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The map label for this gene is resA [H]

Identifier: 39996423

GI number: 39996423

Start: 1447467

End: 1447973

Strand: Direct

Name: resA [H]

Synonym: GSU1321

Alternate gene names: 39996423

Gene position: 1447467-1447973 (Clockwise)

Preceding gene: 39996422

Following gene: 39996424

Centisome position: 37.95

GC content: 61.34

Gene sequence:

>507_bases
ATGAGAAAATTTGTCCGCCTTCTGCCTCTGTTGATCCTGCTGGCGCTCCTGGGCTGCTCCAAGGAGCAGAAGCCCGCCGT
GCAGGGAAACCCCGCCCCCGACTTCACCCTCAACACCCTCAAGGGTGAGGTTGTGAAGCTGTCCGACCTGAAGGGGCAGG
TGGTTCTCGTCAACTTCTGGGCCACCTGGTGCCCCCCCTGCCGGGAGGAGATCCCCTCCATGATGCGGCTTGAGGCAGCC
ATGGCCGGCAAGCCGTTCAAGATGCTCTGCATCTCCATCGACGACGGCGGGCCGGTGGCGGTGGAGGATTTCTTCCGCAA
GACGGGCTTTAATCTGCCCACGCTGATGGACACCGACAAGCAAGCCAGTAAACTCTACGGCGTCACCGGCGTGCCGGAGA
CGTTTGTGGTGGATAAAAATGGGGTTATACTCAAGAAGGTCGTGGGGGGCGTGCAGTGGGACCACCCCGACGTGATCGCC
TATCTCAACGGCGCCCTGGCCAAGTAG

Upstream 100 bases:

>100_bases
ACTGGAATCAGAGTTCGGCGGCGCGCTTTCTTCGCATTCCGCGCCATACACTCATCTACAGGATGGAGAAGTATCAGATC
ACTGCACCGGAGAGAAAAAA

Downstream 100 bases:

>100_bases
GGCACCCCGCCAAGTCGAGGTATTCATGGAATCAACCAACATAACCTTTGTGGGCGCATTCGTGGCGGGACTCCTGTCCT
TCCTGTCCCCCTGCGTGCTG

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MRKFVRLLPLLILLALLGCSKEQKPAVQGNPAPDFTLNTLKGEVVKLSDLKGQVVLVNFWATWCPPCREEIPSMMRLEAA
MAGKPFKMLCISIDDGGPVAVEDFFRKTGFNLPTLMDTDKQASKLYGVTGVPETFVVDKNGVILKKVVGGVQWDHPDVIA
YLNGALAK

Sequences:

>Translated_168_residues
MRKFVRLLPLLILLALLGCSKEQKPAVQGNPAPDFTLNTLKGEVVKLSDLKGQVVLVNFWATWCPPCREEIPSMMRLEAA
MAGKPFKMLCISIDDGGPVAVEDFFRKTGFNLPTLMDTDKQASKLYGVTGVPETFVVDKNGVILKKVVGGVQWDHPDVIA
YLNGALAK
>Mature_168_residues
MRKFVRLLPLLILLALLGCSKEQKPAVQGNPAPDFTLNTLKGEVVKLSDLKGQVVLVNFWATWCPPCREEIPSMMRLEAA
MAGKPFKMLCISIDDGGPVAVEDFFRKTGFNLPTLMDTDKQASKLYGVTGVPETFVVDKNGVILKKVVGGVQWDHPDVIA
YLNGALAK

Specific function: Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalent

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788523, Length=166, Percent_Identity=30.7228915662651, Blast_Score=67, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: NA

Molecular weight: Translated: 18402; Mature: 18402

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFVRLLPLLILLALLGCSKEQKPAVQGNPAPDFTLNTLKGEVVKLSDLKGQVVLVNFW
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCEEEEEEC
ATWCPPCREEIPSMMRLEAAMAGKPFKMLCISIDDGGPVAVEDFFRKTGFNLPTLMDTDK
CCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCH
QASKLYGVTGVPETFVVDKNGVILKKVVGGVQWDHPDVIAYLNGALAK
HHHHHCCCCCCCCEEEECCCCEEHHHHHCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRKFVRLLPLLILLALLGCSKEQKPAVQGNPAPDFTLNTLKGEVVKLSDLKGQVVLVNFW
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCEEEEEEC
ATWCPPCREEIPSMMRLEAAMAGKPFKMLCISIDDGGPVAVEDFFRKTGFNLPTLMDTDK
CCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCH
QASKLYGVTGVPETFVVDKNGVILKKVVGGVQWDHPDVIAYLNGALAK
HHHHHCCCCCCCCEEEECCCCEEHHHHHCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 8631715; 12637552 [H]