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The map label for this gene is zraS [H]

Identifier: 39996421

GI number: 39996421

Start: 1444965

End: 1446068

Strand: Direct

Name: zraS [H]

Synonym: GSU1319

Alternate gene names: 39996421

Gene position: 1444965-1446068 (Clockwise)

Preceding gene: 39996420

Following gene: 39996422

Centisome position: 37.88

GC content: 64.31

Gene sequence:

>1104_bases
ATGAGACTGCCCGGTTCGGCGCGGATTTCATTGCTGGCAGTGTTCATTATCGGGATCAGCCTGTTCCACTATCTGACCCC
CCTTCACCTGCCCGCTCTCCATGATCTGTTCCAGAGACTCTACTATCTTCCGATCATCCTGGCCGCCTTCTGGTTTGGGC
TCAGGGGAGGACTCGGCACGGCAGTCGTCGTCAGTATCCTCTACGTGCCCCACGTCCTGTTCCAGTGGGGGGCGCGGCCG
TCGCTGGAGCTGGAGAAGTTTCTTGAAATTCTCCTCTACAACGTGGTGGGAGGCATCACCGGCTACCTGAGCCAGAAGGA
AGAGGAGCGGAGGAACGAGTTGGAGCGCGCCGCCCGGCGTTTAGAGGATTCCTACCGCACCCTCAGGGGGCAGGCCGACC
TCATCATCGGCATCGAGGAGCAGTTGCGCCGGGCCGAACGCCTGTCGGCACTGGGGGAGATGTCGGCCATGCTGGCCCAC
GAGATCCGAAACCCGCTGGGCTCCATCCGGGGCACGGCGGAGATCCTGCGCGACGACTTCAGCCCCGGCGACCGCAAGTT
CGAGTTCCTGGAGATCCTCATCAAGGAAACCGACCGGCTCAACCGGGTGGTCGAGGATTTCCTGCGCCTGGCGCGGCCGC
TGGATGGGGAGAAAAAACGATGTGACCTGGCGGCCGAGCTGCGTGAACTCGTGACGCTCCAGGAGAGCGAGGCTACCGCC
CGGGGGATCGGACTCAGTCTTGAGGCGGGAGAAGCGCCGACGGTGGCCGGGGACCGGGAGCGGCTGCGCCAAGCCTTTCT
CAACTTGATCCTCAATGCGCTCCAGGCGACCGGCGAGGGCGGTCGCGTGGCCGTGCGTCTGGCAATGCGCGGAGCCAGCG
GCGATATGCCCGCCGGCGTCGAGATCACGGTGTCGGACACGGGGCGTGGGATCGATCCGGCTCAGCGGGAAAAGATCTTT
ACTCCGTTTTTCACCACCAAGGAGGGAGGAACCGGCCTGGGACTCGTCATTACCCAGCGGATCGTGGAGGCCCACGGCGG
CACCATCGGCCTGGAGAGTGAGCCCGGCAGGGGAACCACTTTCAGGGTGTGGCTGCCGGTGTGA

Upstream 100 bases:

>100_bases
TGTAGTTTTACCCTTTTGTCCTTGCATTATCTCCGGTCATGAACTACATAGTTTCCATTCCGCATGCAGGATGGGAAATT
TTCGCTTTCACGGGAATGCC

Downstream 100 bases:

>100_bases
TCGGGGAGATGGGGGAGTGATGGCTGAAGAGCGGCAACCTGCCCGGGTGCTGATCGTCGACGATGACGTATCGCTGCGCC
GGGTACTCGAATACAACCTC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MRLPGSARISLLAVFIIGISLFHYLTPLHLPALHDLFQRLYYLPIILAAFWFGLRGGLGTAVVVSILYVPHVLFQWGARP
SLELEKFLEILLYNVVGGITGYLSQKEEERRNELERAARRLEDSYRTLRGQADLIIGIEEQLRRAERLSALGEMSAMLAH
EIRNPLGSIRGTAEILRDDFSPGDRKFEFLEILIKETDRLNRVVEDFLRLARPLDGEKKRCDLAAELRELVTLQESEATA
RGIGLSLEAGEAPTVAGDRERLRQAFLNLILNALQATGEGGRVAVRLAMRGASGDMPAGVEITVSDTGRGIDPAQREKIF
TPFFTTKEGGTGLGLVITQRIVEAHGGTIGLESEPGRGTTFRVWLPV

Sequences:

>Translated_367_residues
MRLPGSARISLLAVFIIGISLFHYLTPLHLPALHDLFQRLYYLPIILAAFWFGLRGGLGTAVVVSILYVPHVLFQWGARP
SLELEKFLEILLYNVVGGITGYLSQKEEERRNELERAARRLEDSYRTLRGQADLIIGIEEQLRRAERLSALGEMSAMLAH
EIRNPLGSIRGTAEILRDDFSPGDRKFEFLEILIKETDRLNRVVEDFLRLARPLDGEKKRCDLAAELRELVTLQESEATA
RGIGLSLEAGEAPTVAGDRERLRQAFLNLILNALQATGEGGRVAVRLAMRGASGDMPAGVEITVSDTGRGIDPAQREKIF
TPFFTTKEGGTGLGLVITQRIVEAHGGTIGLESEPGRGTTFRVWLPV
>Mature_367_residues
MRLPGSARISLLAVFIIGISLFHYLTPLHLPALHDLFQRLYYLPIILAAFWFGLRGGLGTAVVVSILYVPHVLFQWGARP
SLELEKFLEILLYNVVGGITGYLSQKEEERRNELERAARRLEDSYRTLRGQADLIIGIEEQLRRAERLSALGEMSAMLAH
EIRNPLGSIRGTAEILRDDFSPGDRKFEFLEILIKETDRLNRVVEDFLRLARPLDGEKKRCDLAAELRELVTLQESEATA
RGIGLSLEAGEAPTVAGDRERLRQAFLNLILNALQATGEGGRVAVRLAMRGASGDMPAGVEITVSDTGRGIDPAQREKIF
TPFFTTKEGGTGLGLVITQRIVEAHGGTIGLESEPGRGTTFRVWLPV

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=42.4242424242424, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1788549, Length=266, Percent_Identity=37.9699248120301, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790300, Length=237, Percent_Identity=35.0210970464135, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1789149, Length=290, Percent_Identity=28.6206896551724, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=31.9502074688797, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=31.1740890688259, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=28.4444444444444, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081816, Length=243, Percent_Identity=35.3909465020576, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=250, Percent_Identity=28, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=30.4932735426009, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=30.0448430493274, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=28.7449392712551, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789808, Length=221, Percent_Identity=29.8642533936652, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=32.2448979591837, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=29.0748898678414, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790861, Length=203, Percent_Identity=29.064039408867, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40665; Mature: 40665

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPGSARISLLAVFIIGISLFHYLTPLHLPALHDLFQRLYYLPIILAAFWFGLRGGLGT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AVVVSILYVPHVLFQWGARPSLELEKFLEILLYNVVGGITGYLSQKEEERRNELERAARR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEDSYRTLRGQADLIIGIEEQLRRAERLSALGEMSAMLAHEIRNPLGSIRGTAEILRDDF
HHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SPGDRKFEFLEILIKETDRLNRVVEDFLRLARPLDGEKKRCDLAAELRELVTLQESEATA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RGIGLSLEAGEAPTVAGDRERLRQAFLNLILNALQATGEGGRVAVRLAMRGASGDMPAGV
HCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCC
EITVSDTGRGIDPAQREKIFTPFFTTKEGGTGLGLVITQRIVEAHGGTIGLESEPGRGTT
EEEECCCCCCCCHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCE
FRVWLPV
EEEEECC
>Mature Secondary Structure
MRLPGSARISLLAVFIIGISLFHYLTPLHLPALHDLFQRLYYLPIILAAFWFGLRGGLGT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AVVVSILYVPHVLFQWGARPSLELEKFLEILLYNVVGGITGYLSQKEEERRNELERAARR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEDSYRTLRGQADLIIGIEEQLRRAERLSALGEMSAMLAHEIRNPLGSIRGTAEILRDDF
HHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SPGDRKFEFLEILIKETDRLNRVVEDFLRLARPLDGEKKRCDLAAELRELVTLQESEATA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RGIGLSLEAGEAPTVAGDRERLRQAFLNLILNALQATGEGGRVAVRLAMRGASGDMPAGV
HCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCC
EITVSDTGRGIDPAQREKIFTPFFTTKEGGTGLGLVITQRIVEAHGGTIGLESEPGRGTT
EEEECCCCCCCCHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCE
FRVWLPV
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]