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The map label for this gene is mutA [H]

Identifier: 38233858

GI number: 38233858

Start: 1280321

End: 1282132

Strand: Reverse

Name: mutA [H]

Synonym: DIP1273

Alternate gene names: 38233858

Gene position: 1282132-1280321 (Counterclockwise)

Preceding gene: 38233861

Following gene: 38233857

Centisome position: 51.52

GC content: 50.39

Gene sequence:

>1812_bases
GTGACTGACACACGAATCGCCCAAACTGAAGAGCTCGAGGCTCAGCGACAGGAATGGTATAAAGCTGTTGCTAAAGTTTT
CGCTCGCGTACAGAAAAAAGATGTTGCTGACATTCCGCTCGATATTTGGCAGCGTCTTATTCGCACCACGTACGATGACA
TCAAAGTCAACCCTTTGTATAACCGTGCAGACGAATTAGAAGAAACTCAGATTCCAGGTGCATTCCCATATACACGTGGT
TTTGCTGGCGCAGGGCAAGAGGAAGGCGTCGGCTGGGGAGTAACCGAATCGTTTGGTTCGTCTTCTTCTAACAAAGATGT
TATTCATGCCCTTGACAATGGCACAACCGATATTGTTGTTTATGGAGAAGCCAACATTGAAGAGCTCCTCAAAGAGGTGC
TTTTTCAGTATGCCCCAGTTCGTCTGAACTCTGGTGTCGCGACTGAAGAAATGGCTAATCGTCTTTTCTCGATGGTTGAC
GCTCAGGGTACCGTGCCACGAAGCATCGAGCTTGGAGCATCGCCACTTAGCTCCATGATCGATGGGTCAGCCTCTGTTGA
CCTAGATACCGCGATTAACCTAGCTGTTCGCGCATCTGAGCGTGAAAACACTCGCGCGATCTTGGTCGATGCGGTTTCCT
TCTCAAATCAAGGTGCTACGGATGCGCAGCAGATTGGTCTCGCGCTAGCAGCCGGCGCAGAATATCTCCGTGGCTTGGTA
GCTGCAGGGCTCTCTACAGAGCAAGCTTTACAGCAGCTTTCATTCCGTTATGCAATTACGGACGATCAGTTTGCTCAAAT
TTCTAAATTGCGAGCAGGCCGAGCACTCTGGGCTCGAGTTGCAGAAATTCTTGGCGCTAAAGAACTCGGAAGTGCTCCAC
AACATGCACTGACGGCTCCTGTCATGTTTACTCAGCGTGATCCTTGGGTGAACATGTTGCGTTCCACGGTGGCAGCATTC
GCTGCAGGCGTTGGTGGCGCCAAAGACGTAGAAGTTTTGTGCTTTGACTGGGCAATTGCAGGCGGAATTCCAAATGTTTC
GCGCAGCTTCGCTCACCGTATTGCGCGTAATACGAACCTTCTGCTTCTCGAAGAATCTCACCTAGGTCATGTGATTGACC
CAGCTGGTGGATCGTATTACGTCGAAAGTCTAACTTCATCGATCATCGAGAAGGCATGGAAGGTCTTCACTGATATCGAA
GCAGCTGGTGGCTTCCTTGTAGCCGTCGAAAACGGTTCCGTTAAAGAAATGCTTGACGATGCTCATGAGCGAGTACGCCG
TGATATTGCGCATCGAATCAAGAAGGTCACCGCAATCAACGAATTTCCAAATCTCGCAGAAGCGCCGTTGCCGGCGGAGC
TTCGCGTAGAGCCAACCTGTGTACGCCGTTGGGCTGCAGAATTCGAGTCGTTCCGTAACCGCTCGGATGTTTTCATGGAG
GTCAACGGAAAACGGCCACAAGCTGTACTCATCCCACTAGGCCCACTTGCAAAGCACAATATTCGTACTGGTTTTATTAC
CAATCTTCTTGGTACAGGCGGAATTGAGGCTTTAAACCCAGGGCAGGTTGTTCCAGGAACCCCTGAGTTTGCTGAGGCTG
CGGCTAGCGCCAAGATTGCAGTCATTTGTGGCACGGACGCTGAATACGATGCAACTGGTGCTGAGGCATTGGCTGAACTG
CGCAAGCTCGGTGTAGAAACCATTTTGTTAGCGGGATCGCCAGGACATGATTTCGAACCGGATGACTATTTGAACATGAA
GATCGACGCAGCTACGAAGCTCGATGGTCTACTGAAGAAGTTGGGAGCTTAA

Upstream 100 bases:

>100_bases
ACATAGGTGCGTGGACGCATAAAGTTGAGACGATTCATTTGTCCGTTTTATATTTATGCGCTTCTCGTTCCTTCTACTGT
GAGGGGAGTGGGTTCCACTC

Downstream 100 bases:

>100_bases
CCATGACTACTATCCCAAATTTTGCAGAGTATCCAGCATCTCCTGAGGACCAGAACGTTGCGGACTCAAGTGCGCTTGAG
CAACAAGTTTGGACTACGCC

Product: putative methylmalonyl-CoA mutase small subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MTDTRIAQTEELEAQRQEWYKAVAKVFARVQKKDVADIPLDIWQRLIRTTYDDIKVNPLYNRADELEETQIPGAFPYTRG
FAGAGQEEGVGWGVTESFGSSSSNKDVIHALDNGTTDIVVYGEANIEELLKEVLFQYAPVRLNSGVATEEMANRLFSMVD
AQGTVPRSIELGASPLSSMIDGSASVDLDTAINLAVRASERENTRAILVDAVSFSNQGATDAQQIGLALAAGAEYLRGLV
AAGLSTEQALQQLSFRYAITDDQFAQISKLRAGRALWARVAEILGAKELGSAPQHALTAPVMFTQRDPWVNMLRSTVAAF
AAGVGGAKDVEVLCFDWAIAGGIPNVSRSFAHRIARNTNLLLLEESHLGHVIDPAGGSYYVESLTSSIIEKAWKVFTDIE
AAGGFLVAVENGSVKEMLDDAHERVRRDIAHRIKKVTAINEFPNLAEAPLPAELRVEPTCVRRWAAEFESFRNRSDVFME
VNGKRPQAVLIPLGPLAKHNIRTGFITNLLGTGGIEALNPGQVVPGTPEFAEAAASAKIAVICGTDAEYDATGAEALAEL
RKLGVETILLAGSPGHDFEPDDYLNMKIDAATKLDGLLKKLGA

Sequences:

>Translated_603_residues
MTDTRIAQTEELEAQRQEWYKAVAKVFARVQKKDVADIPLDIWQRLIRTTYDDIKVNPLYNRADELEETQIPGAFPYTRG
FAGAGQEEGVGWGVTESFGSSSSNKDVIHALDNGTTDIVVYGEANIEELLKEVLFQYAPVRLNSGVATEEMANRLFSMVD
AQGTVPRSIELGASPLSSMIDGSASVDLDTAINLAVRASERENTRAILVDAVSFSNQGATDAQQIGLALAAGAEYLRGLV
AAGLSTEQALQQLSFRYAITDDQFAQISKLRAGRALWARVAEILGAKELGSAPQHALTAPVMFTQRDPWVNMLRSTVAAF
AAGVGGAKDVEVLCFDWAIAGGIPNVSRSFAHRIARNTNLLLLEESHLGHVIDPAGGSYYVESLTSSIIEKAWKVFTDIE
AAGGFLVAVENGSVKEMLDDAHERVRRDIAHRIKKVTAINEFPNLAEAPLPAELRVEPTCVRRWAAEFESFRNRSDVFME
VNGKRPQAVLIPLGPLAKHNIRTGFITNLLGTGGIEALNPGQVVPGTPEFAEAAASAKIAVICGTDAEYDATGAEALAEL
RKLGVETILLAGSPGHDFEPDDYLNMKIDAATKLDGLLKKLGA
>Mature_602_residues
TDTRIAQTEELEAQRQEWYKAVAKVFARVQKKDVADIPLDIWQRLIRTTYDDIKVNPLYNRADELEETQIPGAFPYTRGF
AGAGQEEGVGWGVTESFGSSSSNKDVIHALDNGTTDIVVYGEANIEELLKEVLFQYAPVRLNSGVATEEMANRLFSMVDA
QGTVPRSIELGASPLSSMIDGSASVDLDTAINLAVRASERENTRAILVDAVSFSNQGATDAQQIGLALAAGAEYLRGLVA
AGLSTEQALQQLSFRYAITDDQFAQISKLRAGRALWARVAEILGAKELGSAPQHALTAPVMFTQRDPWVNMLRSTVAAFA
AGVGGAKDVEVLCFDWAIAGGIPNVSRSFAHRIARNTNLLLLEESHLGHVIDPAGGSYYVESLTSSIIEKAWKVFTDIEA
AGGFLVAVENGSVKEMLDDAHERVRRDIAHRIKKVTAINEFPNLAEAPLPAELRVEPTCVRRWAAEFESFRNRSDVFMEV
NGKRPQAVLIPLGPLAKHNIRTGFITNLLGTGGIEALNPGQVVPGTPEFAEAAASAKIAVICGTDAEYDATGAEALAELR
KLGVETILLAGSPGHDFEPDDYLNMKIDAATKLDGLLKKLGA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=240, Percent_Identity=31.6666666666667, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1789284, Length=244, Percent_Identity=34.8360655737705, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25144500, Length=252, Percent_Identity=31.3492063492063, Blast_Score=122, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 65119; Mature: 64988

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTRIAQTEELEAQRQEWYKAVAKVFARVQKKDVADIPLDIWQRLIRTTYDDIKVNPLY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCC
NRADELEETQIPGAFPYTRGFAGAGQEEGVGWGVTESFGSSSSNKDVIHALDNGTTDIVV
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCCEEEEE
YGEANIEELLKEVLFQYAPVRLNSGVATEEMANRLFSMVDAQGTVPRSIELGASPLSSMI
ECCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHH
DGSASVDLDTAINLAVRASERENTRAILVDAVSFSNQGATDAQQIGLALAAGAEYLRGLV
CCCCCEEHHHHHEEEEECCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
AAGLSTEQALQQLSFRYAITDDQFAQISKLRAGRALWARVAEILGAKELGSAPQHALTAP
HHCCCHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHCCC
VMFTQRDPWVNMLRSTVAAFAAGVGGAKDVEVLCFDWAIAGGIPNVSRSFAHRIARNTNL
EEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHCCCCE
LLLEESHLGHVIDPAGGSYYVESLTSSIIEKAWKVFTDIEAAGGFLVAVENGSVKEMLDD
EEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHH
AHERVRRDIAHRIKKVTAINEFPNLAEAPLPAELRVEPTCVRRWAAEFESFRNRSDVFME
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
VNGKRPQAVLIPLGPLAKHNIRTGFITNLLGTGGIEALNPGQVVPGTPEFAEAAASAKIA
ECCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCEEE
VICGTDAEYDATGAEALAELRKLGVETILLAGSPGHDFEPDDYLNMKIDAATKLDGLLKK
EEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHH
LGA
HCC
>Mature Secondary Structure 
TDTRIAQTEELEAQRQEWYKAVAKVFARVQKKDVADIPLDIWQRLIRTTYDDIKVNPLY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCC
NRADELEETQIPGAFPYTRGFAGAGQEEGVGWGVTESFGSSSSNKDVIHALDNGTTDIVV
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCCEEEEE
YGEANIEELLKEVLFQYAPVRLNSGVATEEMANRLFSMVDAQGTVPRSIELGASPLSSMI
ECCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHH
DGSASVDLDTAINLAVRASERENTRAILVDAVSFSNQGATDAQQIGLALAAGAEYLRGLV
CCCCCEEHHHHHEEEEECCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
AAGLSTEQALQQLSFRYAITDDQFAQISKLRAGRALWARVAEILGAKELGSAPQHALTAP
HHCCCHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHCCC
VMFTQRDPWVNMLRSTVAAFAAGVGGAKDVEVLCFDWAIAGGIPNVSRSFAHRIARNTNL
EEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHCCCCE
LLLEESHLGHVIDPAGGSYYVESLTSSIIEKAWKVFTDIEAAGGFLVAVENGSVKEMLDD
EEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHH
AHERVRRDIAHRIKKVTAINEFPNLAEAPLPAELRVEPTCVRRWAAEFESFRNRSDVFME
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
VNGKRPQAVLIPLGPLAKHNIRTGFITNLLGTGGIEALNPGQVVPGTPEFAEAAASAKIA
ECCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCEEE
VICGTDAEYDATGAEALAELRKLGVETILLAGSPGHDFEPDDYLNMKIDAATKLDGLLKK
EEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHH
LGA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]