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The map label for this gene is tpx [H]

Identifier: 38233948

GI number: 38233948

Start: 1380544

End: 1381041

Strand: Reverse

Name: tpx [H]

Synonym: DIP1362

Alternate gene names: 38233948

Gene position: 1381041-1380544 (Counterclockwise)

Preceding gene: 38233953

Following gene: 38233947

Centisome position: 55.49

GC content: 46.39

Gene sequence:

>498_bases
ATGGCTATTACACATTTTCAAGAATCAGCGGTAGAAACTAGCGGATCTCTTCCACAAGTTGGGCAGGCTCTTCCGCCTTT
CCTTCTCGTCGACGCAGATTTAACTGATTTTGATGCTGAGCGTTTTGCTGGCAAAAAGATTATTCTCAACATTTTCCCAT
CCATTGATACTGGTGTTTGCGCGCAATCAGTGCGGCACTTTAACAAGGAAGCAGCTGATTTAGCTGACACTGTGGTGATT
TGTGCATCTGCGGATCTACCATTTGCACATTCTCGTTTCTGTGCTGCTGAGGGTCTCGATAATGTCATTACGGGATCATC
ATTCCGTTCTTCTTTTGGTCAAGACTATGGAGTTGTTCTCGAGGGATCACCGTTGAAGGGCTTGTTAGCCCGTGCCGTCA
TCGTTGCTGATGAGCAAGGTACTGTTGTTCATTCCCAGTTGGTCGATGAGATCACGACTGAGCCTGATTATGCTGCTGCT
TTGGCATCCATCAAGTAA

Upstream 100 bases:

>100_bases
CTCGCTATTTGATTACCGTTGGTTAGTCTAGCTTGCCGTTGTGATGCCCCAAAGTTAGAGCCTGTAGCGAGGGAGCGGAT
TCGTCGTTACGCTTGGGGCT

Downstream 100 bases:

>100_bases
CACGGTTGGATGAACCACATGGAGATTTTGAGTTTTCCGGCAGGACCGTATCAAACCAATTGTTACGTGGTGCTGTCGGA
GGAATCTGAGGGGCGTCGAT

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MAITHFQESAVETSGSLPQVGQALPPFLLVDADLTDFDAERFAGKKIILNIFPSIDTGVCAQSVRHFNKEAADLADTVVI
CASADLPFAHSRFCAAEGLDNVITGSSFRSSFGQDYGVVLEGSPLKGLLARAVIVADEQGTVVHSQLVDEITTEPDYAAA
LASIK

Sequences:

>Translated_165_residues
MAITHFQESAVETSGSLPQVGQALPPFLLVDADLTDFDAERFAGKKIILNIFPSIDTGVCAQSVRHFNKEAADLADTVVI
CASADLPFAHSRFCAAEGLDNVITGSSFRSSFGQDYGVVLEGSPLKGLLARAVIVADEQGTVVHSQLVDEITTEPDYAAA
LASIK
>Mature_164_residues
AITHFQESAVETSGSLPQVGQALPPFLLVDADLTDFDAERFAGKKIILNIFPSIDTGVCAQSVRHFNKEAADLADTVVIC
ASADLPFAHSRFCAAEGLDNVITGSSFRSSFGQDYGVVLEGSPLKGLLARAVIVADEQGTVVHSQLVDEITTEPDYAAAL
ASIK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=162, Percent_Identity=61.1111111111111, Blast_Score=196, Evalue=6e-52,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 17441; Mature: 17310

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITHFQESAVETSGSLPQVGQALPPFLLVDADLTDFDAERFAGKKIILNIFPSIDTGVC
CCCCCCHHHHHHCCCCCCHHHHCCCCEEEEECCCCCCCHHHHCCCEEEEEECCCCCHHHH
AQSVRHFNKEAADLADTVVICASADLPFAHSRFCAAEGLDNVITGSSFRSSFGQDYGVVL
HHHHHHHCHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCHHHCCCHHHHHCCCCCCEEE
EGSPLKGLLARAVIVADEQGTVVHSQLVDEITTEPDYAAALASIK
ECCCHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure 
AITHFQESAVETSGSLPQVGQALPPFLLVDADLTDFDAERFAGKKIILNIFPSIDTGVC
CCCCCHHHHHHCCCCCCHHHHCCCCEEEEECCCCCCCHHHHCCCEEEEEECCCCCHHHH
AQSVRHFNKEAADLADTVVICASADLPFAHSRFCAAEGLDNVITGSSFRSSFGQDYGVVL
HHHHHHHCHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCHHHCCCHHHHHCCCCCCEEE
EGSPLKGLLARAVIVADEQGTVVHSQLVDEITTEPDYAAALASIK
ECCCHHHHHHHHHEEECCCCCCHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]