAGGGGAGGCGGAGAAGGCCGGCGGGGTTCTGGAGCAGA
CGCGGGCGGGCAAGGAGGCTTTCGAACGGGCCGAATCGCGGCTGGCGGAGTTGGTGAGTAAAGACAAACAGCGTCGAGAG
GTCGAGAAGGACGTTACCCGCCTTGAAAATGAGACCCAGCGCCTGACGCAGGCAGTCGAGCATGAACAGAAGGAGATTGA
AGGGGAGGGGCGCCGCCTCAGAGAGGAAGAGGACGCCCTTGCCAAAGCCCGGAACGAACTAGAGCCGGACCGGAAGGTGG
TGGACACGGCTGGCCGGCTGCCAGGACTTCGCGACGAGATCAATCGCGTTCGCTCGGAAAAGGGACTCCTGGAAGGGCGC
CGCATCGGACTTCTGGAGGGGCAGGAGAAGCTTGGCGAAGGGACATGCCCCTTTTTCAAGGAGCCCTGCCGGAACGTGGC
CGGAACCACGCCGAAAGACGTGTTCACCACGAGGATTGCCGAGCTTGACCGGAAGATGCAGGCACTCACCGAGGCCTTGG
GCAAACTATCCGTAGAGGTGGCTGACGCCGAGGCGGCCGAGAAACAGCTTGCCGCCCTGACAGTCCGGAGCCAGGAACTG
CACAAACAGACGATGGGCTTGGTTGAACGCCGCGCCAGAAATGAAAAACGCGTCGCTACGTTGCAGACATTGTCAACGCA
ACAGATCGAAGCGGCCACCCGGGCTAAAGCGCGCAGGGACGATCTTCAGGTCTTTGCCGGCCTTGACCATGAGATTGAAC
GTGCAACCGCAGAGCGGGGCCGGTTCCAGGCCGACCGCGATGCCTACCATGCCCACGAAAAGGATGCCCTGGATCTGGAT
AACCGGCGCCAGACCCTGGAGAAGATGCTCCGGCTCCTGGATGAGTTGCAGAAGCAACTCATCGGGAAGAAAGAGGAACT
TATCCGGCTTCAGGAAACCTATAAACCGGGCCAGCACAAGGAAGCCCGTGACCAGAAAGACCGGCTGGTAGCGCAAGTCG
CCTCGCTAGGCCAGCAGATCGAAAATCTGGAGAAGGACCGGAAGCGCCTTGAGGATGAAATCGGCAAACTGAAGCTGCTT
AAAGACGAGATTGGGCGGAAGCAGGCCGAGAGGAACTCCTTCGAACAGAAGGAGAAACTCGTCAAATTCCTCCGCAACCA
GGTCTTCAAGAACGTCTCAGCCCAACTCTCGGAGCGGTTCCGGGAGGAAATCAGCCTCCGCGCCGACCGGATCTACCGCA
CCATTGCCGAGGCCGATGAGGAACTGGTCTGGTCCGAGAACTACCAGATCGTGCTGCGAGACATGACGGACGGCGTTGTT
CGCGAACGGAGCGACGACCAGCTCTCCGGCGGCCAGACCATGAGCGCCGTAGTGGCCCTGCGGCTGGCACTGCTTCAGAC
CATCGGCGCCCGGATCGCATTTTTTGACGAACCGACATCCAACCTTGATGCCTCGCGGCGGGAAAACCTGGCCACCGCAT
TCCGCGCCATCGATGTAGGCCGGGAAGAGGTCACCGAACACTGGTACGACCAACTGTTCCTCATCAGCCATGATGTAGCC
TTCACCGAGATTACGGATCAGATGATTCAACTGGGCGAGTGA

Upstream 100 bases:

>100_bases
ATGAACTGGTGCGGCTCTCCCTGGCGATCCGCGACCAGGTGCTCAAGGGGGAGACGGACGGCGAAGAGTTGCTGGGACTT
CTGATGCGGGAGCCTGCCTG

Downstream 100 bases:

>100_bases
TCTCGGTGATCACGCGAACACAACCACATACCAGTGTAACGGCATATGGCTACTGAACCCGGCTCCGATCAATGCCTTTA
GTCCGGCGCCGGCAAAAGGG

Product: nuclease SbcCD subunit C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MRILSIHLKNIKSHRDTELTFSAGINVLSGPNGVGKSTVFEAIGYALFGVDARDFVSNVDRFLSIGTKKGEIAVAFCTDA
GETWRVTRTVGTPAKWLLAREQGGAFEVEEHARIEETEARIAELLGLDNGRPLAEQFKLVIGPFQNEFLGPFVIKQPTKR
QEAFDEILGIDAWRKTYKSTSSLLSAVQEKIKIIAVEIEAKEAQVAVLPEREDELAKIKTDAEALRKVLSSQADALRDVE
KQLVELDDQEKGIAALQAEIQILVNRITDGEGKIKDQGQRVGEAEKAGGVLEQTRAGKEAFERAESRLAELVSKDKQRRE
VEKDVTRLENETQRLTQAVEHEQKEIEGEGRRLREEEDALAKARNELEPDRKVVDTAGRLPGLRDEINRVRSEKGLLEGR
RIGLLEGQEKLGEGTCPFFKEPCRNVAGTTPKDVFTTRIAELDRKMQALTEALGKLSVEVADAEAAEKQLAALTVRSQEL
HKQTMGLVERRARNEKRVATLQTLSTQQIEAATRAKARRDDLQVFAGLDHEIERATAERGRFQADRDAYHAHEKDALDLD
NRRQTLEKMLRLLDELQKQLIGKKEELIRLQETYKPGQHKEARDQKDRLVAQVASLGQQIENLEKDRKRLEDEIGKLKLL
KDEIGRKQAERNSFEQKEKLVKFLRNQVFKNVSAQLSERFREEISLRADRIYRTIAEADEELVWSENYQIVLRDMTDGVV
RERSDDQLSGGQTMSAVVALRLALLQTIGARIAFFDEPTSNLDASRRENLATAFRAIDVGREEVTEHWYDQLFLISHDVA
FTEITDQMIQLGE

Sequences:

>Translated_813_residues
MRILSIHLKNIKSHRDTELTFSAGINVLSGPNGVGKSTVFEAIGYALFGVDARDFVSNVDRFLSIGTKKGEIAVAFCTDA
GETWRVTRTVGTPAKWLLAREQGGAFEVEEHARIEETEARIAELLGLDNGRPLAEQFKLVIGPFQNEFLGPFVIKQPTKR
QEAFDEILGIDAWRKTYKSTSSLLSAVQEKIKIIAVEIEAKEAQVAVLPEREDELAKIKTDAEALRKVLSSQADALRDVE
KQLVELDDQEKGIAALQAEIQILVNRITDGEGKIKDQGQRVGEAEKAGGVLEQTRAGKEAFERAESRLAELVSKDKQRRE
VEKDVTRLENETQRLTQAVEHEQKEIEGEGRRLREEEDALAKARNELEPDRKVVDTAGRLPGLRDEINRVRSEKGLLEGR
RIGLLEGQEKLGEGTCPFFKEPCRNVAGTTPKDVFTTRIAELDRKMQALTEALGKLSVEVADAEAAEKQLAALTVRSQEL
HKQTMGLVERRARNEKRVATLQTLSTQQIEAATRAKARRDDLQVFAGLDHEIERATAERGRFQADRDAYHAHEKDALDLD
NRRQTLEKMLRLLDELQKQLIGKKEELIRLQETYKPGQHKEARDQKDRLVAQVASLGQQIENLEKDRKRLEDEIGKLKLL
KDEIGRKQAERNSFEQKEKLVKFLRNQVFKNVSAQLSERFREEISLRADRIYRTIAEADEELVWSENYQIVLRDMTDGVV
RERSDDQLSGGQTMSAVVALRLALLQTIGARIAFFDEPTSNLDASRRENLATAFRAIDVGREEVTEHWYDQLFLISHDVA
FTEITDQMIQLGE
>Mature_813_residues
MRILSIHLKNIKSHRDTELTFSAGINVLSGPNGVGKSTVFEAIGYALFGVDARDFVSNVDRFLSIGTKKGEIAVAFCTDA
GETWRVTRTVGTPAKWLLAREQGGAFEVEEHARIEETEARIAELLGLDNGRPLAEQFKLVIGPFQNEFLGPFVIKQPTKR
QEAFDEILGIDAWRKTYKSTSSLLSAVQEKIKIIAVEIEAKEAQVAVLPEREDELAKIKTDAEALRKVLSSQADALRDVE
KQLVELDDQEKGIAALQAEIQILVNRITDGEGKIKDQGQRVGEAEKAGGVLEQTRAGKEAFERAESRLAELVSKDKQRRE
VEKDVTRLENETQRLTQAVEHEQKEIEGEGRRLREEEDALAKARNELEPDRKVVDTAGRLPGLRDEINRVRSEKGLLEGR
RIGLLEGQEKLGEGTCPFFKEPCRNVAGTTPKDVFTTRIAELDRKMQALTEALGKLSVEVADAEAAEKQLAALTVRSQEL
HKQTMGLVERRARNEKRVATLQTLSTQQIEAATRAKARRDDLQVFAGLDHEIERATAERGRFQADRDAYHAHEKDALDLD
NRRQTLEKMLRLLDELQKQLIGKKEELIRLQETYKPGQHKEARDQKDRLVAQVASLGQQIENLEKDRKRLEDEIGKLKLL
KDEIGRKQAERNSFEQKEKLVKFLRNQVFKNVSAQLSERFREEISLRADRIYRTIAEADEELVWSENYQIVLRDMTDGVV
RERSDDQLSGGQTMSAVVALRLALLQTIGARIAFFDEPTSNLDASRRENLATAFRAIDVGREEVTEHWYDQLFLISHDVA
FTEITDQMIQLGE

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of mre11 by unwinding and

COG id: COG0419

COG function: function code L; ATPase involved in DNA repair

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 zinc-hook domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009053
- InterPro:   IPR022982
- InterPro:   IPR007517
- InterPro:   IPR003395
- InterPro:   IPR018159
- InterPro:   IPR013134 [H]

Pfam domain/function: PF04423 Rad50_zn_hook; PF02463 SMC_N [H]

EC number: NA

Molecular weight: Translated: 91976; Mature: 91976

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILSIHLKNIKSHRDTELTFSAGINVLSGPNGVGKSTVFEAIGYALFGVDARDFVSNVD
CCEEEEEHHHHHCCCCCCEEHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
RFLSIGTKKGEIAVAFCTDAGETWRVTRTVGTPAKWLLAREQGGAFEVEEHARIEETEAR
HHHHCCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHECCCCCCEECHHHHHHHHHHHH
IAELLGLDNGRPLAEQFKLVIGPFQNEFLGPFVIKQPTKRQEAFDEILGIDAWRKTYKST
HHHHHCCCCCCCHHHHHHHHHCCCHHHCCCCHHCCCCCHHHHHHHHHHCCHHHHHHHHHH
SSLLSAVQEKIKIIAVEIEAKEAQVAVLPEREDELAKIKTDAEALRKVLSSQADALRDVE
HHHHHHHHHHHEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQLVELDDQEKGIAALQAEIQILVNRITDGEGKIKDQGQRVGEAEKAGGVLEQTRAGKEA
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHCCHHHHHHHHHHH
FERAESRLAELVSKDKQRREVEKDVTRLENETQRLTQAVEHEQKEIEGEGRRLREEEDAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AKARNELEPDRKVVDTAGRLPGLRDEINRVRSEKGLLEGRRIGLLEGQEKLGEGTCPFFK
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHH
EPCRNVAGTTPKDVFTTRIAELDRKMQALTEALGKLSVEVADAEAAEKQLAALTVRSQEL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHH
HKQTMGLVERRARNEKRVATLQTLSTQQIEAATRAKARRDDLQVFAGLDHEIERATAERG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
RFQADRDAYHAHEKDALDLDNRRQTLEKMLRLLDELQKQLIGKKEELIRLQETYKPGQHK
CCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
EARDQKDRLVAQVASLGQQIENLEKDRKRLEDEIGKLKLLKDEIGRKQAERNSFEQKEKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKFLRNQVFKNVSAQLSERFREEISLRADRIYRTIAEADEELVWSENYQIVLRDMTDGVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEHHHHHHH
RERSDDQLSGGQTMSAVVALRLALLQTIGARIAFFDEPTSNLDASRRENLATAFRAIDVG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCC
REEVTEHWYDQLFLISHDVAFTEITDQMIQLGE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRILSIHLKNIKSHRDTELTFSAGINVLSGPNGVGKSTVFEAIGYALFGVDARDFVSNVD
CCEEEEEHHHHHCCCCCCEEHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
RFLSIGTKKGEIAVAFCTDAGETWRVTRTVGTPAKWLLAREQGGAFEVEEHARIEETEAR
HHHHCCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHECCCCCCEECHHHHHHHHHHHH
IAELLGLDNGRPLAEQFKLVIGPFQNEFLGPFVIKQPTKRQEAFDEILGIDAWRKTYKST
HHHHHCCCCCCCHHHHHHHHHCCCHHHCCCCHHCCCCCHHHHHHHHHHCCHHHHHHHHHH
SSLLSAVQEKIKIIAVEIEAKEAQVAVLPEREDELAKIKTDAEALRKVLSSQADALRDVE
HHHHHHHHHHHEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQLVELDDQEKGIAALQAEIQILVNRITDGEGKIKDQGQRVGEAEKAGGVLEQTRAGKEA
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHCCHHHHHHHHHHH
FERAESRLAELVSKDKQRREVEKDVTRLENETQRLTQAVEHEQKEIEGEGRRLREEEDAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AKARNELEPDRKVVDTAGRLPGLRDEINRVRSEKGLLEGRRIGLLEGQEKLGEGTCPFFK
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCHHH
EPCRNVAGTTPKDVFTTRIAELDRKMQALTEALGKLSVEVADAEAAEKQLAALTVRSQEL
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHH
HKQTMGLVERRARNEKRVATLQTLSTQQIEAATRAKARRDDLQVFAGLDHEIERATAERG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
RFQADRDAYHAHEKDALDLDNRRQTLEKMLRLLDELQKQLIGKKEELIRLQETYKPGQHK
CCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
EARDQKDRLVAQVASLGQQIENLEKDRKRLEDEIGKLKLLKDEIGRKQAERNSFEQKEKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKFLRNQVFKNVSAQLSERFREEISLRADRIYRTIAEADEELVWSENYQIVLRDMTDGVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEHHHHHHH
RERSDDQLSGGQTMSAVVALRLALLQTIGARIAFFDEPTSNLDASRRENLATAFRAIDVG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCC
REEVTEHWYDQLFLISHDVAFTEITDQMIQLGE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]