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The map label for this gene is thyX

Identifier: 38234046

GI number: 38234046

Start: 1484623

End: 1485381

Strand: Reverse

Name: thyX

Synonym: DIP1465

Alternate gene names: 38234046

Gene position: 1485381-1484623 (Counterclockwise)

Preceding gene: 38234047

Following gene: 38234045

Centisome position: 59.69

GC content: 47.96

Gene sequence:

>759_bases
ATGGCACAGCAGTCTTTGCTTGATGTTCAGCTGGTGGCATGTAGTACTTTTACTACGCCATCTGGGGTCGACTGGAAAGT
GGATTCCGCAGCAACAGATTCTGAAGCACTAGTCGAATTTGCTGGTCGGGCTTGTTATGAAACTTTTGACAAGCCTAATC
CTCGAACTGCAGCTAATGACGCCTATATCCGGCACATTATGGAGGTAGGGCATATGGCGTTGTTAGAACACCCGACAGCA
ACTGTGTACATTCGAGGGCTTTCACGCTCTGCTACTCACGAGCTTGTTCGGCATCGGCACTTCTCGTTTTCTCAACTTTC
ACAACGGTTTGTGCATAGTGATGAAACACATGTGGTCATACCACCATTGATCGATAATGATCCACAGCTCAGAGAACTCT
TTCTTAGCACCGTTGATGAGGTGCGGTTTGCCTATTCCGAACTGATGACGGCATTAGACAATAAATTAGCCGATGAACCT
AATGCGATTTTGCGACGCAAACAGGCTCGTCAAGCTGCACGGTCGATACTGCCCAATGCGACAGAATCGCGCATCGTGGT
GACAGGAAATTTCCGAGCATGGCGTCACTTCATCGGTATGCGTGCAACCGAACACGCCGATGTTGAAATCCGAAGCCTTG
CTGTTCGATGCCTCGAGATCTTAAAAGAAAAAGCGCCGACGGTATTTTCCGATTTTGAAACTTCTGTGCTCTCAGATGGA
TCGATTATGGCGACGAGTCCATACGTCACTGATTACTAA

Upstream 100 bases:

>100_bases
ACGATCGAACCTCTTTTGTGCCAGGCGTATTGGTCGGAGTGCGAAATGTTGCTCAGCATCTCGGTCTTACGGTCGGACTT
GAGCACTACTTGGACATCTA

Downstream 100 bases:

>100_bases
ATCGTGAGAAAATGTCGATATTTCGGTGAAATGTCGACATAATGATTACTTATCGCCTACAAACGGGTAACCTTGACCAC
CATGAGCACAGGTTTGACAG

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MAQQSLLDVQLVACSTFTTPSGVDWKVDSAATDSEALVEFAGRACYETFDKPNPRTAANDAYIRHIMEVGHMALLEHPTA
TVYIRGLSRSATHELVRHRHFSFSQLSQRFVHSDETHVVIPPLIDNDPQLRELFLSTVDEVRFAYSELMTALDNKLADEP
NAILRRKQARQAARSILPNATESRIVVTGNFRAWRHFIGMRATEHADVEIRSLAVRCLEILKEKAPTVFSDFETSVLSDG
SIMATSPYVTDY

Sequences:

>Translated_252_residues
MAQQSLLDVQLVACSTFTTPSGVDWKVDSAATDSEALVEFAGRACYETFDKPNPRTAANDAYIRHIMEVGHMALLEHPTA
TVYIRGLSRSATHELVRHRHFSFSQLSQRFVHSDETHVVIPPLIDNDPQLRELFLSTVDEVRFAYSELMTALDNKLADEP
NAILRRKQARQAARSILPNATESRIVVTGNFRAWRHFIGMRATEHADVEIRSLAVRCLEILKEKAPTVFSDFETSVLSDG
SIMATSPYVTDY
>Mature_251_residues
AQQSLLDVQLVACSTFTTPSGVDWKVDSAATDSEALVEFAGRACYETFDKPNPRTAANDAYIRHIMEVGHMALLEHPTAT
VYIRGLSRSATHELVRHRHFSFSQLSQRFVHSDETHVVIPPLIDNDPQLRELFLSTVDEVRFAYSELMTALDNKLADEPN
AILRRKQARQAARSILPNATESRIVVTGNFRAWRHFIGMRATEHADVEIRSLAVRCLEILKEKAPTVFSDFETSVLSDGS
IMATSPYVTDY

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_CORDI (Q6NGP3)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939813.1
- ProteinModelPortal:   Q6NGP3
- SMR:   Q6NGP3
- GeneID:   2650350
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1465
- NMPDR:   fig|257309.1.peg.1404
- HOGENOM:   HBG458114
- OMA:   RATEHAD
- ProtClustDB:   PRK00847
- BioCyc:   CDIP257309:DIP1465-MONOMER
- BRENDA:   2.1.1.148
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 28323; Mature: 28192

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQSLLDVQLVACSTFTTPSGVDWKVDSAATDSEALVEFAGRACYETFDKPNPRTAAND
CCCHHHHHHHEEEEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHH
AYIRHIMEVGHMALLEHPTATVYIRGLSRSATHELVRHRHFSFSQLSQRFVHSDETHVVI
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEE
PPLIDNDPQLRELFLSTVDEVRFAYSELMTALDNKLADEPNAILRRKQARQAARSILPNA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
TESRIVVTGNFRAWRHFIGMRATEHADVEIRSLAVRCLEILKEKAPTVFSDFETSVLSDG
CCCEEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
SIMATSPYVTDY
CEEEECCCCCCC
>Mature Secondary Structure 
AQQSLLDVQLVACSTFTTPSGVDWKVDSAATDSEALVEFAGRACYETFDKPNPRTAAND
CCHHHHHHHEEEEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHH
AYIRHIMEVGHMALLEHPTATVYIRGLSRSATHELVRHRHFSFSQLSQRFVHSDETHVVI
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEE
PPLIDNDPQLRELFLSTVDEVRFAYSELMTALDNKLADEPNAILRRKQARQAARSILPNA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
TESRIVVTGNFRAWRHFIGMRATEHADVEIRSLAVRCLEILKEKAPTVFSDFETSVLSDG
CCCEEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
SIMATSPYVTDY
CEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910