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The map label for this gene is relA [H]

Identifier: 38233953

GI number: 38233953

Start: 1384750

End: 1387029

Strand: Reverse

Name: relA [H]

Synonym: DIP1368

Alternate gene names: 38233953

Gene position: 1387029-1384750 (Counterclockwise)

Preceding gene: 38233954

Following gene: 38233948

Centisome position: 55.73

GC content: 48.64

Gene sequence:

>2280_bases
ATGACGCAGGATAAGAAAACAGCGAAGCAGTCCAATTCGATGCGGAGCATGTCAGCTCGATTGGCCAGAAGCCTTACCGG
TAACAGGGTTCGGGTGAACTCTGTACTGGAGCCCATGCTGGCGATTCATAGGGAATTTCATCCTAAAGCAGATGCGGAGG
TGCTCAATCGAGCCTATGCAACTGCGGAACGGCTTCATGACGGAGTATTCCGAAAGTCGGGGGACCCTTATATTACTCAT
CCGCTGGCGGTTGCAACGATCGCAGCGGAAATCGGCATGGATACCACTACATTGGTGGCGGCGTTACTCCATGACACAGT
GGAGGATACGGATTACTCCCTAGAAGATCTCACAGCTGATTTTGGCGCTGAAGTAGCTCGTTTGGTCGATGGTGTTACCA
AACTTGATAAGGTTGCTTTGGGAGCTGCTGCTGAGGCAGAAACAATCCGAAAAATGATTGTCGCGATGAGCCAAGATCCA
CGTGTATTGGTTATCAAAGTAGCTGACCGGCTGCACAATATGCGCACAATGCGCTTCTTGCCTCCAGAAAAGCAGGCTAA
AAAAGCGCGTCAAACCCTTGAGGTCATTGCTCCATTGGCTCACCGCCTCGGTATGGCCAGCGTCAAATGGGAACTTGAAG
ACCTCTCCTTCGCTATCTTGTACCCCAAGAAATACGATGAAGTCGTTCGCTTGGTTGCGGATCGTGCTCCTTCACGAGAC
CGCTACCTTAATCAGGTCATTGCGCAGCTGACTTCTACCCTCAAAGAAAATCATATTGATGCTGAAGTGATGGGTCGACC
TAAGCATTATTGGTCGATCTACCAGAAGATGATTGTTCGAGGTAAGGACTTCGATGAGATTTTTGACCTCGTAGGTATTC
GGGTTCTCGTCGATAATGTGAATAATTGCTATGCGGCAATCGGCGTTGTCCACTCATTGTATTCAGCTATGCCTGGGCGA
TTTAAAGACTATATCTCTTCACCTAAATTCGGTGTCTACCAGTCACTGCACACAACTGTCATGGGGGATGGTGGCAAGCC
TCTTGAGGTACAGGTTCGTACCCATGAGATGCACTACAATGCCGAGTTCGGTATCGCTGCACACTGGCGTTACAAAGAAA
CCAAAGGCAAAAATAGCGGTGAACAGGCCGAAATTGATCAAATGGCGTGGATGCGCCAGCTGCTGGATTGGCAAAAGGAA
GCCGCAGATCCCAATGAGTTTTTGGACTCTTTGCGCTACGACCTGACAAGTAAACAAATTTTTGTGTTCACTCCGAAAGG
CGACGTAGTCAATCTGCCAGTTGACTCCACACCTGTCGATTTTGCTTATGCAGTCCACACTGAGGTGGGGCACCGGTGTA
TTGGTGCGAAAATCAATGGAAAACTTGTTGCGCTGGAGTCCAAGCTTAAATCTGGTGATCGGGTAGAGATTTTTACTTCG
AAAGATCAAAATGCCGGTCCTAGCCGCGACTGGCAAGATTTCGTGGTATCTCCTCGAGCAAAAGCGAAGATTCGCCAATG
GTTTGCCAAGGAACGTCGTGAAGAATATCTCGAAGTTGGTCGCGATGCGCTAGCAACCGAGGTGCAACGTGGTGGTTTGC
CAATGCACCGGCTGTTCACCGCACAATCAATGAAGCAGGTTGCTACTGAACTGCATTACCCTGACGTTGATGCGTTGTAC
ACAGCGATTGGCTCAGGCTCGATCTCCGCAGCACATGTTGCTAATAGACTCATTGCTGCATTTGGTGATACTGAAGACGC
TGAAAATACTTTGGTATCGCGTACACCATTTAGCGAGCTTGTGAGCTCAAAGTCTCAAGTGACCGATAAGAATGGCATTC
TCGTTGAGGGAAGTCCTGATGTTATGGCCAAGTTGGCTAAATGTTGTATGCCAGTTCCAGGCGATGAGATCTTCGGTTTT
GTTACTAGAGGTGGTGGTGTTTCCGTACACCGGACTGACTGCACAAATGCGGATAGCTTGCGTAATGAACCAGAGCGCTT
GATTAATGTCCAGTGGGCCTCTGAAGGTGGAAGCGTTTTTGCAGCTACTTTGCAGCTGGAAGCGCTGGATCGTGAGGGAT
TGCTGATGGATCTAACTCGAGTGATCAATGAGCAACGTGTACAGGTAGTAGCGATGTCATCACATGCTTCAGATGACCAT
GTTGCTACGGTACGTTTTACTTTTTCTGTCTCAGATACTAAACAGCTGGGATCGCTTATGACTCAGCTTCGTAATACAGA
AGCAGTTTTCGATGTTTACCGTGTGACTTCTGGGGGTTAA

Upstream 100 bases:

>100_bases
GATGCACCTTTGGTAGTAATTAATGAAAGCGCTACGGCGTAACTCAAGTTGTTCCGGTACTTTTGGCTAAAAATAGAGTT
GGAAAGGCATATTCGCAACG

Downstream 100 bases:

>100_bases
GTAGCAAAAGTGTGTCCGGTTTTAATGATTTCAGCTGGTTAACCTAACTAAAACGGCCTGGAATAGCTCTTCGGGAGTTA
TTCCAGATTCAATACCAAGT

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MTQDKKTAKQSNSMRSMSARLARSLTGNRVRVNSVLEPMLAIHREFHPKADAEVLNRAYATAERLHDGVFRKSGDPYITH
PLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLEDLTADFGAEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDP
RVLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYDEVVRLVADRAPSRD
RYLNQVIAQLTSTLKENHIDAEVMGRPKHYWSIYQKMIVRGKDFDEIFDLVGIRVLVDNVNNCYAAIGVVHSLYSAMPGR
FKDYISSPKFGVYQSLHTTVMGDGGKPLEVQVRTHEMHYNAEFGIAAHWRYKETKGKNSGEQAEIDQMAWMRQLLDWQKE
AADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVDSTPVDFAYAVHTEVGHRCIGAKINGKLVALESKLKSGDRVEIFTS
KDQNAGPSRDWQDFVVSPRAKAKIRQWFAKERREEYLEVGRDALATEVQRGGLPMHRLFTAQSMKQVATELHYPDVDALY
TAIGSGSISAAHVANRLIAAFGDTEDAENTLVSRTPFSELVSSKSQVTDKNGILVEGSPDVMAKLAKCCMPVPGDEIFGF
VTRGGGVSVHRTDCTNADSLRNEPERLINVQWASEGGSVFAATLQLEALDREGLLMDLTRVINEQRVQVVAMSSHASDDH
VATVRFTFSVSDTKQLGSLMTQLRNTEAVFDVYRVTSGG

Sequences:

>Translated_759_residues
MTQDKKTAKQSNSMRSMSARLARSLTGNRVRVNSVLEPMLAIHREFHPKADAEVLNRAYATAERLHDGVFRKSGDPYITH
PLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLEDLTADFGAEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDP
RVLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYDEVVRLVADRAPSRD
RYLNQVIAQLTSTLKENHIDAEVMGRPKHYWSIYQKMIVRGKDFDEIFDLVGIRVLVDNVNNCYAAIGVVHSLYSAMPGR
FKDYISSPKFGVYQSLHTTVMGDGGKPLEVQVRTHEMHYNAEFGIAAHWRYKETKGKNSGEQAEIDQMAWMRQLLDWQKE
AADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVDSTPVDFAYAVHTEVGHRCIGAKINGKLVALESKLKSGDRVEIFTS
KDQNAGPSRDWQDFVVSPRAKAKIRQWFAKERREEYLEVGRDALATEVQRGGLPMHRLFTAQSMKQVATELHYPDVDALY
TAIGSGSISAAHVANRLIAAFGDTEDAENTLVSRTPFSELVSSKSQVTDKNGILVEGSPDVMAKLAKCCMPVPGDEIFGF
VTRGGGVSVHRTDCTNADSLRNEPERLINVQWASEGGSVFAATLQLEALDREGLLMDLTRVINEQRVQVVAMSSHASDDH
VATVRFTFSVSDTKQLGSLMTQLRNTEAVFDVYRVTSGG
>Mature_758_residues
TQDKKTAKQSNSMRSMSARLARSLTGNRVRVNSVLEPMLAIHREFHPKADAEVLNRAYATAERLHDGVFRKSGDPYITHP
LAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLEDLTADFGAEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPR
VLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYDEVVRLVADRAPSRDR
YLNQVIAQLTSTLKENHIDAEVMGRPKHYWSIYQKMIVRGKDFDEIFDLVGIRVLVDNVNNCYAAIGVVHSLYSAMPGRF
KDYISSPKFGVYQSLHTTVMGDGGKPLEVQVRTHEMHYNAEFGIAAHWRYKETKGKNSGEQAEIDQMAWMRQLLDWQKEA
ADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVDSTPVDFAYAVHTEVGHRCIGAKINGKLVALESKLKSGDRVEIFTSK
DQNAGPSRDWQDFVVSPRAKAKIRQWFAKERREEYLEVGRDALATEVQRGGLPMHRLFTAQSMKQVATELHYPDVDALYT
AIGSGSISAAHVANRLIAAFGDTEDAENTLVSRTPFSELVSSKSQVTDKNGILVEGSPDVMAKLAKCCMPVPGDEIFGFV
TRGGGVSVHRTDCTNADSLRNEPERLINVQWASEGGSVFAATLQLEALDREGLLMDLTRVINEQRVQVVAMSSHASDDHV
ATVRFTFSVSDTKQLGSLMTQLRNTEAVFDVYRVTSGG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=144, Percent_Identity=38.8888888888889, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1790082, Length=723, Percent_Identity=38.5892116182573, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1789147, Length=687, Percent_Identity=36.5356622998544, Blast_Score=504, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84421; Mature: 84290

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDKKTAKQSNSMRSMSARLARSLTGNRVRVNSVLEPMLAIHREFHPKADAEVLNRAYA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TAERLHDGVFRKSGDPYITHPLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLEDLTAD
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
FGAEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPRVLVIKVADRLHNMRTMRFL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCHHHEECC
PPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYDEVVRLVADRAPSRD
CCHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHH
RYLNQVIAQLTSTLKENHIDAEVMGRPKHYWSIYQKMIVRGKDFDEIFDLVGIRVLVDNV
HHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
NNCYAAIGVVHSLYSAMPGRFKDYISSPKFGVYQSLHTTVMGDGGKPLEVQVRTHEMHYN
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHEECCCCCCEEEEEEEEEEEEC
AEFGIAAHWRYKETKGKNSGEQAEIDQMAWMRQLLDWQKEAADPNEFLDSLRYDLTSKQI
CCCCEEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FVFTPKGDVVNLPVDSTPVDFAYAVHTEVGHRCIGAKINGKLVALESKLKSGDRVEIFTS
EEECCCCCEEECCCCCCCCCEEEEEHHHHCCEEECEEECCEEEEEEHHCCCCCEEEEEEC
KDQNAGPSRDWQDFVVSPRAKAKIRQWFAKERREEYLEVGRDALATEVQRGGLPMHRLFT
CCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHH
AQSMKQVATELHYPDVDALYTAIGSGSISAAHVANRLIAAFGDTEDAENTLVSRTPFSEL
HHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHCCEECCCCHHHH
VSSKSQVTDKNGILVEGSPDVMAKLAKCCMPVPGDEIFGFVTRGGGVSVHRTDCTNADSL
HCCHHHCCCCCCEEEECCHHHHHHHHHHCCCCCCCHHEEEEECCCCEEEEECCCCCCHHH
RNEPERLINVQWASEGGSVFAATLQLEALDREGLLMDLTRVINEQRVQVVAMSSHASDDH
CCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCC
VATVRFTFSVSDTKQLGSLMTQLRNTEAVFDVYRVTSGG
EEEEEEEEECCCHHHHHHHHHHHHCHHHHHHHHHCCCCC
>Mature Secondary Structure 
TQDKKTAKQSNSMRSMSARLARSLTGNRVRVNSVLEPMLAIHREFHPKADAEVLNRAYA
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TAERLHDGVFRKSGDPYITHPLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLEDLTAD
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
FGAEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPRVLVIKVADRLHNMRTMRFL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCHHHEECC
PPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYDEVVRLVADRAPSRD
CCHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHH
RYLNQVIAQLTSTLKENHIDAEVMGRPKHYWSIYQKMIVRGKDFDEIFDLVGIRVLVDNV
HHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
NNCYAAIGVVHSLYSAMPGRFKDYISSPKFGVYQSLHTTVMGDGGKPLEVQVRTHEMHYN
HHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHEECCCCCCEEEEEEEEEEEEC
AEFGIAAHWRYKETKGKNSGEQAEIDQMAWMRQLLDWQKEAADPNEFLDSLRYDLTSKQI
CCCCEEEEEEEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FVFTPKGDVVNLPVDSTPVDFAYAVHTEVGHRCIGAKINGKLVALESKLKSGDRVEIFTS
EEECCCCCEEECCCCCCCCCEEEEEHHHHCCEEECEEECCEEEEEEHHCCCCCEEEEEEC
KDQNAGPSRDWQDFVVSPRAKAKIRQWFAKERREEYLEVGRDALATEVQRGGLPMHRLFT
CCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHH
AQSMKQVATELHYPDVDALYTAIGSGSISAAHVANRLIAAFGDTEDAENTLVSRTPFSEL
HHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHCCEECCCCHHHH
VSSKSQVTDKNGILVEGSPDVMAKLAKCCMPVPGDEIFGFVTRGGGVSVHRTDCTNADSL
HCCHHHCCCCCCEEEECCHHHHHHHHHHCCCCCCCHHEEEEECCCCEEEEECCCCCCHHH
RNEPERLINVQWASEGGSVFAATLQLEALDREGLLMDLTRVINEQRVQVVAMSSHASDDH
CCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCC
VATVRFTFSVSDTKQLGSLMTQLRNTEAVFDVYRVTSGG
EEEEEEEEECCCHHHHHHHHHHHHCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9695918; 12948626 [H]