Click here to switch to the map view.

The map label for this gene is csd [H]

Identifier: 38233877

GI number: 38233877

Start: 1299675

End: 1300955

Strand: Reverse

Name: csd [H]

Synonym: DIP1292

Alternate gene names: 38233877

Gene position: 1300955-1299675 (Counterclockwise)

Preceding gene: 38233878

Following gene: 38233876

Centisome position: 52.28

GC content: 48.71

Gene sequence:

>1281_bases
ATGCACACACAATTCGTTACCGAGGCTGGGGAACTTAACTCTGAGGCTATCCGCGCGGAATTTCCAATTCTGGCGCGGAC
GGTACGTGGCGATAAGCCACTGATCTATTTAGATTCTGGAGCTACATCGCAGCGTCCACTGCGCGTGTGGAAGGCCGAAG
AACAATTCGTATTACATACGAATGCTCCGGTTCATAGGGGCGCATATCAACTGGCAGAAGAAGCTACCGATGCATACGAA
GAAGCGCGAGATGCCATCGCGAGCTTTGTTGGTGCTGATGGCTTTGAGCTTGCTTTTACTAAAAATGCCACGGAAGCACT
TAACTCAGTGGCGTATACGCTTGGCGACGACCGAGCTGGGCAGTACCAAGTAAAAGCTGGCGATACAGTGGTCGTGACTG
AACTTGAGCACCATGCTAATCTCGTCCCGTGGCAAGAATTGTGTCGTCGCACTGGTGCGACGCTTAAATGGTACAAGGTG
ACTCCCGATGGCCGTATCGATTTAGATTCACTAGAACTTGATGAATCAGTCAAGGTAGTAGCTTTTACTCATCAGTCCAA
TGTGACCGGAGCTGTCGCGCCGGTCGCTGAATTAGTCAAGCGAGCACGAGCAGTAGACGCACTTGTAATTTTGGATGCTT
GCCAGTCTGTTCCACATATGGCAGTCGATTTTCATGCTCTCGACGTAGATTTTGCCGCGTTTTCAGGGCATAAGATGTGT
GGTCCCTCAGGTGTGGGAGCATTATATGGCAAAGCAGAAATCTTAGAAAAGCTACCACCGTTTTTAACGGGTGGATCTAT
GATTTCTGTGGTGACTATGGAAGAAACTACATTTGCCGATATTCCGCAGCGATTCGAAGCTGGTACTCAGATGACGAGTC
AAGTAGTCGGCCTGGGTGAAGCCGTAAAGTTTCTTTCTGAAATTGGTATGGATAATATTTCGCGTCACGAACACGAAATC
ACGAAGTACGCCTTAGAGAAACTTTCGAAGATCAAAGGACTAGATATATATGGTCCTCGTACAGCCGAAAGCCGCGGGGC
AGCAGTTAGTTTTGCGGTAAAGAGAATACACCCTCACGATCTAGGCCAAGTGCTTGACGATCATGGCGTGTGCATTCGTG
TAGGGCACCATTGTGCGTGGCCAGTACACCGTGAACTTAATGCGCAATCTACGGCGCGGGCTTCATTCTATCTTTACAAC
ACTATCGACGAAGTTGATCGCTTAGTAGAGGCTATCGAAGCTGCAAAGAAGTTTTTCGGAGTGAGTGAGGAAGGAAAGTA
G

Upstream 100 bases:

>100_bases
ATTTTGTCCACGTGTTTGCCAATGGCCAGATCATTACCTCCGGCGGTCCTGAGCTAGCTGATGACCTAGAAGCAAACGGC
TACGACCGGTTCTTGGCATA

Downstream 100 bases:

>100_bases
TTCATGAATCTGGAATCAATGTATCAAGAAGTAATTCTTGATCATTATAAGAATCCTCTTCATGCTGGTCTGCGGGAATC
TTATGATGCAGAAGTGCATC

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MHTQFVTEAGELNSEAIRAEFPILARTVRGDKPLIYLDSGATSQRPLRVWKAEEQFVLHTNAPVHRGAYQLAEEATDAYE
EARDAIASFVGADGFELAFTKNATEALNSVAYTLGDDRAGQYQVKAGDTVVVTELEHHANLVPWQELCRRTGATLKWYKV
TPDGRIDLDSLELDESVKVVAFTHQSNVTGAVAPVAELVKRARAVDALVILDACQSVPHMAVDFHALDVDFAAFSGHKMC
GPSGVGALYGKAEILEKLPPFLTGGSMISVVTMEETTFADIPQRFEAGTQMTSQVVGLGEAVKFLSEIGMDNISRHEHEI
TKYALEKLSKIKGLDIYGPRTAESRGAAVSFAVKRIHPHDLGQVLDDHGVCIRVGHHCAWPVHRELNAQSTARASFYLYN
TIDEVDRLVEAIEAAKKFFGVSEEGK

Sequences:

>Translated_426_residues
MHTQFVTEAGELNSEAIRAEFPILARTVRGDKPLIYLDSGATSQRPLRVWKAEEQFVLHTNAPVHRGAYQLAEEATDAYE
EARDAIASFVGADGFELAFTKNATEALNSVAYTLGDDRAGQYQVKAGDTVVVTELEHHANLVPWQELCRRTGATLKWYKV
TPDGRIDLDSLELDESVKVVAFTHQSNVTGAVAPVAELVKRARAVDALVILDACQSVPHMAVDFHALDVDFAAFSGHKMC
GPSGVGALYGKAEILEKLPPFLTGGSMISVVTMEETTFADIPQRFEAGTQMTSQVVGLGEAVKFLSEIGMDNISRHEHEI
TKYALEKLSKIKGLDIYGPRTAESRGAAVSFAVKRIHPHDLGQVLDDHGVCIRVGHHCAWPVHRELNAQSTARASFYLYN
TIDEVDRLVEAIEAAKKFFGVSEEGK
>Mature_426_residues
MHTQFVTEAGELNSEAIRAEFPILARTVRGDKPLIYLDSGATSQRPLRVWKAEEQFVLHTNAPVHRGAYQLAEEATDAYE
EARDAIASFVGADGFELAFTKNATEALNSVAYTLGDDRAGQYQVKAGDTVVVTELEHHANLVPWQELCRRTGATLKWYKV
TPDGRIDLDSLELDESVKVVAFTHQSNVTGAVAPVAELVKRARAVDALVILDACQSVPHMAVDFHALDVDFAAFSGHKMC
GPSGVGALYGKAEILEKLPPFLTGGSMISVVTMEETTFADIPQRFEAGTQMTSQVVGLGEAVKFLSEIGMDNISRHEHEI
TKYALEKLSKIKGLDIYGPRTAESRGAAVSFAVKRIHPHDLGQVLDDHGVCIRVGHHCAWPVHRELNAQSTARASFYLYN
TIDEVDRLVEAIEAAKKFFGVSEEGK

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=304, Percent_Identity=26.6447368421053, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI156713448, Length=287, Percent_Identity=25.0871080139373, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787970, Length=410, Percent_Identity=41.7073170731707, Blast_Score=347, Evalue=8e-97,
Organism=Escherichia coli, GI1789175, Length=411, Percent_Identity=34.0632603406326, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI48994898, Length=281, Percent_Identity=32.0284697508897, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193211090, Length=384, Percent_Identity=27.6041666666667, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=285, Percent_Identity=23.1578947368421, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319831, Length=404, Percent_Identity=24.7524752475248, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129463, Length=302, Percent_Identity=29.1390728476821, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46618; Mature: 46618

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTQFVTEAGELNSEAIRAEFPILARTVRGDKPLIYLDSGATSQRPLRVWKAEEQFVLHT
CCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCEEEEEC
NAPVHRGAYQLAEEATDAYEEARDAIASFVGADGFELAFTKNATEALNSVAYTLGDDRAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCC
QYQVKAGDTVVVTELEHHANLVPWQELCRRTGATLKWYKVTPDGRIDLDSLELDESVKVV
EEEEECCCEEEEEEHHHCCCCCCHHHHHHHCCCEEEEEEECCCCCEECCCCCCCCCEEEE
AFTHQSNVTGAVAPVAELVKRARAVDALVILDACQSVPHMAVDFHALDVDFAAFSGHKMC
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEHHHCCCCCCC
GPSGVGALYGKAEILEKLPPFLTGGSMISVVTMEETTFADIPQRFEAGTQMTSQVVGLGE
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AVKFLSEIGMDNISRHEHEITKYALEKLSKIKGLDIYGPRTAESRGAAVSFAVKRIHPHD
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHCCHHH
LGQVLDDHGVCIRVGHHCAWPVHRELNAQSTARASFYLYNTIDEVDRLVEAIEAAKKFFG
HHHHHCCCCCEEEECCCCCCCHHHHCCCCCHHHEEEEEEHHHHHHHHHHHHHHHHHHHCC
VSEEGK
CCCCCC
>Mature Secondary Structure
MHTQFVTEAGELNSEAIRAEFPILARTVRGDKPLIYLDSGATSQRPLRVWKAEEQFVLHT
CCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCEEEEEC
NAPVHRGAYQLAEEATDAYEEARDAIASFVGADGFELAFTKNATEALNSVAYTLGDDRAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCC
QYQVKAGDTVVVTELEHHANLVPWQELCRRTGATLKWYKVTPDGRIDLDSLELDESVKVV
EEEEECCCEEEEEEHHHCCCCCCHHHHHHHCCCEEEEEEECCCCCEECCCCCCCCCEEEE
AFTHQSNVTGAVAPVAELVKRARAVDALVILDACQSVPHMAVDFHALDVDFAAFSGHKMC
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEHHHCCCCCCC
GPSGVGALYGKAEILEKLPPFLTGGSMISVVTMEETTFADIPQRFEAGTQMTSQVVGLGE
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AVKFLSEIGMDNISRHEHEITKYALEKLSKIKGLDIYGPRTAESRGAAVSFAVKRIHPHD
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHCCHHH
LGQVLDDHGVCIRVGHHCAWPVHRELNAQSTARASFYLYNTIDEVDRLVEAIEAAKKFFG
HHHHHCCCCCEEEECCCCCCCHHHHCCCCCHHHEEEEEEHHHHHHHHHHHHHHHHHHHCC
VSEEGK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]