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The map label for this gene is helD [H]

Identifier: 38233746

GI number: 38233746

Start: 1144967

End: 1147279

Strand: Reverse

Name: helD [H]

Synonym: DIP1156

Alternate gene names: 38233746

Gene position: 1147279-1144967 (Counterclockwise)

Preceding gene: 38233747

Following gene: 38233741

Centisome position: 46.1

GC content: 49.89

Gene sequence:

>2313_bases
ATGATTCACAGCTTGTTCTTTCATAACAACACGAAAGGCACGCCATCAATGAAACACCCCATCGATTCAATCTCTGCAGA
GATTGAAGACGAACAGGCGTACGTCGATAAGCTTTTTGGAAAACTTGACGAGGAAGTAGTAGCAGCCAATCAGCGTCTCA
ACGACGTTATGCTGCACGTCGACCCTGCTAACCCCGATGCAGAAGCTTTGGTCAGACGTGAAACTGAATATCACGCATTG
AACGAGAAAATCGATCGACTCAATATTGCCCAATTGGGATTAGTTTTTGGCCGAATCGACGTAACCGCCCAGCGCACAGA
CCTCATCGATAATTGGGTTGCAGGGACAGACAACGTCGATCGTCGTTATATCGGACGCATGGGGCTTGATGATCGCCAAA
ATGATTACCGGACCCTCCTATTGGACTGGCGTGCGCCATTAGCCCGACCGTTTTACCTAGCCACTACTGCACATCCCGAA
GGTGTTTTGCATCGTAGACACATCCGAACTCAAGGTCGTTCAGTCGTAGGTGTAGATGATGAAGTGCTCAGTGGTGTTAG
TGCGGAAAGCGCCCACAGTGAGCGTGCAGATGTAGTGAGCGAAACCGCTTTGTACCGCGCTATGTGTTCTGCACGCACAG
GTCACATGCATTCCATCGTAGAAACCATTCAACGCGAACAGGATGACATTATTCGCGACCCAACTCGTGGAGTCATGGTT
GTTGAAGGCGGACCTGGTACAGGTAAAACTGCTGTAGCGCTACACCGAGTAGCATACCTTCTGTATACATGGCGCGATCA
ACTCGCAAAAACTGGTGTACTCATCGTGGGGCCAAACCGTAGCTTTTTGGACTATATCTCTCGAGTTCTTCCAGAATTAG
GCGAGACTGGTGTCGTGTTGTCAACCGTCGGGGACCTCTACCCTGGCATCAGCGGCACCGCTGTTGAAGATTCACTCGCT
CGTGAGATTAAAGGCAGTGAGGAAATGGTCACTGTCCTCCGGCGACTGGTACAAGAATATCAACAGATTCCTTCAGAGCC
ATTCACTATCAAAATCGATGGCCTAGAACTCACAGTCACTCCAGACATAGTGAAAAAAGCACGAACACGAGCTCGCAGAT
CGAGACGACCTCACAATGAAGCTAGGCCACTATTTACTGAGCACTTGACTGAGCTGCTTTCACATCAAATGGCCGACCTT
ATTGGTGCCGACCCCATGGGGGGAAAGAATTTGCTCTCAGCTGCCGATATTGCTCAGTTACATGATGAACTGCTAGAAGA
ATCCGTTGTTGCCGAGATAGTCGATGAGTACTGGCCGCAACTTACCCCCCAGGACACATTAACGAGTCTGCTCGAATCTC
AAAATATGATCAGCACAGTTGCCTACGACTACGACGAGGAAACTCAAGAAGCTCTATGGAGACAACAAGGTAGCCCCTGG
GCCGCCTCAGATGCAGCGTTGCTGGACGAACTAGCTGTCATCATCGGGGTACCGGATCCAGAAAAAGAACGAGCCGAGCA
AGAAAAAGCGTGGCGCGAACAAATCAAAGACGCTCAGGATGCGCTAGAAATCCTCACCGGTTCAGCTAACACAGATCTAG
ATGATGAATCCGACGCTGAAATCCTTTCTGCTCATGATGTCATCGATGCAGAAACATTGGCTCGACGCCAAGAAGTCCGT
GATATTAGATCAACAGCTCAACGAGCACGAGAAGATCTAGCGTGGGCGTACGGCCATGTCATCGTCGACGAAGCTCAAGA
GCTCACTCCCATGGAATGGCGAATGGTCATGCGCCGCTGTCCATCACGATGGATGACACTTGTAGGCGATACCGCACAAA
CTAGTTCCCCAGCCGGAGTTGACTCTTGGGCTGAAGCCCTAGAGCCGTTTGTTAGCGGCCGCTATGTAACCCACCACCTC
ACTATTAACTACCGCACTCCAGCAGAAATCATGGAATGGGCGAATAAAGTCCTGCACGTTTTTGCACCCGATGCAGTCGG
AAGCACCGCTCTACGACAATCAGGCACACCAGTACGATTTGAAAATAGTGATGCACATGCAATTGAGATCGCACAAAAGC
TACGCCAAGATGATCCATCACGCCTTACTGCCATCATCGGACCAGACAGCATGGCGAACAATGAGATTTTCGGCGTTTCA
GATATCAAAGGGTTGGAATACGACCATGTCGTTGTGACCAACCCAATCGATATTGTTAATGGATCCCCACAGGGATGGCA
AGACCTTTATGTTGCACTAACCCGGGCCACACAGTCCCTTTGTATTATCGGCGATCTTCCTGAATTGTCATAA

Upstream 100 bases:

>100_bases
ACGAGTGCTGGCTTTATCACCTAACGAGAGACGGTGTTAAAGCCAGCACTCGCATTTCCCCACTACAACGACTAGATGCA
AGCCGTAGTTGAGAAGCGGT

Downstream 100 bases:

>100_bases
AAAAATGGTGCCATGCGAAAACGCATGGCACCATTGTGTATTTGCTCTTTAGCTTACGGTGTGAACAATCATGACGTCAC
AATCCGACTGACGTGCAACA

Product: putative helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 770; Mature: 770

Protein sequence:

>770_residues
MIHSLFFHNNTKGTPSMKHPIDSISAEIEDEQAYVDKLFGKLDEEVVAANQRLNDVMLHVDPANPDAEALVRRETEYHAL
NEKIDRLNIAQLGLVFGRIDVTAQRTDLIDNWVAGTDNVDRRYIGRMGLDDRQNDYRTLLLDWRAPLARPFYLATTAHPE
GVLHRRHIRTQGRSVVGVDDEVLSGVSAESAHSERADVVSETALYRAMCSARTGHMHSIVETIQREQDDIIRDPTRGVMV
VEGGPGTGKTAVALHRVAYLLYTWRDQLAKTGVLIVGPNRSFLDYISRVLPELGETGVVLSTVGDLYPGISGTAVEDSLA
REIKGSEEMVTVLRRLVQEYQQIPSEPFTIKIDGLELTVTPDIVKKARTRARRSRRPHNEARPLFTEHLTELLSHQMADL
IGADPMGGKNLLSAADIAQLHDELLEESVVAEIVDEYWPQLTPQDTLTSLLESQNMISTVAYDYDEETQEALWRQQGSPW
AASDAALLDELAVIIGVPDPEKERAEQEKAWREQIKDAQDALEILTGSANTDLDDESDAEILSAHDVIDAETLARRQEVR
DIRSTAQRAREDLAWAYGHVIVDEAQELTPMEWRMVMRRCPSRWMTLVGDTAQTSSPAGVDSWAEALEPFVSGRYVTHHL
TINYRTPAEIMEWANKVLHVFAPDAVGSTALRQSGTPVRFENSDAHAIEIAQKLRQDDPSRLTAIIGPDSMANNEIFGVS
DIKGLEYDHVVVTNPIDIVNGSPQGWQDLYVALTRATQSLCIIGDLPELS

Sequences:

>Translated_770_residues
MIHSLFFHNNTKGTPSMKHPIDSISAEIEDEQAYVDKLFGKLDEEVVAANQRLNDVMLHVDPANPDAEALVRRETEYHAL
NEKIDRLNIAQLGLVFGRIDVTAQRTDLIDNWVAGTDNVDRRYIGRMGLDDRQNDYRTLLLDWRAPLARPFYLATTAHPE
GVLHRRHIRTQGRSVVGVDDEVLSGVSAESAHSERADVVSETALYRAMCSARTGHMHSIVETIQREQDDIIRDPTRGVMV
VEGGPGTGKTAVALHRVAYLLYTWRDQLAKTGVLIVGPNRSFLDYISRVLPELGETGVVLSTVGDLYPGISGTAVEDSLA
REIKGSEEMVTVLRRLVQEYQQIPSEPFTIKIDGLELTVTPDIVKKARTRARRSRRPHNEARPLFTEHLTELLSHQMADL
IGADPMGGKNLLSAADIAQLHDELLEESVVAEIVDEYWPQLTPQDTLTSLLESQNMISTVAYDYDEETQEALWRQQGSPW
AASDAALLDELAVIIGVPDPEKERAEQEKAWREQIKDAQDALEILTGSANTDLDDESDAEILSAHDVIDAETLARRQEVR
DIRSTAQRAREDLAWAYGHVIVDEAQELTPMEWRMVMRRCPSRWMTLVGDTAQTSSPAGVDSWAEALEPFVSGRYVTHHL
TINYRTPAEIMEWANKVLHVFAPDAVGSTALRQSGTPVRFENSDAHAIEIAQKLRQDDPSRLTAIIGPDSMANNEIFGVS
DIKGLEYDHVVVTNPIDIVNGSPQGWQDLYVALTRATQSLCIIGDLPELS
>Mature_770_residues
MIHSLFFHNNTKGTPSMKHPIDSISAEIEDEQAYVDKLFGKLDEEVVAANQRLNDVMLHVDPANPDAEALVRRETEYHAL
NEKIDRLNIAQLGLVFGRIDVTAQRTDLIDNWVAGTDNVDRRYIGRMGLDDRQNDYRTLLLDWRAPLARPFYLATTAHPE
GVLHRRHIRTQGRSVVGVDDEVLSGVSAESAHSERADVVSETALYRAMCSARTGHMHSIVETIQREQDDIIRDPTRGVMV
VEGGPGTGKTAVALHRVAYLLYTWRDQLAKTGVLIVGPNRSFLDYISRVLPELGETGVVLSTVGDLYPGISGTAVEDSLA
REIKGSEEMVTVLRRLVQEYQQIPSEPFTIKIDGLELTVTPDIVKKARTRARRSRRPHNEARPLFTEHLTELLSHQMADL
IGADPMGGKNLLSAADIAQLHDELLEESVVAEIVDEYWPQLTPQDTLTSLLESQNMISTVAYDYDEETQEALWRQQGSPW
AASDAALLDELAVIIGVPDPEKERAEQEKAWREQIKDAQDALEILTGSANTDLDDESDAEILSAHDVIDAETLARRQEVR
DIRSTAQRAREDLAWAYGHVIVDEAQELTPMEWRMVMRRCPSRWMTLVGDTAQTSSPAGVDSWAEALEPFVSGRYVTHHL
TINYRTPAEIMEWANKVLHVFAPDAVGSTALRQSGTPVRFENSDAHAIEIAQKLRQDDPSRLTAIIGPDSMANNEIFGVS
DIKGLEYDHVVVTNPIDIVNGSPQGWQDLYVALTRATQSLCIIGDLPELS

Specific function: Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP [H]

COG id: COG3973

COG function: function code R; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 85876; Mature: 85876

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHSLFFHNNTKGTPSMKHPIDSISAEIEDEQAYVDKLFGKLDEEVVAANQRLNDVMLHV
CCEEEEEECCCCCCCCHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
DPANPDAEALVRRETEYHALNEKIDRLNIAQLGLVFGRIDVTAQRTDLIDNWVAGTDNVD
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHCCCCCCCH
RRYIGRMGLDDRQNDYRTLLLDWRAPLARPFYLATTAHPEGVLHRRHIRTQGRSVVGVDD
HHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCH
EVLSGVSAESAHSERADVVSETALYRAMCSARTGHMHSIVETIQREQDDIIRDPTRGVMV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
VEGGPGTGKTAVALHRVAYLLYTWRDQLAKTGVLIVGPNRSFLDYISRVLPELGETGVVL
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCCHH
STVGDLYPGISGTAVEDSLAREIKGSEEMVTVLRRLVQEYQQIPSEPFTIKIDGLELTVT
HHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEC
PDIVKKARTRARRSRRPHNEARPLFTEHLTELLSHQMADLIGADPMGGKNLLSAADIAQL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
HDELLEESVVAEIVDEYWPQLTPQDTLTSLLESQNMISTVAYDYDEETQEALWRQQGSPW
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHCCCCC
AASDAALLDELAVIIGVPDPEKERAEQEKAWREQIKDAQDALEILTGSANTDLDDESDAE
CCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
ILSAHDVIDAETLARRQEVRDIRSTAQRAREDLAWAYGHVIVDEAQELTPMEWRMVMRRC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHC
PSRWMTLVGDTAQTSSPAGVDSWAEALEPFVSGRYVTHHLTINYRTPAEIMEWANKVLHV
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHEEH
FAPDAVGSTALRQSGTPVRFENSDAHAIEIAQKLRQDDPSRLTAIIGPDSMANNEIFGVS
CCCCHHCHHHHHCCCCCEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEECCC
DIKGLEYDHVVVTNPIDIVNGSPQGWQDLYVALTRATQSLCIIGDLPELS
CCCCCCCCCEEEECCHHCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCC
>Mature Secondary Structure
MIHSLFFHNNTKGTPSMKHPIDSISAEIEDEQAYVDKLFGKLDEEVVAANQRLNDVMLHV
CCEEEEEECCCCCCCCHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
DPANPDAEALVRRETEYHALNEKIDRLNIAQLGLVFGRIDVTAQRTDLIDNWVAGTDNVD
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHCCCCCCCH
RRYIGRMGLDDRQNDYRTLLLDWRAPLARPFYLATTAHPEGVLHRRHIRTQGRSVVGVDD
HHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCH
EVLSGVSAESAHSERADVVSETALYRAMCSARTGHMHSIVETIQREQDDIIRDPTRGVMV
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
VEGGPGTGKTAVALHRVAYLLYTWRDQLAKTGVLIVGPNRSFLDYISRVLPELGETGVVL
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCCHH
STVGDLYPGISGTAVEDSLAREIKGSEEMVTVLRRLVQEYQQIPSEPFTIKIDGLELTVT
HHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEC
PDIVKKARTRARRSRRPHNEARPLFTEHLTELLSHQMADLIGADPMGGKNLLSAADIAQL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
HDELLEESVVAEIVDEYWPQLTPQDTLTSLLESQNMISTVAYDYDEETQEALWRQQGSPW
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHCCCCC
AASDAALLDELAVIIGVPDPEKERAEQEKAWREQIKDAQDALEILTGSANTDLDDESDAE
CCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
ILSAHDVIDAETLARRQEVRDIRSTAQRAREDLAWAYGHVIVDEAQELTPMEWRMVMRRC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHC
PSRWMTLVGDTAQTSSPAGVDSWAEALEPFVSGRYVTHHLTINYRTPAEIMEWANKVLHV
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHEEH
FAPDAVGSTALRQSGTPVRFENSDAHAIEIAQKLRQDDPSRLTAIIGPDSMANNEIFGVS
CCCCHHCHHHHHCCCCCEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEECCC
DIKGLEYDHVVVTNPIDIVNGSPQGWQDLYVALTRATQSLCIIGDLPELS
CCCCCCCCCEEEECCHHCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]