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The map label for this gene is cysG1 [H]

Identifier: 38234065

GI number: 38234065

Start: 1505222

End: 1506031

Strand: Reverse

Name: cysG1 [H]

Synonym: DIP1484

Alternate gene names: 38234065

Gene position: 1506031-1505222 (Counterclockwise)

Preceding gene: 38234067

Following gene: 38234063

Centisome position: 60.52

GC content: 50.49

Gene sequence:

>810_bases
ATGAAAAAATTCACGGAGATTTCAAGCCGGAATAGGAAGCTGTTTAAACTGGCAGGTATGTTTTCGTCTTCAGAATCGTG
GACCGCTTCGGTTAGCCTCATTGGTGGTGGCCCTGGTGCGTGGGACCTCATAACAGTTCGAGGTATGCACCGTTTGCAAC
AAGCAGATGTTATTTTGGCAGATCATCTGGGGCCGGCTAGTGAGCTTGCTCAATTATGCGATGTATCCACGAAGGACATC
ATTGATGTATCGAAGTTGCCGTATGGTAAGCAGGTGGCTCAATCTAAGATTAATGAACTCTTGATTGAGCATGCTCAAGC
TGGCAAGAAGGTTGCGCGACTCAAAGGTGGCGATCCTTATATTTTCGGTCGCGGTTTTGAAGAACTCCAAGCGTGTGCCA
AGCATGGAATTGCGTGCGAGGTGGTTCCTGGTGTTACCAGTGCGGTGTCGGTTCCGGCGCTGGCTGGAATTCCGATTACT
CAACGCGGTGTAGTTCATTCCTTTACCGTTATTTCTGGGCATGTCCCTCCGCAGCATCCGCAGTCGCTAAATGATTGGGA
AGCATTAGCCCGCACAGGAGGTACGTTGTCTGTGATTATGGGCGTGAAAAACGCTGGTGCCATCGCTCAAGCGCTTATCG
ACGCTGGTCGAGGCGCTGATACCCCGGTTGCGGTCGTGCAAGAAGGATCGACAGAAAACCAAAAGTCGTTTAAAACGACT
TTGGCTCAGTTGGGGCAAGCGATGAAAGATAATGACATCAAGCCTCCAGCTGTCTATGTCATTGGTGAGGTGGCAGGCCT
TCAGGCCTAG

Upstream 100 bases:

>100_bases
ACGCGGATCAGGCCACTGCTCAGCGCGCCATGGGACTGATAAAGAGGGAACAGCATCGGCGAAGGAGTGAGCAAAGGTAA
GTGGCATGGTTTACAGGATA

Downstream 100 bases:

>100_bases
TCATTGGATTGTCTAGTAATCATTGTGTGATCACTACTGTGAGCTCATGTGGCTTTGAATGTTCTACGGCAAAGCCACAT
TCCTGAGTCATTCCGATGAG

Product: putative uroporphyrinogen III methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKKFTEISSRNRKLFKLAGMFSSSESWTASVSLIGGGPGAWDLITVRGMHRLQQADVILADHLGPASELAQLCDVSTKDI
IDVSKLPYGKQVAQSKINELLIEHAQAGKKVARLKGGDPYIFGRGFEELQACAKHGIACEVVPGVTSAVSVPALAGIPIT
QRGVVHSFTVISGHVPPQHPQSLNDWEALARTGGTLSVIMGVKNAGAIAQALIDAGRGADTPVAVVQEGSTENQKSFKTT
LAQLGQAMKDNDIKPPAVYVIGEVAGLQA

Sequences:

>Translated_269_residues
MKKFTEISSRNRKLFKLAGMFSSSESWTASVSLIGGGPGAWDLITVRGMHRLQQADVILADHLGPASELAQLCDVSTKDI
IDVSKLPYGKQVAQSKINELLIEHAQAGKKVARLKGGDPYIFGRGFEELQACAKHGIACEVVPGVTSAVSVPALAGIPIT
QRGVVHSFTVISGHVPPQHPQSLNDWEALARTGGTLSVIMGVKNAGAIAQALIDAGRGADTPVAVVQEGSTENQKSFKTT
LAQLGQAMKDNDIKPPAVYVIGEVAGLQA
>Mature_269_residues
MKKFTEISSRNRKLFKLAGMFSSSESWTASVSLIGGGPGAWDLITVRGMHRLQQADVILADHLGPASELAQLCDVSTKDI
IDVSKLPYGKQVAQSKINELLIEHAQAGKKVARLKGGDPYIFGRGFEELQACAKHGIACEVVPGVTSAVSVPALAGIPIT
QRGVVHSFTVISGHVPPQHPQSLNDWEALARTGGTLSVIMGVKNAGAIAQALIDAGRGADTPVAVVQEGSTENQKSFKTT
LAQLGQAMKDNDIKPPAVYVIGEVAGLQA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=239, Percent_Identity=39.7489539748954, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322922, Length=240, Percent_Identity=31.25, Blast_Score=119, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 28297; Mature: 28297

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFTEISSRNRKLFKLAGMFSSSESWTASVSLIGGGPGAWDLITVRGMHRLQQADVILA
CCCCHHHHHCCCEEEHHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCEEEE
DHLGPASELAQLCDVSTKDIIDVSKLPYGKQVAQSKINELLIEHAQAGKKVARLKGGDPY
CCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
IFGRGFEELQACAKHGIACEVVPGVTSAVSVPALAGIPITQRGVVHSFTVISGHVPPQHP
EECCCHHHHHHHHHCCCEEEECCCCHHHHCCCHHCCCCCCCCCCEEEEEEEECCCCCCCC
QSLNDWEALARTGGTLSVIMGVKNAGAIAQALIDAGRGADTPVAVVQEGSTENQKSFKTT
CCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHH
LAQLGQAMKDNDIKPPAVYVIGEVAGLQA
HHHHHHHHHCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MKKFTEISSRNRKLFKLAGMFSSSESWTASVSLIGGGPGAWDLITVRGMHRLQQADVILA
CCCCHHHHHCCCEEEHHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCEEEE
DHLGPASELAQLCDVSTKDIIDVSKLPYGKQVAQSKINELLIEHAQAGKKVARLKGGDPY
CCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
IFGRGFEELQACAKHGIACEVVPGVTSAVSVPALAGIPITQRGVVHSFTVISGHVPPQHP
EECCCHHHHHHHHHCCCEEEECCCCHHHHCCCHHCCCCCCCCCCEEEEEEEECCCCCCCC
QSLNDWEALARTGGTLSVIMGVKNAGAIAQALIDAGRGADTPVAVVQEGSTENQKSFKTT
CCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHH
LAQLGQAMKDNDIKPPAVYVIGEVAGLQA
HHHHHHHHHCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA