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The map label for this gene is dirA [C]

Identifier: 38234005

GI number: 38234005

Start: 1438479

End: 1439075

Strand: Reverse

Name: dirA [C]

Synonym: DIP1420

Alternate gene names: 38234005

Gene position: 1439075-1438479 (Counterclockwise)

Preceding gene: 38234007

Following gene: 38234004

Centisome position: 57.83

GC content: 49.75

Gene sequence:

>597_bases
GTGTCTATCTTGACTGTTGGCGAAAAGTTCCCAGAGTTTAACTTGACGGCGCTCAAGGGCGGTGACCTGCACGACGTTAA
CGCATCTCAGCCAGAGGACTACTTCGAAACTGTTTCTTTGGACAAGTACGAAGGTAAGTGGAAGGTTGTCTTCTTCTACC
CAAAGGATTTCACCTTCGTGTGCCCAACTGAGATTGCAGCTTTCGGCAAGCTCGACGAAGAGTTCCAGGACCGCGACACT
CAGATCTTGGGCGGCTCCATTGACAACGAGTTCTCACACTTTAACTGGCGTGCTACCCACCCAGAGCTCAAGACCGTTCC
ATTCCCATTGTTCTCCGACATCAAGCATGATCTGATCAAGGCTCTTGGTGTTGAAAACGAAGAAGGCGTTGCAGATCGTG
CAACTTTCATTATCGATCCTGACGGCATCATTCAGTTCGTATCTGTTACTCCAGATGCGGTTGGCCGTAACGTAGATGAG
GTTCTTCGTGTTCTCGACGCACTTCAGTCTGAAGAGGTCTGTGCCTGCAACTGGCAGAAGAACGACCCAACCAAGAACAT
TGATAAGTTCGCTGAGCTTGAGAAGGGCCTCAACTAA

Upstream 100 bases:

>100_bases
GGTCCAATGAAAGAGCTTGTTTTCTCCTCGGTATATTTACTGCGGTGGAGGAAACAGCAGGCAAACGCTTATAACCGTTC
GATCCTATTTGGAGGAAATT

Downstream 100 bases:

>100_bases
AAATGTCGTTGGATAACCTCAAATCTGGGCTTCCAGAATATGCAAAAGATCTGAAACTCAACCTTGGTAGCTTGGCACGT
TCTACGGAACTTACTGAGCA

Product: iron repressible polypeptide

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MSILTVGEKFPEFNLTALKGGDLHDVNASQPEDYFETVSLDKYEGKWKVVFFYPKDFTFVCPTEIAAFGKLDEEFQDRDT
QILGGSIDNEFSHFNWRATHPELKTVPFPLFSDIKHDLIKALGVENEEGVADRATFIIDPDGIIQFVSVTPDAVGRNVDE
VLRVLDALQSEEVCACNWQKNDPTKNIDKFAELEKGLN

Sequences:

>Translated_198_residues
MSILTVGEKFPEFNLTALKGGDLHDVNASQPEDYFETVSLDKYEGKWKVVFFYPKDFTFVCPTEIAAFGKLDEEFQDRDT
QILGGSIDNEFSHFNWRATHPELKTVPFPLFSDIKHDLIKALGVENEEGVADRATFIIDPDGIIQFVSVTPDAVGRNVDE
VLRVLDALQSEEVCACNWQKNDPTKNIDKFAELEKGLN
>Mature_197_residues
SILTVGEKFPEFNLTALKGGDLHDVNASQPEDYFETVSLDKYEGKWKVVFFYPKDFTFVCPTEIAAFGKLDEEFQDRDTQ
ILGGSIDNEFSHFNWRATHPELKTVPFPLFSDIKHDLIKALGVENEEGVADRATFIIDPDGIIQFVSVTPDAVGRNVDEV
LRVLDALQSEEVCACNWQKNDPTKNIDKFAELEKGLN

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=187, Percent_Identity=39.0374331550802, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI32455266, Length=187, Percent_Identity=39.0374331550802, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI32455264, Length=187, Percent_Identity=39.0374331550802, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI5802974, Length=188, Percent_Identity=39.3617021276596, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI32483377, Length=158, Percent_Identity=43.0379746835443, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI32189392, Length=187, Percent_Identity=37.9679144385027, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI5453549, Length=168, Percent_Identity=40.4761904761905, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4758638, Length=153, Percent_Identity=33.9869281045752, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI33188454, Length=97, Percent_Identity=40.2061855670103, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786822, Length=147, Percent_Identity=36.734693877551, Blast_Score=113, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17554494, Length=194, Percent_Identity=37.6288659793814, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193204376, Length=192, Percent_Identity=38.5416666666667, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32565831, Length=192, Percent_Identity=38.5416666666667, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25153706, Length=152, Percent_Identity=32.8947368421053, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323613, Length=158, Percent_Identity=43.0379746835443, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320661, Length=158, Percent_Identity=41.7721518987342, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319407, Length=152, Percent_Identity=38.8157894736842, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17738015, Length=158, Percent_Identity=43.6708860759494, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24656348, Length=150, Percent_Identity=42, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17864676, Length=150, Percent_Identity=42, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17157991, Length=170, Percent_Identity=38.2352941176471, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24641739, Length=170, Percent_Identity=38.2352941176471, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357347, Length=196, Percent_Identity=32.6530612244898, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17975518, Length=182, Percent_Identity=31.3186813186813, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24652436, Length=182, Percent_Identity=31.3186813186813, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24652434, Length=182, Percent_Identity=31.3186813186813, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24581278, Length=176, Percent_Identity=29.5454545454545, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22365; Mature: 22234

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILTVGEKFPEFNLTALKGGDLHDVNASQPEDYFETVSLDKYEGKWKVVFFYPKDFTFV
CCEEECCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCEEE
CPTEIAAFGKLDEEFQDRDTQILGGSIDNEFSHFNWRATHPELKTVPFPLFSDIKHDLIK
CCHHHHHHCCCCHHHHCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHH
ALGVENEEGVADRATFIIDPDGIIQFVSVTPDAVGRNVDEVLRVLDALQSEEVCACNWQK
HHCCCCCCCCCCCEEEEECCCCCEEEEEECHHHHCCCHHHHHHHHHHHCCCCEEEECCCC
NDPTKNIDKFAELEKGLN
CCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SILTVGEKFPEFNLTALKGGDLHDVNASQPEDYFETVSLDKYEGKWKVVFFYPKDFTFV
CEEECCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEEECCCCEEE
CPTEIAAFGKLDEEFQDRDTQILGGSIDNEFSHFNWRATHPELKTVPFPLFSDIKHDLIK
CCHHHHHHCCCCHHHHCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHH
ALGVENEEGVADRATFIIDPDGIIQFVSVTPDAVGRNVDEVLRVLDALQSEEVCACNWQK
HHCCCCCCCCCCCEEEEECCCCCEEEEEECHHHHCCCHHHHHHHHHHHCCCCEEEECCCC
NDPTKNIDKFAELEKGLN
CCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA