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The map label for this gene is mraY [H]

Identifier: 38234176

GI number: 38234176

Start: 1631702

End: 1632820

Strand: Reverse

Name: mraY [H]

Synonym: DIP1601

Alternate gene names: 38234176

Gene position: 1632820-1631702 (Counterclockwise)

Preceding gene: 38234177

Following gene: 38234175

Centisome position: 65.61

GC content: 50.58

Gene sequence:

>1119_bases
ATGACAGGTGAATCAACAATGACCCAGATCATTATTGCGGGCGCTGTGGGCCTTTTGGTGTCGATCTTTGTTACACCCGT
TTTGATTCGGCGTTTTAGCGCCGAGGGACTGGGGCAAGAGATCCGTGAAGATGGTCCTAAATCGCATTTGCGCAAGCGCG
GCACCCCCACCATGGGTGGTATCGCAATCTTGATCGGTATCACCGTTGCTTATGCAGTCACGGGGATCGTGGGTCAAGTA
ACCGGAACTGGTGGTTTGACAGCTTCTGGTTTGCTGGTTTTAGGCTTGACACTTGCACTCGGTGGTCTTGGTTTTGCTGA
TGACTTTATCAAGCTCTACATGGGGCGCAACCTTGGTTTGAACAAGAAAGCTAAGTTGATCGGACAGTTGGCGATTTCAC
TTATCTTTGGTGCGCTCATTCTTCTTTTCCCTAACGCTGATGGACTAACCCCAGGATCTAGTCACTTAAGCTTCTTGCGT
GATTTGCCCACAGTTGACCTTGCCATTGGGCCTAAGGCAGTAGGAATCGCAATTTTCCTTCTGTTCATTTACATTCTGAT
TTCTGCATGGTCTAACGCAGTAAATCTAACCGATGGCTTGGATGGCTTGGCAGCGGGCTCAACTGCCATCGTGATGGGTA
CGTACACCGTTATTACGTTCTGGCAGTTCCGGAACTCATGCTCGGCAGGAGCACAACCTGGCTGTTACGACGTCCGTGAT
CCATTAGATCTTGCAATTTTGGCTGCTGCTGGTTTGGGCGCGTGTTTGGGCTTTTTGTGGTGGAATGCTGCTCCCGCCAA
GATCTTTATGGGAGATACCGGTTCTCTCGCGCTCGGTGGCCTCGTTGCGGGATTGTCCGTGGCCTCTCGTACAGAGCTTC
TCATGATTATTGTTGGTGCTTTGTTTGTACTCGAAGCTGCTTCGGTGGTTATCCAGGTCGCGGGTTACCGAACAAAGAAG
ATTCGTATTTTCCGGATGGCGCCGTTCCATCATCACTTTGAAAACGGTGGTTGGGCCGAGACAACTGTTGTGATTCGATT
CTGGCTGATCGCCGCGGTGGCTGCGCTCATCGGTGCATCCATTTTCTATGGTGAGTGGCTATCTCTTACAGGAGTATAA

Upstream 100 bases:

>100_bases
GATCAGAATATGGGTTCTGCAGACGTGGCTCTTGTAAAAGCATCTAATGCATATCGTTTGTGGGAAACCGCAGAGATTTT
AGCTTCAAAATAAAGAAAGA

Downstream 100 bases:

>100_bases
AAATATGTCTGCCGCCAAAATGACAGTAAGTGTTGAAGAGCTCAAGGTTTTGCTTCCTGAGTTAGCAGGCCGCGTACTCG
TTGCAGGTGCCGGTGTTTCC

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTGESTMTQIIIAGAVGLLVSIFVTPVLIRRFSAEGLGQEIREDGPKSHLRKRGTPTMGGIAILIGITVAYAVTGIVGQV
TGTGGLTASGLLVLGLTLALGGLGFADDFIKLYMGRNLGLNKKAKLIGQLAISLIFGALILLFPNADGLTPGSSHLSFLR
DLPTVDLAIGPKAVGIAIFLLFIYILISAWSNAVNLTDGLDGLAAGSTAIVMGTYTVITFWQFRNSCSAGAQPGCYDVRD
PLDLAILAAAGLGACLGFLWWNAAPAKIFMGDTGSLALGGLVAGLSVASRTELLMIIVGALFVLEAASVVIQVAGYRTKK
IRIFRMAPFHHHFENGGWAETTVVIRFWLIAAVAALIGASIFYGEWLSLTGV

Sequences:

>Translated_372_residues
MTGESTMTQIIIAGAVGLLVSIFVTPVLIRRFSAEGLGQEIREDGPKSHLRKRGTPTMGGIAILIGITVAYAVTGIVGQV
TGTGGLTASGLLVLGLTLALGGLGFADDFIKLYMGRNLGLNKKAKLIGQLAISLIFGALILLFPNADGLTPGSSHLSFLR
DLPTVDLAIGPKAVGIAIFLLFIYILISAWSNAVNLTDGLDGLAAGSTAIVMGTYTVITFWQFRNSCSAGAQPGCYDVRD
PLDLAILAAAGLGACLGFLWWNAAPAKIFMGDTGSLALGGLVAGLSVASRTELLMIIVGALFVLEAASVVIQVAGYRTKK
IRIFRMAPFHHHFENGGWAETTVVIRFWLIAAVAALIGASIFYGEWLSLTGV
>Mature_371_residues
TGESTMTQIIIAGAVGLLVSIFVTPVLIRRFSAEGLGQEIREDGPKSHLRKRGTPTMGGIAILIGITVAYAVTGIVGQVT
GTGGLTASGLLVLGLTLALGGLGFADDFIKLYMGRNLGLNKKAKLIGQLAISLIFGALILLFPNADGLTPGSSHLSFLRD
LPTVDLAIGPKAVGIAIFLLFIYILISAWSNAVNLTDGLDGLAAGSTAIVMGTYTVITFWQFRNSCSAGAQPGCYDVRDP
LDLAILAAAGLGACLGFLWWNAAPAKIFMGDTGSLALGGLVAGLSVASRTELLMIIVGALFVLEAASVVIQVAGYRTKKI
RIFRMAPFHHHFENGGWAETTVVIRFWLIAAVAALIGASIFYGEWLSLTGV

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan [H]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786275, Length=354, Percent_Identity=36.4406779661017, Blast_Score=194, Evalue=6e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1 [H]

EC number: =2.7.8.13 [H]

Molecular weight: Translated: 38880; Mature: 38749

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS01347 MRAY_1 ; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGESTMTQIIIAGAVGLLVSIFVTPVLIRRFSAEGLGQEIREDGPKSHLRKRGTPTMGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHCCCCCHHH
IAILIGITVAYAVTGIVGQVTGTGGLTASGLLVLGLTLALGGLGFADDFIKLYMGRNLGL
HHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
NKKAKLIGQLAISLIFGALILLFPNADGLTPGSSHLSFLRDLPTVDLAIGPKAVGIAIFL
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHH
LFIYILISAWSNAVNLTDGLDGLAAGSTAIVMGTYTVITFWQFRNSCSAGAQPGCYDVRD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCC
PLDLAILAAAGLGACLGFLWWNAAPAKIFMGDTGSLALGGLVAGLSVASRTELLMIIVGA
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LFVLEAASVVIQVAGYRTKKIRIFRMAPFHHHFENGGWAETTVVIRFWLIAAVAALIGAS
HHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IFYGEWLSLTGV
HHHHCHHHHCCC
>Mature Secondary Structure 
TGESTMTQIIIAGAVGLLVSIFVTPVLIRRFSAEGLGQEIREDGPKSHLRKRGTPTMGG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHCCCCCHHH
IAILIGITVAYAVTGIVGQVTGTGGLTASGLLVLGLTLALGGLGFADDFIKLYMGRNLGL
HHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
NKKAKLIGQLAISLIFGALILLFPNADGLTPGSSHLSFLRDLPTVDLAIGPKAVGIAIFL
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHH
LFIYILISAWSNAVNLTDGLDGLAAGSTAIVMGTYTVITFWQFRNSCSAGAQPGCYDVRD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCC
PLDLAILAAAGLGACLGFLWWNAAPAKIFMGDTGSLALGGLVAGLSVASRTELLMIIVGA
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LFVLEAASVVIQVAGYRTKKIRIFRMAPFHHHFENGGWAETTVVIRFWLIAAVAALIGAS
HHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IFYGEWLSLTGV
HHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]