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The map label for this gene is atoC [H]

Identifier: 39996422

GI number: 39996422

Start: 1446088

End: 1447470

Strand: Direct

Name: atoC [H]

Synonym: GSU1320

Alternate gene names: 39996422

Gene position: 1446088-1447470 (Clockwise)

Preceding gene: 39996421

Following gene: 39996423

Centisome position: 37.91

GC content: 64.06

Gene sequence:

>1383_bases
ATGGCTGAAGAGCGGCAACCTGCCCGGGTGCTGATCGTCGACGATGACGTATCGCTGCGCCGGGTACTCGAATACAACCT
CCAGGAGGAGGGGTACGACGTGATCACGGCGGGCAGCGGCGAGGAGGGGCTGCGCCTGTTCGATGAGCGTTCGCCGGCCC
TGGTGGTCACCGACCTGAAAATGCCCGGCATGGGGGGATTCCGGCTCCTGCAGGAAATCAAGGGACGTTCGCCCGACACG
GCGGTCATCGTGATCACCGCCTTTGGTGCCGTGGAGACGGCGGTCGACGCCATGAAAGCCGGGGCCTACGACTACATCAC
CAAGCCCTTCAACCGTGATGCCTTGAAGCTGACGGTGAAAAAGGCCCTGGAGATGCTCGGGCTTTCCCGGGAAAACCGCC
GCCTGCGGGAGGCTCTCACGGAGCGGGAGGATTACCGGAGTATCGTGGGCATCTCCCGCCGGATGGAGGAGGTCTTCCGG
GTCGTGGACCGGGTGGCCGACACGGACGCTACGGTCCTCATCACCGGCGAATCCGGCACCGGCAAGGAACTGGTGGCCCG
TGCCGTGCACACCCGCAGCTCACGGAGAGCAGCCCCCTTCGTGGCGGTCAACTGCGCGGCCATCCCCCGCGATTTGCTTG
AGAGCGAGCTGTTCGGCCACGTCAAGGGTTCCTTCACCGGCGCTGTGCGCGACAAGGCGGGAAAATTCCAGCAGGCCGAG
GGAGGGACCCTCTTCCTCGACGAAGTGGGCGAGTTGCCCGTTGAACTCCAGTCGAAGCTCCTGCGGGCGCTCCAGGAAAA
GGAGGTTCAGCAGGTGGGGGGCACCGAGGTCCGGAAGCTGGACGTCCGGGTGGTGGCCGCCACCAACGCCGATCTGGAGC
AGGCCATCGAGGAGGGCCGCTTCCGCGAGGACCTCTACTACCGCCTCTCGGTCATACCGATTCACCTGCCGCCGCTGCGG
GAGCGGAAAGAAGACATCCCCCTGCTGGTGCGCCACTTTGCTGCGCGGCACGGCGGCGATCGGGTAGCCTTTGCCCCGGA
GACCCTGGAGGTCATGGCTGACTATGGCTGGCCGGGCAACGTCCGGGAGTTGGAAAATACCGTGGAGCGGCTCCTCATCA
TGCGCTGCAGCGACACTATCACCCCGGCGGACCTTCCCGACAAGGTACGCAGCCGCCGCGCACCGTCGACGGAATGTCCC
GTTATCAGCCTACCCGACGAGGGATACTCCCTTGAGCAACTGGAGCGGGAAATCGTGGTGGAAGCCCTGGAACGGAACAA
CTGGAATCAGAGTTCGGCGGCGCGCTTTCTTCGCATTCCGCGCCATACACTCATCTACAGGATGGAGAAGTATCAGATCA
CTGCACCGGAGAGAAAAAAATGA

Upstream 100 bases:

>100_bases
GTGGAGGCCCACGGCGGCACCATCGGCCTGGAGAGTGAGCCCGGCAGGGGAACCACTTTCAGGGTGTGGCTGCCGGTGTG
ATCGGGGAGATGGGGGAGTG

Downstream 100 bases:

>100_bases
GAAAATTTGTCCGCCTTCTGCCTCTGTTGATCCTGCTGGCGCTCCTGGGCTGCTCCAAGGAGCAGAAGCCCGCCGTGCAG
GGAAACCCCGCCCCCGACTT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MAEERQPARVLIVDDDVSLRRVLEYNLQEEGYDVITAGSGEEGLRLFDERSPALVVTDLKMPGMGGFRLLQEIKGRSPDT
AVIVITAFGAVETAVDAMKAGAYDYITKPFNRDALKLTVKKALEMLGLSRENRRLREALTEREDYRSIVGISRRMEEVFR
VVDRVADTDATVLITGESGTGKELVARAVHTRSSRRAAPFVAVNCAAIPRDLLESELFGHVKGSFTGAVRDKAGKFQQAE
GGTLFLDEVGELPVELQSKLLRALQEKEVQQVGGTEVRKLDVRVVAATNADLEQAIEEGRFREDLYYRLSVIPIHLPPLR
ERKEDIPLLVRHFAARHGGDRVAFAPETLEVMADYGWPGNVRELENTVERLLIMRCSDTITPADLPDKVRSRRAPSTECP
VISLPDEGYSLEQLEREIVVEALERNNWNQSSAARFLRIPRHTLIYRMEKYQITAPERKK

Sequences:

>Translated_460_residues
MAEERQPARVLIVDDDVSLRRVLEYNLQEEGYDVITAGSGEEGLRLFDERSPALVVTDLKMPGMGGFRLLQEIKGRSPDT
AVIVITAFGAVETAVDAMKAGAYDYITKPFNRDALKLTVKKALEMLGLSRENRRLREALTEREDYRSIVGISRRMEEVFR
VVDRVADTDATVLITGESGTGKELVARAVHTRSSRRAAPFVAVNCAAIPRDLLESELFGHVKGSFTGAVRDKAGKFQQAE
GGTLFLDEVGELPVELQSKLLRALQEKEVQQVGGTEVRKLDVRVVAATNADLEQAIEEGRFREDLYYRLSVIPIHLPPLR
ERKEDIPLLVRHFAARHGGDRVAFAPETLEVMADYGWPGNVRELENTVERLLIMRCSDTITPADLPDKVRSRRAPSTECP
VISLPDEGYSLEQLEREIVVEALERNNWNQSSAARFLRIPRHTLIYRMEKYQITAPERKK
>Mature_459_residues
AEERQPARVLIVDDDVSLRRVLEYNLQEEGYDVITAGSGEEGLRLFDERSPALVVTDLKMPGMGGFRLLQEIKGRSPDTA
VIVITAFGAVETAVDAMKAGAYDYITKPFNRDALKLTVKKALEMLGLSRENRRLREALTEREDYRSIVGISRRMEEVFRV
VDRVADTDATVLITGESGTGKELVARAVHTRSSRRAAPFVAVNCAAIPRDLLESELFGHVKGSFTGAVRDKAGKFQQAEG
GTLFLDEVGELPVELQSKLLRALQEKEVQQVGGTEVRKLDVRVVAATNADLEQAIEEGRFREDLYYRLSVIPIHLPPLRE
RKEDIPLLVRHFAARHGGDRVAFAPETLEVMADYGWPGNVRELENTVERLLIMRCSDTITPADLPDKVRSRRAPSTECPV
ISLPDEGYSLEQLEREIVVEALERNNWNQSSAARFLRIPRHTLIYRMEKYQITAPERKK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=42.1286031042129, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=42.9213483146067, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=42.2174840085288, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1788905, Length=383, Percent_Identity=44.6475195822454, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI87082117, Length=346, Percent_Identity=45.3757225433526, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=45.7680250783699, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1789087, Length=338, Percent_Identity=44.9704142011834, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI87082152, Length=300, Percent_Identity=42.6666666666667, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1786524, Length=357, Percent_Identity=41.4565826330532, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=39.0625, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1787583, Length=249, Percent_Identity=42.570281124498, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1789828, Length=286, Percent_Identity=35.3146853146853, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081858, Length=292, Percent_Identity=31.5068493150685, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1789809, Length=103, Percent_Identity=36.8932038834951, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786599, Length=135, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1790863, Length=136, Percent_Identity=32.3529411764706, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787375, Length=103, Percent_Identity=32.0388349514563, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082012, Length=115, Percent_Identity=31.304347826087, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=31.7073170731707, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51723; Mature: 51592

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEERQPARVLIVDDDVSLRRVLEYNLQEEGYDVITAGSGEEGLRLFDERSPALVVTDLK
CCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHCCCCCEEEEEECC
MPGMGGFRLLQEIKGRSPDTAVIVITAFGAVETAVDAMKAGAYDYITKPFNRDALKLTVK
CCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHH
KALEMLGLSRENRRLREALTEREDYRSIVGISRRMEEVFRVVDRVADTDATVLITGESGT
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
GKELVARAVHTRSSRRAAPFVAVNCAAIPRDLLESELFGHVKGSFTGAVRDKAGKFQQAE
CHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCC
GGTLFLDEVGELPVELQSKLLRALQEKEVQQVGGTEVRKLDVRVVAATNADLEQAIEEGR
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHCCC
FREDLYYRLSVIPIHLPPLRERKEDIPLLVRHFAARHGGDRVAFAPETLEVMADYGWPGN
CHHHHEEEEEEEEEECCCCHHHHCCHHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCC
VRELENTVERLLIMRCSDTITPADLPDKVRSRRAPSTECPVISLPDEGYSLEQLEREIVV
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHH
EALERNNWNQSSAARFLRIPRHTLIYRMEKYQITAPERKK
HHHHCCCCCHHHHHHHHHCCCHHHHEEEEEEEECCCCCCC
>Mature Secondary Structure 
AEERQPARVLIVDDDVSLRRVLEYNLQEEGYDVITAGSGEEGLRLFDERSPALVVTDLK
CCCCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHCCCCCEEEEEECC
MPGMGGFRLLQEIKGRSPDTAVIVITAFGAVETAVDAMKAGAYDYITKPFNRDALKLTVK
CCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHH
KALEMLGLSRENRRLREALTEREDYRSIVGISRRMEEVFRVVDRVADTDATVLITGESGT
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
GKELVARAVHTRSSRRAAPFVAVNCAAIPRDLLESELFGHVKGSFTGAVRDKAGKFQQAE
CHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCC
GGTLFLDEVGELPVELQSKLLRALQEKEVQQVGGTEVRKLDVRVVAATNADLEQAIEEGR
CCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHCCC
FREDLYYRLSVIPIHLPPLRERKEDIPLLVRHFAARHGGDRVAFAPETLEVMADYGWPGN
CHHHHEEEEEEEEEECCCCHHHHCCHHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCC
VRELENTVERLLIMRCSDTITPADLPDKVRSRRAPSTECPVISLPDEGYSLEQLEREIVV
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHH
EALERNNWNQSSAARFLRIPRHTLIYRMEKYQITAPERKK
HHHHCCCCCHHHHHHHHHCCCHHHHEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]