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The map label for this gene is mre11 [H]

Identifier: 39996823

GI number: 39996823

Start: 1888023

End: 1889279

Strand: Direct

Name: mre11 [H]

Synonym: GSU1724

Alternate gene names: 39996823

Gene position: 1888023-1889279 (Clockwise)

Preceding gene: 39996821

Following gene: 39996824

Centisome position: 49.5

GC content: 61.18

Gene sequence:

>1257_bases
ATGACGAGATACCGTTTTTTCCACACCGCCGACATCCACCTCGGCAAAACCTACCGCACATCCACCGGTGAGGCTGAACG
CTACGAAGACTTCTTCCGCATGCTCGGCAGCATTGTGTCCGACGCCATTGCGGCAAGGGTCGATTTCGTTCTGATTGCTG
GCGACCTCTTCCACACCGGGCAGATTCTCCCCCGTACCTTCGCCCGGACCATCGAGACACTTCAGCCGCTCAAGAACGCC
GGCATCCCCTGCATTGCCGTGGAAGGGAACCACGACTGGATACACCGCCGCGACAGCATCTCGTGGATGGAAGCGCTGTC
GCAGATGGGTTATATCCACCTGCTGCGCCCCAGCCGTACTGAGACCGGCGGCTACCGCTTCAGTCCCTTTGATTACGAAC
AGGGCATGGGCGGCCACATCGAGGTCAACGGAGTCAACATCTACGGCCTCGGCTACATCGGCACCCAGGCGGGCGCCCAC
GTAGCGCGCATCTGCGAGGCTATCACCACCACGAATAACATCCTCCTCTTCCATGTGGGTGTCTGGACCTACTCACCGGT
TGAGATCGGCAACATGAAGCCGGAGGAGGCGCTCCCCCTGGCCGATGTCTTCGACTACGTGGCCTTGGGCCACGGCCACA
AGCCCTACATCATCGCCACCCCGGAAGGCCGCGCTTACGCCTTCAATCCCGGCTCCCCCGAATGCGTCAACTTTGGCGAG
GAAAAGTACGACAAGGGGTATTACCTCGTTACTGTCAATGACGGAGTCTATACCCATGAGTTTCGGCCGACCAATCCCCG
CCCCATGCTGGTGACCACCATTGACCTGGATGGCGCCGGAGATGCGGAAACGGCTCTGACGCGGTTCCGCAACGTGGTTG
CCGCAAAGATCGCATCGTTCAGCGATGACCGTCAGCCGCTCCTGGAGATCAAGCTCACCGGCCGGGTCGGCTTCCACCCC
TTTGAGCTGGGGCGGGAACGGCTTCGCCTGGCCCTTGAGGAGATCTGCAACCCTCTCCATGTGGAGATCAAGAACCACCT
CTCCCTGGTCACTGCCGGGGGGGGCGCAGAATCCGAAAAGAAGAGCCTCGCCGAGATCGAGCGGGAGGTGCTCAGGGAGT
TGATATCCGCCAAGAGCGAGTACAAGGGGCGGGAGGATGAACTGGTGCGGCTCTCCCTGGCGATCCGCGACCAGGTGCTC
AAGGGGGAGACGGACGGCGAAGAGTTGCTGGGACTTCTGATGCGGGAGCCTGCCTGA

Upstream 100 bases:

>100_bases
TCAAGGGAGCGGCTTCAGAGCCGGGTAGACTCAACCCGACTTTGCCCTTGAACAATGCCGTCGGTTAACTGTATGTTGAC
GCTAAAAGGACACAAGCAGC

Downstream 100 bases:

>100_bases
TGCGGATACTCTCCATCCATCTGAAGAACATAAAATCCCACCGCGACACGGAGCTGACCTTCTCCGCCGGTATCAATGTC
CTTTCCGGCCCCAACGGCGT

Product: nuclease SbcCD subunit D

Products: NA

Alternate protein names: pfMre11 [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTRYRFFHTADIHLGKTYRTSTGEAERYEDFFRMLGSIVSDAIAARVDFVLIAGDLFHTGQILPRTFARTIETLQPLKNA
GIPCIAVEGNHDWIHRRDSISWMEALSQMGYIHLLRPSRTETGGYRFSPFDYEQGMGGHIEVNGVNIYGLGYIGTQAGAH
VARICEAITTTNNILLFHVGVWTYSPVEIGNMKPEEALPLADVFDYVALGHGHKPYIIATPEGRAYAFNPGSPECVNFGE
EKYDKGYYLVTVNDGVYTHEFRPTNPRPMLVTTIDLDGAGDAETALTRFRNVVAAKIASFSDDRQPLLEIKLTGRVGFHP
FELGRERLRLALEEICNPLHVEIKNHLSLVTAGGGAESEKKSLAEIEREVLRELISAKSEYKGREDELVRLSLAIRDQVL
KGETDGEELLGLLMREPA

Sequences:

>Translated_418_residues
MTRYRFFHTADIHLGKTYRTSTGEAERYEDFFRMLGSIVSDAIAARVDFVLIAGDLFHTGQILPRTFARTIETLQPLKNA
GIPCIAVEGNHDWIHRRDSISWMEALSQMGYIHLLRPSRTETGGYRFSPFDYEQGMGGHIEVNGVNIYGLGYIGTQAGAH
VARICEAITTTNNILLFHVGVWTYSPVEIGNMKPEEALPLADVFDYVALGHGHKPYIIATPEGRAYAFNPGSPECVNFGE
EKYDKGYYLVTVNDGVYTHEFRPTNPRPMLVTTIDLDGAGDAETALTRFRNVVAAKIASFSDDRQPLLEIKLTGRVGFHP
FELGRERLRLALEEICNPLHVEIKNHLSLVTAGGGAESEKKSLAEIEREVLRELISAKSEYKGREDELVRLSLAIRDQVL
KGETDGEELLGLLMREPA
>Mature_417_residues
TRYRFFHTADIHLGKTYRTSTGEAERYEDFFRMLGSIVSDAIAARVDFVLIAGDLFHTGQILPRTFARTIETLQPLKNAG
IPCIAVEGNHDWIHRRDSISWMEALSQMGYIHLLRPSRTETGGYRFSPFDYEQGMGGHIEVNGVNIYGLGYIGTQAGAHV
ARICEAITTTNNILLFHVGVWTYSPVEIGNMKPEEALPLADVFDYVALGHGHKPYIIATPEGRAYAFNPGSPECVNFGEE
KYDKGYYLVTVNDGVYTHEFRPTNPRPMLVTTIDLDGAGDAETALTRFRNVVAAKIASFSDDRQPLLEIKLTGRVGFHPF
ELGRERLRLALEEICNPLHVEIKNHLSLVTAGGGAESEKKSLAEIEREVLRELISAKSEYKGREDELVRLSLAIRDQVLK
GETDGEELLGLLMREPA

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003701
- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 46702; Mature: 46570

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYRFFHTADIHLGKTYRTSTGEAERYEDFFRMLGSIVSDAIAARVDFVLIAGDLFHTG
CCEEEEEEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHCC
QILPRTFARTIETLQPLKNAGIPCIAVEGNHDWIHRRDSISWMEALSQMGYIHLLRPSRT
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHHCCEEEEECCCCC
ETGGYRFSPFDYEQGMGGHIEVNGVNIYGLGYIGTQAGAHVARICEAITTTNNILLFHVG
CCCCEECCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEE
VWTYSPVEIGNMKPEEALPLADVFDYVALGHGHKPYIIATPEGRAYAFNPGSPECVNFGE
CEEECCEEECCCCCHHCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCHHHCCCH
EKYDKGYYLVTVNDGVYTHEFRPTNPRPMLVTTIDLDGAGDAETALTRFRNVVAAKIASF
HHCCCCEEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHC
SDDRQPLLEIKLTGRVGFHPFELGRERLRLALEEICNPLHVEIKNHLSLVTAGGGAESEK
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCHHH
KSLAEIEREVLRELISAKSEYKGREDELVRLSLAIRDQVLKGETDGEELLGLLMREPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TRYRFFHTADIHLGKTYRTSTGEAERYEDFFRMLGSIVSDAIAARVDFVLIAGDLFHTG
CEEEEEEEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHCC
QILPRTFARTIETLQPLKNAGIPCIAVEGNHDWIHRRDSISWMEALSQMGYIHLLRPSRT
CHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCCHHHHHHHHHCCEEEEECCCCC
ETGGYRFSPFDYEQGMGGHIEVNGVNIYGLGYIGTQAGAHVARICEAITTTNNILLFHVG
CCCCEECCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEE
VWTYSPVEIGNMKPEEALPLADVFDYVALGHGHKPYIIATPEGRAYAFNPGSPECVNFGE
CEEECCEEECCCCCHHCCCHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCHHHCCCH
EKYDKGYYLVTVNDGVYTHEFRPTNPRPMLVTTIDLDGAGDAETALTRFRNVVAAKIASF
HHCCCCEEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHC
SDDRQPLLEIKLTGRVGFHPFELGRERLRLALEEICNPLHVEIKNHLSLVTAGGGAESEK
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCHHH
KSLAEIEREVLRELISAKSEYKGREDELVRLSLAIRDQVLKGETDGEELLGLLMREPA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11029422 [H]