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The map label for this gene is sbm [H]

Identifier: 38233857

GI number: 38233857

Start: 1278111

End: 1280318

Strand: Reverse

Name: sbm [H]

Synonym: DIP1272

Alternate gene names: 38233857

Gene position: 1280318-1278111 (Counterclockwise)

Preceding gene: 38233858

Following gene: 38233856

Centisome position: 51.45

GC content: 51.45

Gene sequence:

>2208_bases
ATGACTACTATCCCAAATTTTGCAGAGTATCCAGCATCTCCTGAGGACCAGAACGTTGCGGACTCAAGTGCGCTTGAGCA
ACAAGTTTGGACTACGCCAGAAGGCATTGATGTCAAGCGTGTATATAAGCGCAATGACCGAAATGACAGTGTGCCTGCGC
AGCAGCTGGACTCGTACCCAGGTATGGCGCCGTTTATGCGTGGACCATATCCAACCATGTACACCAATCAGCCATGGACA
ATTCGTCAGTACGCAGGATTTTCCACTGCTGCTGAATCAAATGCTTTCTATCGTCGTAACCTCGCAGCAGGCCAGAAAGG
TCTGTCAGTTGCTTTCGATTTGGCTACTCACCGTGGTTATGACTCAGACAATGAGCGCGTAGTCGGCGACGTTGGTATGG
CTGGCGTCGCAATCGATTCAATTTTGGATATGCGCCAACTTTTTGAAGGCATAGACCTTGGAAAAGTATCTGTCTCCATG
ACGATGAATGGCGCTGTGCTTCCAGTGCTTGCTCTCTACATCGTCGTTGCGGAAGAACAAGGTGTCGCACCTGAGCAGCT
AGCCGGAACAATTCAGAATGACATTCTGAAAGAGTTCATGGTTCGTAACACCTATATCTACCCACCAAAGCCTTCAATGC
GCATCATTTCGAATATTTTCGAATACACATCATTGAAGATGCCTCGGTTTAACTCCATTTCAATTTCGGGCTACCACATT
CAGGAAGCCGGTGCGACTGCTGACCTCGAGCTAGCTTATACACTTGCTGATGGTATTGAGTACATCCGCGCTGGTAAAGG
CGTTGGCCTAGATGTTGATAAGTTTGCTCCTCGACTTTCCTTCTTCTGGGGTATTTCCATGAATACGTTCATGGAAATTG
CAAAACTTCGCGCTGGCCGTCTACTTTGGAGCGAACTGGTCGCTAAATTCGATCCAAAGAACCCTAAATCTCAGTCGTTG
CGTACCCACTCACAGACTTCTGGTTGGTCGCTGACCGCCCAAGATGTCTACAACAATGTGGCACGTACCGCTATCGAGGC
AATGGGTGCAACCCAGGGCCATACGCAGTCTTTGCACACCAATGCTCTTGACGAAGCTTTGGCACTGCCAACGGATTTCT
CTGCACGTATCGCGCGTAACACGCAGCTGCTGCTTCAACAAGAATCTGGGACCACGGCACCAGTTGATCCATGGGCCGGT
TCGTATTACATCGAGTGGCTCACTGAGCAGCTAGCTGAGCGAGCTCGTGCCCACATCGAAGAAGTTGAGAACGCTGGCGG
AATGGCTCAGGCCACGATCGAAGGTATTCCAAAACTCCGCATCGAAGAATCCGCTGCACGTACTCAGGCGCGTATTGATT
CCGGCCGTCAAGCTTTGATTGGTGTGAACAAATATGTCGTCGAAGAGGACGAGCAGATCGAAGTTCTCAAGGTCGACAAC
ACCAAGGTACGTGCGGAGCAACTAGCAAAGCTTGAGCAGTTGCGCGCTGAGCGCGATCAAGCTGAGGTCGATCGATGCCT
GAAAGCACTCACCGAAGCCGCTCGCATCGAAGAAAAGGAACCAGGCAACCTAGATCAGAACTTGCTTAAACTAGCAGTCG
ATTGCGCTCGCGCTAAGGCAACTGTGGGTGAGATTTCTGACGCACTCGAAGAGGTATTCGGCCGTCACGAGGCTGAAATT
CGTACGCTCTCCGGCGTGTACAAGGACGAAGTTGGAAAGGAGGGCACTGTGGGTAATGTTTCTAAGGCAATCGCTATGGC
TGATGCTTTTGAAACTGAGGAAGGCCGCCGTCCTCGTATCTTCTTGGCCAAGATGGGGCAGGATGGTCACGATCGCGGAC
AAAAAGTTGTTGCATCTGCATATGCTGACCTCGGCATGGATGTCGATGTCGGACCACTGTTCCAGACCCCAGCAGAGGCA
GCGCGTGCCGCGGTTGATGCGGACGTTCACGTTGTCGGCGTTTCTTCCCTAGCTGCAGGTCACCTGACCTTGGTTCCAGC
TCTCAAGGAAGAGCTTGCCAAGTTGGGCCGTGAAGACATCATGGTCGTCGTTGGTGGCGTTATCCCGCCAGGAGATTTCC
AAGAACTTTACGACGATGGTGCAGTCGCTATTTATCCTCCAGGAACCGTTATCGCAGATGCTGCGATCGATATGCTGGAA
AAGTTGGCGGCTAACCTTGGTATCGACCTCAAGGTCGACGAAGCGTAA

Upstream 100 bases:

>100_bases
GATCGCCAGGACATGATTTCGAACCGGATGACTATTTGAACATGAAGATCGACGCAGCTACGAAGCTCGATGGTCTACTG
AAGAAGTTGGGAGCTTAACC

Downstream 100 bases:

>100_bases
TTAGTTCGTTTCAACACCATGACTATGTTCACCGGCCGCTCGTTTGAGTGGCCGGTGAACGCGTATAAGCAGGAAGGTTT
CACAAAATGTCTGCAGACAA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MTTIPNFAEYPASPEDQNVADSSALEQQVWTTPEGIDVKRVYKRNDRNDSVPAQQLDSYPGMAPFMRGPYPTMYTNQPWT
IRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDNERVVGDVGMAGVAIDSILDMRQLFEGIDLGKVSVSM
TMNGAVLPVLALYIVVAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYHI
QEAGATADLELAYTLADGIEYIRAGKGVGLDVDKFAPRLSFFWGISMNTFMEIAKLRAGRLLWSELVAKFDPKNPKSQSL
RTHSQTSGWSLTAQDVYNNVARTAIEAMGATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTTAPVDPWAG
SYYIEWLTEQLAERARAHIEEVENAGGMAQATIEGIPKLRIEESAARTQARIDSGRQALIGVNKYVVEEDEQIEVLKVDN
TKVRAEQLAKLEQLRAERDQAEVDRCLKALTEAARIEEKEPGNLDQNLLKLAVDCARAKATVGEISDALEEVFGRHEAEI
RTLSGVYKDEVGKEGTVGNVSKAIAMADAFETEEGRRPRIFLAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAEA
ARAAVDADVHVVGVSSLAAGHLTLVPALKEELAKLGREDIMVVVGGVIPPGDFQELYDDGAVAIYPPGTVIADAAIDMLE
KLAANLGIDLKVDEA

Sequences:

>Translated_735_residues
MTTIPNFAEYPASPEDQNVADSSALEQQVWTTPEGIDVKRVYKRNDRNDSVPAQQLDSYPGMAPFMRGPYPTMYTNQPWT
IRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDNERVVGDVGMAGVAIDSILDMRQLFEGIDLGKVSVSM
TMNGAVLPVLALYIVVAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYHI
QEAGATADLELAYTLADGIEYIRAGKGVGLDVDKFAPRLSFFWGISMNTFMEIAKLRAGRLLWSELVAKFDPKNPKSQSL
RTHSQTSGWSLTAQDVYNNVARTAIEAMGATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTTAPVDPWAG
SYYIEWLTEQLAERARAHIEEVENAGGMAQATIEGIPKLRIEESAARTQARIDSGRQALIGVNKYVVEEDEQIEVLKVDN
TKVRAEQLAKLEQLRAERDQAEVDRCLKALTEAARIEEKEPGNLDQNLLKLAVDCARAKATVGEISDALEEVFGRHEAEI
RTLSGVYKDEVGKEGTVGNVSKAIAMADAFETEEGRRPRIFLAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAEA
ARAAVDADVHVVGVSSLAAGHLTLVPALKEELAKLGREDIMVVVGGVIPPGDFQELYDDGAVAIYPPGTVIADAAIDMLE
KLAANLGIDLKVDEA
>Mature_734_residues
TTIPNFAEYPASPEDQNVADSSALEQQVWTTPEGIDVKRVYKRNDRNDSVPAQQLDSYPGMAPFMRGPYPTMYTNQPWTI
RQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDNERVVGDVGMAGVAIDSILDMRQLFEGIDLGKVSVSMT
MNGAVLPVLALYIVVAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYHIQ
EAGATADLELAYTLADGIEYIRAGKGVGLDVDKFAPRLSFFWGISMNTFMEIAKLRAGRLLWSELVAKFDPKNPKSQSLR
THSQTSGWSLTAQDVYNNVARTAIEAMGATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTTAPVDPWAGS
YYIEWLTEQLAERARAHIEEVENAGGMAQATIEGIPKLRIEESAARTQARIDSGRQALIGVNKYVVEEDEQIEVLKVDNT
KVRAEQLAKLEQLRAERDQAEVDRCLKALTEAARIEEKEPGNLDQNLLKLAVDCARAKATVGEISDALEEVFGRHEAEIR
TLSGVYKDEVGKEGTVGNVSKAIAMADAFETEEGRRPRIFLAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAEAA
RAAVDADVHVVGVSSLAAGHLTLVPALKEELAKLGREDIMVVVGGVIPPGDFQELYDDGAVAIYPPGTVIADAAIDMLEK
LAANLGIDLKVDEA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=702, Percent_Identity=61.965811965812, Blast_Score=889, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=696, Percent_Identity=60.0574712643678, Blast_Score=820, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=725, Percent_Identity=61.9310344827586, Blast_Score=914, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 80177; Mature: 80046

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIPNFAEYPASPEDQNVADSSALEQQVWTTPEGIDVKRVYKRNDRNDSVPAQQLDSYP
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHCCC
GMAPFMRGPYPTMYTNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGY
CCCCCCCCCCCCCCCCCCEEEHHHCCCCCHHCCCHHHHHHHHCCCCCCEEEEEHHHHCCC
DSDNERVVGDVGMAGVAIDSILDMRQLFEGIDLGKVSVSMTMNGAVLPVLALYIVVAEEQ
CCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHEECCC
GVAPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYHI
CCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCEEE
QEAGATADLELAYTLADGIEYIRAGKGVGLDVDKFAPRLSFFWGISMNTFMEIAKLRAGR
CCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHHHHH
LLWSELVAKFDPKNPKSQSLRTHSQTSGWSLTAQDVYNNVARTAIEAMGATQGHTQSLHT
HHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHH
NALDEALALPTDFSARIARNTQLLLQQESGTTAPVDPWAGSYYIEWLTEQLAERARAHIE
HHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EVENAGGMAQATIEGIPKLRIEESAARTQARIDSGRQALIGVNKYVVEEDEQIEVLKVDN
HHHHCCCEEHHHHHCCCCEEEHHHHHHHHHHHHCCCEEEEECHHHEECCCCCEEEEEECC
TKVRAEQLAKLEQLRAERDQAEVDRCLKALTEAARIEEKEPGNLDQNLLKLAVDCARAKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
TVGEISDALEEVFGRHEAEIRTLSGVYKDEVGKEGTVGNVSKAIAMADAFETEEGRRPRI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
FLAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAEAARAAVDADVHVVGVSSLAAG
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHCCC
HLTLVPALKEELAKLGREDIMVVVGGVIPPGDFQELYDDGAVAIYPPGTVIADAAIDMLE
CCEEHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCEEEECCCHHHHHHHHHHHH
KLAANLGIDLKVDEA
HHHHHCCCEEEECCC
>Mature Secondary Structure 
TTIPNFAEYPASPEDQNVADSSALEQQVWTTPEGIDVKRVYKRNDRNDSVPAQQLDSYP
CCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHCCC
GMAPFMRGPYPTMYTNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGY
CCCCCCCCCCCCCCCCCCEEEHHHCCCCCHHCCCHHHHHHHHCCCCCCEEEEEHHHHCCC
DSDNERVVGDVGMAGVAIDSILDMRQLFEGIDLGKVSVSMTMNGAVLPVLALYIVVAEEQ
CCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHEECCC
GVAPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYHI
CCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCEEE
QEAGATADLELAYTLADGIEYIRAGKGVGLDVDKFAPRLSFFWGISMNTFMEIAKLRAGR
CCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHHHHH
LLWSELVAKFDPKNPKSQSLRTHSQTSGWSLTAQDVYNNVARTAIEAMGATQGHTQSLHT
HHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHH
NALDEALALPTDFSARIARNTQLLLQQESGTTAPVDPWAGSYYIEWLTEQLAERARAHIE
HHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EVENAGGMAQATIEGIPKLRIEESAARTQARIDSGRQALIGVNKYVVEEDEQIEVLKVDN
HHHHCCCEEHHHHHCCCCEEEHHHHHHHHHHHHCCCEEEEECHHHEECCCCCEEEEEECC
TKVRAEQLAKLEQLRAERDQAEVDRCLKALTEAARIEEKEPGNLDQNLLKLAVDCARAKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
TVGEISDALEEVFGRHEAEIRTLSGVYKDEVGKEGTVGNVSKAIAMADAFETEEGRRPRI
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
FLAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAEAARAAVDADVHVVGVSSLAAG
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHCCC
HLTLVPALKEELAKLGREDIMVVVGGVIPPGDFQELYDDGAVAIYPPGTVIADAAIDMLE
CCEEHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCCCEEEECCCHHHHHHHHHHHH
KLAANLGIDLKVDEA
HHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]