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The map label for this gene is dxr

Identifier: 38234079

GI number: 38234079

Start: 1524586

End: 1525749

Strand: Reverse

Name: dxr

Synonym: DIP1500

Alternate gene names: 38234079

Gene position: 1525749-1524586 (Counterclockwise)

Preceding gene: 38234081

Following gene: 38234078

Centisome position: 61.31

GC content: 52.32

Gene sequence:

>1164_bases
GTGAGAAAGAAAATCTTGATTCTGGGCAGCACTGGTTCCATCGGCACGCAGGCGCTTGAGGTTATAGCTTCGCGCCAAGA
CCAATTTGAGGTGGTAGGTATTGCCGCGGGTGGCCGAGATCCACAATTAATTATCCAGCAAGCTCAGATGCTGGGTTTGG
CGGCAGACCATGTTGCTGTGGCCAATGAGAAATCGGCAACTCAAGTCAGTCGTGCACTTGGGGCAGCGGTATTAAGCGGA
AGGGATGCTGCTACCGACCTCGTTGAGTCAGTGCCAGCGGATACGGTACTTAACGGCCTTGTGGGTTCTATGGGGCTGCG
GGCTACCTTGGCTACGATTCAACTAGGTGAAGTTCTGGCCTTAGCTAATAAGGAATCGTTGGTTGCCGGTGGTACGTTTG
TCACATCTCAGGCTGCCCCAGGGCAAATCGTGCCTGTGGATTCCGAACATTCTGCGATGGCGCAGTGTTTGCGATCAGGG
GCATCAGCGGAAGTGTCAAAGTTGGTTCTGACTGCTTCAGGTGGCCCATTCCGTGGCTGGTCACGGGAGGAGATGTGGGA
TGTTACTCCTGAGCAAGCTGCGGCACATCCAACGTGGTCGATGGGGCAGATGAATACATTGAATTCGGCCACTTTGATAA
ATAAAGGATTGGAGTTAATTGAGGCCACTTTGCTCTTTGACATCCCAGCTGACCGTATTGAGGTGACTGTTCATCCGCAG
TCGATTGTTCATTCGATGGTCACGTTTTGTGATGGTGCAACAATTGCTCAAGCATCGCCACCATCCATGTTGCTGTCAAT
TTCTCATGCTTTGGCATGGCCTCACCGAGTTCCAGAAGCGCAACCGGCTTTGGATTTCTCTCAAGCAAGTACGTGGGATT
TCATGCCAGTAGATAATGAGGCTTTCCCCGCAGTTGAGTTAGCGCGCGAGGTGGCTTTGAAACAGGGAACGTATCCGGCA
GTGTATAACGCGGCAAATGAGCAGGCGGCCGCTGCGTTTCTTCGTGGTCGCATTAAGTTCCCACAGATTGTCGATATTGT
CGGCGAAGTGGTGGCAGGATCTTCACAGTTTGCTGGTGTAGCCTCATCGGTCGAAGAAATTATTGCGCACGAAAGTGAGT
CGCGTAGACGAGCAGACGCGCTCGTCGATAAGCTTTCTCGCTGA

Upstream 100 bases:

>100_bases
ATCCTAAAGATGGCGCCCATAAGGGGGGAATCTATAGTCCGAGTAACGAACAAACGCGCTGAGAATCCCGCAGGTTGTTT
CATGGGACATAATGGATTAG

Downstream 100 bases:

>100_bases
TTAGTTGCGTTGTTGTAGGTACCCTGCAAGGAGTTTGTGCACCCGTGGCCTCATATTTACTTGGCGTTGTTTTATTTGCG
ACTGGCATCGCCATCACTAT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAVANEKSATQVSRALGAAVLSG
RDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLALANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSG
ASAEVSKLVLTASGGPFRGWSREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ
SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNEAFPAVELAREVALKQGTYPA
VYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGVASSVEEIIAHESESRRRADALVDKLSR

Sequences:

>Translated_387_residues
MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAVANEKSATQVSRALGAAVLSG
RDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLALANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSG
ASAEVSKLVLTASGGPFRGWSREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ
SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNEAFPAVELAREVALKQGTYPA
VYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGVASSVEEIIAHESESRRRADALVDKLSR
>Mature_387_residues
MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAVANEKSATQVSRALGAAVLSG
RDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLALANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSG
ASAEVSKLVLTASGGPFRGWSREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ
SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNEAFPAVELAREVALKQGTYPA
VYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGVASSVEEIIAHESESRRRADALVDKLSR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=359, Percent_Identity=39.2757660167131, Blast_Score=227, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CORDI (Q6NGL1)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939846.1
- ProteinModelPortal:   Q6NGL1
- SMR:   Q6NGL1
- GeneID:   2650384
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1500
- NMPDR:   fig|257309.1.peg.1437
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   CDIP257309:DIP1500-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 40705; Mature: 40705

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: BINDING 124-124 BINDING 149-149 BINDING 173-173 BINDING 196-196 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAV
CCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEE
ANEKSATQVSRALGAAVLSGRDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLA
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSGASAEVSKLVLTASGGPFRGW
HCCCCCEEECCCEEECCCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC
SREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ
CCHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEECHH
SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNE
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AFPAVELAREVALKQGTYPAVYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGV
CCCHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHH
ASSVEEIIAHESESRRRADALVDKLSR
HHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAV
CCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEE
ANEKSATQVSRALGAAVLSGRDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLA
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSGASAEVSKLVLTASGGPFRGW
HCCCCCEEECCCEEECCCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC
SREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ
CCHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEECHH
SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNE
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AFPAVELAREVALKQGTYPAVYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGV
CCCHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHH
ASSVEEIIAHESESRRRADALVDKLSR
HHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910