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The map label for this gene is dapA

Identifier: 38234045

GI number: 38234045

Start: 1483636

End: 1484541

Strand: Reverse

Name: dapA

Synonym: DIP1464

Alternate gene names: 38234045

Gene position: 1484541-1483636 (Counterclockwise)

Preceding gene: 38234046

Following gene: 38234044

Centisome position: 59.65

GC content: 50.11

Gene sequence:

>906_bases
ATGAGCACAGGTTTGACAGCGAACAACGGAATCGAAGAGTTTGGAACTATCGCAGTGGCGATGGTAACTCCTTTTGATGC
TAATGGAGCTCTTGACATAAAAGCTGGTCAAAAGCTGGCAGCTCACCTTGTGAGCAATGGCATTGATTCCTTAGTACTCG
CCGGTACGACGGGCGAGTCACCCACTACATCGTTGGAAGAAAAAATCGACCTGCTCAAGGCCGTCAAAGCGGAGGTAGGG
GATAGCGCCAAGCTTATAGCCGGCGCTGGAACCAATAACACCGCAGCTTCGGTCGAGATGGCTCGGGCCTCAGCAGAGGC
CGGAGCTGATGCTTTGCTGGTTGTTACCCCTTACTACTCTAAGCCGAGTCAAGAAGGTATCTATCAGCATTTCCGCACAG
TTTCGGAGGCGACAGACCTGCCGATTTGTGCGTATGACATCCCTCCACGTTCTGTGGTACCCATCGCACCGGATACCTTG
TGTCGATTGGCTGCGTTGCCAATGATTAAAGCTGTGAAGGATGCTAAAGGAGATATTACAGCTGCCACGACGCTTATTGC
AGAGACTGGACTGGCGTGGTACTCGGGTGATGATCCGCTTAATTTGCCATGGTTGTCGGTAGGTGCAACTGGTTTTATTT
CGGTGATTGGTCACTTGGCACCGCAGTTGCTGCGAGAGATGTACACAAACTTTAATCAGGGCAATCTTGAGAAAGCTCGA
GAGATTAATGCCCAACTAGCACCATTAGTTGCTGCTCAAGCTCGTTTGGGTGGCGTTTCTTTGGCAAAAGCAGGTTTGCG
TTTGCAAGGAATTGAGGTTGGAGATCCCCGTCTTCCTATTGTGGCTCCTAGTGAGTCCGAGATTGAGGATCTTCGCCGTG
ATATGAATAAAACTGGAGTATTGTAA

Upstream 100 bases:

>100_bases
ATACGTCACTGATTACTAAATCGTGAGAAAATGTCGATATTTCGGTGAAATGTCGACATAATGATTACTTATCGCCTACA
AACGGGTAACCTTGACCACC

Downstream 100 bases:

>100_bases
ATATGACTGAACCTCGTAGCCGTGCGCGCAAGGTTACCCGTAAAGCTGGACCTCCGGAAGCTGCGGAGACGCCAGTTTTC
CAAGCACCTGATTCTACTGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSTGLTANNGIEEFGTIAVAMVTPFDANGALDIKAGQKLAAHLVSNGIDSLVLAGTTGESPTTSLEEKIDLLKAVKAEVG
DSAKLIAGAGTNNTAASVEMARASAEAGADALLVVTPYYSKPSQEGIYQHFRTVSEATDLPICAYDIPPRSVVPIAPDTL
CRLAALPMIKAVKDAKGDITAATTLIAETGLAWYSGDDPLNLPWLSVGATGFISVIGHLAPQLLREMYTNFNQGNLEKAR
EINAQLAPLVAAQARLGGVSLAKAGLRLQGIEVGDPRLPIVAPSESEIEDLRRDMNKTGVL

Sequences:

>Translated_301_residues
MSTGLTANNGIEEFGTIAVAMVTPFDANGALDIKAGQKLAAHLVSNGIDSLVLAGTTGESPTTSLEEKIDLLKAVKAEVG
DSAKLIAGAGTNNTAASVEMARASAEAGADALLVVTPYYSKPSQEGIYQHFRTVSEATDLPICAYDIPPRSVVPIAPDTL
CRLAALPMIKAVKDAKGDITAATTLIAETGLAWYSGDDPLNLPWLSVGATGFISVIGHLAPQLLREMYTNFNQGNLEKAR
EINAQLAPLVAAQARLGGVSLAKAGLRLQGIEVGDPRLPIVAPSESEIEDLRRDMNKTGVL
>Mature_300_residues
STGLTANNGIEEFGTIAVAMVTPFDANGALDIKAGQKLAAHLVSNGIDSLVLAGTTGESPTTSLEEKIDLLKAVKAEVGD
SAKLIAGAGTNNTAASVEMARASAEAGADALLVVTPYYSKPSQEGIYQHFRTVSEATDLPICAYDIPPRSVVPIAPDTLC
RLAALPMIKAVKDAKGDITAATTLIAETGLAWYSGDDPLNLPWLSVGATGFISVIGHLAPQLLREMYTNFNQGNLEKARE
INAQLAPLVAAQARLGGVSLAKAGLRLQGIEVGDPRLPIVAPSESEIEDLRRDMNKTGVL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=27.2413793103448, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI13540533, Length=279, Percent_Identity=26.5232974910394, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1788823, Length=233, Percent_Identity=35.1931330472103, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1789620, Length=236, Percent_Identity=30.0847457627119, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082415, Length=287, Percent_Identity=25.4355400696864, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1786463, Length=232, Percent_Identity=26.2931034482759, Blast_Score=84, Evalue=9e-18,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_CORDI (Q6NGP4)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939812.1
- ProteinModelPortal:   Q6NGP4
- SMR:   Q6NGP4
- GeneID:   2650349
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1464
- NMPDR:   fig|257309.1.peg.1403
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   Q6NGP4
- ProtClustDB:   PRK03170
- BioCyc:   CDIP257309:DIP1464-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31387; Mature: 31256

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 173-173 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGLTANNGIEEFGTIAVAMVTPFDANGALDIKAGQKLAAHLVSNGIDSLVLAGTTGES
CCCCCCCCCCHHHHCCEEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCCEEEECCCCCC
PTTSLEEKIDLLKAVKAEVGDSAKLIAGAGTNNTAASVEMARASAEAGADALLVVTPYYS
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCC
KPSQEGIYQHFRTVSEATDLPICAYDIPPRSVVPIAPDTLCRLAALPMIKAVKDAKGDIT
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCHH
AATTLIAETGLAWYSGDDPLNLPWLSVGATGFISVIGHLAPQLLREMYTNFNQGNLEKAR
HHHHHHHHCCCEEECCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EINAQLAPLVAAQARLGGVSLAKAGLRLQGIEVGDPRLPIVAPSESEIEDLRRDMNKTGV
HHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEECCCCCCEECCCHHHHHHHHHHHHHCCC
L
C
>Mature Secondary Structure 
STGLTANNGIEEFGTIAVAMVTPFDANGALDIKAGQKLAAHLVSNGIDSLVLAGTTGES
CCCCCCCCCHHHHCCEEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCCEEEECCCCCC
PTTSLEEKIDLLKAVKAEVGDSAKLIAGAGTNNTAASVEMARASAEAGADALLVVTPYYS
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCC
KPSQEGIYQHFRTVSEATDLPICAYDIPPRSVVPIAPDTLCRLAALPMIKAVKDAKGDIT
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCHH
AATTLIAETGLAWYSGDDPLNLPWLSVGATGFISVIGHLAPQLLREMYTNFNQGNLEKAR
HHHHHHHHCCCEEECCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EINAQLAPLVAAQARLGGVSLAKAGLRLQGIEVGDPRLPIVAPSESEIEDLRRDMNKTGV
HHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEECCCCCCEECCCHHHHHHHHHHHHHCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910